The N501Y Mutation of SARS-CoV-2 Spike Protein Impairs Spindle Assembly in Mouse OocytesArticle Published on 2022-10-012022-11-16 Journal: Reproductive Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] accompanied assembly caused control group COVID-19 pandemic demonstrated female functions Health impairment indicated Infection influence maturation mouse mutant mutant spike protein N501Y N501Y variant Oocyte Oocyte maturation oocytes potential risk Protein provided reproductive SARS-CoV-2 SARS-CoV-2 spike protein significantly increased spike spike protein. Spindle spindle assembly the mean [DOI] 10.1007/s43032-021-00809-7 PMC 바로가기
Patient preferences and current practice for adults with steroid-resistant ulcerative colitis: POPSTER mixed-methods studyArticle Published on 2022-10-012022-11-15 Journal: Health technology assessment (Winchester, England) [Category] 진단, [키워드] administration assessment carried Characteristics Consensus COVID-19 pandemic drug duration of symptom Effectiveness evaluate experiment experiments Factor Future greater Health personnel health-care highlight IMPROVE Inflammatory bowel disease influence information journal lack less library Necrosis NHS NIHR offered over Patient Patient preference patients per day predicted Prednisolone preference preferences Probability professional professionals qualitative research randomised controlled trial Randomised controlled trials recommendation Research respond risk sample sizes secondary care Selection bias severity Side effect Side effects subject surveys and questionnaires Symptoms technology therapeutic benefits Tofacitinib Treatment ulcerative ulcerative colitis ulcerative colitis. undergo website [DOI] 10.3310/RHXR5192 PMC 바로가기
Temperature Influences the Interaction between SARS-CoV-2 Spike from Omicron Subvariants and Human ACE2Article Published on 2022-09-302022-11-16 Journal: Viruses [Category] SARS, 변종, [키워드] ACE2 ACE2 affinity ACE2 receptor Affect arising BA.4 BA.5 COVID-19 domain enzyme glycoprotein Human immunogenic include infect influence Interaction multiple mutation mutated omicron other variants plasma RBD receptor SARS-CoV-2 shown significantly increased spike spike glycoprotein temperature the Spike translate Transmission vaccinated individuals variant Variant of concern. Viral transmission VoC [DOI] 10.3390/v14102178 PMC 바로가기
Could Endogenous Glucocorticoids Influence SARS-CoV-2 Infectivity?Article Published on 2022-09-212022-11-15 Journal: Cells [Category] SARS, 변종, 치료제, [키워드] ACE2 ACE2 (angiotensin converting enzyme 2) Affect alteration analogues Antiviral component conformational coronavirus coronavirus diseases cortisol COVID-19 Deleterious Dexamethasone endogenous enzyme glucocorticoid Glucocorticoids groups Host Immunological disorders Infection influence inhibit SARS-CoV-2 Innate immunity Interaction mechanism outcome pathogen produced PROTECT Protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor Signal transduction spike Spike protein spike protein. stimulate subunit surface protein target cells variant [DOI] 10.3390/cells11192955 PMC 바로가기
Vitamin D Supplementation Does Not Influence SARS-CoV-2 Vaccine Efficacy or Immunogenicity: Sub-Studies Nested within the CORONAVIT Randomised Controlled TrialArticle Published on 2022-09-162022-11-15 Journal: Nutrients [Category] SARS, 진단, [키워드] 25-hydroxyvitamin D 95% CI Acute respiratory infection adjusted hazard ratio antibody baseline blood sample BNT162b2 BNT162b2 Pfizer boost Breakthrough SARS-CoV-2 infection cellular response ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 Oxford–AstraZeneca circulating collected Concentration concentrations Controlled deficiency determine dose dried blood spot Effect Efficacy elevated Follow-up IFN-γ IgA IgG IgM influence interferon interferon gamma investigated mean difference neutralising antibody neutralising antibody titre of BNT162b2 offer participant Pfizer Protective randomised controlled randomised controlled trial reported response risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV-2 vaccine significantly supernatant titre titres vaccination venous Vitamin Vitamin D Vitamin D status vitamin D supplement Vitamin D supplementation vitamin D. Whole blood [DOI] 10.3390/nu14183821 PMC 바로가기
Habituating to pandemic anxiety: Temporal trends of COVID-19 anxiety over sixteen months of COVID-19Randomized Controlled Trial Published on 2022-09-152022-10-05 Journal: Journal of affective disorders [Category] COVID19(2023년), SARS, 임상, [키워드] affected Anxiety association BASIL Brazil Burnout COVID-19 deaths dimension distress fear Health implication individual influence Intervention Mental mental health not correlated pandemic Pandemic anxiety participated physical preventive measure putative mechanism randomized clinical trial reduced Result Temporal Worry Worry. [DOI] 10.1016/j.jad.2022.06.077 PMC 바로가기 [Article Type] Randomized Controlled Trial
Immunological memory to common cold coronaviruses assessed longitudinally over a three-year period pre-COVID19 pandemicArticle Published on 2022-09-142022-11-15 Journal: Cell Host & Microbe [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] antibody Antibody titers Antigen CD4 CD4+ T cell common cold common cold coronavirus common cold Coronaviruses comparable coronavirus Endemic Frequency immune immune memory immune response infection prevalence influence longitudinal analysis magnitude memory outcome pandemic performed RBD-specific IgG response reactivity repeated response responses SARS-CoV-2 SARS-CoV-2 immunity SARS-COV-2 infection Steady state steady state. sustained T cells Vaccine development [DOI] 10.1016/j.chom.2022.07.012 PMC 바로가기
Influence of smoking history on the evolution of hospitalized in COVID-19 positive patients: results from the SEMI-COVID-19 registryObservational Study Published on 2022-09-092022-10-04 Journal: Medicina clínica [Category] SARS, 임상, [키워드] Admission Analysis analyzed Charlson index Clinical characteristics coronavirus disease Course COVID-19 difference discharge events Evolution group hospital Hospitalizado Hospitalized ICU ICU admission in-hospital mortality Inconclusive independent influence intensive care male males median age Mortalidad Mortality multicenter multivariate logistic regression Older Patient patients patients with COVID-19 poor prognosis positive Prevalence previous study readmission remained retrospective cohort study SARS-CoV-2 SARS-COV-2 infection severity Smokers smoking Spanish Tabaquismo. the disease the patient were recorded [DOI] 10.1016/j.medcli.2021.10.011 PMC 바로가기 [Article Type] Observational Study
Pre-existing anti-HCoV-OC43 immunity influences the durability and cross-reactivity of humoral response to SARS-CoV-2 vaccinationArticle Published on 2022-09-022022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 진단, 치료기술, [키워드] Analysis anti-HCoV-OC43 anti-nucleoprotein anti-RBD antibodies antibody binding chemiluminescence immunoassay conducted coronavirus coronavirus vaccine correlation cross-protection cross-reactivity demonstrated detect ELISA enzyme-linked immunosorbent HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 humoral Humoral response IgG Immunity Immunoglobulin inactivated individuals influence neutralization Neutralization antibody neutralizing antibody Outbreaks performed positively correlated Protective protective immunity Protein pseudovirus S1 IgG S1 subunit SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine seasonal coronavirus seasonal human coronavirus. second vaccination statistically significant vaccination Vaccine vaccinee vaccinees viral neutralization [DOI] 10.3389/fcimb.2022.978440 PMC 바로가기
Influence of Effort-based Reward Training on Neuroadaptive Cognitive Responses: Implications for Preclinical Behavioral Approaches for Depressive SymptomsResearch article Published on 2022-09-012022-10-05 Journal: Neuroscience [Category] 비임상, [키워드] approach approaches assigned BDNF brain-derived neurotrophic factor (BDNF) cognitive Dehydroepiandrosterone (DHEA) depressive depressive symptom Depressive symptoms disorder Efficacy Effort-based Reward (EBR) examination exhibited faster female group immunoreactivity incidence rate influence lack Lateral habenula (LHb) male males mechanism mechanisms no significant effect offer Preclinical Preclinical model of depression prevented provide response therapeutic intervention Therapies training Trial trials were assessed [DOI] 10.1016/j.neuroscience.2022.08.002 [Article Type] Research article