host genes – Communicable Diseases Research

Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infection

SARS-CoV-2 감염과 관련된 유전자의 유전적 변이 및 임상 표현형과의 연관성에 대한 자연 선택의 영향

Article

Published on 2022-05-242022-09-11
Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종,

The key features of SARS-CoV-2 leader and NSP1 required for viral escape of NSP1-mediated repression

NSP1 매개 억제의 바이러스 탈출에 필요한 SARS-CoV-2 리더 및 NSP1의 주요 기능

Article

Published on 2022-05-012022-09-11
Journal: RNA (New York, N.Y.) [Category] COVID19(2023년), SARS, 유전자 메커니즘,

Genome-wide CRISPR screens identify GATA6 as a proviral host factor for SARS-CoV-2 via modulation of ACE2

게놈 전체의 CRISPR 화면은 ACE2의 변조를 통해 GATA6을 SARS-CoV-2의 프로바이러스 숙주 인자로 식별합니다.

Article

Published on 2022-04-252022-09-11
Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제,

[키워드] ACE2 Alpha Alpha variant Analysis anti-SARS-CoV-2 Beta biogenesis candidate cellular clathrin clinical sample clinical samples collected Comparative analysis component COVID-19 pathogenesis CRISPR CRISPR screen Critical data-set elevated facilitate Factor GATA6 Health heparan sulfate Host host gene host genes identify infected individuals Infection KREMEN2 list loss-of-function modulation pathway pharmacological phosphatidylglycerol regulate required SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 infected individual SARS-CoV-2 infected individuals SARS-COV-2 infection SETDB1 Spread sulfate target therapeutic interventions therapeutic strategy Transcription transcription factor Transport unique variant variants of concern variants of SARS-CoV-2 viral infectivity virus pathogenesis VoC VOCs wild type Zinc
[DOI] 10.1038/s41467-022-29896-z PMC 바로가기 [Article Type] Article

The Potential Mechanism of Cancer Patients Appearing More Vulnerable to SARS-CoV-2 and Poor Outcomes: A Pan-Cancer Bioinformatics Analysis

SARS-CoV-2에 더 취약하고 좋지 않은 결과를 보이는 암 환자의 잠재적 기전: 범암 생물정보학 분석

Immunology

Published on 2022-01-102022-09-11
Journal: Frontiers in Immunology [Category] MERS, 변종, 유전자 메커니즘,

[키워드] ACE2 ACE2 expression adverse outcome adverse outcomes Affect Bioinformatics analysis Cancer cancer patient Cancer patients conducted correlated COVID-19 COVID-19 severity drugs dysregulation Factor Genes Genetic genetic factors Genotype healthy subjects higher risk Host host gene host genes immune infiltration immune response immune responses individual infected with SARS-CoV-2 infiltration inhibit Intervention lower expression negative influence NPC1 OAS1 outcome outcomes overall survival Patient Poor Potential potential mechanism protective factor rs10774671 (OAS1) SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 susceptibility sensitivity survival target Treatment variant variants
[DOI] 10.3389/fimmu.2021.804387 PMC 바로가기 [Article Type] Immunology

HumanNet v3: an improved database of human gene networks for disease research

HumanNet v3: 질병 연구를 위한 인간 유전자 네트워크의 개선된 데이터베이스

AcademicSubjects/SCI00010

Published on 2022-01-072022-09-10
Journal: Nucleic Acids Research [Category] 유전자 메커니즘,

[키워드] accumulated Algorithms approach association citation complex database dataset demonstrated disease Diseases feasible functional functional annotation functional gene Genetic host gene host genes human diseases human gene human genes Interaction network outperform physical protein coding genes Protein–protein interaction provide Research significantly Support user with COVID-19
[DOI] 10.1093/nar/gkab1048 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010

Drug repurposing for COVID-19 using graph neural network and harmonizing multiple evidence

그래프 신경망을 사용하여 COVID-19에 대한 약물 용도 및 여러 증거 조화

Article

Published on 2021-11-302022-08-31
Journal: Scientific Reports [Category] 신약개발, 임상, 치료법, 치료제,

[키워드] 2019 novel coronavirus 2019 novel coronavirus disease acetaminophen albuterol approach Aspirin atorvastatin Azithromycin candidate drug candidate drugs clinical trial collected conducted coronavirus disease COVID-19 COVID-19 knowledge COVID-19 patient COVID-19 treatment demonstrated disease drug drug combination drug combinations Drug development Drug repurposing drugs Efficacy Evidence facilitate FDA approval Genetic highlight host genes in vitro integration Interaction interactions Knowledge graph Novel coronavirus novel coronavirus disease outbreak pandemic Pathways Phenotypes profiles Research Treatment Virtual screening virus was used
[DOI] 10.1038/s41598-021-02353-5 PMC 바로가기 [Article Type] Article

Discovery and validation of a three-gene signature to distinguish COVID-19 and other viral infections in emergency infectious disease presentations: a case-control and observational cohort study

긴급 감염성 질환 프레젠테이션에서 COVID-19 및 기타 바이러스 감염을 구별하기 위한 3개 유전자 서명의 발견 및 검증: 사례 통제 및 관찰 코호트 연구

Observational Study

Published on 2021-11-012022-09-10
Journal: The Lancet. Microbe [Category] MERS, SARS, 유전자 메커니즘, 임상, 진단, 치료기술,

[키워드] 95% CI Admission Adults Analysis approach AUROC AUROCs Bacterial Bacterial infection Bacterial infections benefit Blood C-reactive protein C-reactive protein (CRP Case-control characteristic clinical utility Cohort COVID-19 COVID-19 infection COVID-19 infections criteria CRP decision curve analysis detect diagnoses diagnostic Emergency emergency department expressed Fever finding funding HERC6 hospital host gene host genes IGF1R individual Infection infections Infectious disease Infectious diseases initial lack leukocyte likelihood Medical Research Council NAGK no infection Observational cohort study pandemic participant Participants PCR-positive positive COVID-19 presenting receiver operating characteristic recruited RNA sequencing RT-qPCR SARS-CoV-2-positive participants sensitivities sensitivity signature Specificities specificity transcript transcriptional validation cohort Viral viral infection viral infections was done Wellcome Trust with infection
[DOI] 10.1016/S2666-5247(21)00145-2 PMC 바로가기 [Article Type] Observational Study

The role of microRNAs in modulating SARS-CoV-2 infection in human cells: a systematic review

인간 세포에서 SARS-CoV-2 감염을 조절하는 microRNA의 역할: 체계적인 검토

Article

Published on 2021-07-012022-09-11
Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종,

[키워드] ACE2 addition Analysis applied article association caused cell interactions cleavage Complex network Complex networks COVID-19 COVID-19 patients Critical database disease eligibility criteria Evidence expression level expression levels function Gene Expression gene target Genes Genome Genome sequencing highlight host cells host genes host miRNA host miRNAs host responses human disease human infection in silico independent infected cell Infection infections Interaction microRNA MicroRNAs miRNA miRNAs modulating MOST Mutation Pathologies predicted Prospective PROSPERO Proteins protocol provide Registered regulate reported Research review SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolate SARS-CoV-2 isolates searched selected Sequencing specimen suggested systematic review therapeutic target therapeutic targets TMPRSS2 translation viral genome virus virus infection
[DOI] 10.1016/j.meegid.2021.104832 PMC 바로가기 [Article Type] Article

SARS-CoV-2-Host Chimeric RNA-Sequencing Reads Do Not Necessarily Arise From Virus Integration Into the Host DNA

Microbiology

Published on 2021-06-022022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection

METTL3은 SARS-CoV-2 감염 동안 바이러스 m6A RNA 변형 및 숙주 세포 선천성 면역 반응을 조절합니다

Article

Published on 2021-05-112022-09-11
Journal: Cell Reports [Category] SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adenosine binding clade coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 treatment decrease disease downstream ENhance expression Gene Expression Host host cell host genes Host immune response host innate immunity increase Inflammation Inflammatory inflammatory gene inflammatory genes innate immune innate immune response Innate immunity m(6)A RNA modification. methyltransferase METTL3 Modification molecular mechanism Patient physiological reduced reduction in regulate RIG-I RNA RNA modification SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus severe coronavirus disease signaling pathway the SARS-CoV-2 the SARS-CoV-2 virus Treatment viral genome Viral RNA widespread
[DOI] 10.1016/j.celrep.2021.109091 PMC 바로가기 [Article Type] Article