Myopathy as a cause of fatigue in long-term post-COVID-19 symptoms: Evidence of skeletal muscle histopathology코로나19 이후 장기 증상에서 피로의 원인인 근병증: 골격근 조직병리학의 증거Article Published on 2022-09-012022-09-11 Journal: European journal of neurology [Category] COVID19(2023년), SARS, 변종, [키워드] ABC acute disease acute infection affected age analyzed Antigen basal lamina biopsy Capillaries capillary cells changes changes in COVID-19 symptoms Cytochrome C cytochrome c oxidase diagnosed disease electromyography electron microscopy evidence of expression fatigue fiber histological change histological changes histopathological Histopathology human leukocyte antigen indication indications Inflammation Injury less leukocyte long-term COVID Microscopy Mild mitochondrial Most patients muscle muscle biopsy muscle fiber muscle weakness muscular myalgia myopathic Myopathy Patient patients post-COVID syndrome Quantitative reduced reported SARS-CoV-2 Skeletal muscle skeletal muscles Symptoms syndrome T lymphocyte T lymphocytes two patients variant variety weakness [DOI] 10.1111/ene.15435 PMC 바로가기 [Article Type] Article
Funding Sources of Therapeutic and Vaccine Clinical Trials for COVID-19 vs Non-COVID-19 Indications, 2020-2021COVID-19 대 비-COVID-19 적응증에 대한 치료 및 백신 임상 시험의 자금 출처, 2020-2021Article Published on 2022-08-012022-09-11 Journal: JAMA Network Open [Category] 임상, [키워드] addressed clinical clinical trial clinical trials Cohort collected COVID-19 COVID-19 therapeutics COVID-19 vaccine cross-sectional cross-sectional study effective Evidence examined followed by funding funding source indications maintain market MOST Non-COVID-19 number outcome pandemic Phase 1 public sector reached Registered Regulatory required Research research and development Source therapeutic Therapeutics Trial Vaccine [DOI] 10.1001/jamanetworkopen.2022.26892 PMC 바로가기 [Article Type] Article
Nimotuzumab Increases the Recovery Rate of Severe and Critical COVID-19 Patients: Evaluation in the Real-World Scenario니모투주맙은 중증 및 치명적인 COVID-19 환자의 회복률을 증가시킵니다: 실제 시나리오에서의 평가Article Published on 2022-07-222022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI Administered adverse event age antibody attributable fraction brief research report nimotuzumab Cancer Cohort Combination Comorbidity conducted Control control group control patients COVID-19 Critical critical COVID-19 patients Cuba death doses EGFR EGFR signaling evaluate Expanded access fibrosis fraction hospital humanized increase indicate indications Inflammation intravenous infusion intravenous infusions lung damage median age Mild moderate monoclonal antibody Mortality mortality risk National Patient patients prevented proportion protocol Rate reduce Registered Research retrospective cohort Safe SARS-CoV SARS-CoV-2 SARS-COV-2 infection scenario selected severe and critical patients Signaling Standard of care standard treatment treated treated patients [DOI] 10.3389/fpubh.2022.948520 PMC 바로가기 [Article Type] Article
COVID-19 convalescent plasma코로나19 회복기 혈장Article Published on 2022-07-212022-09-11 Journal: Blood [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody antibody-dependent cellular cytotoxicity benefit CCP collected complement Complement activation convalescent plasma coronavirus coronavirus disease COVID-19 disease early disease Efficacy function Health Health crisis high-titer CCP Hospitalized Immunosuppressed immunosuppressed patient immunosuppressed patients indications location moderate moderate to severe Outpatient pandemic phagocytosis plasma prophylactic therapy provide provided randomized trial respiratory safety profile SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe disease symptom onset the patient The United States therapeutic potential Therapies transfused Treatment Trial United States Viral viral neutralization with COVID-19 [DOI] 10.1182/blood.2021012248 PMC 바로가기 [Article Type] Article
Nationwide Harmonization Effort for Semi-Quantitative Reporting of SARS-CoV-2 PCR Test Results in Belgium벨기에 SARS-CoV-2 PCR 검사 결과 반정량적 보고를 위한 전국적인 조화 노력Article Published on 2022-06-142022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] absence affected Asymptomatic Belgium calculated category clinician Concentration Contact tracing Course cycle threshold database determine driven by effort Factors harmonization indications Infection Infectivity information Laboratory Leuven National National Reference Centre pandemic PCR PCR assay positive PCR result Reporting Result resulting RNA RNA copies/mL SARS-CoV-2 SARS-CoV-2 PCR SARS-CoV-2 test semi-quantitative semi-quantitative PCR semi-quantitative reporting. serological standard curve Standard deviation target gene Test the mean threshold to define viral shedding [DOI] 10.3390/v14061294 PMC 바로가기 [Article Type] Article
Short-term perioperative outcomes among patients with concurrent asymptomatic and mild SARS-CoV-2 infection: A retrospective, multicenter study무증상 및 경증 SARS-CoV-2 감염 환자의 단기 수술 전후 결과: 후향적, 다기관 연구Multicenter Study Published on 2022-06-012022-09-11 Journal: Surgery [Category] COVID19(2023년), SARS, 치료기술, [키워드] 30-Day mortality Admission Asymptomatic categorization center Chinese Cohort Control COVID COVID-19 COVID-19 infection COVID-19 infections COVID-19 symptom criteria determine diagnosed disease control indications Infection initial management Mild mild COVID-19 symptoms morbidity morbidity and mortality Mortality mortality rates multicenter New obtundation operative risk outcome overall mortality Patient patients patients with asymptomatic patients with SARS-CoV-2 performed postoperative prevention Previous studies previous study Primary outcome pulmonary complication pulmonary complications retrospective Retrospective study risk SARS-CoV-2 secondary outcome Secondary outcomes severity surgery surgical was used weighed [DOI] 10.1016/j.surg.2021.12.024 PMC 바로가기 [Article Type] Multicenter Study
The paradigm shift in treatment from Covid-19 to oncology with mRNA vaccinesReview article Published on 2022-06-012022-10-05 Journal: Cancer treatment reviews [Category] COVID19(2023년), SARS, 치료법, [키워드] addition administration Antigen approach Cancer Cancer vaccine circumvent clinical study Combination coronavirus disease COVID-19 Efficacy Ex vivo Immunosuppression indications intranasal intravenous Isolation literature medication mRNA mRNA platform mRNA vaccine mRNA vaccines oncology optimization overcome patients platform Research reveal RNA therapeutic therapy treat Treatment Vaccine Vaccine design Vaccines [DOI] 10.1016/j.ctrv.2022.102405 [Article Type] Review article
Monitoring of alcohol-based hand rubs in SARS-CoV-2 prevention by HS-GC/MS and electrochemical biosensor: A survey of commercial samplesHS-GC/MS 및 전기화학적 바이오센서에 의한 SARS-CoV-2 예방의 알코올 기반 손 문지름 모니터링: 상업용 샘플 조사Article Published on 2022-05-302022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] COVID19(2023년), SARS, 치료기술, [키워드] acidification addition agency alcohol Alcohol-based hand rubs alignment ANOVA ANOVA test approach average Chromatography comparable Control coronavirus 2 correlation COVID-19 data set determine diffusion electrochemical biosensor ethyl alcohol evaluated gas chromatography Gas chromatography. hand hygiene Health highlighting house hygiene identify indicated indication indications isopropyl alcohol limit limit of detection LoQ mass mass spectrometry methyl alcohol monitoring parameter propyl alcohol provided quantification reported respiratory Result SARS-CoV-2 screening method severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spectrometry statistically tested were assessed widespread [DOI] 10.1016/j.jpba.2022.114694 PMC 바로가기 [Article Type] Article
A phase 2 randomized, double-blinded, placebo-controlled, multicenter trial evaluating the efficacy and safety of raloxifene for patients with mild to moderate COVID-19Research article Published on 2022-05-122022-10-05 Journal: EClinicalMedicine [Category] 신약개발, 임상, [키워드] Action acute respiratory syndrome adaptive clinical testing consumer coronavirus disease-2019 Coronavirus-2 COVID COVID-19 COVID-19 disease current decrease doses double-blinded Effect Efficacy and safety Emergency Endpoint enrolled Estrogen European Commission evaluate Evidence finding FIVE funding hospitalized patients immunomodulator indications instrument Italian Italy lack mechanical ventilation Medicine Mild Ministry of Health mitigate moderate Moderate COVID-19 modulate multicenter Multicenter trial Nasopharyngeal swab Occurrence participant Patient pharmacological Phase 2 study Placebo placebo-controlled placebo-controlled trial Prevent Primary outcome progression proinflammatory cytokines proportion raloxifene Randomized receive Registered Replication reported Safety safety profile SARS-CoV-2 Selective estrogen receptor modulator (SERM) Serious Adverse Events Seven supplemental oxygen Supplemental oxygen therapy Support supported therapeutic option treat Treatment Trial undetectable viral shedding [DOI] 10.1016/j.eclinm.2022.101450 [Article Type] Research article
Clinical features of thrombosis and bleeding in COVID-19Research article Published on 2022-04-222022-10-05 Journal: Blood [Category] COVID19(2023년), SARS, 임상, [키워드] Admission appear Arterial thrombosis bleeding clinical COVID-19 COVID-19 disease COVID-19 symptom D-dimer dose events extracorporeal membrane oxygenation Factor feature fibrinogen higher risk hospital include indications Infection intensive care unit less Lymphocyte count Mortality multifactorial Myocardial infarction Other parameter Patient presenting pulmonary receive resulting risk Severe COVID-19 Infection stroke the patient the SARS-CoV-2 virus Thromboprophylaxis thrombosis treated Treatment unique venous Venous thrombosis von Willebrand factor VTE with COVID-19 [DOI] 10.1182/blood.2021012247 [Article Type] Research article