Live-attenuated YF17D-vectored COVID-19 vaccine protects from lethal yellow fever virus infection in mouse and hamster modelsArticle Published on 2022-09-012022-11-15 Journal: EBioMedicine [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome Alpha variant Anti-vector immunity applicability benefit cellular immunity coronavirus COVID-19 vaccine Dual vaccine Efficacy evaluated Fever hamster hamsters highly pathogenic humoral Immunity induce Infection interfere Liver disease mice platform pre-existing immunity PROTECT resulting SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 vaccines single dose subsequent vaccination Vaccine vaccine candidate Vaccines Viral vector vaccine virus virus infection yellow fever Yellow fever vaccine. [DOI] 10.1016/j.ebiom.2022.104240 PMC 바로가기
A Multitrait Locus Regulates Sarbecovirus PathogenesisArticle Published on 2022-08-302022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome Analysis approach CCR9 chromosome 9 collaborative cross conserved coronavirus coronavirus disease Coronavirus infection cross CXCR6 disease facilitate Follow-up Genes Genetic genetic determinant genetic mapping Genetic variation GWAS help highly pathogenic Host host response host susceptibility humans identify implementation Infection Infectious disease influence loci locus mice Mortality mouse model outcome outcomes Pathogenesis pathogenic Precision predict Protective regulate sarbecovirus Sarbecoviruses sarbecoviruses. SARS-CoV SARS-CoV infection SARS-CoV-2 SARS-CoV-2 infections severe disease severity strain susceptibility susceptibility allele variety Viral diseases Virus Disease [DOI] 10.1128/mbio.01454-22 PMC 바로가기
Metalloproteinase-Dependent and TMPRSS2-Independent Cell Surface Entry Pathway of SARS-CoV-2 Requires the Furin Cleavage Site and the S2 Domain of Spike ProteinArticle Published on 2022-08-302022-11-16 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ADAM10 addition bind Cell cell death cell interaction cleavage cleaved complex condition contributed coronavirus SARS-CoV COVID-19 develop domain effective element endosomal pathway entry pathway evade furin furin cleavage motif highly pathogenic Host host protease human coronaviruses identify Immunity independent Infection infection mechanism inhibitor involved membrane membrane fusion metalloproteinase organ damage Pathogenesis pathogenesis of COVID-19 pathway Prevent priming provide required S1/S2 boundary S2 domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein selective sequence siRNAs Site spike Spread surface surface receptor syncytium formation the spike protein therapeutic agent therapeutic target Therapies TMPRSS2 unique vaccination variants virus entry virus variant [DOI] 10.1128/mbio.00519-22 PMC 바로가기
SARS-CoV-2 genome variations and evolution patterns in Egypt: a multi-center study이집트의 SARS-CoV-2 게놈 변이와 진화 패턴: 다기관 연구Multicenter Study Published on 2022-08-252022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 진단, 치료법, [키워드] addition China circulating variants city clade clades Clinical severity collected contribute correlation D614G diagnosed disappearance disease severity Evolution followed by Genetic GISAID global public health highly pathogenic Mild Mutation mutations next generation sequencing Nextstrain nucleocapsid ORF3a ORF8 pandemic Patient Phylogenetic Phylogenetic analysis positive COVID-19 Prevalence sample collection SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 pandemic sequenced sequenced sample Sequencing Spike protein Spread the SARS-CoV-2 variant Variation Viral viral genome viral genomes Viral transmission virus Virus evolution was performed Wuhan [DOI] 10.1038/s41598-022-18644-4 PMC 바로가기 [Article Type] Multicenter Study
Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts에센셜 오일 및 방향족 추출물의 anti-SARS-CoV-2 특성 평가Article Published on 2022-08-202022-09-11 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] anti-SARS-CoV-2 Antiviral available data Coronaviruses COVID-19 outbreak develop Effectiveness Essential exploratory study growth highly pathogenic human coronavirus inhibitory knowledge long term Papain Papain-like protease protease inhibitors Proteases SARS-CoV-2 therapeutic strategy [DOI] 10.1038/s41598-022-18676-w PMC 바로가기 [Article Type] Article
Soluble CD137 as a potential biomarker for severe COVID-19Article Published on 2022-08-012022-10-05 Journal: Immunology letters [Category] 바이오마커, [키워드] 24 hour acute respiratory syndrome Analysis Biomarker Blood Brazil Care caused CD137 characterized Clinical outcome contagious Control coronavirus Coronavirus disease 2019 correlation COVID-19 critical COVID-19 patient Critically ill patient cytokine Cytokines demonstrated disease disease severity evaluate evaluated growth factor Growth factors Health healthy blood donors high risk highly pathogenic hospital ICU ICU admission identify immune increase in increased risk Infection intensive care isoform mechanical ventilation membrane-bound mortality rate Necrosis outcomes pandemic Potential biomarker potential therapy primary endpoint Prospective Study receptor recruitment regulate responsible SARS-CoV-2 severe COVID-19 severe SARS-CoV-2 severity Soluble CD137 Soluble immune checkpoints T-cell activation therapeutic targets TNF was related was used WHO with COVID-19 World Health Organization [DOI] 10.1016/j.imlet.2022.07.003 [Article Type] Article
Virus Infection and Systemic Inflammation: Lessons Learnt from COVID-19 and Beyond바이러스 감염 및 전신 염증: COVID-19 및 그 이후에서 배운 교훈Review Published on 2022-07-142022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 치료제, [키워드] Adaptive immune response addition Antiviral Avian Influenza COVID-19 disease Effectiveness etiological agent facilitate high mortality highlight highly pathogenic highly pathogenic avian influenza human infection human infections immune immune responses immunomodulatory include Infection Inflammatory responses Influenza Influenza virus influenza viruses interferon lesson Local mechanism organ organ-specific pandemic Perturbation Replication respiratory respiratory infections responses responsible SARS-CoV-2 severe disease similarity systemic systemic inflammation target organ therapeutic strategy viral infection viral replication viral spread virus zoonotic [DOI] 10.3390/cells11142198 PMC 바로가기 [Article Type] Review
Distinct Antibody Responses to Endemic Coronaviruses Pre- and Post-SARS-CoV-2 Infection in Kenyan Infants and Mothers케냐 유아와 산모의 SARS-CoV-2 감염 전 및 후 풍토성 코로나바이러스에 대한 독특한 항체 반응Article Published on 2022-07-122022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] alphacoronavirus antibody Antibody binding association Betacoronavirus boosting cause Cohort coronavirus COVID-19 cross-react cross-reactive cross-reactive antibody cross-reactivity Endemic endemic human coronavirus Evidence HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 highly pathogenic IgG IgG antibody titer Infant Infants Kenya lack levels of antibody memory response mother mothers. response risk SARS-CoV-1 SARS-CoV-1 infection SARS-CoV-2 SARS-CoV-2 antibodies SARS-COV-2 infection Seroconversion unlikely women [DOI] 10.3390/v14071517 PMC 바로가기 [Article Type] Article
Molecular modelling identification of phytocompounds from selected African botanicals as promising therapeutics against druggable human host cell targets of SARS-CoV-2SARS-CoV-2의 약물 가능한 인간 숙주 세포 표적에 대한 유망한 치료제로서 선택된 아프리카 식물의 식물 화합물의 분자 모델링 식별Article Published on 2022-07-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 치료제, [키워드] active site acute respiratory syndrome coronavirus African Amino acid amino acid residue angiotensin Angiotensin converting enzyme-2 bafilomycin binding binding energy candidate drug cathepsin cathepsin L caused Cell clinical evaluation clinical evaluations Compound compounds Computational methods coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Critical enzyme galactoside hACE2 highly pathogenic host cell Host cell targets human cell human cells human host in vitro inhibitor inhibitors of TMPRSS2 inhibitory inhibitory action investigated kaempferol mechanism MLN-4760 Modification modifications modulate molecular dynamics Molecular dynamics simulation myricetin nafamostat Phytocompounds Protein Proteins Replication Research respiratory Respiratory disease respiratory diseases rutinoside SARS-CoV-2 selected Serine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Structural analysis subjects subsequent target Therapeutic benefit these compound these compounds TMPRSS2 transmembrane serine protease Verbascoside viral entry viral spike protein viral spike proteins while [DOI] 10.1016/j.jmgm.2022.108185 PMC 바로가기 [Article Type] Article
Emerging Role of ZBP1 in Z-RNA Sensing, Influenza Virus-Induced Cell Death, and Pulmonary InflammationZ-RNA 감지, 인플루엔자 바이러스 유발 세포 사멸 및 폐 염증에서 ZBP1의 새로운 역할Review Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral Apoptosis Cell cell death coronavirus Critical cytopathic death Defense epithelial epithelial cell functional highly pathogenic Host host cell host defense human disease IAV immune sensing immunopathology in vivo Infection Inflammasome Inflammation Inflammatory response Inflammatory responses Influenza influenza A influenza A virus influenza infections influenza viruses Innate Innate immunity Lung infection mechanism necroptosis nucleic acid outbreak Pandemics pathogenic pathogenicity proinflammatory Proinflammatory response promote pulmonary pyroptosis Respiratory illness Respiratory tract infections responses RIPK3 RNA RNA virus role SARS-CoV-2 Signaling triggering understanding viral infections viral strain virus Z-RNA ZBP1 zoonotic transmission [DOI] 10.1128/mbio.00401-22 PMC 바로가기 [Article Type] Review