Immune profile – Page 2 – Communicable Diseases Research

Defining Clinical and Immunological Predictors of Poor Immune Responses to COVID-19 mRNA Vaccines in Patients with Primary Antibody Deficiency

Article

Published on 2022-08-012022-11-15
Journal: Journal of Clinical Immunology [Category] COVID19(2023년), SARS, 진단,

Probing the mutation independent interaction of DNA probes with SARS-CoV-2 variants through a combination of surface-enhanced Raman scattering and machine learning

표면 강화 라만 산란 및 기계 학습의 조합을 통해 SARS-CoV-2 변이체와 DNA 프로브의 돌연변이 독립적 상호작용 조사

Article

Published on 2022-07-152022-09-11
Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antigenicity antisense Antisense oligonucleotide Antisense oligonucleotides ASO binding efficiency Characteristics characterized clinically Combination Concentration coronavirus described detect develop diagnostic diagnostic test DNA Evolution Genetic human population hypothetical Immune profile independent Interaction mechanism mutate Mutation Mutation resistant probe mutations N gene negative sample nucleocapsid Nucleocapsid phosphoprotein Point mutation positive probe probes Probing reveal RNA SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus scattering Selective and ultrasensitive diagnosis sensitivity sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specificity Surface-enhanced Raman scattering technique the SARS-CoV-2 virus therapeutic Transmissibility unique variants virus
[DOI] 10.1016/j.bios.2022.114200 PMC 바로가기 [Article Type] Article

Clinical characteristics and immune profile alterations in vaccinated individuals with breakthrough Delta SARS-CoV-2 infections

Delta SARS-CoV-2 감염이 있는 백신을 접종한 개인의 임상 특성 및 면역 프로필 변경

Article

Published on 2022-07-092022-09-11
Journal: Nature Communications [Category] COVID19(2023년), SARS, 바이오마커, 변종, 임상, 치료기술,

[키워드] absorbance accelerated alteration Breakthrough infection breakthrough infections Characteristics clinical clinical recovery comparable Course cytokine Cytokine storms Delta delta variant facilitate groups Guangzhou Immune profile immunization Inactivated vaccine Inactivated Vaccines Inflammation Local median mononuclear cell observé outbreak PBMCs Peripheral blood Peripheral blood mononuclear cells Pneumonia protective effect Protective effects reduce reduced reported SARS-COV-2 infection significantly the disease transcription profile Transmission unique vaccinated individual vaccinated individuals vaccination Vaccine vaccine group Viral pneumonia viral RNA clearance viral titer VoC
[DOI] 10.1038/s41467-022-31693-7 PMC 바로가기 [Article Type] Article

Paxlovid: Mechanism of Action, Synthesis, and In Silico Study

Paxlovid: 작용 메커니즘, 종합 및 인 실리코 연구

Review

Published on 2022-07-072022-09-11
Journal: BioMed Research International [Category] COVID19(2023년), SARS, 치료제,

Immunogenicity, Effectiveness, and Safety of Inactivated Virus (CoronaVac) Vaccine in a Two-Dose Primary Protocol and BNT162b2 Heterologous Booster in Brazil (Immunita-001): A One Year Period Follow Up Phase 4 Study

브라질에서 2회 용량 1차 프로토콜 및 BNT162b2 이종 부스터(Immunita-001)에서 비활성화된 바이러스(CoronaVac) 백신의 면역원성, 효과 및 안전성: 1년 기간의 후속 조치 4상 연구

Clinical Trial

Published on 2022-06-092022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-spike anti-Spike IgG anti-spike IgG antibodies Anti-spike IgG antibody antibody antibody levels Antibody titer Antibody titers approach association BNT162b2 booster booster dose Brazil Cellular immune response chemokines CoronaVac coronavirus COVID-19 COVID-19 pandemic Critical Cytokines Delta delta variant dose Effectiveness exposure to followed by growth factor Growth factors Heterologous heterologous booster highest IgG immune Immune profile immune response immunogenicity implication individual individuals Interaction maintenance male median mediators Neutralising Antibodies neutralising antibody no increase omicron Omicron variant pandemic Period phase 4 presenting protocol reduction remained respiratory restored robust Safe Safety SARS-CoV-2 Seropositivity severe acute respiratory syndrome Coronavirus significantly Spread timepoint titer titers vaccination Vaccine variant virus Year
[DOI] 10.3389/fimmu.2022.918896 PMC 바로가기 [Article Type] Clinical Trial

Pro-inflammatory immune profile mediated by TNF and IFN-γ and regulated by IL-10 is associated to IgG anti-SARS-CoV-2 in asymptomatic blood donors

TNF 및 IFN-γ에 의해 매개되고 IL-10에 의해 조절되는 전염증성 면역 프로필은 무증상 혈액 기증자의 IgG 항-SARS-CoV-2와 관련이 있습니다

Article

Published on 2022-06-012022-09-12
Journal: Cytokine [Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] adaptive Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibody Asymptomatic blood donor CCL5 Cell chemokine chemokines Concentration condition COVID-19 CXCL10 cytokine evaluate identify IFN-γ IgG IL-10 Immune profile immune response immune systems individual immune response infected individual Infection male microenvironment Mild neutralization neutralizing capacity occur positive positive individual Prevalence prevalent pro-inflammatory prognosis of patients regulated risk factor SARS-CoV-2 SARS-CoV-2 virus serum shown significantly specific antibody the antibodies TNF turn viral neutralization
[DOI] 10.1016/j.cyto.2022.155874 PMC 바로가기 [Article Type] Article

Vaccination-infection interval determines cross-neutralization potency to SARS-CoV-2 Omicron after breakthrough infection by other variants

백신 접종-감염 간격은 다른 변이체에 의한 돌발성 감염 후 SARS-CoV-2 Omicron에 대한 교차 중화 효능을 결정합니다.

Clinical and Translational Report

Published on 2022-03-042022-09-14
Journal: Med (New York, N.Y.) [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] Abstract acute respiratory syndrome AMED ancestors antibodies antibody approach blood sample BNT162b2 mRNA vaccine breadth Breakthrough infection breakthrough infections collected Combination complex complicate Context coronavirus correlated COVID-19 COVID-19 vaccine cross-neutralization Delta demonstrated determine development finding funding heterogeneity immune immune evasion Immune profile Immunity individual Infection Japan magnitude mRNA mRNA vaccine much higher neutralization Neutralizing activity neutralizing antibody omicron Omicron variant other variant overcome population immunity protective immunity resistance to infection robust SARS-CoV-2 sera several variants Significance significantly spike mutations suffered supported susceptibility time interval vaccinated individual vaccination Vaccine vaccinee variant variants
[DOI] 10.1016/j.medj.2022.02.006 PMC 바로가기 [Article Type] Clinical and Translational Report

Increased Interleukin 18-Dependent Immune Responses Are Associated With Myopericarditis After COVID-19 mRNA Vaccination

증가된 인터루킨 18 의존성 면역 반응은 COVID-19 mRNA 백신 접종 후 심근염과 관련이 있습니다

Immunology

Published on 2022-02-182022-09-12
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] abnormality activated Activation administration Cardiac complications caused CD68 Cell characterized chest pain circulating Control controls COVID-19 COVID-19 mRNA Vaccination COVID-19 mRNA vaccine COVID-19 vaccination cytokine Cytokines disease onset dysfunction elevated expressed first dose Flow cytometry analysis healthy individual hearts IL-18 IL-27 Immune profile immune response incidence Increased individuals infiltration interleukin interleukin 18 mechanism mice Mild monocyte mRNA mRNA-1273 COVID-19 vaccine multiplex Myopericarditis NK cell NK cells NLRP3 inflammasome occur Patient phenotype progression response T cell Th1-type immune response the patient troponin I upstream vaccinated individual vaccination were used with COVID-19
[DOI] 10.3389/fimmu.2022.851620 PMC 바로가기 [Article Type] Immunology

Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling

Article

Published on 2022-02-092022-10-04
Journal: Nature Communications [Category] 유전자 메커니즘,

CD4+ T Cell Immune Specificity Changes After Vaccination in Healthy And COVID-19 Convalescent Subjects

건강하고 COVID-19 회복기 대상에서 백신 접종 후 CD4+ T 세포 면역 특이성 변화

Immunology

Published on 2022-01-192022-09-12
Journal: Frontiers in Immunology [Category] 진단, 치료기술,