IL8 – Page 2 – Communicable Diseases Research

SARS-CoV-2/ACE2 Interaction Suppresses IRAK-M Expression and Promotes Pro-Inflammatory Cytokine Production in Macrophages

Immunology

Published on 2021-06-232022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

Neutrophil Extracellular Traps Induce the Epithelial-Mesenchymal Transition: Implications in Post-COVID-19 Fibrosis

호중구 세포외 트랩은 상피-중간엽 전환을 유도합니다: 코로나19 이후 섬유증에 미치는 영향

Immunology

Published on 2021-06-142022-09-12
Journal: Frontiers in Immunology [Category] MERS, 진단,

Viral loads, lymphocyte subsets and cytokines in asymptomatic, mildly and critical symptomatic patients with SARS-CoV-2 infection: a retrospective study

SARS-COV-2 감염을 앓고있는 무증상, 경미하고 중요한 증상 환자의 바이러스 부하, 림프구 서브 세트 및 사이토 카인 : 후 향적 연구

Comparative Study

Published on 2021-06-122022-09-01
Journal: Virology Journal [Category] MERS, SARS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission age ANOVA Asymptomatic asymptomatic individual Asymptomatic individuals asymptomatic patient asymptomatic patients attack B cell B cells biological microscope Cell Chi-square Concentration coronavirus coronavirus disease coronavirus disease-2019 correlated COVID-19 Critical Critical case cytokine Cytokines diabetes Diabetes Mellitus disease enrolled Fisher Fisher's exact test flow cytometer Flow cytometric analysis group hospital Hospitalization IFN-α IFN-γ IL-10 IL-2 IL-5 IL-6 IL-8 IL10 IL2 IL4 IL5 IL6 IL8 infected individuals interleukin laboratory characteristics lymphocyte Lymphocyte subset Lymphocytes lymphopenia marker Microscope Mild Mild symptom mild symptoms NK cell NK cells No statistical differences occurred Patient patients patients with COVID-19 Plasma cytokine Pneumonia positively correlated respiratory Respiratory system Result Retrospective study RT-PCR SARS-CoV-2 SARS-COV-2 infection SCS severe acute respiratory syndrome Coronavirus severity of COVID-19 significant difference source of infection sputum statistical difference statistical differences subject subset symptomatic patient Symptomatic patients T cells T lymphocytes throat-swab TNF-α underlying disease underlying diseases variance Viral Viral load viral loads was used with COVID-19
[DOI] 10.1186/s12985-021-01597-x PMC 바로가기 [Article Type] Comparative Study

Unique inflammatory profile is associated with higher SARS-CoV-2 acute respiratory distress syndrome (ARDS) mortality

독특한 염증 프로파일은 더 높은 SARS-CoV-2 급성 호흡 곤란 증후군(ARDS) 사망률과 관련이 있습니다.

Article

Published on 2021-03-012022-09-12
Journal: American Journal of Physiology - Regulatory, Integrative and Comparative Physiology [Category] MERS, SARS, 진단,

Risk Factors for Mortality of COVID-19 Patient Based on Clinical Course: A Single Center Retrospective Case-Control Study

Immunology

Published on 2021-02-162022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS,

[키워드] Analysis association B cell B cells case-control study CD4 T cells CD8 T cells center chronic disease CK-MB clinical Clinical characteristics Clinical course Clinical outcome Comorbidities complement component 3 complementary Complete correlation cough COVID-19 COVID-19 patient COVID-2019 CPR CRP cured cytokine D-dimer death Deceased Decreased discharged Dyspnea dysregulation electronic medical records evaluate evaluated Factor Factors ferritin Fever hypertension IL6 IL8 immune function immune response mechanisms immunological independent indicated Inflammatory Inflammatory biomarker inflammatory factors Inpatient Laboratory leucocytes logistic regression models lymphocyte Lymphocyte subset Lymphocyte subsets Mortality Most patient multivariable logistic regression myocardial enzymes Neutrophils NK cells outcome parameters Patient patients patients died positively correlated procalcitonin Prognosis Prognostic factor Prognostic value radiological retrospective risk factor ROC Curve SARS-CoV-2 SARS-COV-2 infection single center Spearman correlation analysis subset Symptom T cell T cells Tongji Hospital total bilirubin transferred variable was performed were used Wuhan
[DOI] 10.3389/fimmu.2021.581469 PMC 바로가기 [Article Type] Immunology

Severe COVID-19: A multifaceted viral vasculopathy syndrome

중증 코로나19: 다면적 바이러스성 혈관병증 증후군

Article

Published on 2021-02-012022-09-11
Journal: Annals of diagnostic pathology [Category] SARS, 유전자 메커니즘, 치료기술, 치료제,

[키워드] activate Activation alveolar macrophage Alveolar macrophages Autopsies basement membrane Beta blunting Brain capillary cascade caspase caspase 3 cellular characteristic circulating circulation coagulation cascade complement Complement activation COVID-19 COVID-19 infection cytokine Cytokine storm Cytokines death docked endocytosed endothelial Endothelial cell endothelial cells Endothelialitis eosin expression fat hematoxylin Hematoxylin and eosin Histopathology host response IL6 IL8 In situ Infection Infectious virus macrophages membrane microangiopathy pathophysiology predict prevalent procoagulant Protein pseudovirion pseudovirions reduplication Release removal response to therapies resulting SARS-CoV-2 septal serious COVID-19 severe COVID-19 spike Spike protein subcutaneous fat syndrome the cytokine storm therapy TNF alpha Viral viral capsid Viral load Viral protein Viral proteins Viral RNA viral spike protein zone
[DOI] 10.1016/j.anndiagpath.2020.151645 PMC 바로가기 [Article Type] Article

Functional Exhaustion of Type I and II Interferons Production in Severe COVID-19 Patients

Medicine

Published on 2021-01-272022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] acute respiratory syndrome adaptive Adaptive immune response Admission Asymptomatic carried caused Complication complications coronavirus Coronavirus disease 2019 correlated Course COVID-19 COVID-19 patient COVID-19 patients cytokine level cytokine levels Cytokine storm Cytokines described develop disease severity Exhaustion Follow-up form functional healthy subjects highlight hospital Hospitalization identify IFN IFNs IFNα IFNγ IFNγ level IL1β IL6 IL8 Immune cell immune cells immune factor immunological profile immunology in vitro independent Infectious diseases Inflammatory Inflammatory cytokine interferon majority Mild moderate multivariable analysis non-specific observation outcome Patient Personalized medicine plasma Potential biomarker pro-inflammatory cytokine Production Prospective Study reduced remained restored SARS-CoV-2 secretion severe COVID-19 patient significantly increased Spread Th1 the disease the WHO TNFα Treatment Type type I type II IFN type II interferon were measured Wuhan
[DOI] 10.3389/fmed.2020.603961 PMC 바로가기 [Article Type] Medicine

Broncho-alveolar inflammation in COVID-19 patients: a correlation with clinical outcome

Research Article

Published on 2020-11-162022-10-28
Journal: BMC Pulmonary Medicine [Category] COVID-19, Fulltext, SARS,

[키워드] Activation acute respiratory syndrome alveolar alveolitis Anti-viral antibodies Antiviral BAL Bronchoalveolar lavage Care Cell cell count Clinical outcome Concentration conducted coronavirus correlation COVID-19 Cytokines effector feature fraction groups Hyperactivation ICU ICU patient IL10 IL6 IL8 immunostaining increase in Infection Inflammation inflammatory cascade inflammatory status interleukin intermediate lung lymphocyte Macrophage Medicine Microscopy mononuclear cell Nasopharyngeal swab neutrophil pandemic Patient patients treated patients with moderate patients with SARS-CoV-2 pro-inflammatory cytokine proportions Prospective Study reached Real-time PCR Result SARS-CoV-2 severe COVID-19 severe pneumonia significantly higher steroid supplementary material Survivors sustained Tocilizumab Transmission treated Treatment ultrastructure Variation viral particle ward was performed with COVID-19
[DOI] 10.1186/s12890-020-01343-z PMC 바로가기 [Article Type] Research Article

The association between obesity and poor outcome after COVID-19 indicates a potential therapeutic role for montelukast

Research article

Published on 2020-10-012022-10-05
Journal: Medical Hypotheses [Category] SARS, 신약개발,

[키워드] absence accumulate addition adipocyte adipose allergic rhinitis Anti-viral Antigen association Asthma Bame binding affinity cause Cell clinical trials Combination complications COVID-19 cytokine cytokine release decrease demonstrated disease drug drugs early stage effective elevated enzyme eosinophilia expression extreme greater Human ICU admission IL-1β IL-5 IL5 IL6 IL8 immune response Immune-mediated in silico increased mortality indicate individual Infection inflammatory cells inflammatory disease Injury leukotriene receptor antagonist Local mechanism Montelukast Mortality Multiorgan obesity occurred outcome paracrine Patient patients poor prognosis Pragmatic Prevalence protease reduce Replication resulting risk risk factor Safe SARS-CoV-2 severe COVID-19 severity shown suppress syndrome systemic inflammation the SARS-CoV-2 virus therapeutic therapeutic potential time-consuming tissue tissue damage treat Trigger upper respiratory tract Vaccine virus RNA visceral
[DOI] 10.1016/j.mehy.2020.109883 [Article Type] Research article

Potential Role of Acacia Senegal (Gum Arabic) as Immunomodulatory Agent among newly diagnosed COVID 19 Patients: A structured summary of a protocol for a randomised, controlled, clinical trial

Letter

Published on 2020-09-052022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 1:1 Acacia addition agent Anti-inflammatory Arabic assigned assistant baseline baseline value blind change Clinical guidelines clinical trial computer-generated conducted Control COVID COVID 19 COVID 19 patient COVID-19 COVID-19 patients CRP Cytokines Date death diagnosed dissemination Efficacy element eligible patient Factor Gender group groups Gum Gum Arabic Hospital admission IL10 IL6 IL8 immunomodulation immunomodulatory independent Intervention Local mortality rate number objective outcome parallel-group participant Patient patients PCR Pectin phase Placebo placebo-controlled clinical trial Potential Prospective protocol provided random randomised randomised controlled trial randomization Randomized Randomly Real-time PCR receive Research response role Sample size secondary sequence seropositive Soba standard care state status TNFα Treatment Trial Tumor Two-arm university Version Viral load website
[DOI] 10.1186/s13063-020-04707-2 PMC 바로가기 [Article Type] Letter