Discovery of nanoscale sanal flow choking in cardiovascular system: exact prediction of the 3D boundary-layer-blockage factor in nanotubesArticle Published on 2021-07-292022-10-29 Journal: Scientific Reports [Category] Coronavirus, SARS, [키워드] Asymptomatic Biophysics carried Computational biology and bioinformatics diminishe Engineering Factor in silico in vitro in vivo experiment Lower Mathematics and computing Medical research Nanoscience and technology neuroscience pandemic physical Physiology problem rises Space physics transfer unique with COVID-19 [DOI] 10.1038/s41598-021-94450-8 PMC 바로가기 [Article Type] Article
Therapeutic Potentials of Antiviral Plants Used in Traditional African Medicine With COVID-19 in Focus: A Nigerian PerspectivePharmacology Published on 2021-04-262022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] 2019-nCoV acute respiratory syndrome addition adopted African anti-SARS-CoV-2 Antiviral antiviral drug approach available data carried caused Chinese Combination Community coronavirus coronavirus disease country COVID-19 drug Drug discovery effort Evidence global public health herb-drug interaction herbal immuno-stimulants in silico In vitro assay in vivo experiment increasingly information Interaction Intervention knowledge lethal disease management Medicine non-specific pandemic Phytomedicines plant Potential preventive measures provided recorded reported Research Respiratory disease risk SARS-CoV-2 supportive care TAM Traditional Traditional African Medicine Treatment Vaccines World War II [DOI] 10.3389/fphar.2021.596855 PMC 바로가기 [Article Type] Pharmacology
Polyunsaturated ω-3 fatty acids inhibit ACE2-controlled SARS-CoV-2 binding and cellular entryArticle Published on 2021-03-042022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] addition affected anti-SARS-CoV-2 Antiviral compound antiviral efficacy binding cathepsin L cellular entry Compound COVID-19 Efficacy entry of SARS-CoV-2 expression Fatty acid fatty acids hACE2 hACE2 receptor in vivo experiment inhibit interfere Ligand linolenic acid Lipid Microbiology pandemic Polyunsaturated Proteases protein level provide pseudo-virus receptor reducing reduction SARS-CoV-2 saturated screened sequence shown significantly Spike protein the SARS-CoV-2 TMPRSS2 Treatment Virology vitamins WHO [DOI] 10.1038/s41598-021-84850-1 PMC 바로가기 [Article Type] Article
Evidence of central nervous system infection and neuroinvasive routes, as well as neurological involvement, in the lethality of SARS-CoV-2 infectionSARS-CoV-2 감염의 치사율에 대한 중추 신경계 감염 및 신경 침습 경로 및 신경학적 관여의 증거Review Published on 2021-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 치료기술, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Brain cause of death caused Central nervous system cerebrospinal fluid clinical symptom Clinical symptoms CNS coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 patient COVID-19 patients CSF dead death early stage Evidence evidence of global health Gustatory Health higher risk Hypothesis in vitro in vivo experiment Infection infection with SARS-CoV-2 lethality mechanism Mortality nervous system neuroinvasion Neuroinvasive neurological Neurological deficit neurological deficits Neurological involvement Neurological symptom Neurological symptoms Neuron neurons Neuropathology nine olfactory outbreak pathophysiology Pathways Patient positive provided reported SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe COVID-19 severe COVID-19 patients Support [DOI] 10.1002/jmv.26570 PMC 바로가기 [Article Type] Review
Development of a Physiologically Based Pharmacokinetic Model for Hydroxychloroquine and Its Application in Dose Optimization in Specific COVID-19 PatientsPharmacology Published on 2021-02-122022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Affect Anti-viral application applied Autoimmune diseases can be used Characteristics children China Clinical findings clinical trial concomitant medications conducted COVID-19 COVID-19 patient Critical development distribution dose dosing recommendation dosing regimen drug-drug interaction extrinsic HCQ Hydroxychloroquine impairment in vitro in vivo experiment inhibitor intrinsic lung lung tissues malaria mechanism metabolism Model optimization organ Pandemics Patient pharmacokinetic physiologically-based pharmacokinetic Population populations Potential treatment pregnant women recommendation reduced Research Specific specific populations subject Support supported Treatment [DOI] 10.3389/fphar.2020.585021 PMC 바로가기 [Article Type] Pharmacology
Potential bioactive glycosylated flavonoids as SARS-CoV-2 main protease inhibitors: A molecular docking and simulation studiesSARS-CoV-2 주요 프로테아제 억제제로서의 잠재적 생체 활성 글리코실화 플라보노이드: 분자 도킹 및 시뮬레이션 연구Research Article Published on 2020-10-152022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, [키워드] 3CL pro 6LU7 Acute respiratory infection antiviral molecules approach AutoDock AutoDock vina best binding affinity chemical structures Chymotrypsin-like protease complex Consensus coronavirus docking experiments Docking studies docking study downloaded drug drug treatment evaluate flavonoids flavonoids chemical structure flavonoids chemical structures fruit glycosylated flavonoid glycosylated flavonoids glycosylated forms highest binding affinity in vitro in vivo experiment inhibit inhibitor inhibitors inhibitors of SARS-CoV-2 investigated limit MD simulation MD simulations molecular docking Molecular docking study natural phenolic compound natural phenolic compounds Novel coronavirus performed Perspective physiological activities plants Potential protease Protein Protein Data Bank Protein Data Bank site PubChem quercetin Quercetin-3-O-rhamnoside respiratory respiratory infection responsible rutin SARS-CoV SARS-CoV-2 main protease SARS-CoV-2 protease Simulation study Spread stability tested the SARS-CoV-2 Treatment virus virus expansion was performed [DOI] 10.1371/journal.pone.0240653 PMC 바로가기 [Article Type] Research Article
Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodiesArticle Published on 2020-05-152022-11-01 Journal: Cellular and Molecular Immunology [Category] COVID-19, SARS, [키워드] ACE2 against SARS-CoV amino acid residue analyzed angiotensin-converting enzyme 2 antibody antigenic bind binding site block viral entry caused Coronavirus disease 2019 coronavirus SARS-CoV-2 COVID-19 COVID-19 pandemic cross-neutralizing cross-neutralizing antibody develop drug epitope F486 feature host receptor human ACE2 Humoral immunity immunization in vivo experiment indicate induce Infection mechanism neutralize Neutralizing antibodies neutralizing antibody neutralizing monoclonal antibody Prophylactic public health RBD receptor binding motif recognize representing residue SARS-CoV SARS-CoV RBD SARS-CoV-2 SARS-CoV-2 RBD Spike protein Substitution mutation the RBD the receptor-binding domain the SARS-CoV-2 the spike protein Vaccine viral spike protein viruses [DOI] 10.1038/s41423-020-0458-z PMC 바로가기 [Article Type] Article
A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology AnalysisPerspective Published on 2020-04-242022-10-30 Journal: Nutrients [Category] COVID-19, [키워드] acid acquisition acting activate applied approach biological processe Biology Combination conducted coronavirus CoV CoV infection Curcumin Cytokine storm dietary supplements excessive inflammatory response Genome glycyrrhizic acid Health immune immune response in vitro in vivo experiment Inflammation Inflammatory response Inflammatory responses inhibit inhibiting innate immune response interferon KEGG Kyoto MAPK signaling modulating network analysis NF-κB novel Ontology pathway pathway enrichment Pathways Prevent promote provide regulate Research response responses signaling pathway System System biology T-cells target therapy Vitamin Vitamin C [DOI] 10.3390/nu12041193 PMC 바로가기 [Article Type] Perspective