Combined computational and cellular screening identifies synergistic inhibition of SARS-CoV-2 by lenvatinib and remdesivir결합된 컴퓨터 및 세포 스크리닝은 렌바티닙과 렘데시비르에 의한 SARS-CoV-2의 상승적 억제를 확인합니다Animal Published on 2021-07-282022-09-10 Journal: The Journal of General Virology [Category] SARS, 신약개발, 치료제, [키워드] anti-cancer treatment Antiviral compounds antiviral drug approved cellular Combined Compound COVID-19 diclazuril disease severity docking drug drug synergy DrugBank enzyme exhibited functional Future Host host receptor Human identify in vitro independent independent of inhibit inhibit SARS-CoV-2 inhibited Inhibition assays inhibitor lenvatinib management mechanism nucleoside Pazopanib performed protease Protease inhibitor Rapid Remdesivir Replication SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 replication subsequent sunitinib synergistic synergistic effect synergy target the SARS-CoV-2 therapeutic option tyrosine Vero-CCL81 Vero-CCL81 cells Viral viral replication [DOI] 10.1099/jgv.0.001625 PMC 바로가기 [Article Type] Animal
Discovery of naturally occurring inhibitors against SARS-CoV-2 3CL pro from Ginkgo biloba leaves via large-scale screening대규모 스크리닝을 통해 Ginkgo Biloba 잎에서 SARS-COV-2 3CL Pro에 대한 자연 발생 억제제 발견Article Published on 2021-07-012022-08-31 Journal: Fitoterapia [Category] SARS, 치료제, [키워드] 3CL pro activities Bioflavones broad spectrum Chymotrypsin-like protease Compound Coronaviruses demonstrated docking Ginkgo Ginkgo biloba Ginkgo biloba leaves Ginkgolic acids inhibit SARS-CoV-2 inhibition inhibition activity Inhibition assays inhibitor inhibitors inhibitory Inhibitory mechanism kinetic less mechanism medication offer protease proteinase SARS-CoV-2 SARS-CoV-2 3CL(pro). tested Viral viral replication [DOI] 10.1016/j.fitote.2021.104909 PMC 바로가기 [Article Type] Article