Association between SNPs in microRNAs and microRNAs-Machinery Genes with Susceptibility of Leprosy in the Amazon Population아마존 인구에서 나병에 대한 취약성과 미세 RNA 및 미세 RNA 기계 유전자에서의 SNPs 간의 연관성Article Published on 2022-09-132024-08-24 Journal: International Journal of Molecular Sciences [Category] 한센병, [키워드] Amazon Biomarkers genetics population host-pathogen interaction leprosy mycobacteria SNPs
Insights from a computational analysis of the SARS-CoV-2 Omicron variant: Host-pathogen interaction, pathogenicity, and possible drug therapeuticsSARS-CoV-2 Omicron 변이체의 컴퓨터 분석에서 얻은 통찰력: 숙주-병원체 상호작용, 병원성 및 가능한 약물 치료법Article Published on 2022-07-012022-09-11 Journal: Immunity, Inflammation and Disease [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 Affect Alter Analysis analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach binding affinity Characteristics Comparisons computational analysis correlated correlation correlations COVID-19 COVID-19 case COVID-19 cases docking docking result docking results drug Drug efficacy drugs drugs efficacy effective Effectiveness epidemiological evaluate evaluated Factor genomic sequence Host host-pathogen interaction human receptors insight Interaction lack less Lopinavir molecular docking molecular dynamics Molecular dynamics simulation Mutation mutational spectrum Nirmatrelvir NRP1 occurred omicron Omicron variant pathogenic pathogenicity Phylogenetic tree protease Protein Proteins raised Receptor-binding domain reconstructed Research response significant difference significant differences tested the receptor-binding domain the SARS-CoV-2 therapeutic approaches variant [DOI] 10.1002/iid3.639 PMC 바로가기 [Article Type] Article
Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics녹농균(Pseudomonas aeruginosa): 병인, 독성 인자, 항생제 내성, 숙주와의 상호 작용, 기술 발전 및 새로운 치료법Review Published on 2022-06-252022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, MERS, 유전자 메커니즘, [키워드] addition Antibiotic resistance Antibiotics antimicrobial autophagy Bacterial Bacterial pathogenesis bioinformatics burn wounds Cancer caused Cell signaling cGAS chronic obstructive clinically COPD COVID-19 CRISPR CRISPR-Ca cystic fibrosis Defense develop disorder drug drug resistance Drug screening effective effort Factor Factors fibrosis gram Host host defense host immune responses host-pathogen interaction immune immune responses immunodeficiency IMPROVE infect Infection infections Inflammasome Interaction intractable invasive LPS mammalian cell mechanism metabolomics molecular Non-coding RNAs opportunistic pathogen outer membrane P. aeruginosa pathogen Pathogenesis Pathways Patient platform Pseudomona Pseudomonas aeruginosa rapid progress Regulation Research scRNA-seq secretion Severe infection signaling pathways Strains therapy traits treat use of antibiotics Ventilation Vesicle virulence widespread [DOI] 10.1038/s41392-022-01056-1 PMC 바로가기 [Article Type] Review
Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model인간 만능 줄기 세포 유래 모델에서 SARS-CoV-2 감염에 대한 대식세포 아형의 차등 효과Article Published on 2022-04-192022-09-12 Journal: Nature Communications [Category] COVID19(2023년), SARS, 진단, 치료법, [키워드] ACE2 antibody Apoptosis cell type cells co-culture contribute coronavirus disease-2019 COVID-19 COVID-19 disease severity Effect effective ENhance growth host-pathogen interaction immune response Inflammatory factor inhibition inhibitory effect Interaction involved lung lung cells M2 macrophages Macrophage macrophage phenotypes macrophages pluripotent stem cell progression SARS-COV-2 infection significantly subtype suppress the SARS-CoV-2 virus Therapeutic strategies up-regulate viral entry viral infection [DOI] 10.1038/s41467-022-29731-5 PMC 바로가기 [Article Type] Article
Indomethacin: an exploratory study of antiviral mechanism and host-pathogen interaction in COVID-19인도메타신: COVID-19에서 항바이러스 메커니즘 및 숙주-병원체 상호작용에 대한 탐색적 연구Article Published on 2022-03-012022-09-11 Journal: Expert review of anti-infective therapy [Category] Coronavirus, SARS, 유전자 메커니즘, 치료제, [키워드] Administered affected anti-inflammatory drug Anti-viral Antiviral antiviral action Area caused Characteristics claimed Clinical efficacy Clinical studies Covid patients COVID-19 damage demonstrated Effect effective Endpoint expert exploratory study Genetic genetic interaction genetic interaction network Genome highlight host proteins host-pathogen interaction impacted In-vitro indomethacin Interaction Invasion mechanism mechanism of action Mild-to-moderate NSAID pandemic pathogenic Patient potency Protein–protein interaction Research risk SARS-CoV-2 SARS-CoV-2 protein standalone treatment subject targets Treatment treatment strategy Viral protein [DOI] 10.1080/14787210.2022.1990756 PMC 바로가기 [Article Type] Article
Evaluation of SARS-CoV-2 entry, inflammation and new therapeutics in human lung tissue cells인간 폐 조직 세포에서 SARS-CoV-2 진입, 염증 및 새로운 치료제 평가Research Article Published on 2022-01-132022-09-10 Journal: PLoS Pathogens [Category] SARS, 변종, 신약개발, 치료제, [키워드] ACE2 ACE2 expression alveolar Alveolar Type II anti-inflammatory compound anti-inflammatory compounds anti-SARS-CoV-2 therapeutics Antiviral antiviral activity antiviral drug approaches Behavior can be used candidate CD147 Cell Cell culture cell cultures cell lines cell suspension cells cellular complexity Compound drug candidate Drug evaluation early stage early stages expression Factors growth heterogeneous host-pathogen interaction host-pathogen interactions human lung tissue identify immortalized cell lines immune in viral in vitro Infection Inflammation inhibitor interferon interferons involved Laboratory local inflammatory response lung cell modulate modulated offer overcome pathogen Pathogens physiological platform populations primary cell primary cells primary human cell primary human cells Protein provide required respiratory Respiratory pathogens reveal SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 variants Stimulation surgical resection susceptible cell target Therapeutics TMPRSS2 Viral viral entry viral infection [DOI] 10.1371/journal.ppat.1010171 PMC 바로가기 [Article Type] Research Article
Poking COVID-19: Insights on Genomic Constraints among Immune-Related Genes between Qatari and Italian Populations코로나19 파헤치기: 카타르인과 이탈리아인 사이의 면역 관련 유전자 사이의 게놈 제약에 대한 통찰력Article Published on 2021-11-222022-09-10 Journal: Genes [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] ABCA7 applied candidate gene Care cohorts country COVID-19 COVID-19 cases COVID-19 severity curated Delta demonstrated disease Epicentre Europe FLNA genetic constraints genetic difference genetic differences genomic information genomic variations higher risk highest host-pathogen interaction identify individuals Innate immunity insight involved Italian Italian population Italy laboratory-confirmed lockdown Metrics mortality rate mortality rates MUC5AC National Population Population genetics populations Result selective sequence spread of COVID-19 SSC subset susceptibility vaccination variant whole-genome sequencing [DOI] 10.3390/genes12111842 PMC 바로가기 [Article Type] Article
NK cell receptor and ligand composition influences the clearance of SARS-CoV-2NK 세포 수용체 및 리간드 구성은 SARS-CoV-2의 제거에 영향을 미칩니다Article Published on 2021-11-012022-09-11 Journal: The Journal of Clinical Investigation [Category] Coronavirus, SARS, 바이오마커, [키워드] activity addition Admission CD155 Cell clearance clearance of SARS-CoV-2 Control correlated COVID-19 cytolytic Diversity expressing expression functional host-pathogen interaction host-pathogen interactions Immune cell immune cells immune response immune responses immune system immune systems infected cells Infection influence intensive care intensive care unit Interaction involved Ligand mechanical ventilation modulate natural killer nectin NK cell NK cells pathway Patient platform proteomics receptor receptors SARS-COV-2 infection single-cell subpopulation subset target cell TIGIT Viral viral clearance rate virus-infected cells [DOI] 10.1172/JCI146408 PMC 바로가기 [Article Type] Article
Biology and Pathogenesis of SARS-CoV-2: Understandings for Therapeutic Developments against COVID-19Review Published on 2021-09-192022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] alphacoronavirus Analysis animal models antiviral drugs antivirals Biology caused Characteristics Complete Coronavirus disease 2019 Coronaviruses COVID-19 development EVs extracellular vesicle FIVE Genetic HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HCoVs host-pathogen interaction host-virus interaction Human immune-evasion knowledge MERS-CoV Nidovirale Pathogenesis pathophysiology positive Research RNA virus SARS-CoV SARS-CoV-2 single-stranded the Coronaviridae the disease understanding Vaccine Vaccines virus [DOI] 10.3390/pathogens10091218 PMC 바로가기 [Article Type] Review
Target Discovery for Host-Directed Antiviral Therapies: Application of Proteomics ApproachesMinireview Published on 2021-09-142022-10-29 Journal: mSystems [Category] COVID-19, [키워드] AIDS antiviral activity antiviral therapy application Compound coronavirus disease COVID-19 current Drug repurposing drug-resistant Epidemics flu Health help Host-directed therapies host-pathogen interaction host-pathogen interactions identify knowledge less limitation pandemic Pathogens powerful tool proteomics Spread Systems biology target tested therapeutic vaccination Viral diseases viral replication viral strains while [DOI] 10.1128/mSystems.00388-21 PMC 바로가기 [Article Type] Minireview