Anti-Inflammatory Activity of CIGB-258 against Acute Toxicity of Carboxymethyllysine in Paralyzed Zebrafish via Enhancement of High-Density Lipoproteins Stability and FunctionalityArticle Published on 2022-09-042022-11-15 Journal: International Journal of Molecular Sciences [Category] 진단, [키워드] activity aggregation ameliorated anti-inflammatory activity Autoimmune disease carboxymethyllysine (CML) cascade caused cholesterol CIGB-258 (Jusvinza) CML co-injection coronavirus disease COVID-19 cytokine Cytokine storm death death rate decrease developmental Efficacy Embryo enhancement exhibited faster ferrous ion Final HDL Heat shock high-density high-density lipoproteins (HDL) highest Hsp60 hyperinflammation infiltration Inflammation Inflammatory inflammatory cells infliximab inhibit injected injection kDa Ligand lipoprotein lowest mechanism neutrophil Pain paralysis Particle peptide plasma protective effect Protein resulting stability Stress Survivability systemic inflammation tissue treated Triglyceride was tested zebrafish zebrafish. [DOI] 10.3390/ijms231710130 PMC 바로가기
Impact of hypertension on long-term humoral and cellular response to SARS-CoV-2 infectionArticle Published on 2022-09-022022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, 치료제, [키워드] age airway analyzed Anosmia association Asthma Blood blood collection BMI cellular Cellular immune response cellular response clinical factor confounding factor confounding factors COPD COVID COVID - 19 determine develop diabetes exacerbate HCW HCWs Health care Hospitalized humoral humoral and cellular response hyperinflammation hypertension hypertensive identify immune response immune response. Impact independent Infection less median multivariate regression analysis myalgia Neutralizing antibodies normotensive outbreak PCR positivity regression analysis respiratory tract response Risk factors S1 IgG SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection Sex shown significantly smoking T cell Test transformation viral clearance was done [DOI] 10.3389/fimmu.2022.915001 PMC 바로가기
Infliximab in the treatment of patients with severe COVID-19 (INFLIXCOVID): protocol for a randomised, controlled, multicentre, open-label phase II clinical studyArticle Published on 2022-09-022022-10-04 Journal: Trials [Category] SARS, 임상, 진단, [키워드] 28-day mortality addition Affect Alpha approved assessment Blood changes chronic inflammatory disease clinical study clinical trial collected Course COVID-19 current therapy dose driven by Effectiveness ethics committee EudraCT Friedrich Schiller high mortality hyperinflammation IL-6 IMPROVE infections Infectious diseases infliximab International Laboratory molecular molecular diagnostics monoclonal antibody morbidity multicentre Open-label Patient patients with COVID-19 primary endpoint pro-inflammatory cytokine protocol randomised randomised controlled trial receive Registered Research respiratory respiratory infections. resulting severe COVID-19 Standard of care systemic inflammatory the disease therapy TNF-α Treatment Trial university Urine [DOI] 10.1186/s13063-022-06566-5 PMC 바로가기 [Article Type] Article
Reactivation of EBV and CMV in Severe COVID-19-Epiphenomena or Trigger of Hyperinflammation in Need of Treatment? A Large Case Series of Critically ill Patients심각한 COVID-19-Epiphenomena에서 EBV 및 CMV의 재활성화 또는 치료가 필요한 Hyperinflammation의 트리거? 중환자의 대규모 사례 시리즈Article Published on 2022-09-012022-09-11 Journal: Journal of Intensive Care Medicine [Category] 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed ARDS Chain Reaction Characteristics Clinical deterioration CMV cohort study comparable connection control group coronavirus Corticosteroid Course COVID-19 Critically ill Critically ill patient critically ill patients cytomegalovirus decrease described Diagnosis disease EBV Epstein-Barr virus Follow-up analysis Ganciclovir high risk hyperinflammation ICU in viral incidence increased mortality initiation of treatment intensive care intensive care unit intensive care unit. majority Non-COVID-19 non-COVID-19 patient Non-COVID-19 patients outcome Patient polymerase chain polymerase chain reaction Reactivation remains uncertain retrospective rituximab SARS-CoV-2 screened Sepsis sepsis patient Sery severe acute respiratory syndrome Coronavirus severe COVID-19 single-center survived systemic corticosteroid treated Treatment Trigger Viral load viral reactivation virus virus with COVID-19 [DOI] 10.1177/08850666211053990 PMC 바로가기 [Article Type] Article
Attenuation of SARS-CoV-2 replication and associated inflammation by concomitant targeting of viral and host cap 2′-O-ribose methyltransferasesArticle Published on 2022-09-012022-11-15 Journal: The EMBO Journal [Category] COVID19(2023년), SARS, 치료제, [키워드] AHCY Anti-SARS-CoV-2 Activity Antiviral antiviral activity antiviral drug antivirals attenuation Concomitant COVID-19 COVID-19 treatments Drug screening DZNep enzyme Ex vivo exhibit functional Host host-directed hyperinflammation identify Immune escape immunomodulatory effect in silico in vitro in vivo independent Infection Inflammation inhibitor Interaction Lung fibrosis marker Methylation methyltransferase methyltransferase. pathogen reduce SAM SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Side effects Stage suppresse Treatment Viral RNA virus replication [DOI] 10.15252/embj.2022111608 PMC 바로가기
Dysregulated miRNAs network in the critical COVID-19: An important clue for uncontrolled immunothrombosis/thromboinflammation중요한 COVID-19에서 조절되지 않는 miRNA 네트워크: 통제되지 않는 면역혈전증/혈전염증에 대한 중요한 단서Review Published on 2022-09-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] accompanied activated Activation adenine affecting anti-inflammatory factors Anticoagulant cause clinical complication Coagulation Coagulation system complement complement system Complication components conserved coronavirus disease Coronavirus disease 2019 COVID-19 Critical Cytokine storm Defensive mechanism deviation diffusion Effect expression expression level facilitate Factor function Genetic higher risk homeostasis hyperinflammation immune immunothrombosis incidence Interaction involved life-threatening mechanism microRNA MicroRNAs miRNA miRNAs miRNAs-based therapy. molecules Mortality NADPH nicotinamide nicotinamide adenine dinucleotide Nicotinamide adenine dinucleotide phosphate Non-coding RNAs nucleotide oxygen Pathogens Patient phosphate reactive oxygen species reactive oxygen specy reduction response restrict SARS-CoV-2 severe complications therapeutic approach therapy Thromboinflammation thrombotic underlie vicious cycle [DOI] 10.1016/j.intimp.2022.109040 PMC 바로가기 [Article Type] Review
Human Fungal Infection, Immune Response, and Clinical Challenge-a Perspective During COVID-19 PandemicReview Published on 2022-09-012023-07-09 Journal: Applied biochemistry and biotechnology [Category] COVID19(2023년), [키워드] COVID-19 drug resistance Fungal infection hyperinflammation immunity. [DOI] 10.1007/s12010-022-03979-5 PMC 바로가기 [Article Type] Review
A Randomized Double-Blinded Placebo Controlled Trial of Clazakizumab for the Treatment of COVID-19 Pneumonia With Hyperinflammation고염증을 동반한 COVID-19 폐렴의 치료를 위한 Clazakizumab의 무작위 이중 맹검 위약 대조 시험Clinical Trial Published on 2022-09-012022-09-12 Journal: Critical Care Medicine [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] 1:1 accompanied added Bayesian benefit board changes Clazakizumab Clinical outcome clinical status Controlled COVID-19 COVID-19 disease Critical cumulative double-blinded dropped enrolled Frequency greater High-dose hospitalized patient hyperinflammation ICU ICU admission inhibitor Inpatient interleukin-6 intubation Logistic low-dose measurement monitoring Odds ratio outcome Patient patients patients hospitalized Placebo placebo-controlled Poisson regression model Primary outcome Randomized receiving recommendations risk Safety seamless secondary secondary outcome severe COVID-19 disease significantly suggested survival Trial Ventilation ventilator-free survival were used with COVID-19 [DOI] 10.1097/CCM.0000000000005591 PMC 바로가기 [Article Type] Clinical Trial
Dual effects of supplemental oxygen on pulmonary infection, inflammatory lung injury, and neuromodulation in aging and COVID-19Review article Published on 2022-09-012022-10-05 Journal: Free radical biology & medicine [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] activating Activation acute lung injury acute respiratory distress syndrome (ARDS) age aging analysis Anti-inflammatory antioxidant ARDS attenuate Biomarkers Blood oxygen saturation Brain cause caused cellular cellular damage Central nervous system Cholinergic anti-inflammatory pathway chronic inflammation clinical Clinical outcome COVID-19 COVID-19 patient COVID-19 patients death decrease Defense distress dysregulated Effect function functions humans hyperinflammation IMPROVE increase in infected with SARS-CoV-2 infections Inflammation inflammatory lung injury Inflammatory response inhibiting Innate immunity likelihood lung lung cells Lung inflammation macrophages master regulator Mitochondria morbidity and mortality oxidative oxidative stress oxygen Oxygen therapy pathway positive correlation positively correlated Postmortem prolonged exposure Pulmonary infection reactive oxygen specy receiving receptor regulate regulated resulting ROS Safe Sepsis shown Signaling supplemental oxygen Supplemental oxygen therapy susceptibility syndrome Therapeutic approach Toxicity treat α7 nicotinic acetylcholine receptor α7nAChR [DOI] 10.1016/j.freeradbiomed.2022.08.004 [Article Type] Review article
The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implicationsArticle Published on 2022-08-312022-11-15 Journal: Biochemical Journal [Category] 진단, [키워드] activities amyloid microclots antioxidants biochemical burst Capillaries cell activation conditions COVID disease element Evidence explain hyperinflammation hypoxia implication Inflammatory diseases initiated Injury involved ischaemia–reperfusion injury. Long Long COVID malaise marker mechanism mechanisms metabolite Occurrence oxidative stress pathology produced reactive oxygen specy relapsing reperfusion rheumatoid arthritis Safe therapeutic Therapeutic benefit variety [DOI] 10.1042/BCJ20220154 PMC 바로가기