in vitro model
[용어속성] Term
Identification of Hypericin as a Candidate Repurposed Therapeutic Agent for COVID-19 and Its Potential Anti-SARS-CoV-2 Activity
Microbiology
[키워드] activity
acute respiratory syndrome
agent
Analysis
anti-SARS-CoV-2
Antiviral
Area
bind
candidate
composed
Compound
confirmed case
coronavirus
country
COVID-19
COVID-19 pandemic
cultured cells
cytotoxicity
dose
drug
Drug repurposing
enzyme
evaluated
Health
high affinity
Hypericin
Hypericum
identification
in vitro model
increase in
infected cells
inhibited
maturation
MM/PBSA
MPro
pathogenic
Potential
public health
RdRP
Region
regulatory agency
Replication
rising
RNA
RNA polymerase
SARS-CoV-2
Spread
stages
Still
surface
targets
Treatment
vaccination
variant
VERO-E6
Viral protein
viral replication
Virtual screening
virus
virus replication
[DOI] 10.3389/fmicb.2022.828984 PMC 바로가기 [Article Type] Microbiology
[DOI] 10.3389/fmicb.2022.828984 PMC 바로가기 [Article Type] Microbiology
CTCFL regulates the PI3K-Akt pathway and it is a target for personalized ovarian cancer therapy
Article
[키워드] ACTBL2
Biomarker
Biomarkers
Cancer
candidate
Characteristics
Combination
Computational biology and bioinformatics
CTCF
CTCFL
cytoplasmic membrane
de novo
Diagnosis
driving
effective
enrichment analysis
evaluate
expressed
females
function
HGSC
High-grade
Improving
in vitro model
involved
ITGB3
ITGB6
lack
malignancy
MALT1
molecular
ovarian
ovarian cancer
Pathomechanism
pathway
PCDH7
predict
prognostic
Prognostic marker
progression
regulate
Regulatory
resulting
survival
target
target gene
targeted therapy
targets
therapeutic potential
therapy
tissue
transcriptional
transcriptional change
Treatment
VEGFA
[DOI] 10.1038/s41540-022-00214-z PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41540-022-00214-z PMC 바로가기 [Article Type] Article
Moxidectin and Ivermectin Inhibit SARS-CoV-2 Replication in Vero E6 Cells but Not in Human Primary Bronchial Epithelial Cells
목시덱틴과 이버멕틴은 Vero E6 세포에서 SARS-CoV-2 복제를 억제하지만 인간의 1차 기관지 상피 세포에서는 억제하지 않습니다
Article
[키워드] ALI
alleviate
anti-parasitic
Anti-SARS-CoV-2 Activity
Antiviral
antiviral activity
Antiviral effect
antiviral therapies
bronchial
caution
Cell
cell entry
Concentration
COVID-19 disease
COVID-19 patient
COVID-19 patients
drug
epithelial cells
Evidence
exhibited
experiment
following
head
Head-to-head comparison
Health Organization
High-dose
Human
humans
in vitro
in vitro model
in vitro result
in vivo
Infection
inhibit SARS-CoV-2
Interpretation
Ivermectin
limit
Moxidectin
moxidectin.
performed
regimen
respiratory epithelial cells
SARS-CoV-2
SARS-COV-2 infection
severe COVID-19 disease
shown
switching
therapy
these compound
these compounds
treat
Treatment
triggered
unlikely
Vero Cell
Vero cells
Vero E6
VERO E6 cells
virus
World Health Organization
[DOI] 10.1128/AAC.01543-21 PMC 바로가기 [Article Type] Article
[DOI] 10.1128/AAC.01543-21 PMC 바로가기 [Article Type] Article
Experimental Models of COVID-19
COVID-19의 실험 모델
Review
[키워드] ACE2 receptor
African
African green monkeys
animal model
animal models
balancing
biosafety level
cell line
contribute
COVID-19
COVID-19 disease
different cell
different cells
Epidemic
experimental models of COVID-19
ferret
green
hamster
Hepatitis
Human
human populations
humanized
immortalized
in vitro model
In-vitro
Infection
Laboratory
level 3
macaques
mechanism
MHV-1
mice
mimicking
Model
mouse
mouse hepatitis
murine hepatitis virus
NHPs
non-human primates
pandemic
pathology
Pneumonia
Prevent
primate
receptor
receptors
Replication
Research
rhesus macaques
robustness
SARS-CoV-1
SARS-CoV-2
SARS-COV-2 infection
Scientific community
Spectrum
susceptible
therapy
Transgenic mouse
Transmission
transmitted
treat
variants of concern
Viral
viral infection
virus
[DOI] 10.3389/fcimb.2021.792584 PMC 바로가기 [Article Type] Review
[DOI] 10.3389/fcimb.2021.792584 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Spike Protein Destabilizes Microvascular Homeostasis
SARS-CoV-2 스파이크 단백질은 미세혈관 항상성을 불안정하게 합니다.
Research Article
[키워드] ACE2
ACE2 expression
Activation
adverse effect
adverse effects
Affect
alveolar
alveolar epithelial cell
Analysis
angiotensin
angiotensin converting enzyme
angiotensin converting enzyme 2
Angiotensin II
Apoptosis
Aspirin
bind
blunt
bradykinin
calcium
Calcium signaling
caspase
cause
caused
Cell
Cell signaling
cells
Coagulopathies
complex
Concentration
contribute
contributing to
COVID-19
COVID-19 disease
decreased expression
downregulation
dysfunction
Effect
Endothelial cell
endothelial cells
Endothelial dysfunction
enzymatic activity
enzyme
epithelial
epithelial cells
event
Evidence
exposure
expressed
Factor
homeostasis
immunofluorescence microscopy
in vitro model
increased expression
indicated
infects
Inflammation
Interaction
Interference
Intervention
Krüppel
limit
lung
lung tissue
lung tissues
Lungs
mechanism
molecules
organ dysfunction
Pathogenesis
pathology
primary human cells
pro-inflammatory molecules
rationale
receptor
reduce
reduced
Respiratory function
SARS-CoV-2
SARS-CoV-2 infected individuals
SARS-COV-2 infection
Signaling
significantly
spike
Spike protein
suggested
tested
these cell
These cells
thought
thrombotic
Thrombotic events
understanding
uninfected
Vascular
viability
[DOI] 10.1128/Spectrum.00735-21 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1128/Spectrum.00735-21 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Spike Protein-Induced Interleukin 6 Signaling Is Blocked by a Plant-Produced Anti-Interleukin 6 Receptor Monoclonal Antibody
Article
[키워드] acute respiratory distress
acute respiratory syndrome
anti-IL-6 receptor
anti-IL-6R
caused
coronavirus
COVID-19
COVID-19 pandemic
COVID-19 patients
cytokine signaling
Cytokine storm
death
Efficacy
examined
expressed
feasibility
homogeneity
IL-6
IL-6 receptor (IL-6R)
IL-6 signaling
IL-6R
in vitro model
inhibit
interleukin 6
interleukin 6 (IL-6)
mAb
monoclonal antibody
monoclonal antibody (mAb)
mononuclear cell
Nicotiana benthamiana
Peripheral blood
plant
plant-made antibody
plant-made therapeutics
producing
Proinflammatory cytokine
purification
reducing
sarilumab
SARS-CoV-2
SARS-COV-2 infection
shown
spike
spike protein (S)
suppressed
syndrome
the spike protein
utility
[DOI] 10.3390/vaccines9111365 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/vaccines9111365 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection and replication in human gastric organoids
인간 위 오르가노이드에서의 SARS-CoV-2 감염 및 복제
Article
[키워드] adult stem cells
antiviral response
biopsy
children
COVID-19
described
differentially expressed gene
Differentially expressed genes
differentiation
facilitate
fetal
Gastrointestinal models
Gastrointestinal symptom
gastrointestinal symptoms
generate
in vitro model
induce
infect
Infection
infection with SARS-CoV-2
lack
moderate
observation
Organoid
organoids
pediatric
question
raise
replicate
Replication
Respiratory illness
Respiratory system
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 transmission
significantly lower
stomach
susceptible
the interferon
transcriptomic analysis
Transmission
viral clearance
viral infection
viral replication
viral shedding
virus
[DOI] 10.1038/s41467-021-26762-2 PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41467-021-26762-2 PMC 바로가기 [Article Type] Article
Porcine Epidemic Diarrhea Virus Envelope Protein Blocks SLA-DR Expression in Barrow-Derived Dendritic Cells by Inhibiting Promoters Activation
Immunology
[키워드] Activation
adaptive immune response 3
addition
Alter
Antigen
Antigen presentation
antigen-presenting cell
APCS
block
blocked
caused
CD4
Cell
contagious
DCs
Degradation
dendritic cell
disease
envelope
envelope protein
epidemic diarrhea
expression
had no
in vitro model
in vivo
indicated
Infection
inhibited
inhibitor
interactions
intestinal
intestinal epithelial cells
involved
leukocyte
MG132
MHC-II
MHC-II molecule
not affect
participated
pathogenic mechanism
pathway
PEDV
PEDV-envelope protein
Porcine epidemic diarrhea virus
promoters
Protein
protein level
protein levels
replicated
Replication
reporter
SLA-DR
structural protein
Subunit vaccine
T cell activation
target
transcriptional
transcriptional level
transfected cell
Treatment
virus
[DOI] 10.3389/fimmu.2021.741425 PMC 바로가기 [Article Type] Immunology
[DOI] 10.3389/fimmu.2021.741425 PMC 바로가기 [Article Type] Immunology
Direct SARS-CoV-2 infection of the human inner ear may underlie COVID-19-associated audiovestibular dysfunction
Article
[키워드] ACE2
angiotensin-converting enzyme 2
caused
Cell
cell types
cellular
cofactor
confocal microscopy
Coronavirus disease 2019
COVID-19
COVID-19 patient
demonstrated
Direct
disease
Dizziness
dysfunction
Express
expression
hearing loss
in vitro
in vitro model
infect
Infection
infection rate
Infectious disease
molecular
molecular mechanism
novel coronavirus SARS-CoV-2
Organoid
organoids
pandemic
patients with COVID-19
pluripotent stem cells
precursor
problem
protease
receptor
required
Result
SARS-CoV-2
SARS-CoV-2 entry
SARS-CoV-2 entry factors
SARS-COV-2 infection
SARS-CoV-2 virus
Schwann cell
serine 2
stem cells
susceptible
Symptom
Symptoms
target
these symptoms
tissue
tissues
TMPRSS2
transmembrane
two-dimensional
underlie
vascular disease
Virology
virus entry
with COVID-19
[DOI] 10.1038/s43856-021-00044-w PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s43856-021-00044-w PMC 바로가기 [Article Type] Article