Viral load at hospitalization is an independent predictor of severe COVID-19Comment Published on 2023-01-012023-07-10 Journal: European Journal of Clinical Investigation [Category] COVID19(2023년), [키워드] COVID-19 Hospitalization independent predictor SARS-CoV-2 severity Viral load [DOI] 10.1111/eci.13882 PMC 바로가기 [Article Type] Comment
Association of diaphragm thickness and density measured on chest CT with disease severity in COVID-19 patientsResearch article Published on 2022-11-012022-10-05 Journal: The American journal of emergency medicine [Category] SARS, 진단, [키워드] 95% confidence interval addition Admission age analyses Analysis analyzed Bilateral celiac artery Chest computed tomography Chest CT Clinical course Clinical outcome Comorbidities Computed tomography coronavirus disease correlation COVID-19 COVID-19 patient decrease demographic characteristics demonstrated Diaphragm disease severity evaluate evaluated Hemidiaphragm ICU admission independent predictor independent risk factor investigated Logistic regression Mortality multivariable model muscle mass Odds ratio Patient patients with COVID-19 performed Pneumonia polymerase chain positive Prognosis Prognostic markers reliability Result risk factor severe disease statistically significant the patient threshold value was measured [DOI] 10.1016/j.ajem.2022.08.029 [Article Type] Research article
Association of Interleukin-17F Polymorphism and Mortality Predictors with the Risk of COVID-19Article Published on 2022-10-272022-11-15 Journal: International journal of clinical practice [Category] 변종, 진단, [키워드] age allele Analysis association AUC case-control study CD4 cells Characteristics control subject controls Coronavirus disease-19 COVID-19 COVID-19 infection COVID-19 mortality COVID-19 patient COVID-19 patients cutoff point D-dimer death determine enzyme-linked immunosorbent exhibiting expression Genotype genotyping healthy higher odd hypertension IL-17 immunological injuries in-hospital mortality independent predictor investigated Laboratory no significant difference non-survivor outcome participant polymorphism predictor proinflammatory risk of COVID-19 ROC Curve subset suggested survivor susceptibility T lymphocytes tested variant WBC White blood cell with COVID-19 [DOI] 10.1155/2022/4761631 PMC 바로가기
Hybrid and vaccine-induced immunity against SAR-CoV-2 in MS patients on different disease-modifying therapiesArticle Published on 2022-10-012022-11-15 Journal: Annals of Clinical and Translational Neurology [Category] COVID19(2023년), SARS, 진단, [키워드] age Analysis antibody Antibody Response assays association cellular cellular response Cellular responses center COVID-19 infection COVID-19 vaccination ELISPOT evaluated examined groups hybrid IFNγ IL-2 immune response immune responses Immunity immunoassay immunologic response independent independent predictor Infection laboratory-confirmed Live virus microneutralization mRNA vaccines multivariate multivariate analyses New York no difference Patient post-vaccination response post-vaccine response receptor recruited SAR-CoV-2 SARS CoV-2 Sex significantly increased subset therapy vaccination Vaccine Vaccine-induced immunity were assessed [DOI] 10.1002/acn3.51664 PMC 바로가기
Clinical prediction models in hospitalized patients with COVID-19: A multicenter cohort studyArticle Published on 2022-10-012022-11-15 Journal: Respiratory medicine [Category] 진단, [키워드] Accuracy acute COVID-19 Admission age APACHE II asymptomatic infection calculated Care clinical Clinical decision rules COVID-19 COVID-GRAM Critical CURB-65 death died Hospital stay Hospitalized hospitalized patient IMPROVE In-hospital death independent predictor intubation Italian majority Mortality multicenter cohort study Negative predictive value novel coronavirus disease outbreak PaO2/FiO2 ratio Patient patients with COVID-19 Pneumonia Positive predictive value predict predictor Prognosis prognostic risk SARS-CoV-2 Sepsis severe respiratory failure SOFA [DOI] 10.1016/j.rmed.2022.106954 PMC 바로가기
Interpatient variability in the pharmacokinetics of remdesivir and its main metabolite GS-441524 in treated COVID-19 subjectsArticle Published on 2022-09-302022-11-15 Journal: Journal of Antimicrobial Chemotherapy [Category] SARS, 치료제, [키워드] affected age antiviral drug approved association baseline blood sample BMI calculated collected comparison Concentration COVID-19 COVID-19 patients COVID-19 severity Efficacy enrolled evaluated glomerular filtration rate GS-441524 ICU identify independent predictor Inpatient Inpatients inter-individual Liver function Logistic regression metabolite Multiple linear regression Multiple regression analysis parameter Patient pharmacokinetic plasma Remdesivir renal renal function required Research SARS-CoV-2 SARS-CoV-2 infections Sex Standard-dose statistical subject transaminase treated Treatment Variability variables were assessed were measured were used [DOI] 10.1093/jac/dkac234 PMC 바로가기
Circulating pyruvate is a potent prognostic marker for critical COVID-19 outcomesArticle Published on 2022-09-142022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, [키워드] abundance acute phase acute respiratory syndrome Alter Analysis approach assays body mass index C-reactive protein circulating clinical decision Compromised coronavirus COVID-19 COVID-19 pathogenesis COVID-19 patient creatinine criterion Critical Critically ill cut-off value determine disease disrupt driven by dysregulation energy-related metabolites evaluated Extracellular fluorometric quantification Glucose Health Host Host immune response immune response implicated IMPROVE Increased independent predictor Infection Lactate mechanisms metabolism metabolite metabolomics mitochondrial outcome outcomes Patient Potential biomarker Prognosis Prognostic marker provided pyruvate quantification Quantitative recruited risk SARS-CoV-2 SARS-COV-2 infection semi-targeted metebolomics. serum severe COVID-19 illness severity Signaling Stratification Support validation cohort virus [DOI] 10.3389/fimmu.2022.912579 PMC 바로가기
Predictors of Covid-19 Vaccination Response After In-Vivo T-Cell-Depleted Stem Cell TransplantationArticle Published on 2022-09-012022-11-16 Journal: Transplantation and cellular therapy [Category] COVID19(2023년), SARS, 치료기술, [키워드] age Allogeneic allogeneic transplantation antibody Antibody Response average binding antibody unit Blood donors BNT162b2 chronic GVHD CORD COVID-19 detectable Donor dose Efficacy Graft-versus-host disease GVHD in vivo independent predictor initial involved JNJ-78436735 Johnson & Johnson less Lymphocyte count lymphocyte counts Moderna mRNA-1273 multivariable analysis Patient Predictive Prophylaxis question recipient recipients respond response robust SARS-CoV-2 spike protein SARS-CoV-2 vaccination Serologic response STEM stem cell Stem cell transplantation T cell depletion T-cell T-cell Depletion Transplant transplantation transplants umbilical cord blood vaccination Vaccine [DOI] 10.1016/j.jtct.2022.06.012 PMC 바로가기
Predictive Factors of Extubation Failure in COVID-19 Mechanically Ventilated PatientsObservational Study Published on 2022-09-012022-10-04 Journal: Journal of Intensive Care Medicine [Category] 임상, [키워드] 48 hour 95% CI Admission age Analysis APACHE II score association average Characteristics COVID-19 COVID-19 patient dialysis evaluate evaluated extubation Factor failure ICU increased the risk independent predictor intensive care invasive investigated male mechanical ventilation need for dialysis non-COVID-19 patient Non-COVID-19 patients on mechanical ventilation outcome PaO2/FiO2 ratio parameter Patient Poisson regression model predicted Predictive Predictive Factors predictor Primary outcome Probability progressed retrospective risk Sex single-center statistical analysis Symptom Symptoms the mean the patient was done was performed weaning with COVID-19 [DOI] 10.1177/08850666221093946 PMC 바로가기 [Article Type] Observational Study
Reliability of predictive models to support early decision making in the emergency department for patients with confirmed diagnosis of COVID-19: the Pescara Covid Hospital scoreCOVID-19 진단이 확인된 환자의 응급실에서 조기 의사 결정을 지원하는 예측 모델의 신뢰성: Pescara Covid Hospital 점수Article Published on 2022-08-192022-09-11 Journal: BMC health services research [Category] 변종, [키워드] Abruzzo Accuracy Admission age and gender Algorithm Alpha build calibrated can be used carried Characteristics clinical decision collecting data conditions COVID-19 D-dimer death decision Decision making diabete diabetes diagnosed with COVID-19 Diagnosis disease distribution emergency department heterogeneous higher risk hospital hospital management hospitalisation identify independent predictor independent predictors initial intensive care Italy laboratory parameter Laboratory parameters Lactate lactate dehydrogenase Logistic regression monocyte other variant other variants outcome oxygen oxygen support pandemic parameter Patient patients with COVID-19 prediction Prediction score Predictive model predictive models predictor procalcitonin Prognosis renal renal disease Retrospective study risk Risk scores risk stratification saturation significantly Support survival threshold validation variants of concern virus were used [DOI] 10.1186/s12913-022-08421-4 PMC 바로가기 [Article Type] Article