Rapid Cytokine Release Assays for Analysis of Severe Acute Respiratory Syndrome Coronavirus 2-Specific T Cells in Whole Blood전혈에서 중증 급성 호흡기 증후군 코로나바이러스 2-특이적 T 세포 분석을 위한 신속한 사이토카인 방출 분석Article Published on 2022-08-242022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed anti-receptor-binding domain antibody Blood samples characteristic clinical complicate Complication controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine cytokine Cytokine release assay diagnosed Diagnosis Diagnostic accuracy Donor EudraCT evaluated exhibited high accuracy IgG IgG levels Immunoglobulin Immunoglobulin G induction Infection interferon interferon γ memory memory response nucleocapsid Patient peptide peptides plasma Previous studies protocol Rapid receiver receiver operating characteristic Region Release remained respiratory SARS-CoV-2 seropositive serum severe acute respiratory syndrome Coronavirus spike stimulated study participant supernatant T cells T-cell T-cell immunity Trial vaccine doses waned Whole blood [DOI] 10.1093/infdis/jiac005 PMC 바로가기 [Article Type] Article
From a recombinant key antigen to an accurate, affordable serological test: Lessons learnt from COVID-19 for future pandemicsResearch article Published on 2022-08-012022-10-05 Journal: Biochemical Engineering Journal [Category] 유전자 메커니즘, 진단, 치료기술, [키워드] Analysis antibody Antigen antigen expression Blood collected COVID-19 COVID-19 antibody test cut-off detect Detection of antibodies elicited by infection or vaccination develop dried blood spot Dried blood spot for diagnostic testing ELISA ELISA test enzyme-linked immunosorbent Final finger pricking handling high accuracy immunization Infection lesson pandemic Pandemics pathogen platform Protein Purification of SARS-COV-2 spike protein Receiver operator characteristic Recombinant antigen production in mammalian cells ROC sensitivity serological serological test Serological test development specificity Spike protein Spread Surveillance symptoms onset vaccination venous was performed [DOI] 10.1016/j.bej.2022.108537 [Article Type] Research article
Estimation of timing of infection from longitudinal SARS-CoV-2 viral load data: mathematical modelling study종적 SARS-CoV-2 바이러스 부하 데이터에서 감염 시기 추정: 수학적 모델링 연구Article Published on 2022-07-282022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] analyzed applied approach border control caused Combination confirmed cases Contact Contact trace Contact tracing country COVID-19 COVID-19 epidemic demonstration estimation high accuracy Infection initial interview Local local infection mathematical model Mathematical modelling mitigate MOST Multiple onset of symptoms Outbreaks Prevent recall bia recall bias reported risk SARS-CoV-2 SARS-CoV-2 viral load secondary transmission Singapore suggested the timing Travel variant variants Viral load were infected Wuhan [DOI] 10.1186/s12879-022-07646-2 PMC 바로가기 [Article Type] Article
Coordinated innate and T-cell immune responses in mild COVID-19 patients from household contacts of COVID-19 cases during the first pandemic wave첫 번째 대유행 기간 동안 COVID-19 사례의 가정 접촉에서 경미한 COVID-19 환자의 조정된 타고난 및 T 세포 면역 반응Article Published on 2022-07-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] absence Alpha anti-N antibodies anti-RBD antibody B-cell cell-mediated response Concordance Contact COVID-19 COVID-19 case COVID-19 cases Cycle threshold value cytokine detectable early immune response early immune responses ELISA enrolled evaluated Factor Follow-up greater high accuracy household household contact household contacts IFN-α IFN-γ IL-1ra IL-1β IL-9 immune responses immunofluorescence Immunopathogenesis indirect immunofluorescence individual innate response interferon interferon-alpha Interferon-alpha (IFN-α) Interferon-gamma Interferon-gamma (IFN-γ) release assay (IGRA) IP-10 MCP-1 membrane mild COVID-19 patient MIP-1β moderate Nasopharyngeal swab Neutralizing antibodies nucleocapsid pandemic peptide peptide pools plasma plasma samples positive positive swab Proteins RANTES RBD reported response returned RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 swab screened Seroconversion serological serological response significant negative correlation Spike protein stimulated subject Surveillance Swab Swab test swabs T-cell T-cell immune response T-cell Response T-cell specific virus Whole blood [DOI] 10.3389/fimmu.2022.920227 PMC 바로가기 [Article Type] Article
Impact of the temperature on the interactions between common variants of the SARS-CoV-2 receptor binding domain and the human ACE2SARS-CoV-2 수용체 결합 도메인의 일반적인 변이체와 인간 ACE2 간의 상호작용에 대한 온도의 영향Article Published on 2022-07-072022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] 1:1 ACE2 ACE2 binding acquisition Alpha angiotensin approach B.1.1.529 B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 Beta binding Delta dissimilarity experiment high accuracy human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 Impact Interaction kinetic L452R mutant Mutation offer omicron parameter parameters powerful tool Protein RBD RBD mutation RBD variants Receptor binding domain reproducibility Spike protein Spike protein receptor binding domain surface plasmon surface plasmon resonance temperature the RBD the SARS-CoV-2 the Spike variant wild type Wuhan [DOI] 10.1038/s41598-022-15215-5 PMC 바로가기 [Article Type] Article
Development and evaluation of time-resolved fluorescent immunochromatographic assay for quantitative detection of SARS-CoV-2 spike antigenSARS-CoV-2 스파이크 항원의 정량적 검출을 위한 시간 분해 형광 면역크로마토그래피 분석법의 개발 및 평가Article Published on 2022-07-012022-09-11 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen automated caused coronavirus correlated COVID-19 demonstrated develop development Device Diagnostic method domain evaluated fluorescent high accuracy identify immunochromatographic assay lateral flow Lateral flow device lateral flow immunochromatographic assay Lateral flow test linear methodology Nasopharyngeal swab Nasopharyngeal swab samples nasopharyngeal swabs point-of-care Protein Quantitative RBD antigen RBD protein reproducibility respiratory RT-PCR sample collection SARS-CoV-2 SARS-CoV-2 spike antigen SARS-CoV-2 virus sensitivity severe acute respiratory syndrome Coronavirus specificity spike Spike protein spread of COVID-19 the SARS-CoV-2 time-resolved fluorescence. TRF TRF lateral flow was performed [DOI] 10.1002/jcla.24513 PMC 바로가기 [Article Type] Article
ISW-LM: An intensive symptom weight learning mechanism for early COVID-19 diagnosisResearch article Published on 2022-07-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Analysis blood test Characteristics classification clinician Comorbidities cough country COVID-19 COVID-19 diagnosis COVID-19 infection symptom dataset datasets diagnose diagnosing Diagnosis Diagnostic method early diagnosis early stage Efficiency epidemiological experiment Fever function help high accuracy identify impacted Intensive Isolation Laboratory learning Learning mechanism machine learning models mechanism novel coronavirus disease outcome pandemic Patient patients performed positive result Predictive regions Self-isolation sore throat Spread Symptom Symptom weight Symptoms trajectory Treatment virus weight [DOI] 10.1016/j.compbiomed.2022.105615 [Article Type] Research article
A novel algorithm for detection of COVID-19 by analysis of chest CT images using Hopfield neural networkResearch article Published on 2022-07-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 치료기술, [키워드] Accuracy Algorithm Analysis Chest Chest CT image community-acquired pneumonia Coronavirus disease 2019 COVID-19 COVID-19 symptoms COVID-19 virus CT scans dataset detect disease ENhance help high accuracy Hopfield neural network Image processing machine learning material mathematical network Neural Novel coronavirus Operation research Patient recognize researcher Result Sensitivity and specificity Spread Symptoms tested treat [DOI] 10.1016/j.eswa.2022.116740 [Article Type] Research article
Host protease activity classifies pneumonia etiology숙주 프로테아제 활성은 폐렴 병인을 분류합니다Article Published on 2022-06-212022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] 치료기술, 치료제, [키워드] Algorithm approach Bacterial Bacterial infections bacterial pneumonia classification Classifier cohorts community-acquired pneumonia COVID-19 pandemic detect diagnostic diagnostics disease dysregulated etiology Health health priorities healthy control healthy controls high accuracy Host host protease implicated Infection machine Machine learning algorithms mice mouse model Nanoparticles pathogen Pathogens Pneumonia protease Protease activity proteolytic selected target transcriptomic unique viral infections Viral pneumonia were used [DOI] 10.1073/pnas.2121778119 PMC 바로가기 [Article Type] Article
Investigation of target sequencing of SARS-CoV-2 and immunogenic GWAS profiling in host cells of COVID-19 in Vietnam베트남 코로나19 숙주 세포에서 SARS-CoV-2 표적 염기서열 분석 및 면역원성 GWAS 프로파일링Article Published on 2022-06-192022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] affected AUC Biomarker clade clinical outcomes comprehensive analysis coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity COVID-19 treatment dataset delta variant Disease progression downstream analysis Elastic forest framework global pandemic GWAS Health Healthcare system Healthcare systems high accuracy Hospitalization host cell host cells immune response immune responses immunogenic Impact investigated investigation Predictive Predictive model prevalent Previous studies previous study progression Protein provided PRS Random forest Research risk risk score SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence Sequencing severity severity of COVID-19 SNP SVM the disease therapeutic target therapeutic targets Treatment Vietnam virus virus variant virus variants [DOI] 10.1186/s12879-022-07415-1 PMC 바로가기 [Article Type] Article