Immune cell infiltration – Page 2 – Communicable Diseases Research

HACE2-Exosome-Based Nano-Bait for Concurrent SARS-CoV-2 Trapping and Antioxidant Therapy

동시 SARS-CoV-2 트래핑 및 항산화 요법을 위한 HACE2-엑소좀 기반 나노 미끼

Article

Published on 2022-02-022022-09-11
Journal: ACS applied materials & interfaces
[Category] COVID19(2023년), SARS, 치료제,

Cathepsin B is a potential therapeutic target for coronavirus disease 2019 patients with lung adenocarcinoma

카텝신 B는 폐 선암종을 가진 코로나바이러스 질병 2019 환자를 위한 잠재적인 치료 표적입니다

Article

Published on 2022-02-012022-09-11
Journal: Chemico-biological interactions
[Category] 바이오마커,

[키워드] angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Atla available data Basigin bioinformatics cancers cathepsin cathepsin B cause Cell coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CTSB database determine diagnosed with COVID-19 dipeptidyl peptidase Dipeptidyl peptidase 4 drug therapy explain expressed expression Gene Expression Omnibus GEO global public health Hyperinflammatory Hyperinflammatory response identify Immune cell infiltration implicated lung adenocarcinoma lung cancer lung cancer patient lung cancer patients mortality rate outcome Patient patients patients with COVID-19 positively correlated potential therapeutic target presenting Proinflammatory cytokine SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. severe COVID-19 susceptibility the SARS-CoV-2 therapeutic target therapy for COVID-19 tissue upregulation
[DOI] 10.1016/j.cbi.2022.109796 PMC 바로가기 [Article Type] Article

Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heart

심장 SARS-CoV-2 감염은 심장 내 전염증성 전사체 변화와 관련이 있습니다

Article

Published on 2022-01-292022-09-11
Journal: Cardiovascular Research
[Category] SARS, 유전자 메커니즘, 진단, 치료기술, 치료제,

[키워드] adverse outcome Analysis Atla Autopsy cardiac Cardiac infection Cardiac signature matrix caused cDNA Cell consequence COVID-19 Cytometry Deceased DEGs destruction Diagnosis differentially expressed gene downregulated Effects endothelial Endothelial cell endothelial cells fraction Gene ontology GO term heart heart tissue ICAM1 identify IFI44L Immune cell Immune cell infiltration immune response Immunofluorescent staining immunohistochemistry In situ hybridization Increased Infection interferon interferon pathway investigated MACE marker massive molecular MYPN no difference NPPB paracrine Pathomechanism positive pro-inflammatory pro-inflammatory gene expression q-value Quantitative reveal RNA-Seq RNA-sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2. sequencing data signature matrix single-cell dataset staining tissue transcriptomic alteration TRIM25 upregulated Viral Viral protein virus virus load was performed while
[DOI] 10.1093/cvr/cvab322 PMC 바로가기 [Article Type] Article

Comprehensive and Integrative Analysis of Two Novel SARS-CoV-2 Entry Associated Proteases CTSB and CTSL in Healthy Individuals and Cancer Patients

Bioengineering and Biotechnology

Published on 2022-01-262022-10-31
Journal: Frontiers in Bioengineering and Biotechnology
[Category] COVID-19,

Decreased TMPRSS2 expression by SARS-CoV-2 predicts the poor prognosis of lung cancer patients through metabolic pathways and immune infiltration

Research Paper

Published on 2022-01-152022-10-28
Journal: Aging (Albany NY)
[Category] COVID-19,

[키워드] acute respiratory syndrome Algorithms analysis cellular CIBERSORT clinicopathological parameter coronavirus correlated COVID-19 Cox regression Decreased DNA methylation drug target examined exhibited expression GEO global pandemic GSEA HPA immune Immune cell infiltration immune infiltration investigated KEGG lung cancer lung cancer patient lung cancer patients metabolic pathway molecular function mRNA mRNA expression outcome pathway Patient performed poor prognosis predict predictive power prognostic prognostic biomarker Prognostic value protease protein expression reduced SARS-CoV-2 SARS-CoV-infected cells serine 2 significantly Spread survival therapeutic target TMPRSS2 TMPRSS2 expression transmembrane was determined
[DOI] 10.18632/aging.203823 PMC 바로가기 [Article Type] Research Paper

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

ACE2는 TNF- 및 IFNγ-유도 면역병리학을 가진 새로운 COVID-19 마우스 모델에서 SARS-CoV-2에 대한 중요한 생체 내 수용체입니다

Research Article

Published on 2022-01-132022-09-12
Journal: eLife
[Category] 진단,

Multi‐omics of the expression and clinical outcomes of TMPRSS2 in human various cancers: A potential therapeutic target for COVID‐19

인간의 다양한 암에서 TMPRSS2의 발현 및 임상 결과의 멀티오믹스: COVID-19의 잠재적 치료 표적

Original Article

Published on 2021-12-242022-09-10
Journal: Journal of Cellular and Molecular Medicine
[Category] MERS, 바이오마커,

[키워드] TMPRSS2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed Analysis bioinformatics Biomarker Blood Brain Breast Cancer cancer progression cancers clinical consequence clinical consequences Clinical outcome Colorectal cancer contribute coronavirus coronavirus disease correlated correlation COVID‐19 DEGs effective Evidence expressed gene expression Genes Genetic variations humans Immune cell infiltration immune infiltration incidence Infection lung molecular multi‐omics analysis network analysis outbreak ovarian Pathway analysis Pathways Patient potential therapeutic target Prevent Prognosis prognostic prognostic analysis Prognostic biomarkers Prognostic value progression Protein regulate respiratory Respiratory system SARS‐CoV‐2 SARS‐CoV‐2 infection severe acute respiratory syndrome Coronavirus shown significantly Soft tissue therapeutic target tissue tissues TMPRSS2 transmembrane serine protease transmembrane serine protease 2 Tumours
[DOI] 10.1111/jcmm.17090 PMC 바로가기 [Article Type] Original Article

Microglia Do Not Restrict SARS-CoV-2 Replication following Infection of the Central Nervous System of K18-Human ACE2 Transgenic Mice

소교세포는 K18-인간 ACE2 형질전환 마우스의 중추신경계 감염 후 SARS-CoV-2 복제를 제한하지 않습니다

Pathogenesis and Immunity

Published on 2021-12-222022-09-10
Journal: Journal of Virology
[Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단,

[키워드] accompanied ACE2 Activation addition administration Antiviral causative agent CCL19 CCL2 CCL5 Central nervous system characterized chemokine CNS colony-stimulating factor consequence contribute contributing to COVID-19 COVID-19 patient COVID-19 patients Critical CXCL10 CXCL9 cytokine Defense determined by disease eIF2 evaluate Evidence exhibited expression hACE2 Host host defense human ACE2 IFN-λ Immune cell infiltration immune response immune responses immunological immunological mechanism increased expression infect infecting Infection infection with SARS-CoV-2 infiltration Inflammatory response inhibitor K18 K18-hACE2 Lung pathology macrophages MERS MERS-CoV mice microglia Mild mind Monocytes monocytes/macrophages nervous nervous system Neuroinvasive neurologic Neuron neurons Neuropathology not affect PLX5622 Pro-inflammatory genes proinflammatory Proinflammatory cytokine receptor reduction in replicate responsible RNA sequencing SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severity Signaling survival Symptom System TNF-α transcript transgenic mice understanding Viral viral infection viral pathogen viral replication virus virus viruses
[DOI] 10.1128/jvi.01969-21 PMC 바로가기 [Article Type] Pathogenesis and Immunity

The Causes and Long-Term Consequences of Viral Encephalitis

Neuroscience

Published on 2021-11-302022-10-31
Journal: Frontiers in Cellular Neuroscience
[Category] COVID-19,

[키워드] Affect affected astrocytes Autoimmune disease Brain cause Cell Central nervous system clinical symptom Cognitive impairment Coma Confusion consequence contributing to Coronaviruses degenerative described Diseases disorders Encephalitis Fever Frequency headache herpesviruses Immune cell infiltration impairment individual induce Inflammation local immune response microglia Mild morbidity and mortality neurons Neuropsychiatric neurotropic pathology pediatric populations pro-inflammatory molecule public health report reported secretion Seizures shown subsequent viral clearance viral encephalitis viral infection viral infections virus virus weakness zone
[DOI] 10.3389/fncel.2021.755875 PMC 바로가기 [Article Type] Neuroscience

Neuroinflammation and Its Impact on the Pathogenesis of COVID-19

Medicine

Published on 2021-11-242022-10-31
Journal: Frontiers in Medicine
[Category] COVID-19,

[키워드] activating Activation acute respiratory syndrome astrocytes attack blood-brain barrier caused Cell cellular and molecular cellular mechanism change chemokines clinical manifestation CNS Consequences coronavirus Coronavirus disease 2019 COVID-19 cytokine levels death dry cough fatigue Fever free radical help highlight immune Immune cell infiltration immune system Impact include induce Infectious disease infiltration innate immune system investigated involved knowledge mechanism microglia molecular Neuroinflammation neurological neurological impairment neuronal neuronal death oxidative stress pathogenic Pneumonia Respiratory failure SARS-CoV-2 therapeutic intervention with COVID-19
[DOI] 10.3389/fmed.2021.745789 PMC 바로가기 [Article Type] Medicine