Herb-Induced Liver Injury—A Challenging DiagnosisReview Published on 2022-01-312023-08-30 Journal: International journal for equity in health [Category] E형 간염, [키워드] causality assessment hepatotoxicity herbal quality Herbs Traditional medicine [DOI] 10.3390/healthcare10020278 PMC 바로가기 [Article Type] Review
Molecular Networking for Drug Toxicities Studies: The Case of Hydroxychloroquine in COVID-19 Patients약물 독성 연구를 위한 분자 네트워킹: COVID-19 환자의 하이드록시클로로퀸 사례Article Published on 2021-12-222022-09-10 Journal: International Journal of Molecular Sciences [Category] 치료제, [키워드] addition adverse effect adverse effects adverse event approach biological parameter biological parameters Cell cells clinical trial Cohort Combination COVID-19 COVID-19 patient COVID-19 patients COVID-19 symptom COVID-19 symptoms cytotoxicity determine disease drug drug metabolism fatty acids Fatty liver fatty liver disease HCQ HepaRG hepatic steatosis hepatotoxicity high resolution Hydroxychloroquine illness in vitro in vitro data in vivo induce Liquid chromatography mass spectrometry metabolism metabolite modify molecular molecular networking networking neutral lipid obese obese patient obese patients outcomes pathophysiological feature pathophysiological features Patient plasma Rennes University Hospital risk factor steatosis study drug These cells Toxicity treat treated were used worsened [DOI] 10.3390/ijms23010082 PMC 바로가기 [Article Type] Article
A Case of Hepatotoxicity After Receiving a COVID-19 VaccineInternal Medicine Published on 2021-12-162022-10-31 Journal: Cureus [Category] COVID-19, [키워드] approved Case report clinical manifestation coronavirus disease COVID-19 COVID-19 vaccine COVID19 vaccine drug-induced drug-induced acute liver failure Efficacy Health hepatotoxicity Infection instances Patient patients who survived Pfizer receiving reported safety profile severe complication Side effect Vaccine vaccine side effects Vaccines [DOI] 10.7759/cureus.20455 PMC 바로가기 [Article Type] Internal Medicine
Remdesivir Use in the Setting of Severe Renal Impairment: A Theoretical Concern or Real Risk?심각한 신장 장애 상황에서 렘데시비르 사용: 이론적 우려 또는 실제 위험?Article Published on 2021-12-062022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료제, [키워드] Acute kidney injury adverse event adverse events AEs analyzed approved benefit concern controls coronavirus disease Coronavirus disease 2019 COVID-19 creatinine creatinine clearance Elevation elevations evaluated hepatotoxicity hospitalized patients incidence liver Liver function test Mortality nephrotoxicity not significantly different occurred Older Patient patients RDV Remdesivir renal renal impairment renal impairment. renal replacement therapy replacement therapy reported retrospective Safe serum creatinine setting severe renal impairment significantly SRI theoretical risk Toxicity US FDA while [DOI] 10.1093/cid/ciaa1851 PMC 바로가기 [Article Type] Article
Real-World Data of Tigecycline-Associated Drug-Induced Liver Injury Among Patients in China: A 3-year Retrospective Study as Assessed by the Updated RUCAMOriginal Research Published on 2021-11-022023-08-30 Journal: Frontiers in Pharmacology [Category] E형 간염, [키워드] causality assessment hepatotoxicity Liver injury Roussel Uclaf Causality Assessment Method RUCAM tigecycline [DOI] 10.3389/fphar.2021.761167 PMC 바로가기 [Article Type] Original Research
Hepatotoxicity of iodine-131 ablation for post-surgical differentiated thyroid cancer patients with hepatitis B virus infectionArticle Published on 2021-11-012023-06-12 Journal: Clinics and research in hepatology and gastroenter [Category] B형 간염, [키워드] Hepatitis B virus hepatotoxicity Radioiodine thyroid cancer [DOI] 10.1016/j.clinre.2021.101631
Liver and kidney function in patients with Covid-19 treated with remdesivir렘데시비르 치료를 받은 코로나19 환자의 간 및 신장 기능Randomized Controlled Trial Published on 2021-11-012022-09-11 Journal: British Journal of Clinical Pharmacology [Category] SARS, 임상, 치료제, [키워드] adverse events Alanine Alanine transaminase aspartate Aspartate transaminase contraindication contraindications COVID-19 COVID-19 patients decrease estimated glomerular filtration rate exclusion criteria filtration rate function glomerular filtration rate hepatotoxicity kidney Kidney function liver Liver function nephrotoxicity Patient patient cohort patient population randomized clinical trial randomized clinical trials Remdesivir renal renal function reported Serious Adverse Event Serious Adverse Events the patient treated Treatment treatment initiation [DOI] 10.1111/bcp.14831 PMC 바로가기 [Article Type] Randomized Controlled Trial
A Review of the Health Protective Effects of Phenolic Acids against a Range of Severe Pathologic Conditions (Including Coronavirus-Based Infections)다양한 중증 병리학적 상태(코로나바이러스 기반 감염 포함)에 대한 페놀산의 건강 보호 효과 검토Review Published on 2021-09-062022-09-10 Journal: Molecules [Category] 비임상, [키워드] acid Analysis anti-inflammatory properties antioxidant antioxidants breath Cancer cardiovascular diseases class Clinical research clinical study Compound condition Effect feature Health health properties hepatotoxicity human cells human diseases in vitro in vivo Including ingredient mint neurotoxicity oregano over pathologic condition Phenolic acid phenolic acids protective effect Range Research review rosemary SAGE thyme Viral viral infections [DOI] 10.3390/molecules26175405 PMC 바로가기 [Article Type] Review
Potential inhibitors of the main protease of SARS-CoV-2 and modulators of arachidonic acid pathway: Non-steroidal anti-inflammatory drugs against COVID-19SARS-CoV-2의 주요 프로테아제 및 아라키돈산 경로 조절제의 잠재적 억제제: COVID-19에 대한 비스테로이드성 항염증제Article Published on 2021-09-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 신약개발, 치료제, [키워드] 3CLpro anti-inflammatory drug anti-viral drug Anti-viral drugs antiviral drugs arachidonic acid Arachidonic acid pathway attenuate AutoDock AutoDock vina binding affinities binding affinity Candidates chymotrypsin Chymotrypsin-like protease Compound conducted COVID-19 Cytokine storm dataset develop Disturbed docking docking result docking results downregulation evaluated Final Gene expression profiling hepatotoxicity highlight inflammatory mediator Inflammatory mediators inhibitor inhibitor N3 Interaction investigated Ligand lower binding energy metabolic molecular molecular docking Molecular simulation NCBI GEO non-steroidal anti-inflammatory drug Non-steroidal anti-inflammatory drugs NSAID NSAIDS pathway performed perturbations Potential predicted protease Repository SARS-CoV-2 SARS-CoV2 selected Systems biology Talniflumate target the cytokine storm the SARS-CoV-2 Z-score [DOI] 10.1016/j.compbiomed.2021.104686 PMC 바로가기 [Article Type] Article
Safety of tocilizumab in COVID-19 pregnant women and their newborn: A retrospective studyCOVID-19 임산부와 신생아에서 토실리주맙의 안전성: 후향적 연구Multicenter Study Published on 2021-08-012022-09-11 Journal: Journal of clinical pharmacy and therapeutics [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Admission adverse event adverse events age Algorithm Azithromycin Beta candidate close monitoring collected Coronavirus-2 Corticosteroid Corticosteroids COVID-19 cytomegalovirus demographics detrimental effect detrimental effects discharge during pregnancy electronic medical records Evolution gestational age hepatotoxicity hospital hospitals Hydroxychloroquine IL-6 IL-6 receptor Infection inflammatory phase information inhibitor interferon interferon beta interquartile range laboratory data Lopinavir Lopinavir/ritonavir maternal safety medical history MOST mother Neonatal Newborn newborn safety other immunosuppressive agent other immunosuppressive agents outcome Patient patients Pregnancy pregnant women radiologic resolved respiratory Result Retrospective study Ritonavir Safety SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe COVID-19 Spanish Tocilizumab tocilizumab administration treated Treatment two patients Viral viral reactivation [DOI] 10.1111/jcpt.13394 PMC 바로가기 [Article Type] Multicenter Study