hosts – Page 2 – Communicable Diseases Research

Detection of SARS-CoV-2 clade B.1.2 in three snow leopards

Article

Published on 2022-09-012022-11-15
Journal: Transboundary and emerging diseases
[Category] COVID19(2023년), SARS, 변종, 치료기술,

Co-existence and co-infection of influenza A viruses and coronaviruses: public health challenges

Review article

Published on 2022-08-172022-10-05
Journal: The Innovation
[Category] 비임상,

The influence of new SARS-CoV-2 variant Omicron (B.1.1.529) on vaccine efficacy, its correlation to Delta variants: A computational approach

새로운 SARS-CoV-2 변이체 Omicron(B.1.1.529)이 백신 효능에 미치는 영향, Delta 변이체와의 상관관계: 전산적 접근

Article

Published on 2022-08-012022-09-11
Journal: Microbial pathogenesis
[Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] addition Analysis antibody approach AY.1 B.1.1.529 binding affinity caused computational analysis correlation COVID CR3022 Delta Delta variants docking docking analysis domain Effect Efficacy Host hosts human ACE2 receptor human monoclonal antibodies Human monoclonal antibody immune evasion in silico Approach In-silico analysis Interaction lead MD simulation Modification Mutation neutralizing antibody new SARS-CoV-2 omicron Omicron variant Omicron. pathogenicity promote Proteins RBD RBD variant Reinfection SARS-CoV-2 variant Spike proteins Strains Structure the binding affinity the WHO Vaccine variant
[DOI] 10.1016/j.micpath.2022.105619 PMC 바로가기 [Article Type] Article

Control of an outbreak of COVID-19 at a tertiary hospital in Taiwan

Research article

Published on 2022-08-012022-10-05
Journal: Journal of microbiology, immunology, and infection
[Category] 치료기술,

Predictive Models of within- and between-Species SARS-CoV-2 Transmissibility

종 내 및 종 간 SARS-CoV-2 전염성 예측 모델

Article

Published on 2022-07-192022-09-11
Journal: Viruses
[Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 Amino acid angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Angiotensin converting enzyme 2 (ACE2) Angiotensin-converting enzyme angiotensin-converting enzyme 2 complex Coronaviridae Coronaviridae family coronavirus enzyme expected feature host receptor hosts human ACE2 receptor humans in silico infect Infection interact interfacing residues Model Mutation pandemic Positive selection positively correlated predict predicted Prediction model Protein receptor complex replacement reported reservoir residue residues S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 variant SARS-CoV-2 variants shown species spike spike glycoprotein spike glycoprotein (S). subtype Subtypes susceptible the Coronaviridae the SARS-CoV-2 thought Transmissibility transmissibility of SARS-CoV-2 virus
[DOI] 10.3390/v14071565 PMC 바로가기 [Article Type] Article

Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion

말초 혈액 단핵 세포의 차별적인 염색질 접근성은 혈청 전환 이전의 COVID-19 질병 중증도의 기초가 됩니다

Article

Published on 2022-07-092022-09-11
Journal: Scientific Reports
[Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제,

[키워드] Accessibility anti-spike protein IgG Antiviral ATAC-seq CD14 CD14+ monocytes Cell cell differentiation cell type cell types changes in chromatin classical Course COVID-19 COVID-19 disease severity defined diagnostic disease disease course dysregulated early disease effective epigenome Evolution hosts IgG immune response immune responses individual Infection interleukin interleukin signaling IRF1 IRF7 less Mild mild SARS-CoV-2 infection Mild symptom moderate moderate disease moderate symptom Modification modifications Monocytes mononuclear cell mononuclear cells morphology motif observation occurred offer Outpatient outpatients Pathways PBMC PBMCs performed Peripheral blood Peripheral blood mononuclear cells profile promise Regulation remodeling responses RNA-Seq robust SARS-CoV-2 SARS-COV-2 infection Sequencing Seroconversion severity Signaling single-cell analyses single-cell analysis Stage Symptom symptom severity the disease transcription factor transposase Trigger triggers upregulation with COVID-19
[DOI] 10.1038/s41598-022-15668-8 PMC 바로가기 [Article Type] Article

Comparative genomic analysis of the human genome and six bat genomes using unsupervised machine learning: Mb-level CpG and TFBS islands

비지도 머신 러닝을 사용한 인간 게놈과 6개의 박쥐 게놈 비교 게놈 분석: Mb 수준 CpG 및 TFBS 섬

Comparative Study

Published on 2022-07-082022-09-11
Journal: BMC Genomics
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] 3D structure 3D Structures addition Algorithm Analysis artificial artificial intelligence bat bats binding Centromeric heterochromatin characteristic Characteristics chromosomes class Clustering Comparative conducted contributing to CpG diagnostic dinucleotide disease-causing distribution Ebola Emerging infectious disease feature Features function Gene Expression Genome genomes genomic Genomic analysis help hosts Human Human genome humans Infectious disease information Interaction involved knowledge machine machine learning motif natural reservoir nuclear oligonucleotide Oligonucleotide composition oligonucleotides Protein Region regions Regulation reveal RNA viruses SARS-CoV-2 self-organization Self-organizing map Self-organizing map. sequence TFS the SARS-CoV-2 thought transcription factor transcription factors variety virus viruses zoonotic
[DOI] 10.1186/s12864-022-08664-9 PMC 바로가기 [Article Type] Comparative Study

Animal models for COVID-19: advances, gaps and perspectives

COVID-19에 대한 동물 모델: 발전, 격차 및 전망

Review

Published on 2022-07-072022-09-11
Journal: Signal Transduction and Targeted Therapy
[Category] COVID19(2023년), SARS, 바이오마커, 변종, 유전자 메커니즘, 진단, 치료제,

[키워드] ADE animal animal model animal models Antibody-dependent enhancement caused cells Characteristics clinical feature Clinical features combinations Comorbidity COVID-19 evaluate ferret host receptor Host receptors hosts human tissue human tissues immune response immune responses Infection livestock mice mouse model Mouse models mouse-adapted strain non-human primates outbreak pandemic Pathogenesis pathogenesis of SARS-CoV-2 Perspective populations poultry protease Proteases receptor receptors SARS-CoV-2 SARS-COV-2 infection strain susceptible therapy transduced transgenic variants variants of concern virulence VoC
[DOI] 10.1038/s41392-022-01087-8 PMC 바로가기 [Article Type] Review

The 2022 outbreak and the pathobiology of the monkeypox virus

Article

Published on 2022-07-012022-11-15
Journal: Journal of autoimmunity
[Category] 진단,

[키워드] addition African Antiviral antiviral therapies body fluids CDC center chills clade clades Congo basin Control disease effective Europe fatigue Fever headache Host hosts identity include individual Infection Infectious disease International lymph nodes mitigate Monkeypox Monkeypox outbreak 2022 muscle aches nasopharyngeal National Nigeria North America outbreak pandemic Pathogenesis Prevalence Prevent prevention raised replicate reported Respiratory droplets returned rodent shown specific treatment Spread Symptom The United States through contact Transmission transmitted Travel USA Vaccine Viral pathogenesis. virus virus infection virus spread Washington West while WHO World Health Organization
[DOI] 10.1016/j.jaut.2022.102855 PMC 바로가기

Drug repurposing for identification of potential spike inhibitors for SARS-CoV-2 using molecular docking and molecular dynamics simulations

분자 도킹 및 분자 역학 시뮬레이션을 사용하여 SARS-CoV-2에 대한 잠재적 스파이크 억제제 식별을 위한 약물 용도 변경

Article

Published on 2022-07-012022-09-11
Journal: Methods (San Diego, Calif.)
[Category] COVID19(2023년), SARS, 신약개발, 치료제,

[키워드] ACE2 ACE2 receptor ADME administration Analysis angiotensin antiviral drugs approved drug Asthma average binding binding affinity candidate carried Compound COVID-19 COVID-19 pandemic COVID-19 treatment death develop docking drug Drug repurposing Efficacy estimates FIVE followed by free energy Hepatitis hepatitis C host cell hosts human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 identify Immunocompromised in silico Approach in vitro in vivo inhibitor Interaction leukotriene leukotriene receptor antagonist Ligand Lineage lineages membrane-bound molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations Multiple Multiple studies oral administration parameter plethora Protease inhibitor receptor antagonist recognize SARS-CoV-2 SARS-CoV-2 virus SARS‐CoV‐2 SARS‐CoV‐2. selected Simeprevir Spike protein Spike proteins tested the SARS-CoV-2 virus therapeutic treat Treatment variety virus WHO Zafirlukast
[DOI] 10.1016/j.ymeth.2022.02.004 PMC 바로가기 [Article Type] Article