Assessment of Admission COVID-19 Associated Hyperinflammation Syndrome Score in Critically-Ill COVID-19 PatientsArticle Published on 2023-01-012023-07-10 Journal: Journal of Intensive Care Medicine [Category] COVID19(2023년), [키워드] ChiS COVID-19 hyperinflammation intensive care unit SARS-CoV-2 Score. [DOI] 10.1177/08850666221131265 PMC 바로가기
Immunouniverse of SARS-CoV-2Review Published on 2022-12-012023-07-09 Journal: Immunological medicine [Category] COVID19(2023년), [키워드] Cytokines Hypercoagulation hyperinflammation immune response. [DOI] 10.1080/25785826.2022.2066251 PMC 바로가기 [Article Type] Review
Multisystem inflammatory syndrome in children: clinical presentation, management, and short- and long-term outcomesArticle Published on 2022-12-012023-07-10 Journal: Clinical Rheumatology [Category] COVID19(2023년), [키워드] COVID-19 hyperinflammation MIS-C pediatric. [DOI] 10.1007/s10067-022-06350-5 PMC 바로가기
Antioxidant, Anti-inflammatory, and Immunomodulatory Roles of Nonvitamin Antioxidants in Anti-SARS-CoV-2 TherapyArticle Published on 2022-10-132022-11-15 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 바이오마커, 치료제, [키워드] ACE2 receptor Activation activities alleviate Alleviating alveolar antioxidant antiviral role conformational change COVID-19 Cytokine storm Dipeptidyl peptidase 4 Direct dosage Endothelium favor furin Helicase host receptor hyperinflammation Illness severity immunogenic Inflammatory Inflammatory responses influences membranes Organ failure oxidative stress Papain-like protease pathology pathway protease reactive oxygen specy Receptor binding domain Replication risk RNA-dependent RNA polymerase role serine 2 the spike protein transmembrane vicious cycle viral spike protein [DOI] 10.1021/acs.jmedchem.2c01134 PMC 바로가기
Single-cell transcriptome analyses reveal distinct gene expression signatures of severe COVID-19 in the presence of clonal hematopoiesisArticle Published on 2022-10-012022-11-16 Journal: Experimental & Molecular Medicine [Category] 변종, 유전자 메커니즘, [키워드] analysis ChIP chromatin chromatin architecture classical monocytes clinical impact COVID-19 dissect element exacerbating exhibited facilitate Gene Expression gene expression signature Hematopoiesis highlight hyperinflammation IFN-γ immunological individual Inflammation inflammatory immune response Inflammatory responses interactions mechanism methylated mononuclear cells Patient Peripheral blood putative target gene Region Regulatory reported severe COVID-19 severe COVID-19 patients severity single-cell susceptibility Transcriptome with COVID-19 [DOI] 10.1038/s12276-022-00866-1 PMC 바로가기
Pembrolizumab in combination with tocilizumab in high-risk hospitalized patients with COVID-19 (COPERNICO): A randomized proof-of-concept phase II studyClinical Trial Published on 2022-10-012022-10-05 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] addition antibody Cell cellular Combination COVID-19 deaths discharge Efficacy and safety elevated faster Hospitalization hospitalized patient hyperinflammation immune dysregulation Infection interleukin 6 receptor lymphocyte males mechanical ventilation median age median time objective Open-label Patient Pembrolizumab Pneumonia Randomized reduced Result SARS-COV-2 infection severe SARS-CoV-2 Standard of care TCZ Tocilizumab Trial with COVID-19 [DOI] 10.1016/j.ijid.2022.08.007 [Article Type] Clinical Trial
Covid-19 and adolescent acute kidney injury: Renal recovery with combined enalapril and estrogen therapyCase report Published on 2022-10-012022-10-05 Journal: Clinica chimica acta; international journal of cli [Category] 변종, 유전자 메커니즘, [키워드] ACE-inhibitor acute kidney Against age amenorrhea angiotensin-converting enzyme inhibitor baseline Case report characterized childhood Combined COVID-19 described diagnosed Diagnosis Estrogen Europe feature female functional glomerular filtration rate healthy high risk Hospital admission hyperinflammation Infection Inflammatory Injury Intersection intron Kawasaki disease kidney Kidney injury males mense MIS-C multiorgan failure normalized North America NOTCH4 outcome ovarian Premature reduced renal function Sequencing Shock syndrome therapy transdermal estrogen United Nation variant WGS while WHO whole genome [DOI] 10.1016/j.cca.2022.08.013 [Article Type] Case report
CGRP Plasma Levels Correlate with the Clinical Evolution and Prognosis of Hospitalized Acute COVID-19 PatientsArticle Published on 2022-09-262022-11-15 Journal: Viruses [Category] SARS, 바이오마커, [키워드] baseline Biomarker blood sample calcitonin calcitonin gene-related peptide (CGRP) clinical clinical disease Coagulopathy collected correlated correlation COVID-19 Critical diagnosed disease disease severity eligible etiological agent Evolution heterogenous higher risk highlighting Hospitalization Hospitalized hyperinflammation immune modulation In-hospital investigated involved IP10 Italian Laboratory test Level lung majority moderate pandemic pathophysiology Patient peptide performed plasma predicted prospective cohort study pulmonary intravascular coagulopathy. SARS-CoV-2 SARS-CoV-2 patient severe COVID-19 patients severe respiratory failure Stratification Support Vasoactive [DOI] 10.3390/v14102123 PMC 바로가기
Kynurenine serves as useful biomarker in acute, Long- and Post-COVID-19 diagnosticsArticle Published on 2022-09-232022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 치료기술, [키워드] Admission age Biomarker Blood Concentration concerning controls correlated COVID-19 COVID-19 monitoring CRP CRP value diagnosis and monitoring diagnostics disease Donor elevated group hospital Hospitalized hyperinflammation IL-6 immune system Inflammation inflammation diagnostics Inflammatory Inflammatory marker Inflammatory response innate immune response Innate immunity Inpatient interleukin-6 investigated involved Kynurenine kynurenine reference values. Long Long-COVID biomarkers long-lasting marker material P-value pathophysiology Patient patients with SARS-CoV-2 rehabilitation Saliva SARS-COV-2 infection sera serum significantly significantly higher subset Symptom syndrome the SARS-CoV-2 therapy were measured [DOI] 10.3389/fimmu.2022.1004545 PMC 바로가기
Differential proinflammatory activities of Spike proteins of SARS-CoV-2 variants of concernArticle Published on 2022-09-162022-11-16 Journal: Science Advances [Category] SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome addition angiotensin-converting enzyme 2 canonical coronavirus coronavirus disease COVID-19 CSS Cytokine storm syndrome Genetic hemorrhages Host immune response hyperinflammation Inflammasome Inflammation less life-threatening Local long-lasting Macrophage mechanism neutrophil pandemic proinflammatory proinflammatory activity promoted Protein recruitment rescued SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 variant spike systemic hyperinflammation variant variants variants of concern zebrafish [DOI] 10.1126/sciadv.abo0732 PMC 바로가기