SARS-CoV-2 inhibition using a mucoadhesive, amphiphilic chitosan that may serve as an anti-viral nasal spray항 바이러스 비강 스프레이로서 작용할 수있는 점막 흡착성, 양친 매성 키토산을 사용한 SARS-COV-2 억제Article Published on 2021-10-082022-08-31 Journal: Scientific Reports [Category] SARS, 치료기술, 치료제, [키워드] A549 ACE-2 receptor adverse effect Anti-viral binding Biomedical materials Brain Cell clinical testing Concentration controls Coronavirus infections Course COVID-19 COVID-19 pandemic detect dose dosed effective electrostatic epithelial cells expressing Good host cells human airway human airway epithelial human airway epithelial cells hypothesise Infection inhibit injected limit log mammalian mechanism mice nares nasal nasal epithelial cell open Polymer Practice Prevent preventive intervention Prophylactic RATs reduce respiratory respiratory droplet Respiratory droplets respiratory tract Safe SARS-CoV-2 Spread spread of COVID-19 statistical significance TCID transgenic mice Vero E6 Vero E6 cell VERO E6 cells Viral viral entry viral infection Viral load virus [DOI] 10.1038/s41598-021-99404-8 PMC 바로가기 [Article Type] Article
Sustainability of a school-based health intervention for prevention of non-communicable diseases in marginalised communities: protocol for a mixed-methods cohort studyPublic Health Published on 2021-10-052022-10-28 Journal: BMJ Open [Category] Coronavirus, Fulltext, MERS, SARS, [키워드] adoption Analysis approach association Bay benefit change children clinical assessments cohort study community child health condition conducted COVID-19 pandemic Data collection disease effective Effectiveness enrolled evaluate Evidence Frequency Health hypothesise include increased risk Intervention lack long-lasting maintenance Nelson Mandela Non-communicable disease non-communicable diseases outcome populations positive postintervention Prevalence Preventive medicine protocol public health Quantitative Questionnaires randomised controlled trial resource School South Africa Sports Medicine sustainability [DOI] 10.1136/bmjopen-2020-047296 PMC 바로가기 [Article Type] Public Health
Systematic SARS-CoV-2-testing for asymptomatic cancer patients treated at a public healthcare tertiary centre in BrazilShort Communication Published on 2021-07-262022-10-31 Journal: ecancermedicalscience [Category] COVID-19, [키워드] acute respiratory syndrome adherent affected age anticancer Asymptomatic asymptomatic patient Asymptomatic testing base Brazil Cancer cancer patient carried Characteristics Chemotherapy Cohort Complication consequence coronavirus coronavirus disease COVID-19 demographic demonstrated determine Eligible patients enrolled female gastrointestinal tract healthcare higher risk highest hospital hygiene hypothesise increased risk independent Infection means Measures median metastatic disease Most patient nasal oropharyngeal swab outcome pandemic Patient patients Patients with cancer physical distancing polymerase chain positive pre-symptomatic Prevalence prevalence of COVID-19 proportions public health receiving Result RNA severe disease solid cancer solid tumour tested therapy Transmissibility treated Treatment were excluded white [DOI] 10.3332/ecancer.2021.1269 PMC 바로가기 [Article Type] Short Communication
Low levels of respiratory syncytial virus activity in Europe during the 2020/21 season: what can we expect in the coming summer and autumn/winter?Rapid Communication Published on 2021-07-222022-10-31 Journal: Eurosurveillance [Category] COVID-19, SARS, [키워드] children country COVID-19 COVID-19 pandemic Critical Epidemics Epidemiology Europe expected France hypothesise Iceland Intervention Older respiratory syncytial virus RSV Surveillance surveillance data [DOI] 10.2807/1560-7917.ES.2021.26.29.2100639 PMC 바로가기 [Article Type] Rapid Communication
PEP-CoV protocol: a PEP flute-self-care randomised controlled trial to prevent respiratory deterioration and hospitalisation in early COVID-19PEP-CoV 프로토콜: 초기 COVID-19에서 호흡기 악화 및 입원을 예방하기 위한 PEP 플루트 자가 관리 무작위 대조 시험Article Published on 2021-06-302022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] activities activity assessment Chest chest tightness chronic pulmonary disease clinical trials cohort of patient collapse Contact control arm COPD cough Course COVID-19 COVID-19 symptoms daily living Deterioration disease Dyspnoea Effectiveness enrolment Ethical approval Ethics expiratory Expiratory Pressure Follow-up Health Healthcare systems high mortality rate hospital Hospital admission hospitalisation hypothesise individual Infectious diseases Intervention intervention group journal Local measure non-hospitalised Nurse offer pandemic participant Patient phlegm Pneumonia Prevent Preventive medicine Primary outcome Prognosis public health pulmonary disease randomised controlled trial Randomised trial receive recruit Registered registration number Research Ethics Research Ethics Committee respiratory medicine (see thoracic medicine) respiratory symptom respiratory symptoms Result Safe SARS-CoV-2 SARS-COV-2 infection secondary outcome self-care severe pulmonary disease shown sleep quality susceptibility symptom severity Symptoms Test Thoracic Treatment Trial usual care [DOI] 10.1136/bmjopen-2021-050582 PMC 바로가기 [Article Type] Article
Sleep Apnea and Fetal Growth Restriction (SAFER) study: protocol for a pragmatic randomised clinical trial of positive airway pressure as an antenatal therapy for fetal growth restriction in maternal obstructive sleep apnoea수면 무호흡증 및 태아 성장 제한(SAFER) 연구: 산모 폐쇄성 수면 무호흡증의 태아 성장 제한에 대한 산전 요법으로서 기도 양압에 대한 실용적인 무작위 임상 시험 프로토콜Article Published on 2021-06-292022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] Admission age Anomaly Antenatal APGAR score approved Birth weight Care cause center clinical trial complications Controlled trial COVID-19 Desaturation enrolment Ethics fetal FGR gestation gestational age growth hypothesise IMPROVE include institutional review board institutional review boards intensive care intention-to-treat analysis intrauterine infection Jerusalem maternal medicine morbidity and mortality mother multicentre Neonatal neonatal intensive care unit New York Obstructive obstructive sleep apnoea OSA outcome outcomes oxygen participant perinatology positive airway pressure Pragmatic pregnancies Pregnancy pregnant women Primary outcome proceed protocol questionnaire randomised registration number restriction risk risk factor screened second trimester secondary outcome Secondary outcomes Sleep sleep apnea sleep apnoea Sleep medicine Stage stage 2 standard care Stillbirth therapy Treatment Ultrasound undergo university Washington [DOI] 10.1136/bmjopen-2021-049120 PMC 바로가기 [Article Type] Article
Genetic risk for severe COVID‐19 correlates with lower inflammatory marker levels in a SARS‐CoV‐2‐negative cohortOriginal Article Published on 2021-06-062022-10-31 Journal: Clinical & Translational Immunology [Category] COVID-19, [키워드] acute respiratory syndrome Adaptive immune response Affect age Alpha applied association baseline baseline level Blood Blood level body mass index Cohort coronavirus coronavirus disease COVID‐19 COVID‐19 patients COVID‐19 cytokine Effect electrochemiluminescence method endothelial explain genetic risk genetic risk score genotype data growth factor hypothesise IFN‐γ IFN‐γ increasingly individual Infection Inflammation Inflammatory Inflammatory marker inflammatory markers inflammatory protein Innate immunity interferon gamma marker Necrosis obesity objective overactive profile reduced Result risk SARS‐CoV‐2 SARS‐CoV‐2 serum Support susceptibility susceptible the cytokine storm TNF‐α TNF‐α variable Vascular [DOI] 10.1002/cti2.1292 PMC 바로가기 [Article Type] Original Article
Is carbonic anhydrase inhibition useful as a complementary therapy of Covid-19 infection?탄산수소효소 억제가 Covid-19 감염의 보완 요법으로 유용합니까?Brief Report Published on 2021-06-022022-09-10 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] SARS, 신약개발, 치료제, [키워드] acetazolamide affected affecting Blood carbonic anhydrase caused clinically CO2 complementary contagious contagious disease cough country COVID-19 COVID-19 outbreak COVID-19 patients disease dysregulated Factor Fever globe Healthcare system high-altitude pulmonary oedema hypothesise hypoxaemia hypoxia inhibitor oedema outbreak Patient patients pharmacological treatment problem pulmonary disease pulmonary oedema Shortness of breath similarity specific inhibitor Symptom therapy treat [DOI] 10.1080/14756366.2021.1924165 PMC 바로가기 [Article Type] Brief Report
Serial markers of coagulation and inflammation and the occurrence of clinical pulmonary thromboembolism in mechanically ventilated patients with SARS-CoV-2 infection; the prospective Maastricht intensive care COVID cohortResearch Published on 2021-05-312022-10-29 Journal: Thrombosis Journal [Category] COVID-19, [키워드] addition adjusted age analysed Anticoagulants average Biomarker body mass index C-reactive protein cardiac thrombus clinical Coagulation Cohort Computed tomography Concentration COVID COVID-19 CRP CTPA D-dimer eight excluded ferritin fibrinogen hypothesise incidence Inflammation intensive care Linear regression model Lower marker mechanically ventilated patient Occurrence on mechanical ventilation outcome Patient positive Prospective Study Protein pulmonary angiography Pulmonary embolism pulmonary thrombosis Result risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient sensitivity analysis Sex significantly statistical significance supplementary material therapy Thromboembolism thrombus formation tissue plasminogen activator vessels were measured [DOI] 10.1186/s12959-021-00286-7 PMC 바로가기 [Article Type] Research
Randomised, double-blind, placebo-controlled trial of Probiotics To Eliminate COVID-19 Transmission in Exposed Household Contacts (PROTECT-EHC): a clinical trial protocol노출된 가구 접촉에서 COVID-19 전파를 제거하기 위한 프로바이오틱스의 무작위, 이중 맹검, 위약 대조 시험(PROTECT-EHC): 임상 시험 프로토콜Article Published on 2021-05-052022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] 16S rRNA Affect Analysis approval behavioural changes in clinical trial clinical trials collected conducted Contact COVID-19 COVID-19 infection COVID-19 infection status COVID-19 pandemic disseminate double-blind double-blinded drug Drug administration Duke enrolment Ethics evaluate evaluate the effect Evidence food gastroenterology Gut gut microbiome Health household hypothesise Infection infections Infectious diseases institutional review board International Lactobacillus rhamnosus microbial Microbiology Microbiome mitigate Modification Multivariate analysis nasal swab nasal swabs National New Other outcomes other variable outcomes PCR peer-reviewed Placebo placebo-controlled trial positive predict Probiotic Probiotics PROTECT protocol public health randomised reduce registration number Respiratory tract infections rRNA SARS-CoV-2 Sequencing severity of COVID-19 Severity of disease Spread Stool sample stool samples subject susceptibility Symptom Symptoms tested Trial university [DOI] 10.1136/bmjopen-2020-047069 PMC 바로가기 [Article Type] Article