Low-Dose Fluvoxamine Modulates Endocytic Trafficking of SARS-CoV-2 Spike Protein: A Potential Mechanism for Anti-COVID-19 Protection by AntidepressantsPharmacology Published on 2021-12-162022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 antidepressant antidepressants Cell complex Concentration COVID-19 diversion Drug repurposing endocytosis endosomal trafficking Endosomes fluvoxamine HEK293T cells highlighting host receptor investigated mechanism membrane Potential Prophylactic protection protective effect provide resulting SARS-CoV-2 severe COVID-19 spike Spike protein the SARS-CoV-2 therapeutic upregulated [DOI] 10.3389/fphar.2021.787261 PMC 바로가기 [Article Type] Pharmacology
Indian Herb-Derived Phytoconstituent-Based Antiviral, Antimicrobial and Antifungal Formulation: An Oral Rinse Candidate for Oral Hygiene and the Potential Prevention of COVID-19 OutbreaksArticle Published on 2021-09-022022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acute respiratory syndrome Antifungal antimicrobial Antiviral Antiviral agents antiviral drugs Asparagus Bacopa Bacterial candidate Chrysophanol circulating coronavirus Coronavirus-2 COVID-19 decrease effective Effectiveness FIVE gallic acid gargle growth Health HEK293T cells horizontal transmission inactivation Infectious disease ingredient inhibit lentiviral lung mammalian Mouthwash Multiple natural herb Nigella Sativa novel oral pandemic Phytoconstituents Plasmid Potential prevention question raising reduce reduced reducing respiratory viral infections rhein risk SARS-CoV-2 shedding susceptible Symptom tested topical treated Treatment triggered Vaccine variants of SARS-CoV-2 Viral load Viral transmission virucidal virus yeast cell [DOI] 10.3390/pathogens10091130 PMC 바로가기 [Article Type] Article
Characterization of SARS-CoV-2 worldwide transmission based on evolutionary dynamics and specific viral mutations in the spike protein스파이크 단백질의 진화 역학 및 특정 바이러스 돌연변이를 기반으로 한 SARS-CoV-2 전 세계 전파 특성Research Article Published on 2021-08-212022-09-10 Journal: Infectious Diseases of Poverty [Category] MERS, SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome affinity angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antibody test antigenicity appear binding affinity caused characterization China clade Cluster Clustering composed coronavirus disease Coronavirus disease 2019 Coronavirus-2 country COVID-19 COVID-19 pandemic E484K early stage enzyme evolutionary dynamics facilitate followed by Frequency full-length GISAID database HEK293T cell HEK293T cells immune evasion independent information isolate isolates Italy Japan Malaysia mutants mutated Mutation neutralizing antibody pandemic predicted pseudovirus pseudoviruses R package Receptor-binding domain respiratory Result S477N SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 pseudovirus SARS-CoV-2 pseudoviruses SARS-CoV-2 strain SARS-CoV-2 strains sequence Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus Severe acute respiratory syndrome-related coronavirus-2 significantly Singapore Spike protein supplementary material tested the binding affinity the receptor-binding domain the spike protein Transmission transmission of SARS-CoV-2 USA V367F Viral viral infectivity viral mutation wild-type counterpart [DOI] 10.1186/s40249-021-00895-4 PMC 바로가기 [Article Type] Research Article
No evidence of human genome integration of SARS-CoV-2 found by long-read DNA sequencing긴 판독 DNA 시퀀싱으로 SARS-CoV-2의 인간 게놈 통합 증거 없음Comparative Study Published on 2021-08-172022-09-11 Journal: Cell Reports [Category] SARS, 치료기술, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 applied arising clinical implications coronavirus COVID-19 DNA DNA sequencing event Evidence evidence of experiment explain Genome HBV HEK293T HEK293T cell HEK293T cells Hepatitis hepatitis B Hepatitis B virus Human genome in vitro in vivo infected cells infected with SARS-CoV-2 insertion L1 LINE-1 Liver cancer no evidence of oncogenesis ONT overexpression Oxford Nanopore Technology retrotransposon retrotransposon. SARS-CoV-2 Sequencing severe acute respiratory syndrome Coronavirus tissue unlikely virus [DOI] 10.1016/j.celrep.2021.109530 PMC 바로가기 [Article Type] Comparative Study
DNA vaccination induced protective immunity against SARS CoV-2 infection in hamsterssResearch Article Published on 2021-05-272022-10-28 Journal: PLoS Neglected Tropical Diseases [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome analyses analyzed antibody antigen-specific antibody approach binding blocked cloned collected coronavirus COVID-19 COVID-19 epidemic COVID-19 pandemic COVID-19 vaccine demonstrated DNA DNA vaccine Efficacy Electroporation elicited entry receptor expression expression vectors global public health hamster hamsters Health HEK293T cells humoral immune response immunization in vivo inactivated induce Infection levels of antibody long-lasting mammalian cell neutralizing antibody Neutralizing antibody titer outbreak pandemic Protective protective effect protective immunity Protein respond SARS CoV-2 SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 S SARS-CoV-2 vaccine sera serum antibody Side effects spike gene Spike protein Spike protein expression suggested T cell response Th1 Th1-biased immune response the receptor-binding domain the SARS-CoV-2 transient expression vaccination Vaccine virus [DOI] 10.1371/journal.pntd.0009374 PMC 바로가기 [Article Type] Research Article
The rapid diagnosis and effective inhibition of coronavirus using spike antibody attached gold nanoparticles †Chemistry Published on 2021-01-182022-10-31 Journal: Nanoscale Advances [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome aggregates aggregation angiotensin-converting enzyme 2 anti-spike antibody antibody Antigen baculovirus binding cell receptors Concentration coronavirus coronavirus disease COVID-19 death detect Diagnosis effective Express Gold nanoparticle HEK293T cells human cells Infection inhibit inhibiting Interaction interactions membrane observation probe pseudotyped Raman spectroscopy rapid diagnostic assay reported reporter responsible SARS-CoV-2 SARS-CoV-2 spike protein Spread undergo Vaccine Viral antigen virus virus infection virus particle virus particles [DOI] 10.1039/d0na01007c PMC 바로가기 [Article Type] Chemistry
Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaborationResearch Article Published on 2020-10-262022-10-31 Journal: eLife [Category] COVID-19, SARS, [키워드] ACE-2 ACE2 ACE2 receptor applied approach binding blocked blocking both virus Brain carbohydrate caused Cell cells changes complex COVID-19 CRISPR-Cas9 Critical disrupt domain evaluated examined experiment expressed expressing furin Genetic glycan glycans glycoprotein glycoscience glycosylated glycosylation HEK293T cells helping highlight Host host cells Human human kidney human protein illnesses infect Infectious disease inhibition inhibitor interfere kidney kifunensine Laboratory less Lungs modify post-translational modification Protein RBD receptor ACE2 reduce reduced Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 viral spike spike-ACE2 stick Structure sugar sugar molecule the Spike treat Treatment Vaccines viral entry virus [DOI] 10.7554/eLife.61552 PMC 바로가기 [Article Type] Research Article
Tea Polyphenols EGCG and Theaflavin Inhibit the Activity of SARS-CoV-2 3CL-Protease In VitroResearch Article Published on 2020-09-162022-10-31 Journal: Evidence-based Complementary and Alternative Medicine : eCAM [Category] COVID-19, [키워드] activity addition caused cleavage Concentration COVID-19 cytotoxicity death demonstrated dose-dependent manner effective EGCG functional global pandemic HEK293T cells ingredient inhibit SARS-CoV-2 inhibitory activity inhibitory concentration observé polyphenol polyprotein Protein responsible SARS-CoV-2 Spread tea tested the SARS-CoV-2 theaflavin treat Treatment Vaccine virus [DOI] 10.1155/2020/5630838 PMC 바로가기 [Article Type] Research Article