The serum of COVID-19 asymptomatic patients up-regulates proteins related to endothelial dysfunction and viral response in circulating angiogenic cells ex-vivoCOVID-19 무증상 환자의 혈청은 생체 외 순환하는 혈관 신생 세포에서 내피 기능 장애 및 바이러스 반응과 관련된 단백질을 상향 조절합니다Article Published on 2022-04-092022-09-12 Journal: Molecular Medicine [Category] COVID19(2023년), SARS, 진단, [키워드] Activation acute respiratory syndrome applied approach Asymptomatic Asymptomatic COVID-19 asymptomatic individual Asymptomatic individuals asymptomatic patient caused Cell cellular change circulating Circulating angiogenic cells Coagulation coronavirus correlated COVID-19 COVID-19 negative critical COVID-19 patients death Donor donors endothelial Endothelial dysfunction Endothelial progenitor cells evaluated Ex vivo Factor highest ICAM-1 identify IgG immune response incubated individuals Infection infective Inflammatory Inflammatory response inhibitor initial machine learning algorithm marker pathway PCR platform positive potential long-term sequelae promote promoted Protein protein level proteomics provoke Quantitative responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. serum significantly Stage Symptoms Thromboembolic event TLR2 transmissions treated triggered understanding up-regulate up-regulated Vascular Vascular damage viral infection virus virus entry while [DOI] 10.1186/s10020-022-00465-w PMC 바로가기 [Article Type] Article
Increased resistance of SARS-CoV-2 Omicron variant to neutralization by vaccine-elicited and therapeutic antibodies백신 유도 및 치료 항체에 의한 중화에 대한 SARS-CoV-2 Omicron 변이체의 내성 증가Article Published on 2022-04-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibody Antibody neutralization applied benefit BNT162b2 booster concern decrease disease severity Donor donors effective Effectiveness Efficacy Emergency use highlight immunization Increased incubated lentivirus Lilly luciferase luciferase activity luminometer maintain mapped Moderna monoclonal antibodies monoclonal antibody monoclonal antibody therapies monoclonal antibody therapy mutated neutralization Neutralizing NIH obstacle omicron Omicron variant Pfizer preventing infection PROTECT protein structure pseudotype pseudotyped lentiviruses Regeneron Resistance mutation resistance mutations SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 variant sera serum Sotrovimab Spike protein T cells target cells the vaccine the vaccines therapeutic Therapies therapy titre Vaccine vaccine efficacy vaccine. variant was measured [DOI] 10.1016/j.ebiom.2022.103944 PMC 바로가기 [Article Type] Article
Humoral and Cellular Immune Responses to SARS-CoV-2 mRNA Vaccination in Patients with Multiple Sclerosis: An Israeli Multi-Center Experience Following 3 Vaccine Doses다발성 경화증 환자의 SARS-CoV-2 mRNA 백신 접종에 대한 체액 및 세포 면역 반응: 3회 백신 접종 후 이스라엘의 다기관 경험Multicenter Study Published on 2022-04-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Affect Autoimmunity Blood BNT162b2 booster cell-mediated immune response cellular response Cellular responses Cladribine contribute COVID-19 disease Disease modifying therapies (DMTs) evaluated experience fingolimod Fingolimod- healthy control humoral Humoral response humoral responses IFNγ IgG IgG level IgG levels immune immune response immune responses incubated Longevity MOST mRNA mRNA vaccine Multiple multiple sclerosis multiple sclerosis. Ocrelizumab Patient patients proportion recovering from COVID-19 recruited response SARS-CoV-2 secretion seropositive subgroup analysis T-cell T-cell immune response T-cell Response T-cell responses therapy time interval treated vaccination Vaccinations was collected were measured with COVID-19 within 6 months [DOI] 10.3389/fimmu.2022.868915 PMC 바로가기 [Article Type] Multicenter Study
Evaluation of saliva self-collection devices for SARS-CoV-2 diagnosticsSARS-CoV-2 진단을 위한 타액 자가 수집 장치 평가Article Published on 2022-03-252022-09-11 Journal: BMC Infectious Diseases [Category] SARS, 치료기술, 치료법, [키워드] affected analyzed assistance bottleneck buffer Community condition COVID-19 pandemic current determined by diagnostic Diagnostic method diagnostic testing diagnostics evaluate evaluated expand funnel implementation incubated individual individuals Large-scale testing no significant difference Pathogens problems professionals profiles quantity respiratory pathogen Respiratory pathogens RNase P Safe Saliva SARS-CoV-2 SARS-CoV-2 nucleocapsid sensitivity significant difference Supply chain temperature were used [DOI] 10.1186/s12879-022-07285-7 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet AggregationSARS-CoV-2 스파이크 단백질 1은 미세혈관 내피 세포 및 보체 시스템을 활성화하여 혈소판 응집을 유도합니다Article Published on 2022-03-072022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] ACE2 Activation addition adhesive molecule aggregate aggregation AMPK amplified Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 antibody blockade blocking antibody Blot C3a C5a circulating complement Complement activation complement inhibitors complement system complexity conditions coronavirus disease Coronavirus disease 2019 COVID-19 detection element ELISA endothelial Endothelial cell endothelial cells endothelial damage Endothelial dysfunction enzyme evaluated Exocytosis experiment expression human host immunofluorescence incubated induce infect Inflammation Inflammatory inhibitors investigated leading leukocyte lung Microvascular thrombosis microvasculature Mortality multiorgan failure P-selectin performed phenotype Platelet platelet aggregation pro-inflammatory recruitment replicate robust S1 protein SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 spike protein 1 selectin sera severe COVID-19 patient severe COVID-19 patients significant level spike Spike protein System thromboembolic thromboembolic complication thromboembolic complications thrombomodulin thrombosis thrombosis. thrombotic thrombotic complication Thrombotic complications viral infection von Willebrand factor were assessed western blot Western blot analysis [DOI] 10.3389/fimmu.2022.827146 PMC 바로가기 [Article Type] Article
Glycosite-deleted mRNA of SARS-CoV-2 spike protein as a broad-spectrum vaccine407 Published on 2022-02-112022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] acute respiratory syndrome addition Affect Alpha antibody antigens Apoptosis broad spectrum can be used CD8 Cell conserved coronavirus COVID-19 DCs deleted dendritic cell development domain effective Efficacy elicited Endoplasmic reticulum epitope expressed expression glycosite deletion glycosylation histocompatibility complex immune response incubated induce Messenger RNA MHC I Modification mRNA mRNA vaccine mRNA vaccines Omicron variants Pathogens Protective Protein provide RBD S2 domain SARS-CoV-2 SARS-CoV-2 spike protein Significance Spike protein Spread subunit T cell response the RBD the receptor-binding domain translated vaccination Vaccine variant variants of concern viral spike protein wild type XBP1 [DOI] 10.1073/pnas.2119995119 PMC 바로가기 [Article Type] 407
Efficient discovery of potential inhibitors for SARS-CoV-2 3C-like protease from herbal extracts using a native MS-based affinity-selection method천연 MS 기반 친화성 선택 방법을 사용하여 허브 추출물에서 SARS-CoV-2 3C 유사 프로테아제에 대한 잠재적 억제제의 효율적인 발견Article Published on 2022-02-052022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CL 3CL Protease 3CLpro acquisition acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 applied baicalein binding affinity characterized China Cirsium Complexes Compound compounds conducted Coronaviral coronavirus COVID-19 COVID-19 therapy Data acquisition Data processing Effectiveness efficient effort flavonoids Forsythia fraction Fractions Glycyrrhiza uralensis identify incubated Infection inhibitor investigated life cycle Ligand Lonicera japonica Native Native MS natural natural product outcomes protease protein-ligand resources SARS-CoV-2 scutellarein Scutellaria baicalensis severe acute respiratory syndrome Coronavirus small molecule Standard TCM therapy Traditional Chinese medicine traditional Chinese medicine. traditional Chinese medicines Treatment UHPLC Virus life cycle were used [DOI] 10.1016/j.jpba.2021.114538 PMC 바로가기 [Article Type] Article
Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particlesResearch Article Published on 2022-01-242022-10-30 Journal: Journal of Oral Microbiology [Category] COVID-19, [키워드] Cetylpyridinium cetylpyridinium chloride chloride Including incubated inhibitor mandatory membrane disaggregation membranes mouthwashe promote prophylactic strategy Result rupture SARS-CoV-2 Transmission Virology Virus-like particle virus-like particles VLP VLPs w/v [DOI] 10.1080/20002297.2022.2030094 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Spike protein is not pro-inflammatory in human primary macrophages: endotoxin contamination and lack of protein glycosylation as possible confoundersOriginal Article Published on 2022-01-112022-10-31 Journal: Cell Biology and Toxicology [Category] COVID-19, SARS, [키워드] Abstract caused Concentration conducted confounder Contamination E. coli Effect ELISA endotoxin evade expressed expression FIVE glycosylated glycosylation host innate immunity Human human macrophages humans in vitro incubated Inflammation Inflammatory lack lipopolysaccharide LPS Macrophage marker objective pro-inflammatory produced Protein qPCR Result SARS-CoV-2 SARS-COV-2 infection spike Spike protein supernatant supplementary material tested triggered [DOI] 10.1007/s10565-021-09693-y PMC 바로가기 [Article Type] Original Article
Development of a RT-LAMP assay for detection of SARS-CoV-2Article Published on 2022-01-012022-11-15 Journal: The Indian journal of medical research [Category] SARS, 치료기술, [키워드] amplification assays carried caused clones country COVID-19 detect development diagnostic equipment evaluate evaluated in vitro transcription incubated isothermal isothermal amplification less N gene nucleocapsid pandemic platform polymerase chain primer reaction reduce Result RNA rRT-PCR RT-LAMP SARS-CoV-2 SARS-CoV-2 RNA Sensitivity and specificity tested throat swab visual detection. were recorded Wuhan, China [DOI] 10.4103/ijmr.IJMR_713_21 PMC 바로가기