Ongoing Mycophenolate Treatment Impairs Anti-SARS-CoV-2 Vaccination Response in Patients Affected by Chronic Inflammatory Autoimmune Diseases or Liver Transplantation Recipients: Results of the RIVALSA Prospective Cohort진행중인 미코페놀레이트 치료는 만성 염증성 자가면역 질환 또는 간 이식 수혜자의 영향을 받는 환자에서 항-SARS-CoV-2 백신 반응을 손상시킵니다: RIVALSA 예상 코호트의 결과Observational Study Published on 2022-08-122022-09-11 Journal: Viruses [Category] SARS, 임상, 진단, 치료기술, [키워드] 95% CI administration Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG anti-SARS-CoV-2 vaccination Antibody Response Antibody titers ARMS Arthritis Autoimmune Autoimmune disease Autoimmune diseases Autoimmune hepatitis calcineurin calcineurin inhibitors chronic cohort of patients Complete connective tissue disease Connective tissue diseases detectable develop Diagnosis dose dose reduction Effect effective Eligible patients enrolled evaluate evaluated example first dose healthy subjects hepatology identify IgG immunogenicity immunosuppressive immunosuppressive therapy Immunosuppressive treatment independent predictor independent predictors individual inhibitor liver liver transplant Liver transplantation MMF mRNA COVID-19 vaccine mRNA COVID-19 vaccines mRNA vaccine mRNA-based Multivariate analysis mycophenolate mycophenolate. neoplasia Novara observational study organ other diseases overlapped Patient patients performed predictor Prevent Prospective prospective observational study receiving recipients rejection required response Result rheumatoid arthritis rheumatological SARS-COV-2 infection selected Seroconversion seroconversion failure spondyloarthritis subgroups of patient suffered Suspension Tertiary therapy transplantation transplants treated Treatment unit Univariate analysis university vaccinated individual vaccination Vaccine vaccine response Vasculitis [DOI] 10.3390/v14081766 PMC 바로가기 [Article Type] Observational Study
Evaluation of hematological parameters and inflammatory markers in children with COVID-19COVID-19 소아의 혈액학적 매개변수 및 염증 표지자 평가Article Published on 2022-08-012022-09-11 Journal: Irish Journal of Medical Science [Category] 바이오마커, [키워드] 95% CI abnormality applied best blood cell C-reactive protein C-reactive protein (CRP can be used children children with COVID-19 COVID-19 CRP cutoff value D-dimer determine distribution Effect evaluate hematological hematological parameter hematological parameters hemoglobin Hospitalization identify independent predictor independent predictors Inflammatory biomarker inflammatory biomarkers Inflammatory marker inflammatory markers Inpatient Inpatients lymphocyte lymphopenia mean platelet volume monocyte multivariate logistic regression neutrophil Outpatient outpatients Patient Platelet platelet counts procalcitonin procalcitonin level Red cell retrospective risk factor Risk factors ROC analysis separated significantly higher significantly lower single-center study study population two groups Volume was performed WBC White blood cell [DOI] 10.1007/s11845-021-02762-5 PMC 바로가기 [Article Type] Article
Out-of-hospital cardiac arrest and in-hospital mortality among COVID-19 patients: A population-based retrospective cohort studyResearch article Published on 2022-08-012022-10-05 Journal: Journal of microbiology, immunology, and infection [Category] 바이오마커, [키워드] 95% confidence interval absence adjusted odds ratio Admission age circulation cohort study Community Comorbidities COVID-19 COVID-19 patient COVID-19 patients death Deceased defined demographics determine discharge disease severity Factor Fever hospital Hypoxemia in-hospital mortality independent predictor Isolation laboratory-confirmed Logistic regression Mortality Occurrence Older age Out-of-hospital cardiac arrest oxygen saturation Patient patients predictor recruited Result retrospective cohort study SARS-CoV-2 symptom onset Taiwan time vital sign were used [DOI] 10.1016/j.jmii.2022.07.009 [Article Type] Research article
Past COVID-19 and immunosuppressive regimens affect the long-term response to anti-SARS-CoV-2 vaccination in liver transplant recipients과거의 COVID-19 및 면역억제 요법은 간 이식 수혜자의 항 SARS-CoV-2 백신 접종에 대한 장기 반응에 영향을 미칩니다Article Published on 2022-07-012022-09-11 Journal: Journal of hepatology [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] Affect anti-RBD anti-receptor-binding domain anti-SARS-CoV-2 anti-SARS-CoV-2 vaccination anti-SARS-CoV-2 vaccine anti-SARS-CoV-2 vaccines Antibody Response Antibody titer ascites baseline BNT162b2 BNT162b2 vaccine Control controls COVID-19 COVID-19 recovered patient daily dose dose effective enrolled Frequency IgG IgG antibody immunogenicity immunosuppressive independent predictor independent predictors less leukocyte liver liver transplant Liver transplantation median MMF mRNA mRNA vaccine mycophenolate mycophenolate mofetil naïve negative controls negativity patients positive Protein recipient recipients regimen second vaccination serum significantly lower tested U/mL vaccination vaccine dose [DOI] 10.1016/j.jhep.2022.02.015 PMC 바로가기 [Article Type] Article
Seroprevalence in health care workers during the later phase of the second wave: Results of three hospitals in Serbia, prior to vaccine administration2차 유행 후반기 의료 종사자의 혈청 유병률: 백신 접종 전 세르비아의 3개 병원 결과Article Published on 2022-07-012022-09-12 Journal: Journal of infection and public health [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] adjusted Analysis Anosmia/ageusia Antibody test Belgrade Blood center Characteristics conducted country COVID COVID-19 COVID-19 infection COVID-19 pandemic cross-sectional disease Emergency evaluate Fever HCW HCWs Health care worker Healthcare workers hospital IgG antibody independent predictor later phase multivariate logistic regression outbreak Patient PCR Personal protective equipment positive positive result Prevalence problem public health measure questionnaire Result Risk perception SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 PCR testing second wave Sensitivity and specificity serology Seroprevalence serum IgG Shortness of breath similar study socio-demographic Symptom tested vaccination vaccine administration [DOI] 10.1016/j.jiph.2022.05.009 PMC 바로가기 [Article Type] Article
Impaired Kallikrein-Kinin System in COVID-19 Patients’ SeverityObservational Study Published on 2022-06-222022-10-05 Journal: Frontiers in Immunology [Category] 임상, [키워드] Accuracy ACE2 Admission analyzed Bradykinin (BK) C1 esterase inhibitor cascade characterized clinical laboratory Coagulation Combination Concentration consecutive patient control group COVID-19 CPN1 cutoff value D-dimer D-dimer level disease disease severity dysregulated dysregulation enzyme Factor healthy subject ICU ICU admission Impaired independent independent predictor Inflammation intensive care involved Kallikrein-kinin system KLKB1 lymphopenia multivariate multivariate logistic regression multivariate model NLRP3 NLRP3 inflammasome Observational cohort study Odds ratio pathophysiology patients with COVID-19 peptide plasma concentration plasma protein Protein reported retained Severe COVID-19 pneumonia severity subunit System Thromboinflammation vascular homeostasis was related [DOI] 10.3389/fimmu.2022.909342 PMC 바로가기 [Article Type] Observational Study
Clinical Characteristics and Risk Factors for Mortality in Critical Coronavirus Disease 2019 Patients 50 Years of Age or Younger During the Delta Wave: Comparison With Patients > 50 Years in Korea2019년 델타파 중 50세 이하 환자 중대 코로나바이러스 감염증의 임상적 특성 및 사망률 위험인자: 국내 50세 이상 환자와의 비교Article Published on 2022-06-062022-09-11 Journal: Journal of Korean medical science [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval Adult patients age analyses Analysis analyzed Blood stream infection BMI body mass body mass index Case fatality rate clinical Clinical characteristics clinical feature Clinical features condition conditions coronavirus disease Coronavirus disease 2019 COVID-19 creatinine Critical critical condition death Delta delta variant diabetes Diabetes Mellitus died dominant eight electronic medical record enrolled evaluate Factor Fatality rate General population globe highest highlight hospital Hospitalized hypertension identify independent predictor independent predictors Infection measure mechanical ventilation Mortality mortality risk factor mortality risk factors Multivariate analysis nasal nasal cannula Numerous obese obesity Odds ratio Older older patient older patients oxygen Oxygen therapy Patient PCR-confirmed COVID-19 Prevent progression respiratory Respiratory Support risk risk factor Risk factors Secondary infection severity statistically study period study population the patient therapy total patients underlying disease vaccination vaccination rate Vaccinations variant while women Year Young younger patient younger patients [DOI] 10.3346/jkms.2022.37.e175 PMC 바로가기 [Article Type] Article
Cardiopulmonary predictors of mortality in patients with COVID-19: What are the findings?Research article Published on 2022-06-012022-10-05 Journal: Archives of cardiovascular diseases [Category] COVID19(2023년), SARS, 바이오마커, [키워드] 95% CI 95% confidence interval association cardiac injury Characteristics clinical collected Computed tomography Concentration consecutive patient coronavirus disease COVID-19 CT score Deceased determine Electrocardiography groups haematological malignancy identify independent predictor initial Injury Kaplan-Meier analysis Laboratory Mortality mortality rate Odds ratio Patient patients with COVID-19 predictor pulmonary disease Result severity significantly shorter ST depression subgroups survival troponin was performed with COVID-19 [DOI] 10.1016/j.acvd.2022.04.008 [Article Type] Research article
Cytokeratin 18 cell death assays as biomarkers for quantification of apoptosis and necrosis in COVID-19: a prospective, observational studyCOVID-19에서 세포자멸사 및 괴사의 정량화를 위한 바이오마커로서의 Cytokeratin 18 세포 사멸 분석: 전향적 관찰 연구Observational Study Published on 2022-06-012022-09-11 Journal: Journal of Clinical Pathology [Category] Coronavirus, COVID19(2023년), MERS, SARS, 바이오마커, 임상, [키워드] admitted patients Adult patients Apoptosis appear assays Biomarker blood sample Blood samples Care caspase cell damage cell death clinical trials collected Control controls COVID-19 COVID-19 patient COVID-19 patients cytokeratin discharged patients elevated emergency department enrolled enzyme epithelial epithelial cell estimation hospitalisation hospitalised hospitalised COVID-19 patients ICU admission independent predictor independent predictors Intact intensive care unit mechanism multivariable logistic regression Necrosis non-ICU Patient patients patients with COVID-19 presenting quantification relative contribution relative contributions respiratory respiratory symptom respiratory symptoms risk stratification SARS-CoV-2 severe disease sick therapeutic efficacy Trigger triggers Virology [DOI] 10.1136/jclinpath-2020-207242 PMC 바로가기 [Article Type] Observational Study
An analysis of antibody response following the second dose of CoronaVac and humoral response after booster dose with BNT162b2 or CoronaVac among healthcare workers in Turkey터키 의료 종사자의 코로나백 2차 접종 후 항체 반응 및 BNT162b2 또는 코로나백 추가 접종 후 체액성 반응 분석Article Published on 2022-05-012022-09-11 Journal: Journal of medical virology [Category] Fulltext, MERS, 변종, 진단, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration age Analysis Anti-RBD IgG anti-receptor-binding domain antibody antibody levels Antibody Response asked blood draw BNT162b2 booster booster dose booster doses chronic disease circulating variants Complete CoronaVac coronavirus dose evaluated Follow-up groups healthcare worker Healthcare workers Heterologous heterologous vaccination homologous or heterologous humoral Humoral response IgG Immunoglobulin Immunoglobulin G Inactivated vaccine independent predictor independent predictors levels of antibody Limited Messenger RNA Odds ratio participant Participants prospective cohort study Quantitative questionnaire RBD reduction respiratory risk SARS-CoV-2 second dose Seropositivity severe acute respiratory syndrome Coronavirus single booster dose the median Turkey university hospital vaccination Vaccine waning immunity were infected were measured [DOI] 10.1002/jmv.27620 PMC 바로가기 [Article Type] Article