Single-cell transcriptomics reveal a unique memory-like NK cell subset that accumulates with ageing and correlates with disease severity in COVID-19단일 세포 전사체는 노화와 함께 축적되고 COVID-19의 질병 중증도와 상관관계가 있는 고유한 기억 유사 NK 세포 하위 집합을 나타냅니다.Article Published on 2022-05-032022-09-11 Journal: Genome Medicine [Category] Coronavirus, 유전자 메커니즘, 치료제, [키워드] accumulate accumulated age Ageing analysed Analysis antiviral responses applied CD52 Cell Characteristics COVID-19 COVID-19 disease COVID-19 patient dataset disease severity distribution dysfunction exhibited exhibiting flow cytometry function healthy control healthy donor healthy donors identify IFN-α immune system immunotherapies Immunotherapy Impact in vitro individual Infectious disease Infectious diseases influence innate lymphoid cell Innate lymphoid cells interferon lymphocyte Lymphocytes natural NK cell NK cells Peripheral blood peripheral blood samples phenotype positively correlated proinflammatory proportion scRNA-seq Sequencing Seurat single-cell single-cell level single-cell RNA-seq single-cell transcriptome single-cell transcriptomes Single-cell transcriptomics subpopulation subset Transcriptome type I interferon Type-I interferon. unique [DOI] 10.1186/s13073-022-01049-3 PMC 바로가기 [Article Type] Article
Imaging immunity in patients with cancer using positron emission tomography Reviews Published on 2022-04-072022-10-05 Journal: NPJ Precision Oncology [Category] 바이오마커, [키워드] Biomarker cancer patient changes clinically Combination facilitate heterogeneity imaging immune immune microenvironment Immunity immunomodulatory immunotherapies Immunotherapy information inhibitor initial Local measure morbidity outcomes Patient Patients with cancer pet PET imaging Predictive Prognosis prognostic reduce respond subsequent subset survival Therapies therapy tomography Treatment treatment regimens [DOI] 10.1038/s41698-022-00263-x [Article Type] Reviews
CD8 + T Cell Senescence: Lights and Shadows in Viral Infections, Autoimmune Disorders and CancerCD8 + T 세포 노화: 바이러스 감염, 자가면역 장애 및 암의 빛과 그림자Review Published on 2022-03-212022-09-11 Journal: International Journal of Molecular Sciences [Category] Coronavirus, SARS, 바이오마커, [키워드] Adaptive immune response addition Ageing Antigen Autoimmune Autoimmune disease Autoimmune diseases autoimmune disorder Autoimmune disorders Cancer cause caused CD28 CD28− CD57+ CD8+ T cells CD57 CD8 CD8+ Cell circulating clearance CMV condition contributing to cytotoxic function Diseases Effect Efficacy enrichment exacerbate favor function functions heterogeneous HIV immune-senescence immunological immunotherapies Immunotherapy implication IMPROVE Infection inflammaging inflammaging. life LIGHT low-grade inflammation lowering Lymphocytes memory Memory cells novel antigen novel antigens pathogen Pathogens phenotype Prevent progression reduction SARS-CoV-2 senescent shadow Stress switching T cell T cells T lymphocyte T lymphocytes the disease thymic Transformed cell transformed cells Tumor tumor microenvironment turn Vaccine vaccine efficacy Viral viral infection viral infections [DOI] 10.3390/ijms23063374 PMC 바로가기 [Article Type] Review
Inhibition of Protein N- Glycosylation Blocks SARS-CoV-2 InfectionResearch Article Published on 2022-02-152022-10-29 Journal: mBio [Category] COVID-19, MERS, [키워드] N-glycosylation Ablation acute respiratory syndrome Antiviral agents B.1.1.7 B.1.351 B.1.617.2 Beta binding block Cell conditions coronavirus Coronavirus-2 COVID-19 Critical Delta FDA-approved drugs Gamma glycan glycosylate glycosylation Host host cell host immunity host receptor immunotherapies Infection inhibition inhibitors Invasion investigated modulate N -glycosylation P.1 pathway predicted produced Protein reduced RNA interference SARS-CoV-2 SARS-CoV-2 N Spike proteins Spread Treatment Vaccine variant viral infection virion [DOI] 10.1128/mbio.03718-21 PMC 바로가기 [Article Type] Research Article
The Human Nose Organoid Respiratory Virus Model: an Ex Vivo Human Challenge Model To Study Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pathogenesis and Evaluate TherapeuticsResearch Article Published on 2022-02-152022-10-29 Journal: mBio [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Administered Air-liquid interface air-liquid interface (ALI) culture airway Airway organoids airways ALI cultures basolateral compartment challenge cilia ciliary ciliated cell circulation coronavirus coronavirus 2 Culture Cytokines Efficacy epithelium evaluated event Ex vivo feasibility generate Human human airway human respiratory virus human respiratory viruses immunoprophylaxis immunotherapies Infants Infection innate immune responses invasive lung organoid Model Mucus noninvasive technique nose nose organoids occurred Organoid organoids palivizumab Pathogenesis Patient predict Prevent prevented respiratory respiratory syncytial virus respiratory syncytial virus (RSV) respiratory viral respiratory virus RSV SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Therapeutics unmet need viral infection viral shedding [DOI] 10.1128/mbio.03511-21 PMC 바로가기 [Article Type] Research Article
Immune responses to mRNA vaccines against SARS-CoV-2 in patients with immune-mediated inflammatory rheumatic diseases면역 매개 염증성 류마티스 질환 환자에서 SARS-CoV-2에 대한 mRNA 백신에 대한 면역 반응Article Published on 2022-01-012022-09-12 Journal: RMD Open [Category] SARS, 진단, [키워드] abatacept age Autoimmune Autoimmune diseases B-cell CD4 CD8 Cellular immune response cellular response Cellular responses correlated COVID-19 cumulative deleterious effects demonstrated depleting dose drug Effect Efficacy elicited Gender glucocorticoid healthy controls humoral humoral responses identify immune response immune system immune system diseases Immune-mediated Immunosuppression immunotherapies infections Inflammatory introduced investigated leflunomide methotrexate mRNA mRNA vaccine mRNA vaccines naïve Patient patients with SARS-CoV-2 phase III trial preserved receiving reduce reduced responders response rheumatic disease rituximab SARS-CoV-2 SARS-CoV-2 vaccine selected Seroconversion seroconversion rate T-cell immune response T-lymphocyte subsets the vaccine Therapies therapy titre treated two-dose regimen vaccination Vaccine were excluded [DOI] 10.1136/rmdopen-2021-001898 PMC 바로가기 [Article Type] Article
Therapeutic cancer vaccines revamping: technology advancements and pitfallsReview Published on 2021-12-012023-06-19 Journal: Annals of oncology : official journal of the Europ [Category] Fulltext, SARS, [키워드] Cancer immunotherapies Vaccines [DOI] 10.1016/j.annonc.2021.08.2153 PMC 바로가기 [Article Type] Review
Efficacy and Safety of Immunotherapies in Refractory Myasthenia Gravis: A Systematic Review and Meta-Analysisarticle Published on 2021-12-012024-09-02 Journal: Frontiers in Neurology [Category] 대상포진, [키워드] eculizumab (monoclonal antibody to C5) immunotherapies Refractory Myasthenia Gravis rituximab-ofatumumab-ibrutinib-idelalisib tacrolimus [DOI] 10.3389/fneur.2021.725700 PMC 바로가기 [Article Type] article
Intravenous immunoglobulin as an important adjunct in the prevention and therapy of coronavirus 2019 disease코로나바이러스 2019 질병의 예방 및 치료에 중요한 보조제로서의 정맥 면역글로불린Review Published on 2021-09-162022-09-10 Journal: Scandinavian journal of immunology [Category] MERS, SARS, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adult patients affected attenuate Autoimmune disease Autoimmune diseases Autoimmunity benefit caused clinically contributing to control group control groups coronavirus coronavirus 2019 disease coronavirus disease Coronavirus disease‐19 Corticosteroids COVID‐19 COVID‐19 patients COVID‐19 COVID‐19 vaccination Critically ill Cytokines disease early administration Evidence heterogeneity ICU Immunoglobulin immunomodulation immunotherapies Immunotherapy in some Intravenous immunoglobulin IVIG lack limitation Long‐COVID lung mechanical ventilation mechanism morbidity and mortality New coronavirus outcome pandemic pathogenic Patient patients Post‐COVID presenting Pulmonary function rapid response reduce reduction in mortality respiratory SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus severe disease syndrome target the disease therapy Treatment vaccination Vascular vascular system [DOI] 10.1111/sji.13101 PMC 바로가기 [Article Type] Review
Cellular Immunotherapy and the LungReview Published on 2021-09-132022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] administration antibody Cancer Care cause cellular Cellular Immunotherapy clinical study DC vaccine death Diseases global pandemic Immune checkpoint inhibitors immunotherapies Immunotherapy infections inhalation Inhaled lung NK cell provided Respiratory disease respiratory viral infection respiratory viruses T cell Therapies Treatment Vaccines viral respiratory infections [DOI] 10.3390/vaccines9091018 PMC 바로가기 [Article Type] Review