Hyper/neuroinflammation in COVID-19 and suicide etiopathogenesis: Hypothesis for a nefarious collision?COVID-19의 과/신경염과 자살 병인: 악의적 충돌에 대한 가설?Review Published on 2022-05-012022-09-11 Journal: Neuroscience and biobehavioral reviews [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] acute COVID-19 alleviate Analysis approach Biomarker cells cellular mechanism clinical evidence Consequences COVID-19 COVID-19 survivors Cytokines disease focus Health hyperinflammation Hyperinflammation, neuroinflammation Hypothesis ideation Immunomodulatory agent Immunomodulatory agents Inflammation Inflammatory inflammatory mediator Inflammatory mediators Inflammatory peripheral cells, neural cells knowledge Long Long COVID-19 syndrome Longitudinal studies mental health molecular Neuroinflammation Neuropsychiatric observation overlapping risk SARS-COV-2 infection stages Suicidal behavior Suicidal ideation Suicide suicide risk survivor syndrome systemic systemic inflammation while [DOI] 10.1016/j.neubiorev.2022.104606 PMC 바로가기 [Article Type] Review
New AKT-dependent mechanisms of anti-COVID-19 action of high-CBD Cannabis sativa extracts Research Published on 2022-03-112022-10-05 Journal: Cell Death Discovery [Category] 진단, 치료기술, 치료법, [키워드] ACE2 AKT cannabis caused Cell Combination components COVID-19 COX2 downregulated Epigenetic expression Extract Factor Features fibroblast highlighting IL-6 IL-8 inflammatory mediator inhibited Interaction lung mechanism miRNA modulated New pathway proinflammatory suppressed target cell the SARS-CoV-2 virus TMPRSS2 TMPRSS2 expression [DOI] 10.1038/s41420-022-00876-y [Article Type] Research
AMP5A modulates Toll-like receptors 7 and 8 single-stranded RNA immune responses in PMA-differentiated THP-1 and PBMCResearch Published on 2022-03-032022-10-29 Journal: Translational Medicine Communications [Category] COVID-19, [키워드] activate activated Activation acute respiratory syndrome addition agonist AhR AMP5A And Chemokines antagonist antiviral immunity Aryl hydrocarbon receptor Autoimmunity biologic chemokines clinical investigation condition coronavirus coronavirus disease Course COVID-19 CXCL10 cytokine Cytokines decrease detect differentially expressed dysregulated Effect ELISA enrichment analysis evaluate experiment fraction Human serum albumin hyperinflammation Hyperinflammatory IL-12 IL-1β IL-6 Imbalance Immune cell immune response immunomodulatory implicated Infection Inflammation inflammatory mediator Inflammatory response inhibit Intervention involved low molecular weight Lung disease mechanism modulate mononuclear cells myeloid cell myeloid cells NF-κB NF-κB activation Osteoarthritis pathway PBMC Peripheral blood PPARγ pro-inflammatory pro-inflammatory cytokine profiles progression Protective provided receptor REP Result resulting RNA Severe case Signaling single-stranded ssRNA suppresse Therapeutic approach THP-1 TLR TLR7 TLR7/8 Toll-like receptor toll-like receptor 7 Toll-like receptor 8 transcription factor transcription factors treat Treatment viral sequences were used with COVID-19 [DOI] 10.1186/s41231-022-00110-y PMC 바로가기 [Article Type] Research
A New Approach to the Management of COVID-19. Antagonists of IL-6: SiltuximabCOVID-19 관리에 대한 새로운 접근 방식. IL-6의 길항제: 실툭시맙Review Published on 2022-03-012022-09-12 Journal: Advances in therapy [Category] SARS, 진단, [키워드] administration antagonist caused Characteristics clinical evidence clinical study clinical trial conducted COVID-19 COVID-19 patient Cytokine release syndrome death downregulate drug drugs Effect effort IL-6 IL-6 level IL-6 levels inflammatory mediator inflammatory process information interleukin-6 International mechanism mechanism of action monoclonal antibodies monoclonal antibody National New overexpression pandemic pathway Patient patients patients with COVID-19 poor prognosis Prevent produced provided reducing Respiratory complications Respiratory disease SARS-COV-2 infection severe respiratory disease siltuximab Symptom therapeutic use Treatment [DOI] 10.1007/s12325-022-02042-3 PMC 바로가기 [Article Type] Review
Emerging Insights on Caspases in COVID-19 Pathogenesis, Sequelae, and Directed TherapiesCOVID-19 발병, 후유증 및 직접 요법의 카스파제에 대한 새로운 통찰력Review Published on 2022-02-212022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] accumulating activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Apoptosis apoptotic approved benefit broad spectrum caspase Caspases caused Cell cell death characterized clinical manifestation clinical manifestations Clinical use coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 current therapy cytokine cytokine release death disease disease severity downstream dysregulated effective effort Evidence expressed expression family members health emergency high risk highest highlight Hypercoagulation IL-18 IL-1β immune immune responses immunological immunological mechanism in some in vitro individual inflammasomes Inflammation inflammatory mediator Inflammatory mediators inhibitor insight Manifestations mediators multi-organ failure multiprotein complex non-immune observational studies observational study occur outcomes pathology Pathways Prevent progression pyroptosis receptor signaling respiratory risk SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe COVID-19 therapeutic therapeutic intervention upstream Vaccines variant [DOI] 10.3389/fimmu.2022.842740 PMC 바로가기 [Article Type] Review
MS-based targeted profiling of oxylipins in COVID-19: A new insight into inflammation regulationCOVID-19에서 MS 기반 옥시리핀 표적 프로파일링: 염증 조절에 대한 새로운 통찰력Observational Study Published on 2022-02-202022-09-12 Journal: Free radical biology & medicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, 진단, [키워드] analysed Anti-inflammatory AUC Biomarker canonical characterisation characteristic collected computation COVID-19 COVID-19 patients cytokine Cytokines dataset Fisher ICU patient ICUs Inflammation Inflammation regulation inflammation response inflammatory cascade inflammatory mediator intensive care unit Lipid lipid mediator Lipid mediator class switching magnitude Oxylipins Patient PCA pilot study plasma plasma concentration platform Pneumonia principal component analysis pro-inflammatory status Regulation respond resulting retrospective risk ROC ROC Curve selected severe COVID-19 severity predictors shown switching targeting the cytokine storm UHPLC-MS/MS. university with COVID-19 [DOI] 10.1016/j.freeradbiomed.2022.01.021 PMC 바로가기 [Article Type] Observational Study
Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profilingSARS-CoV-2 감염으로 인한 폐 손상 모델로서의 시리아 햄스터: 병리학, 생리학 및 상세한 분자 프로파일링Article Published on 2022-02-012022-09-12 Journal: Translational research : the journal of laboratory [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Acute inflammation acute lung injury acute respiratory distress acute respiratory syndrome acute SARS-CoV-2 infection Analysis animal model Apoptosis ARDS caused characterized clearance coronavirus coronavirus disease COVID-19 demonstrated driving evaluate Evidence exhibited feature Ferroptosis hamster histologic host response Hypoxemia indicated infected with SARS-CoV-2 Infection inflammatory mediator intranasal lack lung Lung injury molecular molecular mechanism pulmonary permeability RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe COVID-19 significant difference syndrome Syrian Golden hamsters systemic illness upregulation Viral pneumonia virus [DOI] 10.1016/j.trsl.2021.10.007 PMC 바로가기 [Article Type] Article
Cutaneous and systemic hyperinflammation drives maculopapular drug exanthema in severely ill COVID-19 patients피부 및 전신 고인 염증은 심하게 아픈 Covid-19 환자에서 황반 약물 엑스 산마를 유도합니다.Article Published on 2022-02-012022-08-31 Journal: Allergy [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analyzed CCL11 CD8 cellular chemokine chemokines Cluster Clustering coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 patient COVID-19 patients Cutaneous cytokine Cytokine storm Cytometry demonstrated Diagnosis drug rash drug-induced maculopapular exanthema. eosinophil eosinophilia Exanthema Features healthy controls hypersensitivity hypersensitivity reaction hypersensitivity reactions IFN-γ IL-4 IL-5 IL-6 inflammatory mediator Inflammatory mediators Macrophage MCP-3 MDR mediators nasopharyngeal Patient PCR performed positive promote proteomic rashe respiratory RNA sequencing robust SARS-CoV-2 serum severe acute respiratory syndrome Coronavirus severe COVID-19 patients skin biopsies skin biopsy systemic cytokine systemic hyperinflammation systemic symptom systemic symptoms T cell T cells TNF Transcriptome turn upregulation [DOI] 10.1111/all.14983 PMC 바로가기 [Article Type] Article
Analysis of Early Biomarkers Associated with the Development of Critical Respiratory Failure in Coronavirus Disease 2019 (COVID-19)Article Published on 2022-01-282022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] acute respiratory distress Admission Analysis analyzed association Biomarker C-reactive protein Concentration consecutive patient coronavirus disease COVID-19 COVID-19 patients Cox proportional hazard CRP d -dimer death development elevated failure high-mobility group box-1 protein hospital IL-6 independent Inflammatory cytokine inflammatory mediator Injury interleukin-6 Krebs von den Lungen-6 mechanical ventilation Multivariate analysis outcome Platelet predict Protein receiver operating characteristic regression analysis reported respiratory Respiratory failure syndrome type II pneumocytes Ventilation [DOI] 10.3390/diagnostics12020339 PMC 바로가기 [Article Type] Article
Potential Immune Indicators for Predicting the Prognosis of COVID-19 and Trauma: Similarities and DisparitiesImmunology Published on 2022-01-202022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] Affect alteration C-reactive protein cellular and molecular Complication complications COVID-19 COVID-19 prognosis COVID-19 symptom CTL cytokine disease disparity ferritin help IFNs IL-1 IL-10 IL-4 IL-6 immune Immune cell immune system Indicator inflammatory disease inflammatory mediator inflammatory property monocyte neutrophil outcomes Pathogenesis patients with COVID-19 polyphasic Potential predict procalcitonin Prognosis prognostic indicator researcher serum amyloid severity of COVID-19 similarity subsequent subtype T cell Th1 Th17 Th2 TNF-α trauma Treg various inflammatory disease [DOI] 10.3389/fimmu.2021.785946 PMC 바로가기 [Article Type] Immunology