Characterization of a Preclinical In Vitro Model Derived from a SMARCA4-Mutated Sinonasal TeratocarcinosarcomaArticle Published on 2023-12-302024-09-05 Journal: Cells [Category] update2024, [키워드] exome sequencing in vitro model Preclinical drug testing Sinonasal cancer SMARCA4 mutation teratocarcinosarcoma [DOI] 10.3390/cells13010081 PMC 바로가기 [Article Type] Article
Standardized In Vitro Models of Human Adipose Tissue Reveal Metabolic Flexibility in Brown Adipocyte ThermogenesisResearch Article Published on 2023-12-072024-09-05 Journal: Endocrinology [Category] update2024, [키워드] bioenergetics bioinformatics brown adipose tissue in vitro model white adipose tissue [DOI] 10.1210/endocr/bqad161 PMC 바로가기 [Article Type] Research Article
Human lung organoid: Models for respiratory biology and diseasesReview Published on 2023-02-012023-07-11 Journal: Developmental biology [Category] COVID19(2023년), [키워드] in vitro model lung organoid Lung stem cell SARS-CoV-2 [DOI] 10.1016/j.ydbio.2022.12.001 [Article Type] Review
Salmonella enterica Infection of Human and Mouse Colon Organoid-Derived Monolayersarticle Published on 2022-12-312024-09-01 Journal: Methods in molecular biology (Clifton, N.J.) [Category] 살모넬라증, [키워드] Cell culture Colonoids Host–pathogen interaction in vitro model Infection intestinal epithelial cells organoids Salmonella [Article Type] article
Nanosponges: An overlooked promising strategy to combat SARS-CoV-2Article Published on 2022-10-012022-11-15 Journal: Drug discovery today [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome Antiviral Antiviral delivery approach Biological Biological neutralization biosafety complex coronavirus Coronavirus 2019 COVID-19 exhibited in vitro model inactivation inhibitory effect mechanism Nanosponges neutralization SARS-CoV-2 SARS-COV-2 infection therapeutic target translational viral inactivation [DOI] 10.1016/j.drudis.2022.07.015 PMC 바로가기
Human Nasal Organoids Model SARS-CoV-2 Upper Respiratory Infection and Recapitulate the Differential Infectivity of Emerging VariantsArticle Published on 2022-08-302022-11-16 Journal: mBio [Category] SARS, 변종, [키워드] acidic pH airway Airway organoids Cell cellular ciliary ciliary damage ciliated cell Culture Delta Efficiency generate higher infectivity Human imperative in vitro model Infection Infectivity Interaction maturation Model monolayer morphologically nasal nasal epithelial cell nasal epithelium nasal organoids nasopharyngeal omicron Organoid Primary infection protocol remained replicative fitness respiratory respiratory viruses robust SARS-CoV-2 tight junction tight junctions Transmissibility Transmission upper upper respiratory infection upper respiratory tract variant variants viral pathogenesis virus spread [DOI] 10.1128/mbio.01944-22 PMC 바로가기
Treatment with metformin glycinate reduces SARS-CoV-2 viral load: An in vitro model and randomized, double-blind, Phase IIb clinical trial메트포르민 글리시네이트로 치료하면 SARS-CoV-2 바이러스 부하 감소: 시험관 내 모델 및 무작위, 이중 맹검, IIb상 임상 시험Randomized Controlled Trial Published on 2022-08-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] adaptive aligned Alpha caused Cell Clinical data clinical trial conducted control group coronavirus disease COVID-19 COVID-19 patients COVID-19 treatment dose doses double-blind drug effort Epsilon evaluate exposure to Health Health crisis highlight highlighting identify IIb in vitro in vitro model in vitro result in vitro study in vivo increased survival indicate inhibit metformin Metformin glycinate New coronavirus new coronavirus SARS-CoV-2 new treatment strategy new virus oxygen phase Randomized reduce reduced SARS-CoV-2 SARS-CoV-2 variants SARS-CoV-2 viral SARS-CoV-2 viral load severe disease supplementary oxygen tested the SARS-CoV-2 therapeutic option treated Treatment Treatment effectiveness triggered variant variants of interest Vero E6 VERO E6 cells viral infection Viral load viral replication [DOI] 10.1016/j.biopha.2022.113223 PMC 바로가기 [Article Type] Randomized Controlled Trial
In vitro high-content tissue models to address precision medicine challengesReview article Published on 2022-08-012022-10-05 Journal: Molecular aspects of medicine [Category] SARS, 비임상, [키워드] Accuracy arising bioprinting Combination coronavirus disease COVID-19 demonstrated Diagnosis diagnostic diagnostics disease Efficacy Efficiency faster highlight IMPROVE in vitro in vitro model individual lack Mutation Organ-on-a-chip pandemic Pandemics Patient Precision precision medicine reduce Reinfection SARS-CoV-2 Side effect tissue Toxicity Treatment vaccinated individuals vaccination Vaccine virus [DOI] 10.1016/j.mam.2022.101108 [Article Type] Review article
Cyanidin-3-O-glucoside and Peonidin-3-O-glucoside-Rich Fraction of Black Rice Germ and Bran Suppresses Inflammatory Responses from SARS-CoV-2 Spike Glycoprotein S1-Induction In Vitro in A549 Lung Cells and THP-1 Macrophages via Inhibition of the NLRP3 Inflammasome Pathway시아니딘-3-O-글루코사이드 및 피오니딘-3-O-글루코사이드-풍부 검정 쌀 배아 및 겨 분획은 A549 폐 세포 및 THP-1 대식세포에서 SARS-CoV-2 스파이크 당단백질 S1-유도 시험관 내 염증 반응을 억제합니다 NLRP3 Inflammasome 경로의 억제Article Published on 2022-06-302022-09-11 Journal: Nutrients [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] A549 Activation anthocyanin anthocyanins Anti-inflammation anti-inflammatory property ASC attenuate benefit black black rice bran C3G Cell cell lines Concentration counteraction COVID-19 COVID-19 infection cytokine secretion dose-dependent manner downregulation Effect exhibited exposure to fraction functional functional food Gene Expression Germ Health health benefits HPLC IL-18 IL-1β IL-6 immune cells in vitro model Inflammasome Inflammation Inflammatory Inflammatory response Inflammatory responses inhibition innate immune cell Innate immune cells long-COVID lung tissue Macrophage macrophages mechanism NF-kB NLRP3 NLRP3 inflammasome P3G pathway post-acute COVID protective effect Protective effects Protein protein level protein levels reported response responsible Rice S1 subunit SARS-CoV-2 spike spike glycoprotein spike glycoprotein S1. THP-1 treated was determined [DOI] 10.3390/nu14132738 PMC 바로가기 [Article Type] Article
Molnupiravir combined with different repurposed drugs further inhibits SARS-CoV-2 infection in human nasal epithelium in vitro다양한 용도 변경 약물과 결합된 몰누피라비르는 시험관 내 인간 비강 상피에서 SARS-CoV-2 감염을 추가로 억제합니다Article Published on 2022-06-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] accelerated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Air-liquid interface antiviral activity Antiviral treatment antiviral treatments antivirals caused cellular Clinical efficacy clinical testing clinically Combination combinations complex Compound Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 drug drug combination drug combinations Drug repurposing effective effective antiviral treatment effort Emergency use evaluated highlighting identify Immunity in vitro in vitro model inhibit inhibiting molnupiravir nasal epithelium Potential treatment Repurposed drug SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selected severe acute respiratory syndrome Coronavirus short duration tested the vaccine These data Treatment Vaccine variant worldwide pandemic [DOI] 10.1016/j.biopha.2022.113058 PMC 바로가기 [Article Type] Article