hepcidin – Page 2 – Communicable Diseases Research

SARS-CoV-2 Infects Red Blood Cell Progenitors and Dysregulates Hemoglobin and Iron Metabolism

SARS-COV-2는 적혈구 전구체를 감염시키고 헤모글로빈과 철 대사를 조절시킨다

Article

Published on 2022-02-182022-09-10
Journal: Stem cell reviews and reports [Category] COVID19(2023년), MERS, SARS, 변종,

Zinc protoporphyrin levels in COVID-19 are indicative of iron deficiency and potential predictor of disease severity

Covid-19의 아연 프로토 포르피린 수준은 철분 결핍 및 질병 중증도의 잠재적 예측 인을 나타냅니다.

Research Article

Published on 2022-02-032022-09-10
Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 바이오마커,

[키워드] 95% CI Analysis Anemia anemic Biomarker Biomarkers Clinical management coronavirus coronavirus disease COVID-19 COVID-19 patient D-dimer deficiency determine diagnose diagnostic disease disease severity elevated evaluate evaluated ferritin FIVE follow-up study hemoglobin hemoglobin values hepcidin hospital hospitalized patient increase in Inflammation interface iron iron deficiency iron deficiency anemia Iron metabolism laboratory-confirmed Laboratory-confirmed COVID-19 Logistic regression Logistic regression analysis lymphocyte Lymphocyte count marker metabolism moderate N/L neutrophil parameter Patient Patient care patients performed Probability Prognosis Prognostic marker receiver receptor Regression reported Result ROC severity severity of COVID-19 Severity of disease significantly significantly increased specific biomarker tested the disease the patient Transferrin Validity Zinc Zinc protoporphyrin
[DOI] 10.1371/journal.pone.0262487 PMC 바로가기 [Article Type] Research Article

Iron Related Biomarkers Predict Disease Severity in a Cohort of Portuguese Adult Patients during COVID-19 Acute Infection

철 관련 바이오 마커는 COVID-19 급성 감염 동안 포르투갈 성인 환자의 코호트에서 질병 중증도를 예측합니다.

Article

Published on 2021-12-102022-08-31
Journal: Viruses [Category] SARS, 바이오마커,

[키워드] Admission assigned Biomarker blood sample Blood samples Clinical outcome clinical outcomes collected Comorbidities Comorbidity correlated COVID-19 cytokine Cytokines demographic demographic data Diagnosis Disease progression evaluated ferritin ferritin level five group five groups hepcidin hospital hypoferremia of inflammation IL-6 immune response interleukin interleukin-6 iron Iron metabolism Laboratory laboratory parameter Laboratory parameters Laboratory test lowest macrophage chemoattractant protein-1 MCP-1 metabolism monocyte monocyte chemoattractant protein 1 outcomes Patient patients Portugal positive predict progression Protein SARS-CoV-2 serum severity tested Transferrin Variability were recorded worse prognosis
[DOI] 10.3390/v13122482 PMC 바로가기 [Article Type] Article

Increased serum catalytic iron may mediate tissue injury and death in patients with COVID-19

증가 된 혈청 촉매 철분은 Covid-19 환자에서 조직 손상 및 사망을 매개 할 수 있습니다.

Article

Published on 2021-10-042022-09-10
Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 임상, 치료기술,

[키워드] 95% CI active form Adult patients adverse outcome adverse outcomes age age and gender Analysis association baseline levels Biomarkers catalytic Clinical diagnosis Composite COVID-19 cross-sectional death determine disease disease severity enrolled examined Factor ferritin ferritin level ferritin levels hepcidin in-hospital mortality Increased Infectious diseases iron iron chelation Iron metabolism joint kidney males mechanical ventilation median age metabolism Molecular biology Molecular medicine occurred outcome parameter Pathogenesis pathophysiologic pathophysiology pathway Patient patients patients hospitalized patients with COVID-19 Previous studies previous study Primary outcome Prognostic markers raising replacement therapy serum significantly therapy tissue injury Transferrin Ventilation was done
[DOI] 10.1038/s41598-021-99142-x PMC 바로가기 [Article Type] Article

The relationship between serum erythropoietin, hepcidin, and haptoglobin levels with disease severity and other biochemical values in patients with COVID-19

COVID-19 환자의 질병 중증도 및 기타 생화학적 수치와 혈청 에리트로포이에틴, 헵시딘, 합토글로빈 수치 간의 관계

Comparative Study

Published on 2021-07-012022-09-11
Journal: International journal of laboratory hematology [Category] SARS, 바이오마커,

[키워드] affected analyzed Anemia biochemical Biochemistry Blood blood cell Cell control group coronavirus disease COVID-19 COVID-19 patient Critical Critical disease Deceased diagnosed with COVID-19 disease severity distribution EPO erythropoietin evaluate ferritin group groups haptoglobin Health health problem healthy volunteer hemoglobin hepcidin hospital Hospitalized ICU intensive care intensive care unit Intubated intubation iron iron homeostasis Iron metabolism mean value metabolism Mild Mortality nine participant Patient patient groups patients with COVID-19 positively correlated red blood cell serum severity shown significantly higher significantly lower Spread SPSS survived the mean the patient Transferrin Variation
[DOI] 10.1111/ijlh.13479 PMC 바로가기 [Article Type] Comparative Study

BCG-induced non-specific effects on heterologous infectious disease in Ugandan neonates: an investigator-blind randomised controlled trial

우간다 신생아의 이종 감염성 질환에 대한 BCG- 유도 비특이적 영향 : 조사관 맹인 무작위 대조 시험

Articles

Published on 2021-07-012022-09-06
Journal: The Lancet. Infectious Diseases [Category] Communicable Disease,

[키워드] 1:1 Abstract addition age all-cause mortality Alter analysed analyses assigned BCG BCG vaccination benefit Birth blind block size block sizes blood sample Blood samples change clinically clinician Comparisons computer-generated Concentration Consent contributed Controlled Controlled trial Cord blood discharged Effect Effects eligible enrolled Entebbe Families finding Follow-up for inclusion funding geometric geometric mean geometric mean ratios gestational age group hazard ratio healthy hepcidin Heterologous hospital IFNγ IL-10 IL-1β IL-6 IL1B IL6 immunological incidence increase in Infant Infants infections Infectious disease inhibited Innate immunity international standard investigated investigators life Luganda material medical intervention modified intention-to-treat mononuclear cell morbidity morbidity and mortality mother Neonatal neonatal period no significant difference non-specific number outcome parent parents participant Peripheral blood Peripheral blood mononuclear cells primary clinical outcome promoter promoter region PROTECT randomisation randomised randomised controlled trial Randomly receive recruited reduce reductions reductions in Registered required saturation Standard Standard dose stratified by sex TNF Transferrin translation Trial Tuberculosis Uganda vaccination Wellcome Trust were excluded with HIV withdrawn
[DOI] 10.1016/S1473-3099(20)30653-8 PMC 바로가기 [Article Type] Articles

Serum ferritin levels in inflammation: a retrospective comparative analysis between COVID-19 and emergency surgical non-COVID-19 patients

염증에서의 혈청 페리틴 수치: COVID-19와 응급 수술 비-COVID-19 환자 간의 후향적 비교 분석

Observational Study

Published on 2021-03-082022-09-01
Journal: World Journal of Emergency Surgery : WJES [Category] 바이오마커, 임상, 진단,

[키워드] Acute inflammation affected Analysis appear change COVID Covid negative patients COVID-19 Cutoff Cytokine storm defined disease ferritin ferritin level group hepcidin implicated Infection Inflammation inflammatory process Inflammatory response interquartile range involved IQR iron Iron metabolism leucocytosis Leukocytosis Mann-Whitney test marker mechanism median metabolism Modification negative patients non-COVID-19 patient pathogenic Patient phlogistic Prognostic factor Prognostic factors progression Result retrospective Retrospective analysis SARS-CoV-2 SARS-COV-2 infection Sepsi Serum ferritin significantly higher Spread surgery surgical Swab the median total blood Transferrin two-tailed
[DOI] 10.1186/s13017-021-00354-3 PMC 바로가기 [Article Type] Observational Study

Cancer Related Anemia: An Integrated Multitarget Approach and Lifestyle Interventions

Review

Published on 2021-02-012023-06-13
Journal: Nutrients [Category] MERS,

[키워드] cancer-related anemia gut microbiota hepcidin iron supplementation lifestyle
[DOI] 10.3390/nu13020482 PMC 바로가기 [Article Type] Review

Low iron mitigates viral survival: insights from evolution, genetics, and pandemics—a review of current hypothesis

Review

Published on 2020-12-162022-11-01
Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19,

Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients’ performance: a prospective observational cohort study

Research

Published on 2020-10-212022-10-28
Journal: Respiratory Research [Category] COVID-19, MERS,

[키워드] alteration Anemia C-reactive protein Chest computed tomography clinical examination cohort study computed tomography scan coronavirus disease correlation Course COVID-19 Critical cytokine deficiency demonstrated Determination disease onset evaluated ferritin first COVID-19 symptom hepcidin hospital Hyperferritinemia hyperinflammation increased mortality individual Inflammation inflammation marker interleukin-6 investigated iron homeostasis Iron metabolism Laboratory testing Lung pathology majority Mild MONITOR mononuclear cell mRNA expression multicentre parameter participant Patient patients performance status Peripheral blood physical prospective observational cohort Result SARS-CoV-2 serum severe lung pathology significantly Still subject survived Treatment
[DOI] 10.1186/s12931-020-01546-2 PMC 바로가기 [Article Type] Research