Growth factors – Page 2 – Communicable Diseases Research

Soluble CD137 as a potential biomarker for severe COVID-19

Article

Published on 2022-08-012022-10-05
Journal: Immunology letters [Category] 바이오마커,

Exploring the Immunomodulatory Aspect of Mesenchymal Stem Cells for Treatment of Severe Coronavirus Disease 19

중증 코로나바이러스 질환 치료를 위한 중간엽 줄기세포의 면역조절 측면 탐색 19

Review

Published on 2022-07-122022-09-11
Journal: Cells [Category] COVID19(2023년), SARS, 치료법,

[키워드] ACE-2 acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 administration affected Alpha alveolar epithelial cell alveolar epithelial cells angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-apoptotic Anti-inflammatory anti-oxidative aspect Asymptomatic average Betacoronavirus breathlessness cause cellular characterized chemokines chest pain Clinical outcome Clinical symptoms colony-stimulating factor coronavirus 2 COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients curative cytokine Cytokine storm Cytokine storms damaged dependent on Deterioration disease severity dry cough Effectiveness Effects elicited endothelial engage enzyme epithelial cells excessive inflammation family Coronaviridae fatigue Fever fibroblast fibroblast growth factor functional GCSF genus genus Betacoronavirus granulocyte granulocyte colony-stimulating factor growth factor Growth factors Health healthy histological IL-6 IL-7 IL-8 IL-9 immune cells immune response immune responses immunomodulation immunomodulatory immunomodulatory capabilities immunomodulatory capability Incubation period individual infected individual infected individuals infiltrating immune cells Inflammatory Inflammatory cytokines inflammatory protein inhalation Injury Intention interferon interleukin intravenous intravenous infusion Invasion IP10 lung Lungs Macrophage majority MCP1 Mesenchymal stem cells MIP1A mitigate monocyte monocyte chemotactic protein-1 MSC MSCs multitude myriad Necrosis organ PDGFB persistence Platelet platelet-derived growth factor positioned positive Protein receptor reduce respiratory Respiratory droplets RNA SARS-CoV-2 SARS-COV-2 infection secretion Secretome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sore throat STEM stem cell stem cells subunit supportive therapy symptomatic therapeutic therapy tissue TNF-α translational transmitted Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha undergo Vascular virus widespread
[DOI] 10.3390/cells11142175 PMC 바로가기 [Article Type] Review

Immunogenicity, Effectiveness, and Safety of Inactivated Virus (CoronaVac) Vaccine in a Two-Dose Primary Protocol and BNT162b2 Heterologous Booster in Brazil (Immunita-001): A One Year Period Follow Up Phase 4 Study

브라질에서 2회 용량 1차 프로토콜 및 BNT162b2 이종 부스터(Immunita-001)에서 비활성화된 바이러스(CoronaVac) 백신의 면역원성, 효과 및 안전성: 1년 기간의 후속 조치 4상 연구

Clinical Trial

Published on 2022-06-092022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-spike anti-Spike IgG anti-spike IgG antibodies Anti-spike IgG antibody antibody antibody levels Antibody titer Antibody titers approach association BNT162b2 booster booster dose Brazil Cellular immune response chemokines CoronaVac coronavirus COVID-19 COVID-19 pandemic Critical Cytokines Delta delta variant dose Effectiveness exposure to followed by growth factor Growth factors Heterologous heterologous booster highest IgG immune Immune profile immune response immunogenicity implication individual individuals Interaction maintenance male median mediators Neutralising Antibodies neutralising antibody no increase omicron Omicron variant pandemic Period phase 4 presenting protocol reduction remained respiratory restored robust Safe Safety SARS-CoV-2 Seropositivity severe acute respiratory syndrome Coronavirus significantly Spread timepoint titer titers vaccination Vaccine variant virus Year
[DOI] 10.3389/fimmu.2022.918896 PMC 바로가기 [Article Type] Clinical Trial

Timeline Kinetics of Systemic and Airway Immune Mediator Storm for Comprehensive Analysis of Disease Outcome in Critically Ill COVID-19 Patients

Article

Published on 2022-06-032023-07-09
Journal: Frontiers in Immunology [Category] COVID19(2023년),

[키워드] airway chemokines COVID Cytokines Growth factors immune mediators Prognostic biomarkers systemic
[DOI] 10.3389/fimmu.2022.903903 PMC 바로가기

Stem cell therapy for COVID-19 pneumonia

Review

Published on 2022-02-172022-10-30
Journal: Molecular Biomedicine [Category] COVID-19,

[키워드] acute respiratory distress syndrome ARDS Autoimmune disease build Cell chemokines chronic inflammation Complication complications conducted contagious coronavirus coronavirus 2 COVID-19 COVID-19 symptoms Cytokines diabetes disease effective fibrosis Growth factors Hematopoietic stem cell immune system immunomodulatory properties immunomodulatory property increase Infection modulate multiple sclerosis Mutation patients Pneumonia priming Protective rapid progress reduce regenerative researcher respiratory risk SARS-CoV-2 severe inflammation Side effect Spread stem cell stem cells therapy therapy for COVID-19 tissue regeneration Treatment virus
[DOI] 10.1186/s43556-021-00067-8 PMC 바로가기 [Article Type] Review

Role of SARS-CoV-2 -induced cytokines and growth factors in coagulopathy and thromboembolism

Review

Published on 2022-02-012023-07-07
Journal: Cytokine & growth factor reviews [Category] COVID19(2023년),

[키워드] Coagulopathy COVID-19 Cytokines Growth factors Inflammation platelet activation Thromboembolism
[DOI] 10.1016/j.cytogfr.2021.10.007 PMC 바로가기 [Article Type] Review

Association and predictive value of biomarkers with severe outcomes in hospitalized patients with SARS-CoV-2 infection

SARS-COV-2 감염이있는 입원 환자에서 심각한 결과를 가진 바이오 마커의 연관 및 예측 가치

Multicenter Study

Published on 2022-01-012022-08-31
Journal: Cytokine [Category] MERS, SARS, 바이오마커,

[키워드] Admission Analysis analyzed association Biomarker Biomarkers Blood urea nitrogen Chi-square chi-square tests Coagulation COVID-19 Critical care Cytokines Cytokines and inflammatory mediators D-dimer disease severity Factor frequencies Frequency Growth factors hematological hospitalized patient hyper-inflammation ICU IL-6 IMV in-hospital mortality Inflammation Inflammatory Inflammatory marker inflammatory markers Inflammatory mediators intensive care Invasive mechanical ventilation Kidney function Mann-Whitney U Mechanical mechanical ventilation Mortality multivariable logistic regression Multivariable logistic regression analysis nitrogen outcome outcomes PaO Patient patients hospitalized Platelet Platelet count predict Predictive reduced respiratory Respiratory function risk Risk factors SARS-COV-2 infection suffered the disease urea Ventilation was performed with COVID-19
[DOI] 10.1016/j.cyto.2021.155755 PMC 바로가기 [Article Type] Multicenter Study

A Deep Look Into COVID-19 Severity Through Dynamic Changes in Blood Cytokine Levels

혈액 사이토카인 수치의 동적 변화를 통한 COVID-19 심각성 심층 조사

Immunology

Published on 2021-11-092022-09-12
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단,

[키워드] Analysis can be used change chemokine comprehensive analysis Course COVID-19 COVID-19 patient cytokine cytokine release Cytokines deep disease disease severity dynamic excessive inflammatory response expand FIVE G-CSF GM-CSF groups Growth factors help hyperinflammation ICU identify IFN-α2 IL-10 IL-6 Immunity initial intensive care IP-10 large cohort Level longitudinal M-CSF marker MIG Mortality nine Patient patients with COVID-19 performed Peripheral blood predictor required SARS-CoV-2 severity severity predictors significantly higher significantly increased Stage symptom onset the disease therapy thought TNF-α two group
[DOI] 10.3389/fimmu.2021.771609 PMC 바로가기 [Article Type] Immunology

Endothelial Dysfunction through Oxidatively Generated Epigenetic Mark in Respiratory Viral Infections

Review

Published on 2021-11-072022-10-31
Journal: Cells [Category] COVID-19, SARS, 신종인플루엔자,

[키워드] addition alveolar epithelium antiviral drugs Blood blood flow changes in clinical care Control current Cytokines decrease disease distress edema effective Electrolytes endothelial endothelial cells Epigenetic fluids Gene Expression Growth factors host immune system immune cells implication Infection Influenza influenza H1N1 lack leukocyte macromolecule management MARK morbidity and mortality oxidative stress Oxygenation pathological change Patient pulmonary complications Pulmonary edema Pulmonary pathology regulate respiratory Respiratory distress syndrome Respiratory failure respiratory syncytial virus respiratory viral infection respiratory viral infections response risk RSV SARS-CoV-2 syndrome Treatment triggered Vascular Vascular endothelium viral genome viral infections
[DOI] 10.3390/cells10113067 PMC 바로가기 [Article Type] Review

CXCL10 levels at hospital admission predict COVID-19 outcome: hierarchical assessment of 53 putative inflammatory biomarkers in an observational study

입원 시 CXCL10 수준으로 COVID-19 결과 예측: 관찰 연구에서 추정되는 53개의 염증성 바이오마커에 대한 계층적 평가

Observational Study

Published on 2021-10-182022-09-10
Journal: Molecular Medicine [Category] MERS, SARS, 바이오마커, 임상,

[키워드] 95% CI Abstract age alarmins analysed Analysis approach AUC best Biomarker Biomarkers C-reactive protein C-reactive protein (CRP cART cause classification Combination Concentration confounding factors contribute COVID-19 COVID-19 patient COVID-19 severity predictors creatinine CXCL10 Cytokines data-driven death Decision tree determine discharge disease Growth factors healing Hierarchical hospital Hospital admission humoral hypoxia ICU identify Inflammation Inflammatory biomarker innate immune iron Iron metabolism Lactate lactate dehydrogenase LDH life-threatening lymphocyte metabolism Mild neuroendocrine neutrophil NLR outcome outcomes Patient Potential biomarker potential biomarkers predict Predictive prognostic Prognostic biomarkers Result risk Risk assessment robust SARS-COV-2 infection selected supplementary material survival survivor transfer was selected were used
[DOI] 10.1186/s10020-021-00390-4 PMC 바로가기 [Article Type] Observational Study