Genetically Engineered MRI-Trackable Extracellular Vesicles as SARS-CoV-2 Mimetics for Mapping ACE2 Binding In VivoArticle Published on 2022-08-232022-11-16 Journal: ACS Nano [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 receptor approach binding complex coronavirus event EVs Extracellular extracellular vesicle Genetic genetic engineering hazard in vivo Interaction interactions ligand−receptor binding mapping mechanism MRI Mutagenesis mutant pandemic pathogenic virus platform predicted Protein raised RBD Receptor binding domain Safe SARS-CoV-2 subjects superparamagnetic iron oxide nanoparticles (SPIONs) the RBD tissues variant virus virus mimetics. viruses [DOI] 10.1021/acsnano.2c03119 PMC 바로가기
SARS-CoV-2 antibodies and breakthrough infections in the Virus Watch cohortVirus Watch 코호트의 SARS-CoV-2 항체 및 획기적인 감염Article Published on 2022-08-182022-09-12 Journal: Nature Communications [Category] SARS, 진단, [키워드] 95% confidence interval anti-S anti-S antibody antibody BNT162b2 booster vaccination Breakthrough infection ChAdOx1 clinically Cohort Course Delta Effectiveness Efficacy Evidence geometric hazard higher risk Increasing individual Infection nine Older protective effect provide Ratio reduced risk risk risk of infection SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 vaccine second dose Support the timing total effect Vaccine [DOI] 10.1038/s41467-022-32265-5 PMC 바로가기 [Article Type] Article
Long-term cardiovascular outcomes in COVID-19 survivors among non-vaccinated population: A retrospective cohort study from the TriNetX US collaborative networksResearch article Published on 2022-08-112022-10-05 Journal: EClinicalMedicine [Category] 치료기술, [키워드] age Analysis arrhythmia Atrial fibrillation calculated cardiac disorders Cardiomyopathy cardiovascular disease Cardiovascular health Cardiovascular outcomes cerebrovascular diseases CIs Cohort conducted confidence controls COVID-19 COVID-19 test disease disorder disorders Elite endpoints female finding Follow-up Fund funding hazard heart failure Hospitalization HRs increased risk Infection Inflammatory initiated Inpatient interval male Mortality myocarditis network Non-COVID-19 outcome outcomes outpatients participant Patient performed Post-acute sequelae Probability Program public welfare recruited Research retrospective cohort study risk SARS-COV-2 infection SARS-CoV-2 testing scientist severity of COVID-19 Sex stratified stroke subgroup analysis survival survivor Survivors thromboembolic TriNetX two group [DOI] 10.1016/j.eclinm.2022.101619 [Article Type] Research article
2-deoxy-D-glucose as an adjunct to standard of care in the medical management of COVID-19: a proof-of-concept and dose-ranging randomised phase II clinical trialClinical Trial Published on 2022-08-042022-10-04 Journal: BMC Infectious Diseases [Category] SARS, 임상, [키워드] 2-deoxy-D-glucose 2-DG acute COVID-19 addition Administered adverse event age analyzed approach clinical benefit clinical recovery clinical study clinical trial conducted COVID-19 CTRI discharge dose efficacious therapeutic Efficacy Efficacy and safety evaluate evaluated hazard In-vitro intensive care Isolation limit management median metabolic inhibitor Mild moderate Mortality Negative conversion Normalisation Open-label outcomes Patient progression randomised randomised clinical trial Randomized receive reported RT-PCR SARS-CoV-2 severe COVID-19 severe COVID-19 patients shown significantly shorter standard care Standard of care time Tolerability treated Treatment Trial vital sign WHO [DOI] 10.1186/s12879-022-07642-6 PMC 바로가기 [Article Type] Clinical Trial
Presence of SARS-CoV-2 antibodies following COVID-19 diagnosis: a longitudinal study of patients at a major urgent care provider in New YorkCOVID-19 진단 후 SARS-CoV-2 항체의 존재: 뉴욕의 주요 긴급 진료 제공자의 환자에 대한 종단 연구Article Published on 2022-08-012022-09-11 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] 95% CI age Analysis antibody Antibody test Care care provider Clinical characteristics COVID-19 demographic and clinical characteristics Demographic factors detectable detectable anti-SARS-CoV-2 antibodies detectable anti-SARS-CoV-2 antibody diagnosed Diagnosis diagnostic examined hazard Infection less levels of antibody median natural infection New York older patient older patients Patient persistence Presence SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody Serological testing seroreversion study population survival survival analysis the median younger patients [DOI] 10.1016/j.diagmicrobio.2022.115720 PMC 바로가기 [Article Type] Article
Efficacy and effectiveness of SARS-CoV-2 vaccines for death prevention: A protocol for a systematic review and meta-analysis사망 예방을 위한 SARS-CoV-2 백신의 효능 및 효과: 체계적인 검토 및 메타 분석을 위한 프로토콜Article Published on 2022-07-282022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, meta-analysis, SARS, [키워드] adverse event all-cause mortality analyzed approved assessment Bia calculated case-control studies case-control study Cohort controlled trials COVID-19 death deaths effective Effectiveness Efficacy Egger eligible Evidence exploratory for inclusion forest plot forest plots funnel plot hazard hazard ratios heterogeneity Hospitalization incident independent intervals Intervention Meta-analysis Mortality Observational data outcome Placebo Prevent Primary outcome PROSPERO protocol Publication bia publication bias randomized control trial Randomized controlled trials RCT Record reducing Registered risk reduction SARS-CoV-2 vaccine SARS-CoV-2 vaccines Secondary outcomes Severe case severe cases statistical statistical test systematic review the vaccine the vaccines university vaccination Vaccination Status Vaccine visual inspection York [DOI] 10.1371/journal.pone.0265414 PMC 바로가기 [Article Type] Article
Estimation of vaccine efficacy for variants that emerge after the placebo group is vaccinated위약군 백신 접종 후 나타나는 변이체에 대한 백신 효능 추정Article Published on 2022-07-202022-09-11 Journal: Statistics in medicine [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] approach assumption clinical trial Cox regression demonstrated develop distribution Effects Efficacy estimation evaluate Follow-up hazard illustration misspecification Observational data Placebo placebo group Poisson proportion proportional hazards model proportions Randomized rare disease reflect SARS-CoV-2 Sensitivity analyses sensitivity analysis sieve analysis strain Strains Surveillance surveillance data the placebo group the vaccine vaccination Vaccine vaccine efficacy vaccine trial variant variants [DOI] 10.1002/sim.9405 PMC 바로가기 [Article Type] Article
Interleukin-6 inhibitors reduce mortality in coronavirus disease-2019: An individual patient data meta-analysis from randomized controlled trialsInterleukin-6 억제제는 코로나바이러스 질병-2019의 사망률을 감소시킵니다: 무작위 대조 시험의 개별 환자 데이터 메타 분석Meta-Analysis Published on 2022-07-012022-09-11 Journal: European journal of internal medicine [Category] 임상, [키워드] 95%CI age Analysis confidence confidence interval coronavirus COVID-19 COVID-19 patients data extraction database death discharge discharge rate Efficacy eligible hazard hazard ratio hospitalized COVID-19 patient hospitalized COVID-19 patients IL-6 IL-6 inhibitor IL-6 inhibitors individual inhibitor inhibitors Inteleukin-6 intubation Kaplan-Meier curve meta-analyses Meta-analysis outcome Patient patient data patients Randomized control trials Randomized controlled trial randomized trial randomized trials Ratio RCTs reduce reduce mortality risk risk of death significantly SOC. Standard of care synthesis systematic review the mean the MEDLINE Trial two group two groups was performed [DOI] 10.1016/j.ejim.2022.04.004 PMC 바로가기 [Article Type] Meta-Analysis
Clinical characteristics, risk factors, and rate of severity of a nationwide COVID-19 Saudi cohortResearch article Published on 2022-07-012022-10-05 Journal: Saudi Journal of Biological Sciences [Category] 임상, [키워드] 95% CI age Analysis baseline Characteristics clinical Clinical characteristics clinical factor Clinical severity Cohort Comorbidity COVID-19 COVID-19 case COVID-19 patients COVID-19 severity COVID19 COVID19 patient death rate Deceased demographic characteristics demographics Dexamethasone Diabetes Mellitus Elderly patient evaluate Favipiravir female patient Gender hazard highest Hospital stay Hospitalization Hospitalized hospitalized patient hypertension increased risk indicate Invasive mechanical ventilation invasive respiratory support Jeddah lymphocyte male Male sex medications Mortality multivariate logistic regression neutrophil obesity objective Odds ratio oxygen participant Patient prevalent prospective cohort study recruited required Result Risk factors Saudi Arabia severity stratified [DOI] 10.1016/j.sjbs.2022.103315 [Article Type] Research article
Tocilizumab effectiveness in mechanically ventilated COVID-19 patients (T-MVC-19 Study): a multicenter real-world evidence기계적으로 환기되는 COVID-19 환자에 대한 토실리주맙 효과(T-MVC-19 연구): 다기관 실제 세계 증거Multicenter Study Published on 2022-07-012022-09-12 Journal: Expert review of anti-infective therapy [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome Admission Analysis conducted confidence interval control arm coronavirus coronavirus disease COVID-19 COVID-19 patient diagnosed effective Effectiveness Endpoint evaluate Evidence hazard hazard ratio Invasive mechanical ventilation inverse majority mechanical ventilation mechanically ventilated mechanically ventilated patient Mortality multicenter Nasopharyngeal swab on mechanical ventilation participant Patient polymerase chain propensity score matching PSM reducing mortality reduction in mortality Research design Retrospective multicenter study risk RT-PCR SARS-CoV-2 Tocilizumab treated Treatment was performed Weighting [DOI] 10.1080/14787210.2022.2046462 PMC 바로가기 [Article Type] Multicenter Study