Niclosamide shows strong antiviral activity in a human airway model of SARS-CoV-2 infection and a conserved potency against the Alpha (B.1.1.7), Beta (B.1.351) and Delta variant (B.1.617.2)Niclosamide는 SARS-COV-2 감염의 인간기도 모델에서 강한 항 바이러스 활성과 알파 (B.1.1.7), 베타 (B.1.351) 및 델타 변형 (B.1.617.2)에 대한 보존 된 효능을 보여줍니다.Research Article Published on 2021-12-022022-09-10 Journal: PLoS ONE [Category] SARS, 변종, 치료제, [키워드] Alpha anti-SARS-CoV-2 antiviral activity antiviral efficacy B.1.1.7 B.1.351 B.1.617.2 Beta clinical development conserved COVID-19 D614G Delta delta variant highlight highlighting human airway medical need niclosamide SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants Support therapeutic therapeutic agent Therapies Transmissibility variants [DOI] 10.1371/journal.pone.0260958 PMC 바로가기 [Article Type] Research Article
An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection기도 오르가노이드 기반 스크린은 SARS-CoV-2 감염에서 HIF1α-해당 축의 역할을 식별합니다Article Published on 2021-10-152022-09-11 Journal: Cell Reports [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] 2-furoic acid Abstract acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 airway airway organoid Alpha Analysis Anti-viral drugs B.1.351 block cells Chemical Compound coronavirus develop Disease model disease models dissect fatty Fatty acid fatty acid synthesis Genetic Glycolysis GW4671 high content drug screen hPSC-derived colonic organoid hPSC-derived colonic organoids human airway Human airway epithelium hypoxia hypoxia-inducible factor 1-alpha identify Infection inhibiting inhibitor mechanism metabolic MONITOR Organoid platform pluripotent stem cell respiratory reveal RNA sequencing RNA-Seq SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant Screen severe acute respiratory syndrome Coronavirus stem cells subunit suppress Transcriptome Treatment xanthohumol [DOI] 10.1016/j.celrep.2021.109920 PMC 바로가기 [Article Type] Article
SARS-CoV-2 inhibition using a mucoadhesive, amphiphilic chitosan that may serve as an anti-viral nasal spray항 바이러스 비강 스프레이로서 작용할 수있는 점막 흡착성, 양친 매성 키토산을 사용한 SARS-COV-2 억제Article Published on 2021-10-082022-08-31 Journal: Scientific Reports [Category] SARS, 치료기술, 치료제, [키워드] A549 ACE-2 receptor adverse effect Anti-viral binding Biomedical materials Brain Cell clinical testing Concentration controls Coronavirus infections Course COVID-19 COVID-19 pandemic detect dose dosed effective electrostatic epithelial cells expressing Good host cells human airway human airway epithelial human airway epithelial cells hypothesise Infection inhibit injected limit log mammalian mechanism mice nares nasal nasal epithelial cell open Polymer Practice Prevent preventive intervention Prophylactic RATs reduce respiratory respiratory droplet Respiratory droplets respiratory tract Safe SARS-CoV-2 Spread spread of COVID-19 statistical significance TCID transgenic mice Vero E6 Vero E6 cell VERO E6 cells Viral viral entry viral infection Viral load virus [DOI] 10.1038/s41598-021-99404-8 PMC 바로가기 [Article Type] Article
Abnormal Airway Mucus Secretion Induced by Virus InfectionImmunology Published on 2021-09-282022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] airway airway mucus secretion caused component disease experimental evidence human airway induce induced mechanism mechanisms mucin Mucus Pathogenesis PROTECT Research respiratory respiratory tract respiratory virus SARS-CoV-2 secretion signaling pathway treat Treatment understanding virus [DOI] 10.3389/fimmu.2021.701443 PMC 바로가기 [Article Type] Immunology
Risk Assessment of Infection by Airborne Droplets and Aerosols at Different Levels of Cardiovascular ActivityS.I.: Modeling and Simulation of Infectious Diseases Published on 2021-07-012022-10-28 Journal: Archives of Computational Methods in Engineering [Category] COVID-19, [키워드] activity aerosol assessment cardiovascular caused Concentration conditions COVID-19 disease COVID-19 pandemic develop distribution droplet Effect expiratory Frame globe human airway human airways infection control information Inhaled investigated knowledge Level Local lower airways observation OpenFOAM pandemic particle size distribution pathogen progression provide reported resolved Respiratory disease risk Spread the disease the SARS-CoV-2 virus Transmission routes Transport virus Volume [DOI] 10.1007/s11831-021-09613-7 PMC 바로가기 [Article Type] S.I.: Modeling and Simulation of Infectious Diseases
JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cellsJAK 억제제는 인간 기도 상피 세포에서 ACE2 이소형의 인터페론 자극 전사 활성화를 억제합니다Article Published on 2021-06-022022-09-10 Journal: Communications Biology [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] ACE2 ACE2 expression ACE2 gene activate activated activating Activation airway angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Baricitinib bronchial cells Cell cell tropism cells ChIP-seq COVID-19 patients element enhancer enhancers epithelial cells expression Gene Expression Gene regulation Genetic High-throughput screening highlight human airway human airway epithelial human airway epithelial cells Human airway epithelium hyperinflammation identify inhibitors interferon interferons Intronic isoform Jak JAK inhibitor jak inhibitors Janus kinase locus producing promoter receptor Regulation RNA-Seq ruxolitinib SARS-CoV-2 SARS-COV-2 infection suppress the cell Transcription Transcriptome transcriptomes [DOI] 10.1038/s42003-021-02167-1 PMC 바로가기 [Article Type] Article
Noninvasive Measurement of Pulmonary Function in Experimental Mouse Models of Airway Disease기도 질환의 실험적 마우스 모델에서 폐 기능의 비침습적 측정Review Published on 2021-05-192022-09-12 Journal: Lung [Category] MERS, SARS, 진단, [키워드] airway Airway hyperresponsiveness allergic Allergic asthma animal models Asthma Compliance conscious disease function gold standard human airway in vivo include invasive Laboratory lung Lung function lung mechanics marker measurement mice Model mouse mouse model noninvasive parameter Pathogenesis performed provide provided pulmonary Pulmonary function Pulmonary function testing repeated required Research respiratory infection respiratory parameter SARS-CoV-2 sensitivity translational validation study [DOI] 10.1007/s00408-021-00443-9 PMC 바로가기 [Article Type] Review
The SARS-CoV-2 and other human coronavirus spike proteins are fine-tuned towards temperature and proteases of the human airwaysSARS-CoV-2 및 기타 인간 코로나바이러스 스파이크 단백질은 인간 기도의 온도 및 프로테아제에 맞게 미세 조정됩니다.Research Article Published on 2021-04-222022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 변종, 유전자 메커니즘, [키워드] activate activated Activation of SARS-2-S adaptive mechanism adaptive mechanisms adjusted airway adaptation airways alternative route authentic virus replication Author cathepsin L cathepsin L pathway cathepsin-rich cells caused cell tropism common cold common cold coronavirus contrary contributed coronavirus coronavirus spike protein coronavirus virulence coronaviruses SARS-CoV COVID-19 pandemic Critical D614 variant D614G mutation deletion mutants effective ENhance explain extended loop length feature furin furin recognition motif G614 variant HCoV HCoV-229E high transmissibility of SARS-CoV-2 highly pathogenic human airway human airways human coronaviruses human host human respiratory tract increase indicate intrinsic temperature preference loop deletion mutant loop deletion mutants lower airways mechanism MERS MERS-CoV mild common cold other coronavirus other coronaviruses pathogenic HCoV-229E virus pathology predominant processing produced promote property protease protease condition protease conditions Proteases Protein pseudoviruses pseudoviruses of SARS-CoV-2 replaced Replication respiratory respiratory tract S protein S protein stability S proteins S1/S2 cleavage loop SARS-2-S SARS-2-S-driven entry SARS-CoV SARS-CoV-2 SARS-CoV-2 epidemiology SARS-CoV-2 spike SARS-CoV-2 stability severe pneumonia significantly increased spike activator spike property Spike protein Spike proteins spike stability spike-D614 spike-G614 variant Spread surface protease surface proteases temperature temperature and protease conditions the S protein the SARS-CoV-2 the spike protein TMPRSS13 TMPRSS13 protease TMPRSS2 transmissibility of SARS-CoV-2 upper airways upper or lower airways Usage Viral viral spike protein virulent coronavirus virulent coronaviruses virus virus entry virus preference virus spread virus transmission Zoonotic introduction [DOI] 10.1371/journal.ppat.1009500 PMC 바로가기 [Article Type] Research Article
Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptationResearch Advance Published on 2021-04-092022-10-31 Journal: eLife [Category] COVID-19, SARS, [키워드] airway Airway organoids Calu-3 can be used Cell Cell culture cell culture adaptation cell culture conditions cell line COVID-19 Culture expresse facilitate facilitated furin cleavage site Human human airway human airway cell knowledge MBCs multibasic cleavage site mutate Prevent SARS-CoV-2 SARS-CoV-2 propagation Serine serine protease serine proteases specimens the spike protein VeroE6 cells viral mutation virus [DOI] 10.7554/eLife.66815 PMC 바로가기 [Article Type] Research Advance
Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes인간 기도 상피에서 SARS-CoV-2 감염에 대한 단일 세포 종단 분석은 표적 세포, 유전자 발현의 변경 및 세포 상태 변화를 식별합니다Research Article Published on 2021-03-172022-08-13 Journal: PLoS Biology [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome air–liquid interface alteration basal and club cells bronchial epithelial cell bystander cells Cell cell tropism cell types cell-intrinsic expression change ciliated cell ciliated cells Club cells coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Course COVID-19 Critical Culture cultures drug Drug administration enhanced epithelial cell epithelial cell type epithelial cell types epithelial cells expand expression food Gene Expression Genes HBECs host–viral interaction human airway human airway epithelial human airway epithelial cells Human airway epithelium human bronchial epithelial cells identify IFNs IL-1 IL6 immunofluorescence microscopy induce infected with SARS-CoV-2 Infection interactions interferon interferon-stimulated gene interferon-stimulated genes interferons interleukin ISGs longitudinal analysis novel over Pathogenesis performed polyadenylated viral transcript polyadenylated viral transcripts provide respiratory resulting reveal RNA sequencing RNA-Seq SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 single-cell single-cell analysis target cells the cell Therapeutics Treatment type I type I and type III IFNs type I and type III interferons Type III IFN type III interferon Vaccine Viral viral replication viral transcripts [DOI] 10.1371/journal.pbio.3001143 PMC 바로가기 [Article Type] Research Article