The Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell function코로나바이러스 네트워크 탐색기: SARS-CoV-2가 숙주 세포 기능에 미치는 영향에 대한 대규모 지식 그래프 마이닝Software Published on 2021-05-032022-09-10 Journal: BMC Bioinformatics [Category] 신약개발, 유전자 메커니즘, [키워드] Activation approach approaches Biological functions clinical observations clinical trial clinical trials co-morbidities co-morbidity coronavirus COVID-19 COVID-19 pathogenesis curated direction Diseases driven by drug Drug repurposing drug target drugs drugs targeting Effect Endpoint experimental evidence exploration functional functions gene expression signature Host host cell host gene host genes human host hypothese identify immunological Interaction interfere knowledge Knowledge graph machine learning modulated morbidities network network biology observation offer pathway Pathways potential mechanism potential mechanisms Protein Proteins Result SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 viral supplementary material Viral Viral proteins Virological [DOI] 10.1186/s12859-021-04148-x PMC 바로가기 [Article Type] Software
siRNA Therapeutics against Respiratory Viral Infections—What Have We Learned for Potential COVID‐19 Therapies?호흡기 바이러스 감염에 대한 siRNA 치료제 - 잠재적인 COVID-19 치료제에 대해 우리는 무엇을 배웠습니까?Review Published on 2021-01-272022-09-10 Journal: Advanced Healthcare Materials [Category] 치료제, [키워드] addition Antiviral antiviral drug antiviral drugs cause choice conserved COVID‐19 death develop Economy effective emerging respiratory virus evaluated FIVE global health Health highlighting host gene host genes host–viral interactions Infection infection sites Influenza inhalation inhibiting life Modification nanomedicine offer outbreak pandemic Potential Prevalence Prevent progress report prophylactically provide pulmonary pulmonary delivery Region regions Replication respiratory respiratory virus respiratory viruses resulting RNAi pathway SARS‐CoV‐1 SARS‐CoV‐2 SARS‐CoV‐2 sequence siRNA siRNAs swine flu target cell target cells target gene therapeutic use Therapeutics Treatment Vaccine Viral viral genome viral infection viral replication viral respiratory viruses [DOI] 10.1002/adhm.202001650 PMC 바로가기 [Article Type] Review
Population-Specific ACE2 Single-Nucleotide Polymorphisms Have Limited Impact on SARS-CoV-2 Infectivity In Vitro인구 특이적 ACE2 단일 뉴클레오티드 다형성은 시험관 내 SARS-CoV-2 감염성에 제한적인 영향을 미칩니다Communication Published on 2021-01-062022-09-10 Journal: Viruses [Category] 유전자 메커니즘, [키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus Affect Analysis analyzed angiotensin angiotensin-converting enzyme 2 causative agent cell entry coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Efficiency eight enzyme except for host gene host genes human populations Impact in vitro indicated Infectivity Interaction Limited molecular dynamics Molecular dynamics simulation molecular dynamics simulations Mutation nonsense mutation performed polymorphism Population receptor Receptor binding reduced respiratory responsible SARS-2-S SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity single-nucleotide Single-nucleotide polymorphisms SNP SNPs Spike protein susceptibility the SARS-CoV-2 validation study Viral viral cell viral cell entry [DOI] 10.3390/v13010067 PMC 바로가기 [Article Type] Communication
Dynamic data-driven meta-analysis for prioritisation of host genes implicated in COVID-19COVID-19와 관련된 숙주 유전자의 우선 순위를 지정하기 위한 동적 데이터 기반 메타 분석Meta-Analysis Published on 2020-12-182022-09-10 Journal: Scientific Reports [Category] MERS, 바이오마커, 유전자 메커니즘, 임상, 치료제, [키워드] Algorithm Betacoronavirus CD3E CD4 chromosome chromosome 3 conducted content COVID-19 COVID-19 pathogenesis CXCL10 cyclosporine data-driven datasets described disease-associated dynamic evaluate Evidence experiment Factor Factors FYCO1 GWAS Host host gene host genes human betacoronavirus IL1A Immunogenetics immunology implicated Infection Infectious diseases Interpretation list list of gene locus MERS MERS-CoV Meta-analysis Other PPIA Prognostic factor Prognostic factors resource robust SARS-CoV SARS-CoV-2 seasonal coronaviruses systematic review therapeutic target Therapies viral infection Weighting [DOI] 10.1038/s41598-020-79033-3 PMC 바로가기 [Article Type] Meta-Analysis
A Network-Based Analysis Reveals the Mechanism Underlying Vitamin D in Suppressing Cytokine Storm and Virus in SARS-CoV-2 Infection네트워크 기반 분석은 SARS-CoV-2 감염에서 사이토카인 폭풍과 바이러스를 억제하는 비타민 D의 기본 메커니즘을 보여줍니다.Immunology Published on 2020-12-092022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, 치료제, [키워드] 2019 activating Antiviral antiviral response approach bind bioinformatics cause Cell Cluster Combination coronavirus COVID-19 Critical cytokine Cytokine storm Cytokines Defense depth analysis differentially expressed epithelial experimental validation expression Extensive fibrosis finding Functional enrichment analysis generate Genes highest host gene host genes host response human immune response IFN-α immune in-depth analysis infect Inflammatory Inflammatory response inhibit initiate ISGs leads Lower respiratory tract Lung fibrosis MCODE score mechanism molecular mechanism NFkB1 NHBE Organ failure pandemic pathway Pathways Patient potential mechanism POU2F2 pro-inflammatory cytokine pro-inflammatory cytokines protein-protein interaction receptor reducing referred to Regulation regulatory network respiratory Result resulting RNA sequencing robust antiviral response SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe COVID-19 patients severe pneumonia Signaling signaling pathway STAT Stat1 STAT2 STAT3 storm suggested Suppressing Systems biology the cells the cytokine storm TNF transcription factor transcription factors Transcriptome Tuberculosis up-regulated Viral viral infection Vitamin Vitamin D were used [DOI] 10.3389/fimmu.2020.590459 PMC 바로가기 [Article Type] Immunology
Comparative Transcriptome Analysis Reveals the Intensive Early Stage Responses of Host Cells to SARS-CoV-2 InfectionMicrobiology Published on 2020-11-252022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] accompanied acute respiratory syndrome Analysis antiviral response Bioinformatics analysis Calu-3 cell caused Comparative coronavirus coronavirus disease COVID-19 cytokine cytokine production disease pathogenesis Efficiency Evidence Gene Expression growth highly pathogenic host antiviral response host antiviral responses host cell host cells host early response host gene host genes host response host transcriptome implicated Infection Intensive Interaction late stage mechanism MERS-CoV Middle East molecular outbreak pathogenicity performed respiratory syndrome coronavirus response SARS-CoV SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection Sequencing Stage the SARS-CoV-2 time-series transcriptome TMPRSS2 triggered up-regulated virus virus genome while widespread [DOI] 10.3389/fmicb.2020.593857 PMC 바로가기 [Article Type] Microbiology
COVID-19 research risks ignoring important host genes due to pre-established research patternsCOVID-19 연구는 미리 설정된 연구 패턴으로 인해 중요한 숙주 유전자를 무시할 위험이 있습니다.Feature Article Published on 2020-11-242022-09-10 Journal: eLife [Category] SARS, 유전자 메커니즘, [키워드] Analysis bias Community consequence COVID-19 COVID-19 research disease Genes Genome Project host gene host genes Human human gene human genes Human genetics Human Genome Project human physiology implicated investigated Meta-research meta-science random random selection Research risk SARS-CoV-2 SARS-COV-2 infection scientific literature skewed virus while [DOI] 10.7554/eLife.61981 PMC 바로가기 [Article Type] Feature Article
Epigenetic Regulator miRNA Pattern Differences Among SARS-CoV, SARS-CoV-2, and SARS-CoV-2 World-Wide Isolates Delineated the Mystery Behind the Epic Pathogenicity and Distinct Clinical Characteristics of Pandemic COVID-19SARS-CoV, SARS-CoV-2 및 SARS-CoV-2 전 세계 분리주 사이의 후성유전 조절자 miRNA 패턴 차이로 팬데믹 COVID-19의 서사적 병원성과 독특한 임상적 특징 뒤에 숨겨진 미스터리Genetics Published on 2020-07-102022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] alleviate anomalies Anomaly antiviral miRNAs autophagy binding breathing complications cardiovascular diseases cellular miRNA cellular pathway clinical Comorbidities Complication computational approach Computational approaches country COVID-19 COVID-19 patients death death rates diabetes difference disease effective epigenetic modulator epigenetic regulator experiments Factors functional Gene Expression Host host antiviral miRNA host genes host immunity host miRNA host's miRNAs human cell IFN-I IFN-I signaling immune regulation immune-escape mechanism immune-signaling pathways implication isolate latency lead Microarray miRNA miRNA clusters miRNA-mediated interaction miRNA-microRNA miRNAs mode modulate molecular mechanism Neutralizing normalized over representation analysis Pathogenesis Pathways patients with comorbidity pattern predict predicted profile regulator RNA therapeutics RNA-Seq SARS virus SARS viruses SARS-CoV SARS-CoV and SARS-CoV-2 viral miRNAs SARS-CoV and SARS-CoV-2 viruses SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 miRNAs SARS-CoV-2 pathogenesis SARS-CoV-2 viral SARS-CoV-2 virus SARS-infected human cell microarray signaling pathways Support symptoms of COVID-19 target targets the SARS-CoV-2 Viral viral miRNA viral miRNAs viral pathogenesis viruses [DOI] 10.3389/fgene.2020.00765 PMC 바로가기 [Article Type] Genetics
Exome-wide association study reveals largely distinct gene sets underlying specific resistance to dengue virus types 1 and 3 in Aedes aegypti엑솜 전체의 연관성 연구는 이집트숲모기(Aedes aegypti)에서 뎅기열 바이러스 유형 1 및 3에 대한 특이적 내성을 기본으로 하는 크게 구별되는 유전자 세트를 보여줍니다Research Article Published on 2020-05-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adjusted Aede allelic variant allelic variants association ATP average binding activity compatibility Dengue dengue virus DENV-1 DENV-3 Exome exomes exposure to Frequency Gabon Genes Genetic genetic architecture genetic marker Genetic polymorphism genetic polymorphisms Genetic variation Genome group Host host gene host genes host-pathogen interactions hosts identify indicate Infection Interaction invertebrate invertebrates investigated involved mechanism Mosquito natural population p values pathogen pathogen genotype pathogen-specific Pathogens phenotype phenotypic polymorphism Region reveal sequenced significantly single-nucleotide single-nucleotide polymorphism SNP specific resistance specificity statistical strain Strains sulfur susceptible the mosquito transmembrane variant Variation with infection Zinc zinc ion [DOI] 10.1371/journal.pgen.1008794 PMC 바로가기 [Article Type] Research Article
Competing endogenous RNA network profiling reveals novel host dependency factors required for MERS-CoV propagationArticle Published on 2020-03-302022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, [키워드] Analysis Antiviral antiviral strategy biological pathways biological processe Calu-3 Cell cells cellular change characterized circRNA Circular competing endogenous RNA demonstrated epithelial expression expression pattern Factor function group highly pathogenic Host host genes human lung in viral Infection investigated involved KEYWORDS: MERS-CoV knockdown MAPK MERS-CoV MERS-CoV infection metabolic processes Middle East miRNA modulate mRNA noncoding RNA Pathways perturbations predicted proportion Protein provided reaction recent reduced Regulatory required respiratory syndrome coronavirus reveal RNA selected significantly siRNA Specific Structure target mRNA targets unique Variation viral infections [DOI] 10.1080/22221751.2020.1738277 PMC 바로가기 [Article Type] Article