The persistence of anti-Spike antibodies following two SARS-CoV-2 vaccine doses in patients on immunosuppressive therapy compared to healthy controls-a prospective cohort studyArticle Published on 2022-10-052022-11-15 Journal: BMC Medicine [Category] COVID19(2023년), SARS, 진단, [키워드] 95% CI analyzed anti-RBD antibodies binding antibody antibody level blood sample bowel collected combination treatment Control controls COVID-19 declined defined disease dose enrolled Factor greater healthy healthy control healthy individuals Humoral immunity identify Immune-mediated inflammatory disease immunosuppressive Immunosuppressive medication Inflammatory bowel disease inhibitor initial interval median Multivariable regression Necrosis participant Patient patients persistence prospective cohort study Protein provided psoriatic arthritis RBD reduction reduction in Rheumatic diseases rheumatoid arthritis SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine serologic Serologic response spike spondyloarthritis Support the receptor-binding domain the SARS-CoV-2 Therapies therapy ulcerative colitis vaccination vaccine dose [DOI] 10.1186/s12916-022-02587-8 PMC 바로가기
Immunogenicity decay and case incidence six months post Sinovac-CoronaVac vaccine in autoimmune rheumatic diseases patientsArticle Published on 2022-10-032022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] anti-SARS-CoV-2 anti-TNF antibody Autoimmune booster dose cellular immunity Control COVID-19 case COVID-19 cases cumulative Decline decrease delta variant dose geometric mean titer IgG positivity IgG response Immunity immunogenicity immunosuppressive Inactivated vaccine incidence individuals Logistic regression analysis male multivariate Neutralizing Neutralizing antibodies outcome Patient patients Prednisone Primary outcome reduce reduction in rheumatic disease SARS-CoV-2 IgG SARS-CoV-2 immunity secondary Spread stability Therapies Vaccine vaccine dose [DOI] 10.1038/s41467-022-33042-0 PMC 바로가기
COVID-19 outcomes in patients with Dermatomyositis: A registry-based cohort analysisResearch article Published on 2022-10-012022-10-05 Journal: Seminars in arthritis and rheumatism [Category] 변종, [키워드] 1:1 Acute kidney injury acute respiratory distress adjust African American AKI Analysis ARDS association Black race Cancer patients cohort analysis confounders Control controls COVID-19 database dermatomyositis determine develop Disease activity drug Gender General population glucocorticoid heterogeneous nature High dose higher odd hospitalisation ICU admission identify ILD Immunosuppressant immunosuppressive individual Infection Interstitial lung disease lower risk male mechanical ventilation Mortality neoplasm Neoplasms outcome outcomes Patient patients with COVID-19 Precaution receiving renal replacement therapy required retrieved retrospective data rheumatic disease risk RRT score Sepsis severe COVID-19 Severe COVID-19 Infection severity of COVID-19 stroke subgroup analysis syndrome therapy Treatment Venous Thromboembolism VTE was used with COVID-19 [DOI] 10.1016/j.semarthrit.2022.152034 [Article Type] Research article
Factors Associated With COVID-19 Vaccine Response in Transplant Recipients: A Systematic Review and Meta-analysisArticle Published on 2022-10-012022-11-15 Journal: Transplantation [Category] 진단, [키워드] 95% CI 95% confidence interval age Allogeneic calcineurin Cell combating Comorbidity coronavirus disease COVID-19 COVID-19 vaccination COVID-19 vaccines dose Effects Factor General population healthy control higher risk humoral Immunocompromised Immunosuppressant immunosuppressive inclusion criteria increased risk inhibitor inhibitors mammalian medication Meta-analysis much lower Organ transplant outcome pandemic performed pooled rate Population Rapamycin receiving recipient recipients regimen response review risk factor second dose Seroconversion seroconversion failure Steroids systematic review the vaccine Transplant Vaccine vaccine response [DOI] 10.1097/TP.0000000000004256 PMC 바로가기
Prevalence of Viral Hepatitis in Unselected, Consecutively Enrolled Patients Hospitalised for SARS-CoV-2Article Published on 2022-10-012022-11-15 Journal: Journal of community health [Category] COVID19(2023년), SARS, 진단, [키워드] 95% CI absence Care cirrhosis diagnostic eradication evaluate HBcAb HBsAg HBV HCV Hepatitis Hepatitis screening hospital hospitalised immunosuppressive Infection Italy Laboratory liver male median age Patient patients positive Prevalence Retrospective study risk factor SARS-CoV-2 SARS-COV-2 infection screened serologic test study period study population Symptom tested Viral hepatitis was performed were excluded [DOI] 10.1007/s10900-022-01111-6 PMC 바로가기
Association Between Maintenance Immunosuppressive Regimens and COVID-19 Mortality in Kidney Transplant RecipientsArticle Published on 2022-10-012022-11-15 Journal: Transplantation [Category] 진단, [키워드] age association baseline baseline characteristics cardiovascular disease cohort study Comorbidity conducted coronavirus disease Corticosteroid COVID-19 death diabete died evaluated False positive form French high risk hypertension immune function Immunosuppression immunosuppressive immunosuppressive drug impair inhibitor kidney transplant Logistic regression lower risk maintenance mammalian men Mortality MOST multiple imputation Odds ratio outcome p value performed Rapamycin recipient recipients regimen registry retrieved risk of death serum creatinine significantly lower Solid solid organ solid organ transplant statistically significant Transplant was used with COVID-19 [DOI] 10.1097/TP.0000000000004254 PMC 바로가기
Seroepidemiological study of factors affecting anti-spike IgG antibody titers after a two-dose mRNA COVID-19 vaccination in 3744 healthy Japanese volunteersArticle Published on 2022-09-292022-11-15 Journal: Scientific Reports [Category] 진단, [키워드] 1.26 Adverse reaction affecting age anti-S anti-S antibody anti-S IgG anti-Spike IgG antibody Antibody titer Antibody titers BNT162b2 vaccine conducted COVID-19 vaccination cross-sectional dose Effect elapsed Factor Factors female females Gender healthy healthy volunteer identify IgG antibody titer immunosuppressants immunosuppressive IQR Japanese magnitude median age mRNA mRNA-1273 mRNA-1273 vaccine Multiple positive questionnaire SARS-COV-2 infection significantly smoking tested the vaccine therapy vaccination Vaccine Volunteer [DOI] 10.1038/s41598-022-20747-x PMC 바로가기
Targeting Doublecortin-Like Kinase 1 (DCLK1)-Regulated SARS-CoV-2 Pathogenesis in COVID-19Article Published on 2022-09-142022-11-15 Journal: Journal of Virology [Category] SARS, 치료기술, 치료제, [키워드] Activation amplified amplify analyzed blocked Blood Cell chemokine chronic liver disease Chronic Liver Diseases circulating comorbid disease Comorbidity contribute controls correlated COVID-19 COVID-19 patients Critical cytokine cytokine secretion DCLK1 DDCLK1 decrease disease severity dysregulation expression Factor Factors Gain growth factor hospitalized patient Host Hyperinflammatory response immune Immune cell immune response immunosuppressive in viral in vitro infected cells Inflammation Inflammatory cytokine inflammatory pathway inhibition inhibitor Innate immunity involved kinase Live virus liver livers loss of function lung Lung disease Macrophage mononuclear cell mononuclear cells Mortality neutrophil normalized Pathogenesis pathology Patient Peripheral blood potential therapeutic target Prevalence pro-inflammatory profile proinflammatory promoted promoter Protein S100A9 SARS-CoV-2 SARS-CoV-2-infected cell secretion severity of COVID-19 Signaling subject targeting Treatment Viremia virus production virus replication with COVID-19 β-catenin [DOI] 10.1128/jvi.00967-22 PMC 바로가기
IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spikeArticle Published on 2022-09-052022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] Adaptive immune response bind binding Cancer Cancer therapy cells cleavage cleave enzyme expressed expression facilitate homology identify IL4I1 immune immunosuppressive immunosuppressive enzymes Immunotherapy involved Lymphocytes mechanism of action monocyte Monocyte-derived macrophages moonlighting protein negative control Protease activity Protein Pseudotyped virus Region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein secreted spike surface protein survival the spike protein TMPRSS13 TMPRSS2 transmembrane serine protease virus [DOI] 10.3389/fimmu.2022.982839 PMC 바로가기
Serological Response and Clinical Protection of Anti-SARS-CoV-2 Vaccination and the Role of Immunosuppressive Drugs in a Cohort of Kidney Transplant PatientsArticle Published on 2022-09-022022-11-15 Journal: Viruses [Category] SARS, 진단, [키워드] administration antibody antibody response rate Antibody titer Breakthrough infection clinical Cohort conducted COVID-19 COVID-19 vaccination dose drug enrolled evaluate evaluated first dose IgG Immunosuppression immunosuppressive Immunosuppressive treatment incidence kidney transplant kidney transplant recipient lowest mRNA vaccine Patient positive Prevent protection Protective rate of seroconversion recipient recipients regimen regimens reported response retrospective cohort study role SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 second dose serological serological response significantly Solid solid organ transplant study period Transplant vaccination Vaccine vaccine dose Vaccines [DOI] 10.3390/v14091951 PMC 바로가기