Treatment of SARS-CoV-2-induced pneumonia with NAD+ and NMN in two mouse models Research Published on 2022-04-292022-10-05 Journal: Cell Discovery [Category] 유전자 메커니즘, [키워드] caused cell death COVID-19 epidemic COVID-19 patients death develop dysregulation effect of treatment effective strategy Gene Expression Hemolysis immune response in vivo inflammatory cell infiltration investigated lung metabolism mice mouse model mouse-adapted SARS-CoV-2 NAD+ pathway Phenotypes Pneumonia PROTECT rescued SARS-COV-2 infection significantly Spread Support suppressed treat treating COVID-19 patient Trial [DOI] 10.1038/s41421-022-00409-y [Article Type] Research
Pegcetacoplan for paroxysmal nocturnal hemoglobinuriaResearch article Published on 2022-03-292022-10-05 Journal: Blood [Category] 비임상, [키워드] Anemia approach clinical study complement Complement inhibitor derivatives effective Hemolysis inhibit inhibitor paroxysmal nocturnal hemoglobinuria Patient resulting Sequencing symptomatic Treatment [DOI] 10.1182/blood.2021014868 [Article Type] Research article
Performance evaluation of an automatic chemiluminescence immune platform for SARS-CoV-2 neutralizing antibody after vaccination in real worldSARS-COV-2를위한 자동 화학 발광 면역 플랫폼의 성능 평가 현실에서 예방 접종 후 항체Research Published on 2022-02-152022-09-01 Journal: BMC Infectious Diseases [Category] COVID19(2023년), Fulltext, MERS, SARS, 진단, [키워드] Adolescent BBIBP-CorV changes in Characteristics chemiluminescence China CLIA Cohort CoronaVac doses evaluated exceeded Follow-up followed by Hemolysis high correlation icterus immune immunity after vaccination immunoassays inactive injection inoculation investigated less linearity lipemia measure Neutralizing activity Neutralizing antibodies neutralizing antibody objective occurred performance Physical examination Plaque reduction neutralization test platform predominant PRNT Real world recipient recruited repeatability Result robust SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 vaccine schedule Sensitivity and specificity Serological assay serological assays seropositive Shenzhen significantly lower Sinovac strength Trial vaccination Vaccination Status Vaccinations Vaccine Variation volunteers [DOI] 10.1186/s12879-022-07141-8 PMC 바로가기 [Article Type] Research
Red Blood Cell Abnormalities as the Mirror of SARS-CoV-2 Disease Severity: A Pilot StudyPhysiology Published on 2022-01-202022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] abnormality activate Admission age Analysis Anemia apoptotic association biochemical Blood calcium ion Care caspase-3 Cell cell clearance Chest Chest CT chest infiltration coagulation analysis component Concentration Control control group controls correlated COVID-19 COVID-19 disease COVID-19 patients dehydrogenase demographic Diagnosis disease disease severity distribution Effect elevated enzyme erythrocyte evaluated exhibited expressed feature flow cytometry free hemoglobin G6PD G6PDH H b healthy controls healthy subject healthy volunteer hemoglobin Hemolysis hepatic impairment hospitalized patient hypoxia IgG IgGs Immunoglobulin infiltration Intracellular Laboratory LDH Lung function male malignancy marker material mechanical stress mechanism membrane-bound Mirror osmotic oxidative pathophysiology Patient patients performed Peripheral blood Phosphatidylserine pilot study plasma Protein pulmonary CT pulmonary infiltrate RBC RBCs reactive Red red blood cell renal Result ROS SARS-CoV-2 SARS-COV-2 infection senescent serum severe COVID-19 disease severity significant effect significantly significantly lower the disease the mean the patient the SARS-CoV-2 thrombotic Treatment virus was used were measured were recorded with COVID-19 [DOI] 10.3389/fphys.2021.825055 PMC 바로가기 [Article Type] Physiology
Computational study, synthesis and evaluation of active peptides derived from Parasporin-2 and spike protein from Alphacoronavirus against colorectal cancer cellsCancer Published on 2021-12-222022-10-28 Journal: Bioscience Reports [Category] Coronavirus, [키워드] 5-FU activated active against alphacoronavirus anticancer anticancer peptides binding Cancer cells Cell cells characterized Circular Colon cancer Colorectal cancer computational simulations Concentration Evidence exhibited experiments Fmoc synthesis HCoV-229E Hemolysis hemolytic activity human APN Interaction intrinsic apoptosis investigated kDa less mechanism of action molecular docking Parasporin PS2Aa1 peptide produced Protein receptor shown significantly lower Spike protein these compound Toxicity virus spike protein α-helix [DOI] 10.1042/BSR20211964 PMC 바로가기 [Article Type] Cancer
Synthesis, Molecular Docking and Antiplasmodial Activities of New Tetrahydro-β-Carbolines신합성, 분자 도킹 및 새로운 테트라하이드로-β-카르볼린의 항말라리아 활성이미지Communication Published on 2021-12-172024-08-08 Journal: International Journal of Molecular Sciences [Category] 말라리아, [키워드] Plasmodium falciparum (P. falciparum) antimalarial Antiparasitic agents cytotoxicity Hemolysis molecular docking tetrahydro-β-carbolines [DOI] 10.3390/ijms222413569 PMC 바로가기 [Article Type] Communication
COVID-19 and Immune-Mediated RBC Destruction A Systematic ReviewArticle Published on 2021-12-172023-06-16 Journal: American journal of clinical pathology [Category] COVID19(2023년), MERS, SARS, [키워드] autoimmune hemolytic anemia Cold agglutinin disease COVID-19 Hemolysis SARS-CoV-2 SARS-CoV-2 vaccine [DOI] 10.1093/ajcp/aqab210 PMC 바로가기
First diagnosis of thrombotic thrombocytopenic purpura after SARS-CoV-2 vaccine – case reportCase Report Published on 2021-12-112022-10-28 Journal: BMC Nephrology [Category] COVID-19, SARS, [키워드] Acute kidney injury addition Admission alteration antibody Case report Corticosteroid COVID-19 vaccines described Diagnosis diagnostic differential diagnosis disintegrin dose excluded Fever Final first dose first symptom headache Hematuria Hemolysis hemolytic anemia immune initial initiated malaise male Mild Moderna motif mRNA-1273 mRNA-based nausea neurological normalized pathophysiological Patient petechial bleeding plasma exchange Platelet purpura receive receiving reported resolved SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine Symptom the patient therapy thrombocyte thrombocytopenia thrombotic Thrombotic thrombocytopenic Thrombotic thrombocytopenic purpura USA vaccination Vaccine Vaccines vomiting while [DOI] 10.1186/s12882-021-02616-3 PMC 바로가기 [Article Type] Case Report
A Case of Coombs-Negative Hemolytic Anemia Prompting Diagnosis of SARS‐CoV‐2Internal Medicine Published on 2021-11-302022-10-31 Journal: Cureus [Category] COVID-19, [키워드] - hematology acute respiratory syndrome antiglobulin test Case report caused coombs' negative coronavirus coronavirus disease Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 illness COVID-19 patient COVID-19 treatments help Hemolysis hemolytic hemolytic anaemia hemolytic anemia Patient positive presenting reported SARS-CoV-2 SARS‐CoV‐2 supportive care Treatment [DOI] 10.7759/cureus.20034 PMC 바로가기 [Article Type] Internal Medicine
Autoimmune Cytopenias and Covid-19 Vaccination: Relapse and Suggested TreatmentConference abstract Published on 2021-11-232022-10-05 Journal: Blood [Category] 치료법, [키워드] Adult patient Anemia anemic autoantibody Autoimmune Autoimmune disease autoimmune thrombocytopenia B cells Blood circulating Complete Course COVID-19 cytopenia described develop Dexamethasone disease Evan FIVE full recovery hematological hematology hemoglobin Hemolysis hemolytic anemia High dose Immune complexes include induce material molecular Older Pathogenesis pathway Patient patients patients with COVID-19 Platelet reached Relapse response SARS-CoV2 Support Symptom syndrome Treatment Two patient vaccination Vaccine viral infection Viral protein [DOI] 10.1182/blood-2021-145532 [Article Type] Conference abstract