inflammatory condition – Page 2 – Communicable Diseases Research

Protease Activated Receptors: A Pathway to Boosting Mesenchymal Stromal Cell Therapeutic Efficacy in Acute Respiratory Distress Syndrome?

Review

Published on 2022-01-242022-10-29
Journal: International Journal of Molecular Sciences [Category] Coronavirus,

Immune function and dysfunction are determined by lymphoid tissue efficacy

Review

Published on 2022-01-012022-10-31
Journal: Disease Models & Mechanisms [Category] COVID-19,

Osteopontin as a biomarker for COVID-19 severity and multisystem inflammatory syndrome in children: A pilot study

어린이의 COVID-19 중증도 및 다기관 염증 증후군에 대한 바이오마커로서의 오스테오폰틴: 파일럿 연구

Article

Published on 2022-01-012022-09-11
Journal: Experimental Biology and Medicine [Category] SARS, 바이오마커,

[키워드] age analyzed Asymptomatic Atlanta Biomarker blood sample C-reactive protein category center children Clinical data clinical utility conditions Control correlated COVID-19 COVID-19 severity diagnosis of COVID-19 disease control elevated ELISA kit erythrocyte sedimentation erythrocyte sedimentation rate evaluate ferritin Hospitalized Inflammation Inflammatory inflammatory condition Inflammatory marker inflammatory markers interleukin interleukin-6 lymphocyte marker MIS-C moderate Non-COVID-19 osteopontin Patient pediatrics pilot study plasma Platelet platelet counts Positive predictive value Predictive value prevention Research residual Retrospective analysis SARS-CoV-2 sedimentation rate severe COVID-19 severity significantly specificity symptomatic syndrome
[DOI] 10.1177/15353702211046835 PMC 바로가기 [Article Type] Article

Association of Complement and MAPK Activation With SARS-CoV-2–Associated Myocardial Inflammation

SARS-CoV-2–관련 심근 염증과 보체 및 MAPK 활성화의 연관성

Research

Published on 2021-12-152022-09-10
Journal: JAMA Cardiology [Category] MERS, SARS, 유전자 메커니즘,

[키워드] abundance age Analysis assessment biopsies C1q capture capture sequencing cardiac Cardiomyopathy cascade case sery CD163 center Characteristics characterized clade Cohort cohort of patients collected complement Complement cascade component confirmation cysteine Endomyocardial biopsy Ethnicity Exome exploratory exposure Factor finding Future Germany highest histologic Hospitalized immune pathway immune signature Immune-mediated implication Importance individual Infection Inflammatory inflammatory condition inflammatory conditions inhibitor Injury kinases lymphocyte Lymphocyte count lymphocyte counts Macrophage macrophages male MAPK mass mass spectrometry Maximilian measure median age mitogen mitogen-activated protein kinase Munich Myocardial inflammation myocardial injury myocarditis objective participant Participants pathway Pathways Patient patients with SARS-CoV-2 phenotype Point Protein protein kinase protein kinases proteinase Proteins proteomic Proteomic analysis reduce Referral Relevance Result RNA SARS-COV-2 infection Sequencing Serine setting signaling cascade similarities specimen specimens subunit the median threonine tissue transcript transcriptomic transcriptomic analysis Treatment strategies treatment strategy Tübingen university upregulated upregulation Viral viral myocarditis were measured
[DOI] 10.1001/jamacardio.2021.5133 PMC 바로가기 [Article Type] Research

Purinergic receptor ligands: the cytokine storm attenuators, potential therapeutic agents for the treatment of COVID-19

퓨린성 수용체 리간드: 사이토카인 폭풍 감쇠제, COVID-19 치료를 위한 잠재적 치료제

Review

Published on 2021-12-012022-09-11
Journal: Immunopharmacology and immunotoxicology [Category] SARS, 바이오마커,

[키워드] Activation acute respiratory distress syndrome adenosine anti-inflammatory effect ARDS attenuate chemokine chemokines complication of COVID-19 coronavirus coronavirus disease Coronavirus disease-19 COVID-19 COVID-19 patient Critical CSS cytokine Cytokine storm Cytokine storm syndrome Cytokines distress drug hemodynamic Inflammation inflammatory condition investigated multiple organ failure pandemic potential therapeutic agent Purinergic purinergic receptors. receptor receptors reported respiratory distress Signaling subtype suggested suppress syndrome systemic inflammation the cytokine storm therapeutic drug Treatment Wuhan Wuhan, China
[DOI] 10.1080/08923973.2021.1988102 PMC 바로가기 [Article Type] Review

Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases

Immunology

Published on 2021-11-232022-11-01
Journal: Frontiers in Immunology [Category] COVID-19,

Hematuria as an Early Sign of Multisystem Inflammatory Syndrome in Children: A Case Report of a Boy With Multiple Comorbidities and Review of Literature

Pediatrics

Published on 2021-10-272022-10-31
Journal: Frontiers in Pediatrics [Category] COVID-19,

[키워드] abdominal pain Antibiotic therapy arrhythmia Asymptomatic Boy Case report children Clinical course clinical feature clinical suspicion criteria CRP cultures D-dimer defined Diagnosis disorder dysfunction elevated elicited ESR Fever fibrinogen Hematuria IgG SARS-CoV-2 antibodies include Inflammation Inflammatory inflammatory condition instantaneous Intravenous immunoglobulin Kawasaki disease kidney Laboratory literature manifestation marker mechanism microbial Mild MIS-C Multiple multiple comorbidity multisystem inflammatory syndrome in children (MIS-C) outcome Patient pediatric positive Rash report reported review SARS-CoV-2 SARS-COV-2 infection SIGN supported Symptom syndrome Treatment ventricular virus vomiting while with COVID-19 worsened
[DOI] 10.3389/fped.2021.760070 PMC 바로가기 [Article Type] Pediatrics

Multicellular spatial model of RNA virus replication and interferon responses reveals factors controlling plaque growth dynamics

Research Article

Published on 2021-10-252022-10-28
Journal: PLoS Computational Biology [Category] COVID-19,

[키워드] acute respiratory syndrome Analysis antiviral response Cell Cell culture coefficients condition coronavirus COVID-19 cultures cytokine cytokine signaling Cytokine storm diffusion drug candidates early stage epithelial evaluated evidenced excessive inflammation exhibit experiment Factor flu form growth H1N1 influenza H3N2 help highlight immune immune response immunopathology IMPROVE in some in vitro include induce Infection inflammatory condition Inflammatory response Influenza inhibit innate immune response interferon interferon response interferon signaling interferons involved JAK/STAT pathway lesion linear local concentration lung lung cell Lung epithelial cells Lung infection Lungs manifestation mechanism molecular multicellular Occurrence pandemic Pandemics parameter pathway performed plaque plaques protective effect public health radial growth Replication respiratory Respiratory disease respiratory infection responsible reveal RNA virus RNA viruses SARS-CoV-2 severe cases severe inflammation severity Signaling signaling molecule Spanish the disease tissue Treatment Trigger type I interferons understanding Variation viral growth Viral load viral replication virus virus-infected cell
[DOI] 10.1371/journal.pcbi.1008874 PMC 바로가기 [Article Type] Research Article

Blood Fatty Acids Profile in MIS-C Children

Communication

Published on 2021-10-222022-10-30
Journal: Metabolites [Category] COVID-19,

[키워드] acid activities Admission adult COVID-19 patient affecting albumin All the patient alteration Anti-inflammatory arachidonic acid arising Aspartate aminotransferase AST biochemical Blood C-reactive protein (CRP children compounds Critical D-dimer Diagnosis docosahexaenoic acid Eicosanoids elevated enrolled evaluated Evidence fatty Fatty acid ferritin Fever fibrinogen hospital Inflammation Inflammatory inflammatory condition inflammatory parameter Inflammatory response inflammatory state Intervention Laboratory lack Lipid marker metabolite MIS-C NT-proBNP observation onset of symptoms organs patients physiological Polyunsaturated pro-inflammatory profile provide reported SARS-COV-2 infection specialized pro-resolution mediators subject Symptom syndrome systemic inflammatory
[DOI] 10.3390/metabo11110721 PMC 바로가기 [Article Type] Communication

Unraveling the mechanisms of IVIG immunotherapy in MIS-C

MIS-C에서 IVIG 면역요법의 기전 규명

Comment

Published on 2021-10-192022-09-12
Journal: Cell Reports Medicine [Category] MERS, SARS, 진단,

[키워드] anti-inflammatory effect children clinical IL-1β Immunotherapy Inflammatory inflammatory condition Intravenous immunoglobulin investigation journal mechanism MIS-C neutrophil syndrome target with COVID-19
[DOI] 10.1016/j.xcrm.2021.100431 PMC 바로가기 [Article Type] Comment