In silico screening of some compounds derived from the desert medicinal plant Rhazya stricta for the potential treatment of COVID-19 Research Published on 2022-07-012022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 치료기술, 치료법, 치료제, [키워드] Acidic Analysis antiviral activity aromatic group average binding affinities binding affinity binding free energy binding interaction Ceftazidime Cell Compound coronavirus COVID-19 demonstrated docking exceptional exhibited FIVE fraction functional greater groups Health high stability HPLC Hydrogen bond in silico in vitro study Interaction less lowest MD simulation Molecular dynamics simulation occurred oxygen pandemic penetration Potential treatment predict Protein RBD RBD residue Receptor binding domain required retained SARS-CoV-2 SARS-CoV-2 viral selected similarity suggested the RBD the SARS-CoV-2 these compound Toxicity Treatment [DOI] 10.1038/s41598-022-15288-2 [Article Type] Research
Cyanidin-3-O-glucoside and Peonidin-3-O-glucoside-Rich Fraction of Black Rice Germ and Bran Suppresses Inflammatory Responses from SARS-CoV-2 Spike Glycoprotein S1-Induction In Vitro in A549 Lung Cells and THP-1 Macrophages via Inhibition of the NLRP3 Inflammasome Pathway시아니딘-3-O-글루코사이드 및 피오니딘-3-O-글루코사이드-풍부 검정 쌀 배아 및 겨 분획은 A549 폐 세포 및 THP-1 대식세포에서 SARS-CoV-2 스파이크 당단백질 S1-유도 시험관 내 염증 반응을 억제합니다 NLRP3 Inflammasome 경로의 억제Article Published on 2022-06-302022-09-11 Journal: Nutrients [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] A549 Activation anthocyanin anthocyanins Anti-inflammation anti-inflammatory property ASC attenuate benefit black black rice bran C3G Cell cell lines Concentration counteraction COVID-19 COVID-19 infection cytokine secretion dose-dependent manner downregulation Effect exhibited exposure to fraction functional functional food Gene Expression Germ Health health benefits HPLC IL-18 IL-1β IL-6 immune cells in vitro model Inflammasome Inflammation Inflammatory Inflammatory response Inflammatory responses inhibition innate immune cell Innate immune cells long-COVID lung tissue Macrophage macrophages mechanism NF-kB NLRP3 NLRP3 inflammasome P3G pathway post-acute COVID protective effect Protective effects Protein protein level protein levels reported response responsible Rice S1 subunit SARS-CoV-2 spike spike glycoprotein spike glycoprotein S1. THP-1 treated was determined [DOI] 10.3390/nu14132738 PMC 바로가기 [Article Type] Article
Favipiravir (SARS-CoV-2) degradation impurities: Identification and route of degradation mechanism in the finished solid dosage form using LC/LC-MS methodFavipiravir(SARS-CoV-2) 분해 불순물: LC/LC-MS 방법을 사용하여 완성된 고체 제형의 분해 메커니즘 식별 및 경로Article Published on 2022-06-012022-09-11 Journal: Biomedical chromatography : BMC [Category] COVID19(2023년), SARS, 치료기술, [키워드] acetonitrile Analysis analyte approved buffer column temperature Compound concentrations condition country Degradation degradation impurities, favipiravir, LC/LC-MS, related substances, SARS-CoV-2, stability indicating. dosage Emergency use Favipiravir flow rate Forced harmonization HPLC identification injection International Conference LC-MS limit linear linearity mechanism Mobile molecular pathway performed physical Precision Quality control quantification reaction recovery study Research research and development robust SARS-CoV-2 SARS-CoV-2 patients separation stability Standard deviation stationary stationary phase stress conditions supported tablets temperature treat Volume water [DOI] 10.1002/bmc.5363 PMC 바로가기 [Article Type] Article
Rapid Assay for the Therapeutic Drug Monitoring of EdoxabanEdoxaban의 치료 약물 모니터링을 위한 신속한 분석Article Published on 2022-04-172022-09-11 Journal: Biomolecules [Category] COVID19(2023년), SARS, 치료기술, [키워드] acetonitrile administration Anticoagulant blood plasma Care Concentration detect DOAC drug edoxaban followed by hotspot HPLC indicated lab limit lowest methanol monitoring pathology Patient pharmacokinetic Pulmonary embolism quantification R 2 Raman spectroscopy Rapid receiving reporter Safe SARS-CoV-2 infections standard sample standard samples surface enhanced Raman spectroscopy therapeutic therapeutic drug Therapeutic Drug Monitoring therapeutic index thiol Treatment Variability was used [DOI] 10.3390/biom12040590 PMC 바로가기 [Article Type] Article
Two Green Micellar HPLC and Mathematically Assisted UV Spectroscopic Methods for the Simultaneous Determination of Molnupiravir and Favipiravir as a Novel Combined COVID-19 Antiviral Regimen새로운 결합된 COVID-19 항바이러스 요법으로서 Molnupiravir와 Favipiravir의 동시 측정을 위한 2개의 Green Micellar HPLC 및 수학 보조 UV 분광법Article Published on 2022-04-042022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] adjusted Analytical chemistry Antiviral applied Brij-35 classical Combination Combined composed conditions construction COVID-19 COVID-19 pandemic COVID-19 regimen Determination drug Efficacy extraction Favipiravir FIVE flow rate Genetic Genetic algorithm green harmony HPLC increase initiated isocratic less Liquid chromatography lung Lungs medication micellar liquid chromatography molnupiravir monobasic potassium phosphate novel overlapping partial least square partial least squares PCR phosphate plateau Potassium potassium phosphate predicted prevented Principal component regimen released SARS-CoV-2 virus SDS similarity Simultaneous Spread Tablet the SARS-CoV-2 virus trials UV–VIS Spectrophotometry Viral transmission [DOI] 10.3390/molecules27072330 PMC 바로가기 [Article Type] Article
Structural characterization and SARS-CoV-2 inhibitory activity of a sulfated polysaccharide from Caulerpa lentilliferaCaulerpa lentillifera의 황산화 다당류의 구조적 특성 및 SARS-CoV-2 억제 활성Article Published on 2022-03-152022-09-11 Journal: Carbohydrate polymers [Category] SARS, 치료제, [키워드] addition Analysis applied backbone Caulerpa Caulerpa lentillifera Chemical structure COVID-19 Degradation HeLa cell HeLa cells HPLC hydrolysis indicated information inhibitory activity Mild mono polysaccharide prevalent PROTECT Result saccharide SARA-CoV-2 SARS-CoV-2 SARS-COV-2 infection separated sequence sugar sulfate sulfated Sulfated polysaccharide. Virus neutralization Xyl [DOI] 10.1016/j.carbpol.2021.119006 PMC 바로가기 [Article Type] Article
Cannabidiol and Terpene Formulation Reducing SARS-CoV-2 Infectivity Tackling a Therapeutic StrategyImmunology Published on 2022-02-152022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, COVID19(2023년), SARS, [키워드] A549 alveolar analyzed Anti-inflammatory Antiviral approach Caco-2 cannabidiol cannabis CBD - cannabidiol cell line cell lines cell receptor cellular Colon Combination COVID-19 Effectiveness endocannabinoid system (ECS) epithelial essential oil (EO) evaluate evaluated Formulation formulations GC-MS HaCaT Health Host HPLC human cell lines Impact in vitro study Infectivity Inflammation inflammation response Interaction kidney knowledge Origanum purified reduce reducing SARS-CoV-2 Strategy terpene terpenes Therapeutic compounds Therapeutic strategies Therapeutics therapy thymus virus infectivity Virus life cycle Wuhan, China [DOI] 10.3389/fimmu.2022.841459 PMC 바로가기 [Article Type] Immunology
Metabolomics study of COVID-19 patients in four different clinical stages4 가지 임상 단계에서 Covid-19 환자의 대사체 연구Article Published on 2022-01-312022-09-10 Journal: Scientific Reports [Category] 바이오마커, 진단, [키워드] (COronaVIrus Disease 2019) acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Admission Analysis Asymptomatic disease bile acid bile acids biological pathway Biomarker Biomarkers change Clinical outcome Clinical stage coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 illness COVID-19 patient Deceased defined diagnose disease early stage fatty acids Final groups help hospital hospital discharge hospitalized patient hospitalized patients HPLC Human individual Infection information involved ketone ketone bodies mass spectrometry metabolism metabolite metabolomics Mild Mild disease negative control omeprazole outcome pandemic Patient patients plasma plasma sample plasma samples positive patient Potential biomarker potential biomarkers predict produced Prognosis purines respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe disease subsequent Tryptophan viral infection with mild disease [DOI] 10.1038/s41598-022-05667-0 PMC 바로가기 [Article Type] Article
Development and Validation of a Novel HPLC Method to Analyse Metabolic Reaction Products Catalysed by the CYP3A2 Isoform: In Vitro Inhibition of CYP3A2 Enzyme Activity by Aspirin (Drugs Often Used Together in COVID-19 Treatment)Article Published on 2022-01-292022-10-30 Journal: Molecules [Category] Coronavirus, SARS, [키워드] 6β-hydroxydexamethasone Accuracy activity applied Aspirin bridge Chromatography competitive inhibitor Concentration COVID-19 CYP3A activity CYP3A2 cytochrome P450 development Dexamethasone drug drug interaction enzyme activity evaluate Fever harmonization healthcare HPLC ICH in vitro indicated Inflammation inhibit inhibition inhibitor International Conference limit limit of detection liquid liver metabolic moderate novel Pain Precision product quantification reaction reversed risk Severe case stability Toxicity treat validation [DOI] 10.3390/molecules27030927 PMC 바로가기 [Article Type] Article
Development and Validation of HPLC Method for Efinaconazole: Application to Human Nail Permeation Studies에피나코나졸의 HPLC 방법 개발 및 검증: 인간 손톱 침투 연구에의 적용Article Published on 2022-01-282024-08-17 Journal: AAPS PharmSciTech [Category] 백선증, [키워드] efinaconazole HPLC method development and validation Nail permeation Onychomycosis