immune function – Page 2 – Communicable Diseases Research

The efficacy of combined therapy of qingfeiPaidu capsule and lianhuaqingwen capsule nursing interventions for hospitalized patients with COVID-19: A retrospective study of medical records

Randomized Controlled Trial

Published on 2022-08-122022-10-04
Journal: Medicine [Category] 임상,

Alterations in CD39/CD73 axis of T cells associated with COVID-19 severity

COVID-19 중증도와 관련된 T 세포의 CD39/CD73 축 변경

Article

Published on 2022-08-012022-09-11
Journal: Journal of cellular physiology [Category] MERS, 바이오마커, 진단,

[키워드] Activation adenosine adenosine triphosphate alteration Annexin Apoptosis ATP Blood CD25 CD27 CD28 CD4 CD73 CD8 Cell collected controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytokine Cytokines decrease effector cell expression Extracellular Frequency healthy controls healthy donor immune function Immunopathogenesis immunopathology in vitro Inflammation involved knowledge memory T mild COVID-19 patient mild COVID-19 patients modulate Monocytes mononuclear cell nuclear pathway patients PD-1 Peripheral blood plasma samples Purinergic purines purines. reduced Regulation Regulatory Regulatory T cell SARS-CoV-2 severe COVID-19 patient severe COVID-19 patients severity Signaling T cell T cells T lymphocytes T-cell These data triphosphate Viral viral infections with COVID-19
[DOI] 10.1002/jcp.30805 PMC 바로가기 [Article Type] Article

Roles of mitochondrial DNA in dynamics of the immune response to COVID-19

Review article

Published on 2022-08-012022-10-05
Journal: Gene [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] Absent in melanoma 2 ACE2angiotensin-converting enzyme 2 addition Affect AIM2Absent in melanoma 2 angiotensin-converting enzyme 2 ccf-mtDNAcirculating cell-free mitochondrial DNA CFcystic fibrosis cGASCyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) (cGAMP) synthase chronic obstructive pulmonary disease circulating circulating cell-free mitochondrial DNA COPDchronic obstructive pulmonary disease Coronavirus disease 2019 COVID-19 COVID-19coronavirus disease 2019 Critical Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) (cGAMP) synthase cystic fibrosis damage-associated molecular pattern DAMPdamage-associated molecular pattern Diseases DNA Endoplasmic reticulum ERendoplasmic reticulum gasdermin D GSDMDgasdermin D HIVhuman immunodeficiency virus host cells HPVhuman papillomavirus Human immunodeficiency virus human papillomavirus ICUIntensive Care Unit Idiopathic pulmonary fibrosis immune function immune response Infection inflammasome activation Inflammatory response intensive care unit interferon stimulatory gene IPFidiopathic pulmonary fibrosis ISGinterferon stimulatory gene leucine rich repeat lncRNAlong non-coding RNA long non-coding RNA LRRleucine rich repeat MAVSmitochondrial antiviral signaling mesenchymal stem cell Mitochondria mitochondrial mitochondrial antiviral signaling mitochondrial DNA mitochondrial reactive oxygen species mitochondrial- damage-associated molecular pattern MSCMesenchymal stem cell Mt-DAMPmitochondrial- damage-associated molecular pattern MtDNAmitochondrial DNA mtROSmitochondrial reactive oxygen species MyD88myeloid differentiation factor 88 myeloid differentiation factor 88 NBDnucleotide binding domain NLRnucleotide binding domain and leucine rich repeat nucleotide binding domain nucleotide binding domain and leucine rich repeat Open reading frame ORFopen reading frame pathogen-recognition receptors Pathogens pathway Prognosis provide PRRpathogen-recognition receptors reactive oxidative stress Regulation role ROSreactive oxidative stress SARS-CoV-2 SARS-CoV-2severe acute respiratory coronavirus 2 severe acute respiratory coronavirus 2 severity signaling pathways stimulator of interferon genes STINGstimulator of interferon genes targeting therapeutic strategy TLRToll-like receptor TMPRSS2transmembrane serine protease 2 Toll-like receptor transmembrane serine protease 2
[DOI] 10.1016/j.gene.2022.146681 [Article Type] Review article

Host genomics of SARS-CoV-2 infection

SARS-CoV-2 감염의 숙주 유전체학

Review

Published on 2022-08-012022-09-11
Journal: European Journal of Human Genetics [Category] COVID19(2023년), SARS, 바이오마커, 변종, 신약개발, 유전자 메커니즘, 치료제,

[키워드] acute infection approach approaches association Asymptomatic causal variant complications COVID-19 COVID-19 pneumonia demographic disease disease severity downstream Exome explain exploration Factor fraction functional genetic determinant genetic determinants Genetic variant Genome sequencing Genome-wide association studies genomic study highlighting host-virus interactions Human human genetic variation immune function individuals International involved life-threatening locus management Mild outcome pandemic Pathogenesis pathway Pathways Pneumonia Region required SARS-CoV-2 SARS-CoV-2 infected individuals SARS-COV-2 infection SARS-CoV-2 pathogenesis severe cases shown therapeutic targets type I interferon type I interferon response Variability with COVID-19
[DOI] 10.1038/s41431-022-01136-4 PMC 바로가기 [Article Type] Review

Human surfactant protein D facilitates SARS-CoV-2 pseudotype binding and entry in DC-SIGN expressing cells, and downregulates spike protein induced inflammation

인간 계면활성제 단백질 D는 DC-SIGN 발현 세포에서 SARS-CoV-2 유사형 결합 및 진입을 촉진하고 스파이크 단백질 유도 염증을 하향 조절합니다

Article

Published on 2022-07-282022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술,

[키워드] ACE2 Analysis Anti-viral binding carbohydrate cause Cell cell interaction cell line cell surface receptor cells chemokine chemokines collectins controls COVID-19 cytokine cytokine response Cytokines DC-SIGN dendritic cell domain downregulate downregulated eight epithelial expressing facilitate fragment of HEK 293T HEK293T cell HEK293T cells help Human IFN-α IL- 6 IL-1β IL-8 immune function immune response immunomodulatory effect increase independent independent of infection assay infection assays Inflammation inhibit SARS-CoV-2 innate immune innate immune system Interaction intercellular involved Macrophage macrophages MHC class MHC class II modulating mRNA expression mRNA level mRNA levels N-terminal naïve T cell naïve T cells NF-κB pathogen Pathogens pro-inflammatory cytokine pro-inflammatory cytokines Protein pseudotype RANTES receptors Replication rfhSP-D. RNA virus RT-qPCR SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 spike protein shown SIGN spike Spike protein surface receptor T cells the Spike THP-1 TNF-α treated Treatment Vero Cell Vero cells viral entry viruses
[DOI] 10.3389/fimmu.2022.960733 PMC 바로가기 [Article Type] Article

[Clinical features of children with coronavirus disease 2019 Delta variant infection after vaccination with inactivated SARS-CoV-2 vaccine]

[SARS-CoV-2 비활성화 백신 접종 후 코로나바이러스 질환 2019 델타 변이체 감염 아동의 임상적 특징]

Article

Published on 2022-07-152022-09-11
Journal: Zhongguo dang dai er ke za zhi = Chinese journal o [Category] COVID19(2023년), SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Admission Alanine alanine aminotransferase aspartate Aspartate aminotransferase B lymphocyte B lymphocytes C-reactive protein caused CD3 Child children children with COVID-19 China Chinese clinical clinical feature Clinical features clinical symptom Clinical symptoms coronavirus coronavirus disease Coronavirus disease 2019 cough Course COVID-19 creatine creatine kinase Creatine kinase-MB creatinine Ct value cytokine Cytokines Delta delta variant disease disease classification elevated English enrolled epidemiological data expectoration feature Fever Gender hospital Hospitalized IgG immune function inactivated incidence rate incidence rates Infection Laboratory laboratory examination Lactate lactate dehydrogenase leukocyte lymphocyte myocardial injury no significant difference nucleic acid Peripheral blood positive rate procalcitonin proportion reduce Retrospective analysis SARS-CoV-2 SARS-CoV-2 vaccine serum creatinine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant difference significantly higher significantly lower T lymphocyte two group two groups vaccination Vaccine was performed
[DOI] 10.7499/j.issn.1008-8830.2203174 PMC 바로가기 [Article Type] Article

Infectious complications, immune reconstitution, and infection prophylaxis after CD19 chimeric antigen receptor T-cell therapy

Reviews

Published on 2022-07-152022-10-05
Journal: Bone marrow transplantation [Category] 치료제,

In Vitro Exposure of Primary Human T Cells and Monocytes to Polyclonal Stimuli Reveals a Basal Susceptibility to Display an Impaired Cellular Immune Response and Develop Severe COVID-19

다클론 자극에 대한 1차 인간 T 세포 및 단핵구의 체외 노출은 손상된 세포 면역 반응을 표시하고 심각한 COVID-19를 발생시키는 기초 감수성을 나타냅니다

Article

Published on 2022-07-012022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커,

[키워드] (PD-1 acute respiratory syndrome acute respiratory syndrome coronavirus Alpha analyzed Anosmia anti-CD3 Antibody titer Antibody titers basal baseline characteristics biochemical blood sample Blood samples CD14 CD16 CD4+ CD8+ T cell CD8+ T cells Cellular immune response cellular immunity classical classical monocytes clinical recovery conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression disease display distress drug Evidence exposure expression Fever Follow-up headache healthy volunteer Human Humoral immunity hypoxia IFN-alpha IFN-gamma IL-2 immune function immune response Immunoglobulin Immunoglobulin G Impaired in vitro interferon interleukin interleukin-2 Invasive mechanical ventilation lipopolysaccharide Mild mild cases monocyte monocyte subsets Monocytes Neutralizing no difference no differences non-classical monocyte Non-classical monocytes not differ participant Patient PD-1 Pneumonia polyclonal predisposition programmed cell death programmed cell death protein prospective cohort study Protein receiving Registered required respiratory respiratory distress response S1 protein SARS-CoV-2 SARS-COV-2 infection serum titer Severe case severe cases severe COVID-19 severity significantly subset Symptom T cell T cells virus worsening
[DOI] 10.3389/fimmu.2022.897995 PMC 바로가기 [Article Type] Article

Psychoneuroimmunology in the time of COVID-19: Why neuro-immune interactions matter for mental and physical health

Research article

Published on 2022-07-012022-10-05
Journal: Behaviour research and therapy [Category] COVID19(2023년), SARS, 비임상, 치료제,

Hamster models of COVID-19 pneumonia reviewed: How human can they be?

COVID-19 폐렴의 햄스터 모델 검토: 어떻게 인간이 될 수 있습니까?

Review

Published on 2022-07-012022-09-11
Journal: Veterinary pathology [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age alveolar damage animal model characteristic clinically Coagulopathy condition consequence coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 diagnostic Diffuse alveolar damage examined facilitate feature hamster hamsters Histopathology Human human disease humans immune function immune functions Infection Inference Inflammation information limit manifestation Mesocricetus mice moderate molecular outcome pandemic pathology pathway Patient Phodopus Pneumonia Preclinical research Research respiratory respiratory tract review rodents SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 similarity Still susceptible susceptible patient the disease therapy Vaccines variants of concern Vascular virus
[DOI] 10.1177/03009858211057197 PMC 바로가기 [Article Type] Review