hydrolysis – Page 2 – Communicable Diseases Research

Integrated autolysis, DNA hydrolysis and precipitation enables an improved bioprocess for Q-Griffithsin, a broad-spectrum antiviral and clinical-stage anti-COVID-19 candidate

Research article

Published on 2022-04-012022-10-05
Journal: Biochemical Engineering Journal [Category] 임상, 치료제,

Structural characterization and SARS-CoV-2 inhibitory activity of a sulfated polysaccharide from Caulerpa lentillifera

Caulerpa lentillifera의 황산화 다당류의 구조적 특성 및 SARS-CoV-2 억제 활성

Article

Published on 2022-03-152022-09-11
Journal: Carbohydrate polymers [Category] SARS, 치료제,

Characterization of a SARS-CoV-2 spike protein reference material

SARS-COV-2 스파이크 단백질 기준 물질의 특성

Paper in Forefront

Published on 2022-03-092022-09-10
Journal: Analytical and bioanalytical chemistry [Category] COVID19(2023년), Fulltext, MERS, SARS, 치료기술,

[키워드] absorbance Amino acid Analysis assist calculated Canada changes in characterization Combination Community Concentration Council COVID-19 COVID-19 pandemic density development diagnostic diagnostic testing Dilution fraction glycoprotein glycosylated homogeneity hydrolysis Isotope dilution lack leads Liquid chromatography mass spectrometry material molar concentration molecular weight National Research Council Canada Protein reference reference material Reference materials reported Research SARS-CoV-2 SARS-CoV-2 spike protein scattering Spike protein stability Standardization supplementary material Tandem mass spectrometry test results the spike protein trimeric Tryptophan tyrosine value were assessed
[DOI] 10.1007/s00216-022-04000-y PMC 바로가기 [Article Type] Paper in Forefront

Identification of Crucial Genes and Key Functions in Type 2 Diabetic Hearts by Bioinformatic Analysis

생물정보학적 분석을 통한 제2형 당뇨병 심장의 핵심 유전자 및 주요 기능 식별

Endocrinology

Published on 2022-02-152022-09-11
Journal: Frontiers in Endocrinology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘,

[키워드] Acute cardiac injury Analysis Autopsy Bioinformatic bioinformatic analysis bioinformatics calpain calpain small subunit 1 (capn4) CAPNS1 cardiac cardiac injury conducted COVID-19 cytoplasmic Cytoscape dataset datasets dead DEGs DESeq2 develop diabete diabetes differentially expressed gene Differentially expressed genes down-regulated endopeptidase event events exhibited expression profile expression profiles function functions Gene ontology healthy heart hearts highlight homologous Hospitalized Human hydrolysis hydrolyzed identification identify Infection Interaction Kyoto leads less mechanism membrane mice Mitochondria molecular Mybpc3 Myocardium NCBI-Gene NCBI-GEO nuclear translocation overlapping pathogenic pathway patients with SARS-CoV-2 performed PPI PPI network prognostic progression protein-protein interaction reduced RNA-sequencing SARS-COV-2 infection self-protective role Serine Signaling significantly significantly increased small subunit specimen substrate syndrome T2D therapy Tnni3 Transcription transcriptional change transcriptional level Transcriptional upregulation transcriptomics Type type 2 diabetes unique up-regulated with COVID-19
[DOI] 10.3389/fendo.2022.801260 PMC 바로가기 [Article Type] Endocrinology

Green products from herbal medicine wastes by subcritical water treatment

Article

Published on 2022-02-152023-07-06
Journal: Journal of hazardous materials [Category] COVID19(2023년),

[키워드] amino acids Herbal medicine waste hydrolysis Organic acids Subcritical extraction Sugars.
[DOI] 10.1016/j.jhazmat.2021.127294

Selenium, selenoprotein P, and oxidative stress levels in SARS-CoV-2 patients during illness and recovery

SARS-CoV-2 환자의 질병 및 회복 중 셀레늄, 셀레노단백질 P 및 산화 스트레스 수준

Original Article

Published on 2022-02-142022-09-10
Journal: Inflammopharmacology [Category] COVID19(2023년), MERS, SARS, 치료기술,

Production and use of encapsidated RNA mimics as positive control reagents for SARS-CoV-2 RT-qPCR diagnostics

Article

Published on 2022-02-012022-10-30
Journal: Journal of virological methods [Category] COVID-19, COVID19(2023년), MERS, SARS,

[키워드] American CDC Berlin can be used Charité Chinese CDC Combination Control COVID-19 Cowpea mosaic virus Diagnosis diagnostics Efficiency Genome gold standard hydrolysis in vivo In-tube control MONITOR multiplex RT-qPCR Multiplexing Nicotiana benthamiana novel nucleic acid extraction packaged Particle Patient PCR amplification plant virus polymerase chain positive control produced Production protocols Pseudogenome purified Reactions reagent reverse transcription RNA RNA extraction RT-qPCR SARS-CoV-2 sequence Specific swab sample transient expression virus virus particle Virus-like particle virus-like particles VLP
[DOI] 10.1016/j.jviromet.2021.114372 PMC 바로가기 [Article Type] Article

Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase

Article

Published on 2022-01-102022-10-04
Journal: Nature Communications [Category] 변종,

[키워드] biochemically Biosynthesis biosynthetic canonical characterized domain Enzyme mechanisms Enzymes example expand facilitate highlight hydrolysis mechanism NRPs NRPSs peptide responsible reveal subunit Synthetase transfer translocation unique utility
[DOI] 10.1038/s41467-021-27512-0 PMC 바로가기 [Article Type] Article

Discovery of juglone and its derivatives as potent SARS-CoV-2 main proteinase inhibitors

강력한 SARS-CoV-2 주요 단백질분해효소 억제제로서의 주글론 및 그 유도체의 발견

Article

Published on 2021-12-052022-09-11
Journal: European journal of medicinal chemistry [Category] MERS, SARS, 신약개발, 진단,

[키워드] acetyl active site Amino acid amino acid residue Analysis antiviral activity caused Characteristics characterized Concentration concentrations contributed coronavirus COVID-19 demonstrated derivative Drug discovery Efficacy enzyme evaluated exhibited Host host cells hydrogen Hydrogen bond hydrogen bonds hydrolysis in vitro ingredient inhibit inhibitor inhibitors inhibitory inhibitory activity Juglone M pro M(pro) inhibitors molecular docking studies much higher naphthoquinone Naphthoquinones non-toxic outbreak peptide polyprotein positive control positive-sense single-stranded RNA protease proteinase Replication replication of SARS-CoV-2 Research RNA coronavirus SARS SARS-CoV-2 significantly suppress tested Transcription Vero E6 Vero E6 cell VERO E6 cells Viral virus
[DOI] 10.1016/j.ejmech.2021.113789 PMC 바로가기 [Article Type] Article

Theoretical basis for stabilizing messenger RNA through secondary structure design

AcademicSubjects/SCI00010

Published on 2021-10-112022-10-31
Journal: Nucleic Acids Research [Category] COVID-19, MERS, SARS,

[키워드] Algorithm approach average B.1.1.7 variant B.1.351 changes in cleavage coding Degradation double-stranded effective feature hydrolysis in vitro in vivo increase Messenger RNA mRNA mRNAs platform Probability problem Proteins reduce regions RNA RNA stability robust SARS-CoV-2 spike protein secondary structure sequence stability target protein temperature translation Vaccine
[DOI] 10.1093/nar/gkab764 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010