Supplying the trip to antibody production—nutrients, signaling, and the programming of cellular metabolism in the mature B lineage항체 생산으로의 이동 - 영양소, 신호 전달, 성숙한 B 계통의 세포 대사 프로그래밍 제공Review Published on 2021-11-152022-09-11 Journal: Cellular and Molecular Immunology [Category] Fulltext, MERS, 유전자 메커니즘, 진단, [키워드] antibody B lymphocyte Cell cell surface receptor cell surface receptors cell type cell types cellular cellular metabolism COVID cytokine Cytokines elicit enzyme exhibiting Fatty acid focus gene transcription Germinal centres Glucose Glutamine Glycoproteins immune defense Infection Intermediary metabolism interstitium lead Lineage Lymphocytes mechanism metabolism microbe microbes microenvironment molecular nutrient pandemic Plasma cell Plasma cells plasmablast plasmablasts programming proliferate receive Recognition regulate secrete secreted secreting secretion Signal transduction Signaling Somatic hypermutation Stage sustained the cells Transcription translation turn Vaccine [DOI] 10.1038/s41423-021-00782-w PMC 바로가기 [Article Type] Review
Exploiting viral sensing mediated by Toll-like receptors to design innovative vaccinesReview Article Published on 2021-10-282022-10-04 Journal: NPJ Vaccines [Category] 치료제, [키워드] antiviral response downstream signaling pathway effective elicit immune immune defense immune responses Infectious diseases invading pathogen involved knowledge ligands long-lasting mechanism microbial pathogen-associated molecular patterns receptor receptors Signaling Surveillance TLR TLRs Toll-like receptor Transcriptional upregulation transmembrane protein triggered understanding Vaccine Vaccines viral pathogen virus [DOI] 10.1038/s41541-021-00391-8 PMC 바로가기 [Article Type] Review Article
COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-AnalysisSystematic Review Published on 2021-10-142022-10-30 Journal: Nutrients [Category] COVID-19, MERS, SARS, [키워드] ACE2 Achieved Affect age analyzed angiotensin antibody ARDS Blood Blood level calcidiol calcitriol caused clinical study correlation COVID-19 COVID-19 mortality CRS Cytokine release syndrome D3 dataset deficiency diabetes escape mutation Evidence Hospital admission identify immune defense Immune status immunodeficiency independent dataset Infection Inflammation IQR Linear regression median mitigate Mortality mortality risk outbreak Pearson correlation Prevent raising Rate Regression Renin reported Research Result retrospective cohort review SARS-CoV-2 SARS-COV-2 infection serum Seven severity Sex Side effect status suggested Topic Vaccinations virus infection Vitamin D Vitamin D3 was performed zero [DOI] 10.3390/nu13103596 PMC 바로가기 [Article Type] Systematic Review
mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection statusmRNA 백신 유도 T 세포는 우려되는 SARS-CoV-2 변이체에 동일하게 반응하지만 이전 감염 상태에 따라 수명과 귀환 특성이 다릅니다.Research Article Published on 2021-10-122022-09-10 Journal: eLife [Category] MERS, SARS, 변종, [키워드] activate activated Analysis antibodies antibody Antigen-specific T cells B.1.1.7 B.1.351 B.1.351 variant best boost immunity booster dose both groups caused Cell changed Characteristics conducted convalescent coronavirus coronavirus SARS-CoV-2 COVID-19 COVID-19 convalescent donor COVID-19 convalescent donors CyTOF Cytometry determine dose doses elicit Epitopes Examining flight Focusing generate highlight homing Human identity Immune cell immune cells immune defense immune response immune system IMPROVE individuals Infection investigated killing longitudinal study Lungs Lymphocyte subsets mimicking MOST mRNA mRNA vaccine mRNA vaccines naïve vaccinees nasopharynx natural infection nose not need offer persistence phenotype Phenotypes phenotypic phenotypic feature phenotypic features Prevent PROTECT Protein Proteins quantity reassurance recognizing Research researcher respiratory tract respond SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells second dose severe COVID-19 spike epitope spike epitopes spike-specific T cell Stimulation Strains surface protein surface proteins T cell T cell response T cells the cells the vaccine These cells two group two groups unique vaccination Vaccine vaccine dose vaccine doses vaccine-elicited T cell vaccinee vaccinees variant variants Viral Viral variants virus viruses while [DOI] 10.7554/eLife.72619 PMC 바로가기 [Article Type] Research Article
COVID-19 Vaccines for HIV-Infected PatientsHIV에 감염된 환자를위한 COVID-19 백신Review Published on 2021-09-222022-09-01 Journal: Viruses [Category] SARS, 진단, [키워드] adaptive AIDS appear can be used clinical trial complementary Complementary DNA COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines death defense mechanisms Diagnosis disease entity DNA effective enzyme etiologic agent General population helper T cell helper T cells HIV HIV infection HIV/AIDS HIV/AIDS patients immune defense immune parameter immune systems Immunocompromised immunodeficiency disease implementation include infecting Infection initial lead Limited mechanism microbial molecular test Molecular tests mRNA new virus outcomes Pathogens PCR progeny Protective reverse transcriptase Safe SARS-CoV-2 SARS-CoV-2 vaccines shown susceptibility susceptible T cell T cells transcriptase unique vaccination Vaccine variety Viral Viral RNA virus wake [DOI] 10.3390/v13101890 PMC 바로가기 [Article Type] Review
The Anti-SARS-CoV-2 Antibody Response in a Centenarian Woman: A Case of Long-Term Memory?100 세 여성의 항 -SARS-COV-2 항체 반응 : 장기 기억의 사례?Case Reports Published on 2021-08-272022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] absence addressed affected Anti-spike appear Asymptomatic B cell B cell memory B cells Blood cell-ELISA Centenarian classical clinical consequence clinical consequences conditions COVID-19 COVID-19 pandemic described ELISA heterogeneity heterogeneous highest highlight Host immune response IgG immune defense immune memory in vitro in vitro IgG increase in Infection long-term memory low-grade inflammation Manifestations memory memory B cells Mild mortality rate observation Occurrence Older plasma positive potential mechanism produced reached released reported respiratory response responsible SARS-CoV-2 SARS-COV-2 infection Serological testing serum severity specific antibodies specific antibody susceptibility syndrome the SARS-CoV-2 turn virus virus infection virus infections was tested while [DOI] 10.3390/v13091704 PMC 바로가기 [Article Type] Case Reports
At the frontline of COVID research: an interview with Akiko Iwasaki on her groundbreaking COVID projects and advocacy for women and minorities in STEMQ&A Published on 2021-08-102022-10-31 Journal: Communications Biology [Category] Coronavirus, MERS, SARS, [키워드] Academy Action addition ART collected Connecticut COVID generate health care workers Howard Hughe immune defense Implementing in both groups infectious agents mechanism Medicine mucosal surfaces Patient Professor Public Research Science specimen Toronto university virus women [DOI] 10.1038/s42003-021-02456-9 PMC 바로가기 [Article Type] Q&A
Full-Length Recombinant hSP-D Binds and Inhibits SARS-CoV-2전장 재조합 HSP-D는 SARS-COV-2를 결합하고 억제한다Article Published on 2021-07-282022-09-10 Journal: Biomolecules [Category] Coronavirus, SARS, 변종, [키워드] ACE2 aggregation Anti-inflammatory Anti-viral bind binding binding assay Binding assays bronchoalveolar lavage sample bronchoalveolar lavage samples Caco-2 Caco-2 cell Caco-2 cells cells clearance Combined Concentration COVID-19 COVID-19 patient COVID-19 patients Critical driven by ELISA ELISAs epithelial evaluated facilitate followed by gel electrophoresis glycosylated healthy control healthy controls host cell host cells immune defense immune response in vitro induce inhibit initiate invading pathogen invading pathogens lung lung type II pneumocytes Lungs median member Pathogens Patient performed potential therapy Protein pulmonary recognize recombinant Replication reported Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication silver SP-D spike-protein staining Structure surfactant the SARS-CoV-2 type II pneumocytes variants Viral viral replication virus Virus Disease virus replication viruses were measured [DOI] 10.3390/biom11081114 PMC 바로가기 [Article Type] Article
A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19Public Health Published on 2021-07-282022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] accelerate ACE2 ACE2 receptor Affect aggravate airways alveolar cells article ASL blood glucose carbohydrates Cell cell damage cell death cells Combination Complication computational modeling Concentration condition COVID-19 Critical care Cytokine storm database diagnostic disease disease severity dysregulated dysregulation Effect elevated Elevation evade Evidence explain facilitate feasibility Glucose glycemia glycemic control Glycolysis glycosylation hyper-inflammation hyperglycemia Hypothesis immune defense inactivation induce Infection infection process infections Inflammation information innate immune system involved Ketogenic diet knowledge Level lung Lungs machine learning model MOST multi-organ failure multiple mechanism pandemic potential treatments progression proportion provide pulmonary inflammatory response Quantitative reached replicate Replication Research risk role SARS-CoV-2 Severe case severe COVID-19 severity subsequent Symptoms tested the cytokine storm the disease the patient the SARS-CoV-2 Thrombotic events treatment strategy View viral infection Viral load virus weakened [DOI] 10.3389/fpubh.2021.695139 PMC 바로가기 [Article Type] Public Health
Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injuryArticle Published on 2021-07-032022-10-04 Journal: Cell Death & Disease [Category] 바이오마커, [키워드] Activation acute lung injury Affect autophagic flux autophagy biogenesis circulating deficiency DNA dysfunction immune defense induction Infection inflammatory storm interfere interferon Lung injury lysosomal mechanism mitochondrial organ damage pathogenic pathway patients Protective Regulatory Sepsis without affecting [DOI] 10.1038/s41419-021-03961-9 PMC 바로가기 [Article Type] Article