Drug repositioning: Progress and challenges in drug discovery for various diseases약물 재배치 : 다양한 질병에 대한 약물 발견의 진보 및 도전Review Published on 2022-04-152022-08-31 Journal: European journal of medicinal chemistry [Category] 신약개발, [키워드] addition antimicrobial Antiviral benefit Cancer candidate Candidates Clinical efficacy Combination comprehensive analysis COVID-19 pandemic de novo different disease different diseases disease Diseases drug Drug discovery drug repositioning Effect Efficiency Follow-up indication indications mechanism mechanism of action Neurological diseases other diseases Progress public health emergency Research synergistic synergistic effect [DOI] 10.1016/j.ejmech.2022.114239 PMC 바로가기 [Article Type] Review
ACE2 protein expression in lung tissues of severe COVID-19 infection중증 코비드 -19 감염의 폐 조직에서의 ACE2 단백질 발현Article Published on 2022-03-082022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 진단, 치료기술, [키워드] ACE2 ACE2 expression ACE2 protein acute lung injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alveolar damage angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antigen Biomarkers bronchopneumonia CD163 cells Complication controls Coronavirus-2 Correlation analysis COVID-19 COVID-19 disease DAD died Diffuse alveolar damage disease severity Diseases enzyme expression Histomorphology host protein Hypothesis hypothesised IHC immunohistochemistry immunostaining increased expression increased risk indications lung Lung injury lung tissue Macrophage Macrophage infiltration macrophages Medical research microthrombi Molecular biology non-COVID-19 patient Non-COVID-19 patients Pathogenesis Patient performed Platelet positively correlated post-mortem lung Protein protein expression random respiratory Risk factors Sample size SARS-CoV-2 SARS-CoV-2 viral Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe COVID-19 severe COVID-19 disease Severe COVID-19 Infection Severe infection significantly higher subset tested tissue Viral Virus Disease was performed were used [DOI] 10.1038/s41598-022-07918-6 PMC 바로가기 [Article Type] Article
Proposing a novel deep network for detecting COVID-19 based on chest imagesArticle Published on 2022-02-242022-10-04 Journal: Scientific Reports [Category] MERS, 바이오마커, 진단, 치료기술, [키워드] Analysis approach AUC Chest Chest computed tomography Chest CT chest imaging Computational models coronavirus COVID-19 CT-scan CXR Data mining dataset diagnostic Efficiency epidemiological evaluated exclusion criteria experiments extension feature inclusion criteria Inconclusive indications Infectious diseases limitation Lungs outbreak overcome Patient polymerase chain positive Research researcher RT-PCR SARS-CoV-2 sensitivity significantly transfer [DOI] 10.1038/s41598-022-06802-7 PMC 바로가기 [Article Type] Article
Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lungDiltiazem은 SARS-CoV-2 세포 부착 및 내재화를 억제하고 마우스 폐의 바이러스 감염을 감소시킵니다Research Article Published on 2022-02-172022-09-10 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] ACE2 Affect affecting anti-SARS-CoV-2 antiviral drug antiviral drugs appear approved attachment Author binding blocker Breakthrough infection breakthrough infections calcium calcium channel Cell Clinical practice coronavirus COVID-19 COVID-19 treatment decrease Diltiazem drug drugs Effectiveness Emergency use FDA-approved drug highlight hospitalized COVID-19 patients indications inhibit interact internalization L-type lung occurred raise recipient recipients Remdesivir Research research and development respiratory Respiratory Coronavirus Safe SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike protein SARS-CoV-2 vaccine SARS-CoV-2 vaccines severe acute respiratory coronavirus Spike protein subunit Support the vaccine the vaccines treat Treatment US FDA variant variants variants of SARS-CoV-2 Viral viral entry viral infection [DOI] 10.1371/journal.ppat.1010343 PMC 바로가기 [Article Type] Research Article
Immune Cells Profiles in the Different Sites of COVID-19-Affected Lung Lobes in a Single PatientMedicine Published on 2022-02-162022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] alveolar Analysis analyzed AQP3 Basal cell basal cells COVID-19 COVID-19 disease cytokine determine died Diffuse alveolar damage FIVE help identify Immune cell immune cells immunohistochemistry increase in indications Inflammation Inflammatory response lobe lung lung lobe lung lobes moderate mRNA expression pathological pathophysiology pathway Patient patient with COVID-19 profile Protective RNA-sequencing SARS-CoV-2 severe inflammation Site stages tissue Ventilation Viral transmission virus [DOI] 10.3389/fmed.2022.841170 PMC 바로가기 [Article Type] Medicine
Convalescent plasma in the treatment of moderate to severe COVID-19 pneumonia: a randomized controlled trial (PROTECT-Patient Trial)중등도 내지 중증의 코비드 -19 폐렴의 치료에서의 회복기 혈장 : 무작위 대조 시험 (보호 환자 시험)Clinical Trial Published on 2022-02-152022-09-01 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료법, 치료제, [키워드] 1:1 95% CI anti-SARS-CoV-2 antiviral activity benefit blueprint clinical Clinical improvement Clinical trial design clinical trials clinically contribute Controlled trial convalescent plasma convalescent plasma group COVID-19 COVID-19 pneumonia COVID-19 severity Data and Safety Monitoring Board double-blinded effective therapy Efficacy enrolment Evidence feasibility futility Grade 1 HIV HIV positive hospital hospital discharge hospitalized patient hospitalized patients improvement indications individuals investigated median moderate multicenter neutralizing antibody Non-invasive observational studies observational study occurred Ordinal Scale oxygen participant Participants performed placebo group plasma Pneumonia Premature Prevalence Primary outcome primary outcome measure public sector Randomized Randomized controlled trial Randomized controlled trials receive recommendation reducing Relative risk risk Safety Safety Monitoring Board saline solution scale severe COVID-19 South Africa suggested Support the placebo group therapeutic option titre transfusion-related adverse event Treatment Trial with COVID-19 World Health Organisation [DOI] 10.1038/s41598-022-06221-8 PMC 바로가기 [Article Type] Clinical Trial
Maternal-Fetal Implications of SARS CoV-2 Infection during Pregnancy, Viral, Serological Analyses of Placenta and Cord Blood임신 중 SARS CoV-2 감염의 모체-태아 관련, 태반 및 제대혈의 바이러스, 혈청학적 분석Article Published on 2022-02-132022-09-10 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] Anal anal swab antibody APGAR score Apgar scores Blood blood sample Blood samples Cesarean section clinical form CORD Cord blood coronavirus COVID-19 detect detection diagnosed diagnosed with COVID-19 digestive distress elevated evaluate fetal fetal tachycardia growth Hospitalization Hospitalized ICU admission IgM indications intrauterine growth retardation investigated maternal–fetal transmission maternity mechanism MOST mother multiparous nasopharyngeal Neonatal Newborn NPSs outcome outcomes PCR pediatric Placenta placental Placentas positive Pregnancy pregnant women Premature presenting preterm births Prospective Study real time-PCR remained required retardations RT-PCR SARS CoV-2 infection SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody SARS-CoV-2 IgM SARS-COV-2 infection serology severe pneumonia Swab swabs Symptoms Tachycardia tested transmission of SARS-CoV-2 umbilical umbilical artery Vaginal vaginal delivery was performed women [DOI] 10.3390/ijerph19042105 PMC 바로가기 [Article Type] Article
Differential Dynamics of SARS-CoV-2 Binding and Functional Antibodies upon BNT162b2 Vaccine: A 6-Month Follow-UpBNT162B2 백신에 대한 SARS-COV-2 결합 및 기능적 항체의 차등 역학 : 6 개월 추적 관찰Article Published on 2022-02-022022-09-01 Journal: Viruses [Category] COVID19(2023년), Fulltext, MERS, SARS, 진단, [키워드] anti-RBD Anti-RBD IgG anti-Spike IgG antibody association binding BNT162b2 characteristic collected comparable correlates of protection COVID-19 cutoff point decrease Definition demonstrated dose Dynamics functional high correlation Humoral response IgG indications Laboratory laboratory procedures lack less maturation mRNA NAb NAbs Neutralizing antibodies neutralizing antibody of BNT162b2 receiver operating characteristic receiver operating characteristic curve receiving resulting SARS-CoV-2 serum sample serum samples vaccination were measured WHO [DOI] 10.3390/v14020312 PMC 바로가기 [Article Type] Article
Towards Fixed Dosing of Tocilizumab in ICU-Admitted COVID-19 Patients: Results of an Observational Population Pharmacokinetic and Descriptive Pharmacodynamic StudyICU에 입원한 COVID-19 환자에서 토실리주맙의 고정 용량을 향하여: 관찰 인구 약동학 및 기술 약력학 연구의 결과Observational Study Published on 2022-02-012022-09-12 Journal: Clinical pharmacokinetics [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] added Admission age Analysis applied AUC average clearance Concentration concomitant therapy coronavirus disease covariate COVID-19 COVID-19 patients COVID-19 treatment guidelines Dexamethasone dexamethasone 6 mg distribution dose dose administration Dosing dosing schedules eligible elimination rate enrolled Evidence Final first dose fixed fixed dose ICU identify IMPROVE increase indications intensive care intravenous tocilizumab investigated linear mechanical ventilation mixed-effects model nasal obesity Older Open-label outcome oxygen support parameter pathway Patient patients performed Pharmacodynamic pharmacokinetic plasma sample polymerase chain Population provide raised Randomized controlled trial receptor REMAP-CAP Result risk factor Safe saturated severe COVID-19 shown Support survival Tocilizumab Variability Volume was performed [DOI] 10.1007/s40262-021-01074-2 PMC 바로가기 [Article Type] Observational Study
The impact of COVID-19 on pregnancy outcomes in a diverse cohort in EnglandArticle Published on 2022-01-182022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] analysed applied association Asymptomatic case attack rate Cohort complications Confirmed Control controls coronavirus disease COVID-19 COVID-19 case COVID-19 pandemic COVID-19 transmission death Effect England Epidemiology Evidence examined Factor groups iatrogenic increase in indications Neonatal no increase outcome outcomes overlap pandemic performed Pregnancy Preterm birth Regression model risk risk factor Risk factors risk of COVID-19 SARS-COV-2 infection Stillbirth symptomatic case trend viral infection women [DOI] 10.1038/s41598-022-04898-5 PMC 바로가기 [Article Type] Article