Autoimmune Hemolytic Anemia Exacerbation Associated With COVID-19 Infection and Markedly Elevated Inflammatory MarkersInternal Medicine Published on 2021-12-142022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute exacerbation Admission Anemia association Autoimmune Autoimmune diseases autoimmune hemolytic anemia (aiha) Case report caused childhood clinical symptom coronavirus disease Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 infection Cytokine storms diagnosed Exacerbation female hemolytic hemolytic anemia Hyperinflammatory syndrome Infection Inflammatory marker Inflammatory mediators past medical history reveal sars-cov-2 (severe acute respiratory syndrome coronavirus -2) SLE systemic lupus erythematosus warm autoimmune hemolytic anemia [DOI] 10.7759/cureus.20416 PMC 바로가기 [Article Type] Internal Medicine
How Immunosenescence and Inflammaging May Contribute to Hyperinflammatory Syndrome in COVID-19Review Published on 2021-11-212022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] accumulation aging alteration B-cell characterized CMV contribute coronavirus disease COVID-19 Cytokine storm Factor Hematopoiesis Hyperinflammatory syndrome Immune cell immune cells immune responses immune stimulation immune system immunosenescence Infection inflammaging Inflammatory mediators innate immune system low-grade inflammation Lymphocytes memory memory T modulate naïve occur peripheral circulation Phenotypes Population pro-inflammatory cytokines proportion reduced secrete secreting senescence-associated secretory phenotype (SASP) senescent severity stressors T-cell thymic [DOI] 10.3390/ijms222212539 PMC 바로가기 [Article Type] Review
Plasma zinc status and hyperinflammatory syndrome in hospitalized COVID-19 patients: An observational studyObservational Study Published on 2021-11-012022-10-05 Journal: International immunopharmacology [Category] SARS, 임상, [키워드] 95% CI acute respiratory distress antiviral response association Biomarker cHIS. Clinical outcome Cohort Complication Concentration conducted control group correlated COVID-19 COVID-19 patient CRS cytokine releasing syndrome deficiency diagnosed with COVID-19 early stage eligible patient Hospital stay hospitalized COVID-19 hospitalized COVID-19 patient hospitalized COVID-19 patients Hyperinflammatory syndrome Infection Inflammation interquartile range IQR majority median median age morbidity Mortality Non-COVID-19 outcome outcomes Patient PCR-confirmed plasma zinc concentration Prevalence Prognostic marker retrospective risk robust SARS-CoV-2 severe SARS-CoV-2 significantly single-center Support syndrome tested the disease university hospital Zinc [DOI] 10.1016/j.intimp.2021.108163 PMC 바로가기 [Article Type] Observational Study
COVID-19 in children: an approach for multisystem inflammatory syndromeReview Published on 2021-10-262022-10-31 Journal: Egyptian Pediatric Association Gazette [Category] COVID-19, [키워드] acute respiratory syndrome Adults approach article cause characterized children clinical evidence clinical feature coronavirus coronavirus disease Coronavirus-2 Corticosteroids COVID-19 COVID-19 patients database diagnosed Diagnosis elevated exaggerated immune response exclusion Fever gastrointestinal involvement Hyperinflammatory Hyperinflammatory syndrome immunoglobulins Infection Inflammatory inflammatory markers information Intravenous immunoglobulin IVIG Kawasaki lack lower mortality management mechanism Mild symptom MIS-C multiorgan failure Multisystem inflammatory syndrome Organ failure pathophysiologic pathophysiology pediatric pediatrics Rash retrieved SARS-CoV-2 SARS-COV-2 infection searched Specific subsequent syndrome Tocilizumab Topic treated Trial [DOI] 10.1186/s43054-021-00082-y PMC 바로가기 [Article Type] Review
Basophils and Mast Cells in COVID-19 PathogenesisReview Published on 2021-10-142022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] “cytokine storm” Activation Adaptive immune response Airway inflammation allergic anti-parasitic Antigen antigen-presenting cell basophil basophils boost cell differentiation cells characteristic COVID-19 disease epithelial greater humoral humoral immune responses Hyperinflammatory syndrome immune response inducer Infection Inflammatory innate immune response lung cells mast cell Mast cells memory nasal prognostic protective immunity pulmonary fibrosis reducing reduction SARS-CoV-2 susceptibility Th2 Th2 response the antibody response the disease therapeutic target virus worse prognosis [DOI] 10.3390/cells10102754 PMC 바로가기 [Article Type] Review
Case Report: Lymphohistiocytic Myocarditis With Severe Cardiogenic Shock Requiring Mechanical Cardiocirculatory Support in Multisystem Inflammatory Syndrome Following SARS-CoV-2 InfectionCardiovascular Medicine Published on 2021-09-092022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] Affect Asymptomatic blockade cardiogenic children COVID-19 differential diagnosis dysfunction febrile full recovery High-dose histological hospital Hyperinflammatory syndrome Immune cell immunomodulatory therapy Immunosuppressive treatment Impella® Intravenous immunoglobulin lack male Mechanical MIS MIS-C multi-organ failure multisystem inflammatory syndrome in children myocardial biopsy myocardial necrosis myocarditis offer Patient patients pediatric Prognosis progressed SARS-CoV-2 SARS-COV-2 infection Shock Steroids Support symptomatic the disease the patient V-A ECMO [DOI] 10.3389/fcvm.2021.716198 PMC 바로가기 [Article Type] Cardiovascular Medicine
Cytokine storm in severe COVID-19 pneumonia심각한 COVID-19 폐렴의 사이토카인 폭풍Article Published on 2021-09-012022-09-11 Journal: Journal of medical virology [Category] SARS, 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome addition Alanine ALT Anemia anti-cytokine anti-cytokine therapy ARDS aspartate AST clinic Confirmed COVID-19 infection coronavirus COVID-19 COVID-19 infection COVID-19 patient COVID-19 pneumonia criteria Cytokine storm decrease determine develop disease elevated elevated lactate dehydrogenase feature ferritin help hemoglobin hemophagocytic lymphohistiocytosis Hospitalized Hyperferritinemia hyperfibrinogenemia Hyperinflammatory syndrome ICU ICU admission identify immnopathology immune immune responses in some include Inflammation intensive care intensive care unit Laboratory laboratory parameter Laboratory parameters Lactate lactate dehydrogenase LDH leukocyte Liver function Liver function test lymphocyte lymphocytopenia Macrophage macrophage activation syndrome Novel coronavirus occurred parameter parameters Patient patients Planning Platelet Pneumonia predict procalcitonin progression reduced respiratory distress Respiratory distress syndrome retrospective cohort study secondary hemophagocytic lymphohistiocytosis Severe COVID-19 pneumonia Severe patient severe pneumonia sHLH significant changes in significantly significantly increased Symptom syndrome the cytokine storm the patient thrombocytopenia transferred Triglyceride troponin two subgroups virus virus classification with COVID-19 worsened worsening [DOI] 10.1002/jmv.27068 PMC 바로가기 [Article Type] Article
Inflammatory biomarkers in COVID-19-associated multisystem inflammatory syndrome in children, Kawasaki disease, and macrophage activation syndrome: a cohort studyResearch article Published on 2021-08-012022-10-05 Journal: The Lancet Rheumatology [Category] 바이오마커, [키워드] Acute kidney injury Altered mental status Analysis approach Biomarker center characteristic chemokine children Cincinnati clinical Coagulopathy cohort of patient cohort study Concentration concentrations conditions CXCL9 Deutsche Forschungsgemeinschaft diagnosed Diagnosis eight elevated ELISA enrolled family finding FIVE foundation Frequency funding Hyperinflammatory Hyperinflammatory syndrome IL-18 IL-6 Inflammatory Inflammatory biomarker juvenile idiopathic arthritis Kawasaki disease Laboratory laboratory feature Ligand macrophage activation macrophage activation syndrome management median median age MIS-C motif Myocardial dysfunction nine non-parametric test occur Pathogenesis pathophysiology Patient potentially life-threatening prospective cohort Protein provide S100A12 SARS-COV-2 infection Sensitivity and specificity Seven severity Shock significantly higher skin Stratification Support syndrome systemic inflammatory marker USA was done were assessed [DOI] 10.1016/S2665-9913(21)00139-9 [Article Type] Research article
Limited utility of the HScore in detecting secondary haemophagocytic lymphohistiocytosis in COVID-19: responseCOVID-19에서 2차 혈구포식세포 림프조직구증을 감지하는 데 HScore의 제한된 유용성: 반응Comment Published on 2021-08-012022-09-11 Journal: British Journal of Haematology [Category] SARS, 치료기술, [키워드] Abstract COVID-19 Hyperinflammatory Hyperinflammatory syndrome immunosuppressive immunosuppressive therapy Limited secondary haemophagocytic lymphohistiocytosis therapy utility [DOI] 10.1111/bjh.17535 PMC 바로가기 [Article Type] Comment
Kawasaki-like multisystem inflammatory syndrome associated with SARS-CoV-2 infection in an adult성인의 SARS-CoV-2 감염과 관련된 가와사키 유사 다기관 염증 증후군Case Reports Published on 2021-07-232022-09-11 Journal: BMJ case reports [Category] SARS, 치료기술, [키워드] Admission Adults buttocks Cardiomyopathy cardiovascular medicine conjunctivitis COVID-19 described diarrhoea Diseases dry cough Echocardiogram Ejection fraction erythematous erythematous rash Fever followed by hands healthy High-flow nasal oxygen hospital Hyperinflammatory syndrome Infectious diseases Inflammatory left ventricle manifestation Measures nasopharyngeal swabs occur oxygen Oxygen therapy paediatric patients Patient physician positive Rash resolved respiratory compromise reverse transcription PCR reversed SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection sensitivity significantly sputum Stool stool samples syndrome therapy troponin I vomiting [DOI] 10.1136/bcr-2020-240845 PMC 바로가기 [Article Type] Case Reports