Vaccines based on the replication-deficient simian adenoviral vector ChAdOx1: Standardized template with key considerations for a risk/benefit assessmentResearch article Published on 2022-08-012022-10-05 Journal: Vaccine [Category] COVID19(2023년), SARS, 비임상, [키워드] adenoviral vector Adenovirus administration Antigen approved assessment benefit Benefit/Risk booster capillary leak syndrome cell line Cellular immune response ChAdOx1 circumvent clinical evaluation clinical trial collaboration conducted COVID-19 COVID-19 vaccination Deletion dose effective Emergency use authorization evaluate evaluated expressing Extensive feature fevers Genetic Guillain-barrè syndrome Hemorrhagic HIV humoral immune response Immune thrombocytopenia impair Influenza key consideration malaria manuscript MERS-CoV New Nipah virus Oxford-AstraZeneca platform pre-existing immunity Prophylactic Prostate cancer Replication reported risk Safety SARS-CoV-2 Serious Adverse Event serotype surveillance data syndrome therapeutic thrombosis Tuberculosis University of Oxford Vaccine Vaccine development Vaccines vectored vaccine virus Zika [DOI] 10.1016/j.vaccine.2022.06.008 [Article Type] Research article
Defibrotide Therapy for SARS-CoV-2 ARDSClinical Trial Published on 2022-08-012022-10-04 Journal: Chest [Category] COVID19(2023년), SARS, 임상, [키워드] 95% CI Administered adverse event age all-cause mortality antiinflammatory Antithrombotic ARDS baseline bleeding Course COVID-19 D-dimer D-dimer level Day decrease defibrotide defibrotide. died dysregulation Endothelial dysfunction fibrinolytic Hemorrhagic high mortality rate initial limit management mechanical ventilation median median age occurred Older Open-label outcome parameter participant pathway Patient patient population patients died polymerase chain positive pulmonary disease Radiographic receiving reported Respiratory function Safe SARS-CoV-2 SARS-CoV-2 ARDS serum severe SARS-CoV-2 single-center survived therapy thrombotic complication Tolerability tolerable treated Trial vasopressor support [DOI] 10.1016/j.chest.2022.03.046 PMC 바로가기 [Article Type] Clinical Trial
Bleeding Complications in Patients With Perioperative COVID-19 Infection Undergoing Cardiac Surgery: A Single-Center Matched Case-Control StudyObservational Study Published on 2022-07-012022-10-05 Journal: Journal of cardiothoracic and vascular anesthesia [Category] 임상, [키워드] age bleeding Blood blood component body mass index cardiac Cardiac surgery Cardiopulmonary cardiopulmonary bypass Case-control chest tube Coagulation system Complication complications consecutive patient Control control group coronavirus Coronavirus 2019 correlation COVID-19 COVID-19 infection COVID-19 patient Deleterious described deviate diagnosis of COVID-19 died exacerbate Hemorrhagic Hemostasis incidence increased risk Infection inflammatory reaction intensive care intensive care unit Matched measurement multiple organ failure Non-COVID-19 patients operative risk outcome Patient patients without COVID-19 Perioperative positive postoperative previous study renal reported Respiratory failure retrospective severe respiratory failure Sex Shock significantly higher Society study group study period surgical the study group Thromboembolic events [DOI] 10.1053/j.jvca.2021.11.013 PMC 바로가기 [Article Type] Observational Study
Encephalopathy as a prognostic factor in adults with acute disseminated encephalomyelitis following COVID-19COVID-19에 따른 급성 파종성 뇌척수염 성인의 예후 인자로서의 뇌병증Case Reports Published on 2022-05-012022-09-11 Journal: Journal of Neurology [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI absence Acute disseminated encephalomyelitis Acute necrotizing hemorrhagic leukoencephalitis ADEM affected ANHLE cerebrospinal fluid Clinical outcome clinical variable clinical variables COVID-19 Descriptive analysis Disseminated encephalomyelitis Encephalomyelitis Encephalopathy females Hemorrhagic Hemorrhagic Leukoencephalitis Infection Logistic regression median age morbidity and mortality Mortality Neurological symptoms Numerous observation Occurrence other variable other variables outcomes Patient patients performed predict Prognostic factor Prognostic factors proportion retrospective SARS-CoV-2 SARS-COV-2 infection Support Treatment variant worse prognosis [DOI] 10.1007/s00415-021-10947-2 PMC 바로가기 [Article Type] Case Reports
Stop of proton-pump inhibitor treatment in patients with liver cirrhosis (STOPPIT): study protocol for a prospective, multicentre, controlled, randomized, double-blind trial간경변 환자에서 양성자 펌프 억제제 치료 중단(STOPPIT): 전향적, 다기관, 대조, 무작위, 이중 맹검 시험을 위한 연구 프로토콜Article Published on 2022-04-122022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 bleeding bleeding event cirrhosis clinical Clinical outcome clinical outcomes clinical trial complications composite endpoint control group death defined Diagnosis double-blind trial double-blinded Effect Endpoint Esomeprazole EU Clinical Trials EudraCT evaluate excluded gastritis gastrointestinal bleeding Germany Hemorrhagic hepatic Hepatic encephalopathy Hospitalization Hospitalized Hypothesis IMPROVE include increased risk indication infections Infectious complications inhibitor intervention group intestinal liberal liver Liver cirrhosis liver failure manifestation medication microbiota Mortality multicentre observational studies observational study Occurrence outcome Pantoprazole parallel-group Patient peptic ulcer Placebo placebo-controlled PPI primary composite endpoint Prophylactic Proton-pump inhibitors Randomized rationale receive recruitment reflux esophagitis Registered risk secondary Secondary endpoints Side-effects STOP Study protocol therapy Treatment Trial variable Withdrawal [DOI] 10.1186/s13063-022-06232-w PMC 바로가기 [Article Type] Article
The development of broad-spectrum antiviral medical countermeasures to treat viral hemorrhagic fevers caused by natural or weaponized virus infectionsReview Published on 2022-03-082022-10-28 Journal: PLoS Neglected Tropical Diseases [Category] COVID-19, [키워드] acute viral infection animal animal challenge studies anticipated Antiviral antiviral activity approval approved Biological breadth caused CFR Chemical clinical clinical benefit clinical development clinical evaluation clinical study conducted coronavirus 2 COVID-19 development disease drug drugs targeting Ebola Ebola virus Ebola virus disease Efficacy effort enzyme Evidence examined example facilitated FDA feasible Fever filoviruses food GS-5734 Hemorrhagic high-consequence pathogen highlight Hospitalization humans include Infection infectious agents inhibitor Laboratory testing Level 4 mechanism medical countermeasure NHP NHPs numbers of patient office outbreak outcome pandemic pathogen pathway Patient performed Prevent Program randomized clinical trials randomized, controlled trial RCTs Regulatory regulatory pathway Remdesivir Research respiratory RNA virus RNA-dependent RNA polymerase robust rule Safe SARS-CoV-2 severe disease Support therapeutic therapy treat Treatment Trial Vaccine viral infection viral pathogen viral replication virus virus infection while [DOI] 10.1371/journal.pntd.0010220 PMC 바로가기 [Article Type] Review
The case of fatal acute hemorrhagic necrotizing encephalitis in a two-month-old boy with Covid-19코로나19에 걸린 2개월 남아의 치명적인 급성 출혈성 괴사성 뇌염 1례Case Reports Published on 2022-03-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] acute infection Agitation apathy basal ganglia Brain Brain death brain MRI Brainstem change Child children COVID-19 CSF death Diagnosis elevated Encephalitis Fever ganglia Gray matter healthy healthy children hemorrhages Hemorrhagic Infants Infection intubation irritability lactic acid life-threatening male manifestation nasal swab natural history neurological neurological manifestation neurological manifestations nystagmus oedema outcome PCR pediatric pleocytosis Protein punctate hemorrhage reported required respiratory tract infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 Support transferred withdrawn [DOI] 10.1016/j.ijid.2021.12.334 PMC 바로가기 [Article Type] Case Reports
Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19Randomized Controlled Trial Published on 2022-03-012022-10-05 Journal: JAMA Network Open [Category] 임상, [키워드] 95% CI adults hospitalized African American age Asian Aspirin benefit Blood calculated cerebral hemorrhage Characteristics Cohort cohort study Complication conditions COVID COVID-19 Efficacy enrolled evaluate gastrointestinal hemorrhage groups health system Hemorrhagic Hospitalization Hospitalized hospitalized patient in-hospital mortality include inverse IQR logistic regression models Moderate COVID-19 Mortality observational study occur occurred Odds ratio outcome Patient patients patients older patients with comorbidity patients with moderate Primary outcome Probability randomized clinical trial receiving reduce reduced screened secondary outcome significantly lower study inclusion the United State thrombosis Treatment was used Weighting white with COVID-19 [DOI] 10.1001/jamanetworkopen.2022.3890 PMC 바로가기 [Article Type] Randomized Controlled Trial
Study of Alteplase for Respiratory Failure in SARS-CoV-2 COVID-19: A Vanguard Multicenter, Rapidly Adaptive, Pragmatic, Randomized Controlled TrialClinical Trial Published on 2022-03-012022-10-05 Journal: Chest [Category] SARS, 임상, [키워드] activated alteplase ARDS baseline benefit bleeding event Brain Combination control group Controlled COVID-19 cross-sectional early administration eight Enrollment failure fibrinolysis Hemorrhagic IMPROVE Improvements improvements in oxygenation in-hospital mortality IQR maintain mechanism microthrombi Mortality neurologic observation occurred outcome Participants Patient patients Phase 1 Phase 2 phase 3 study Primary outcome pulmonary pulmonary failure Pulmonary function randomization Randomized receiving respiratory Respiratory failure Safe SARS-CoV-2 secondary severe COVID-19 significantly Standard-of-care statistically significant difference stroke therapeutic tissue plasminogen activator Tissue plasminogen activator (tPA) Treatment Vascular ventilator-free day VFD were excluded [DOI] 10.1016/j.chest.2021.09.024 PMC 바로가기 [Article Type] Clinical Trial
An integrative review of oral manifestations in patients with COVID-19: signs directly related to SARS-CoV-2 infection or secondary findings?COVID-19 환자의 구강 증상에 대한 통합 검토: SARS-CoV-2 감염과 직접 관련된 징후 또는 이차 소견?Review Published on 2022-03-012022-09-12 Journal: International journal of dermatology [Category] MERS, SARS, 진단, [키워드] affected article association carried conducted current database described diagnosed differential diagnosis Evidence exclusion criteria Hemorrhagic histopathological immunohistochemistry Inclusion lesion lesions longitudinal study manifestation Manifestations molecular MOST mucositis oral mucosa other COVID-19 symptoms Patient patients patients with COVID-19 positive reported SARS-COV-2 infection SARS-CoV-2 test tongue virus [DOI] 10.1111/ijd.15881 PMC 바로가기 [Article Type] Review