Metabolic biomarkers related to cardiac dysfunction in metabolic-dysfunction-associated fatty liver disease: a cross-sectional analysisArticle Published on 2022-01-182022-10-04 Journal: Nutrition & Diabetes [Category] 바이오마커, [키워드] 95% CI age Analysis average Biomarker cardiac cardiovascular diseases cardiovascular risk Cer ceramide conducted confounding factor confounding factors controls correlated cross-sectional cross-sectional analysis Decreased diastolic disease distribution dysfunction Effect Ejection fraction Endocrine system and metabolic diseases evaluated Fatty liver females Gender GLS hepatic IQR LVEF male material median age metabolic metabolite Multiple linear regression P -value participant Patient reduced remained Result risk significantly steatosis tyrosine ventricular [DOI] 10.1038/s41387-022-00182-7 PMC 바로가기 [Article Type] Article
Evaluation of Hepatic Biochemical Parameters during Antiviral Treatment in COVID-19 PatientsArticle Published on 2021-12-232022-10-28 Journal: Biology [Category] COVID-19, [키워드] addition Admission affecting Alter analyzed Antigen Antiviral antiviral therapy Antiviral treatment antivirals biochemical cholestasis clinical Clinical practice Combination Community complex coronavirus COVID-19 COVID-19 disease diagnosed discharge drug evaluate Evolution hepatic hepatic parameters Hospitalization identify information Kaletra liver Liver damage liver enzyme Liver function Lopinavir/ritonavir observé Occurrence parameter Patient patients patients hospitalized produced producing Registered Repurposed drugs Romania RT-PCR SARS-CoV-2 viral infection SARS-CoV-2 virus Side effects Side-effect simple slight increase statistically target the disease the mean the SARS-CoV-2 virus therapeutic therapy treat treated Treatment [DOI] 10.3390/biology11010013 PMC 바로가기 [Article Type] Article
Biliary atresia in a neonate with a history of COVID-19: A case reportCase Report Published on 2021-12-202022-10-30 Journal: International Journal of Surgery Case Reports [Category] COVID-19, [키워드] alkaline phosphatase ALT atresia Biliary Biliary atresia Case report clinical complications concerning contribute contributed COVID-19 COVID-19 disease COVID-19 infection COVID-19 testing demonstrated develop diagnosed diagnosis of COVID-19 disease elevated emesis etiology female hepatic heterogenous hospital icterus Inflammation Kasai Laboratory testing Liver damage Liver injury Neonatal Novel coronavirus novel coronavirus SARS-CoV-2 obliterative outcomes Patient positive presenting quarantine respiratory symptoms scleral shown suggested tested Trigger virus [DOI] 10.1016/j.ijscr.2021.106705 PMC 바로가기 [Article Type] Case Report
Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsuleLianhuaqingwen Capsule을 투여 한 후 글리 시르 시리 사르 우랄 렌 시스 뿌리 (Gancao)에서 유래 한 슈도 알로 스테 겐 화합물의 약동학 적 식별Clinical Trial Published on 2021-12-012022-08-31 Journal: Acta pharmacologica Sinica [Category] 바이오마커, 임상, 치료제, [키워드] 11β-hydroxysteroid dehydrogenase 2 24-hydroxyglycyrrhetic acid access acid activated bile characterized China circulating metabolite colonic colonic microbiota Combination component components Compound condition COVID-19 COVID-19 treatment dehydrogenase exposure to facilitate feces Gancao-induced pseudoaldosteronism glycyrrhetic acid Glycyrrhiza uralensis glycyrrhizin hepatic human kidney Human plasma implication in vitro induce inhibit inhibiting intestinal intestinal absorption LianhuaQingwen licorice licorice-induced pseudoaldosteronism. liquiritigenin liver membrane permeability metabolism metabolite microbiota pharmacokinetic plasma protein Plasma Protein Binding Protein binding receiving renal Safe Saponin significant level systemic Therapeutic benefit Transport Treatment treatment for COVID-19 tubular reabsorption Volunteer volunteers [DOI] 10.1038/s41401-021-00651-2 PMC 바로가기 [Article Type] Clinical Trial
Infection of Human Cells by SARS-CoV-2 and Molecular Overview of Gastrointestinal, Neurological, and Hepatic Problems in COVID-19 PatientsReview Published on 2021-10-202022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] ACE2 alteration angiotensin-converting enzyme-2 Brain cell receptors coronavirus disease 19 COVID-19 COVID-19 patient Diseases disorder events Evidence explained expression Gastrointestinal gastrointestinal tract Gut gut flora help hepatic hepatic derangements higher risk Host Human infected with SARS-CoV-2 Infection intestinal permeability likelihood liver liver cells Lungs manifestation Microbiome molecular mechanism neurological Neurological symptoms overexpressed pandemic Pathogens pathophysiological problem recent receptor SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Spike protein suggested [DOI] 10.3390/jcm10214802 PMC 바로가기 [Article Type] Review
Preliminary studies on drug delivery of polymeric primaquine microparticles using the liver high uptake effect based on size of particles to improve malaria treatmentarticle Published on 2021-09-302024-09-01 Journal: Mater Sci Eng C Mater Biol Appl [Category] 말라리아, [키워드] hepatic in vivo analyses malaria microparticles Treatment [Article Type] article
The importance of endothelial protection: the emerging role of defibrotide in reversing endothelial injury and its sequelaeReview Article Published on 2021-09-282022-10-04 Journal: Bone marrow transplantation [Category] 바이오마커, [키워드] Activation Anti-inflammatory anti-oxidative Antithrombotic approved Cancer CAR-T cell transplantation chimeric antigen receptor Clinical data clinical study condition Cytokine release syndrome defibrotide disease disorder downregulating downstream driven by dysfunction Effects endothelial Endothelial cell endothelial cell damage Endothelial dysfunction endothelial injury Endotheliitis Europe European Commission fibrinolytic Haematological cancer HCT hepatic homeostasis inhibiting Interaction MAPK membrane potentially life-threatening Protective Protein resulting Support syndrome T-cell the United State thrombotic utility [DOI] 10.1038/s41409-021-01383-x PMC 바로가기 [Article Type] Review Article
Renal and Hepatic Toxicity Analysis of Remdesivir Formulations: Does What Is on the Inside Really Count?렘데시비르 제형의 신장 및 간 독성 분석: 내부에 무엇이 실제로 중요한가?Article Published on 2021-09-172022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] SARS, 치료제, [키워드] 95% CI 95% confidence interval Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus baseline clearance confounder coronavirus creatinine creatinine clearance cyclodextrin evaluated hepatic hospitalized patient Liver function test logistic regression model lyophilized nephrotoxic no significant difference Odds ratio Patient Remdesivir renal renal failure SARS-CoV-2 SBECD severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant difference significantly solution solution. sulfobutylether-β-cyclodextrin [DOI] 10.1128/AAC.01045-21 PMC 바로가기 [Article Type] Article
High Prevalence of Pre-Existing Liver Abnormalities Identified Via Autopsies in COVID-19: Identification of a New Silent Risk Factor?Article Published on 2021-09-172022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] abnormality Admission albumin albumin level analysed antibodies arteriopathy Autopsy cirrhosis Cohort correlation COVID-19 COVID-19 patients death demonstrated disease English Evidence hepatic hepatic dysfunction hepatic pathology hospital Hospital admission hypertension identification Identified increased mortality indicated interferon dysregulation literature review liver Liver disease Liver function liver function tests moderate Mortality New observation outcome pathologist pathology Patient patients Post-mortem potential mechanism Prevalence reduced renal reported risk Risk factors risk of COVID-19 SARS-CoV-2 SARS-COV-2 infection significantly significantly increased steatosis subsequent type 2 diabete venous Via [DOI] 10.3390/diagnostics11091703 PMC 바로가기 [Article Type] Article
Jaundice in patients with COVID ‐19Original Article Published on 2021-08-242022-10-29 Journal: JGH Open: An Open Access Journal of Gastroenterology and Hepatology [Category] COVID-19, [키워드] activities addressed Admission alanine aminotransferase alkaline phosphatase analyzed Bilirubin Care characterized clinical consequence Clinical features Concentration coronavirus disease COVID COVID‐19 COVID‐19 defined determine elevated etiology Fever Frequency hallmark hepatic Hepatitis hepatocellular high mortality Hospitalized Hypoxemia Injury intensive care Invasive mechanical ventilation jaundice laboratory abnormalities Leukocytosis leukopenia liver liver dysfunction Liver injury mortality rate Patient procalcitonin reported Result Sepsis serum serum creatinine severe acute respiratory syndrome coronavirus 2 significantly higher survival systemic inflammation total bilirubin while [DOI] 10.1002/jgh3.12645 PMC 바로가기 [Article Type] Original Article