homolog – Page 2 – Communicable Diseases Research

LinearTurboFold: Linear-time global prediction of conserved structures for RNA homologs with applications to SARS-CoV-2

408

Published on 2021-12-092022-10-29
Journal: Proceedings of the National Academy of Sciences of
[Category] COVID-19, SARS,

SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein

SARS-CoV-2는 스파이크 단백질을 통해 뇌 혈관주위세포의 면역 기능과 면역 기능을 완화합니다.

Article

Published on 2021-12-012022-09-11
Journal: Neurobiology of disease
[Category] SARS, 유전자 메커니즘,

[키워드] accompanied accumulated ACE2 ACE2 expression acquisition Actin Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 assays binding Brain brain damage calcium cause caused cerebrovascular cerebrovascular disorders change characterized collagen Comorbidity contractile coronavirus disease coronavirus disease 19 Coronavirus-2 COVID-19 COVID-19 pathogenesis Cytokines deregulated develop disorder enzyme exacerbate Express expressing expression Fibronectin fluctuations function functional homolog host cell host cells human ACE2 Human brain hypoxia immune Immune cell immune function immune reaction impair infect infection with SARS-CoV-2 Inflammation inhibitory intranasal involved lipid peroxidation locus Macrophage mechanism mechanisms mice MIF Migration morphology Myofibrogenic transition nasal mucosa Neurological disorder Neurological disorders Neurovascular Neurovascular interface NF-κB NOTCH3 nuclear oxidative pericyte pericytes phenotypic pro-inflammatory cytokine pro-inflammatory cytokines promoted Protein Proteins provide reached reactivity receptor recognize Regulatory Respiratory illness S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 S protein. Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown signaling pathway spike Stress therapeutic interventions transgenic mice translated transmembrane triggered Vascular viral spike was increased
[DOI] 10.1016/j.nbd.2021.105561 PMC 바로가기 [Article Type] Article

Regulation of Angiotensin-Converting Enzyme 2: A Potential Target to Prevent COVID-19?

안지오텐신 전환 효소 2의 조절: COVID-19 예방을 위한 잠재적 표적?

Review

Published on 2021-10-222022-09-12
Journal: Frontiers in Endocrinology
[Category] MERS, SARS, 진단,

Angiotensin–Converting Enzyme (ACE) 1 Gene Polymorphism and Phenotypic Expression of COVID-19 Symptoms

안지오텐신-전환 효소(ACE) 1 유전자 다형성 및 COVID-19 증상의 표현형 발현

Review

Published on 2021-10-012022-09-10
Journal: Genes
[Category] MERS, SARS, 변종, 유전자 메커니즘,

[키워드] ACE1 I/D polymorphism ACE ACE1 ACE1 gene ACE2 Affect aldosterone Alu angiotensin appear article Asia association biochemical candidate Candidates Clinical outcome Comorbidities component concert conducted country COVID-19 COVID-19 symptoms diagnosis of SARS-CoV-2 East evaluate Evidence explain expression Frequency Genes Genotype group homolog Hypothesis I/D polymorphism Infection infections influence insertion Interaction involved mechanisms Medline database Mortality MOST numbers of patient opposite organ Pathogenesis pathogenesis of COVID-19 pathophysiology phenotypic Phenotypic Expression polymorphism Polymorphisms pulmonary disease RAAS reported Research risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections searched selected severity subgroups subgroups of patients Support Treatment West
[DOI] 10.3390/genes12101572 PMC 바로가기 [Article Type] Review

Fatal cytokine release syndrome by an aberrant FLIP/STAT3 axis

비정상적인 FLIP/STAT3 축에 의한 치명적인 사이토카인 방출 증후군

Article

Published on 2021-09-132022-09-10
Journal: Cell Death and Differentiation
[Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제,

[키워드] approach caspase caspase-8 characterized clinical phenotype Control COVID-19 CRS cytokine Cytokine release syndrome Cytokines death detect dysregulated elevated expressed expression homolog immune disorders immune response immune responses Inflammation Inflammatory inflammatory pathology Inflammatory responses inflammatory state Intervention life-threatening Lung injury Lungs lymphopenia mice multiple organ dysfunction myeloid cell myeloid cells organ dysfunctions Organ failure organ failures pandemic pathogen invasion pathophysiology pathway Pathways Protein provoke regulated response SARS-CoV-2 pandemic STAT3 suppress syndrome the SARS-CoV-2 triggered Viral
[DOI] 10.1038/s41418-021-00866-0 PMC 바로가기 [Article Type] Article

Annelid genomes: Enchytraeus crypticus , a soil model for the innate (and primed) immune system

Article

Published on 2021-09-062022-10-29
Journal: Lab Animal
[Category] COVID-19, MERS, SARS,

Human Basigin (CD147) Does Not Directly Interact with SARS-CoV-2 Spike Glycoprotein

Research Article

Published on 2021-08-112022-10-30
Journal: mSphere
[Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome Basigin binding CD147 complex coronavirus coronavirus disease COVID-19 effective effort erythrocytes Escherichia coli expressed Factor full-length spike glycoprotein Health homolog Hospitalization Host host cells Human IgG IMPROVE Inclusion Infection Interaction Invasion ligands mammalian cells morbidity Mortality observation Plasmodium falciparum malaria polyclonal positive control preventing infection Protein Proteins RBD Receptor binding domain Replication reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike glycoprotein size exclusion chromatography spike the RBD the spike protein therapeutic target Treatment VERO E6 cells viral entry virus entry Virus-host interactions with COVID-19
[DOI] 10.1128/mSphere.00647-21 PMC 바로가기 [Article Type] Research Article

NOD: a web server to predict N ew use of O ld D rugs to facilitate drug repurposing

Article

Published on 2021-06-292022-10-04
Journal: Scientific Reports
[Category] 신약개발, 치료제,

[키워드] accelerate approach candidate Characteristics Compound Computational biology and bioinformatics drug Drug discovery DrugBank DrugBank database drugs facilitate homolog identify information investigated predict Protein similarity
[DOI] 10.1038/s41598-021-92903-8 PMC 바로가기 [Article Type] Article

Benchmarking the Ability of Common Docking Programs to Correctly Reproduce and Score Binding Modes in SARS-CoV-2 Protease Mpro

SARS-CoV-2 Protease Mpro에서 결합 모드를 올바르게 재현하고 점수를 매기는 일반적인 도킹 프로그램의 능력 벤치마킹

Article

Published on 2021-06-282022-09-11
Journal: Journal of Chemical Information and Modeling
[Category] SARS, 치료제,

Immunoglobulin Y for Potential Diagnostic and Therapeutic Applications in Infectious Diseases

Immunology

Published on 2021-06-092022-11-01
Journal: Frontiers in Immunology
[Category] COVID-19,