A novel property of hexokinase inhibition by Favipiravir and proposed advantages over Molnupiravir and 2 Deoxy D glucose in treating COVID-19Favipiravir에 의한 헥소키나아제 억제의 새로운 특성 및 COVID-19 치료에서 Molnupiravir 및 2 Deoxy D 포도당보다 제안된 이점Article Published on 2022-07-012022-09-11 Journal: Biotechnology letters [Category] COVID19(2023년), SARS, 치료제, [키워드] 2 Deoxy D glucose activity affected antiviral drug Concentration COVID-19 Cyan Ebola exhibited Favipiravir flu Glucose Health Hexokinase Host inhibiting Inhibition assays molecular docking molecular docking studies molnupiravir Remdesivir SARS-CoV-2 shown Spread supported treat treating COVID-19 treatment regimen Trial trials wake [DOI] 10.1007/s10529-022-03259-6 PMC 바로가기 [Article Type] Article
Cross-Reactivity of IgG Antibodies and Virus Neutralization in mRNA-Vaccinated People Against Wild-Type SARS-CoV-2 and the Five Most Common SARS-CoV-2 Variants of Concern야생형 SARS-CoV-2 및 가장 흔한 5가지 우려되는 SARS-CoV-2 변이체에 대한 mRNA 예방접종을 받은 사람들의 IgG 항체 교차 반응성 및 바이러스 중화Article Published on 2022-06-152022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE-2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against Alpha angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 angiotensin-converting enzyme-2 (ACE-2) approval Beta binding BNT162b2 common concern coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 domain Efficacy ELISA enzyme expressed FIVE house human cells IgG IgG titer IgG titers immune response in-house ELISA induce Infectious disease inhibit inhibited Inhibition assays initiated interaction site less MOST mRNA mRNA vaccine mRNA vaccines mRNA-1273 much lower neutralization neutralizing effect omicron Protein provided RBD RBDs receptor Receptor-binding domain Receptor-binding domain (RBD) recognizing respiratory S-protein SARS-CoV-2 SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus the RBD the SARS-CoV-2 vaccination Vaccine variants variants of concern virus VOCs wild-type wild-type SARS-CoV-2 [DOI] 10.3389/fimmu.2022.915034 PMC 바로가기 [Article Type] Article
Herbal inhibitors of SARS-CoV-2 M pro effectively ameliorate acute lung injury in miceSARS-CoV-2 M pro의 허브 억제제는 쥐의 급성 폐 손상을 효과적으로 개선합니다Article Published on 2022-06-012022-09-11 Journal: Iubmb Life [Category] COVID19(2023년), SARS, 치료제, [키워드] acute lung injury acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ALI/ARDS Anti-inflammatory ARDS bacterial lipopolysaccharide cell death China Chinese Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 patients distress effective effective drug effective drugs enzymatic activity functions Herbal identify in vitro in vivo Infectious disease Inhibition assays inhibitors of SARS-CoV-2 lipopolysaccharides Lung injury M pro mice MPro pan-anti-inflammatory protease respiratory distress Respiratory distress syndrome SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spread surface plasmon surface plasmon resonance syndrome the disease Traditional Chinese medicine treating COVID-19 patient Virtual screening virus [DOI] 10.1002/iub.2616 PMC 바로가기 [Article Type] Article
Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 강력한 억제제로서의 다가 9-O-아세틸화-시알산 글리코클러스터Article Published on 2022-05-102022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] affinity angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 receptor Anti-viral atomic bind binding Cell develop event Factor glycans Host host cell Infection inhibition Inhibition assays inhibitor Microscopy moderate molecular multivalent Perspective receptor residues SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sialic acid therapeutic purpose therapeutic purposes Topology Treatment virus while [DOI] 10.1038/s41467-022-30313-8 PMC 바로가기 [Article Type] Article
A cell-based ELISA as surrogate of virus neutralization assay for RBD SARS-CoV-2 specific antibodiesRBD SARS-CoV-2 특이적 항체에 대한 바이러스 중화 분석의 대리인 세포 기반 ELISAArticle Published on 2022-03-182022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] alternative methods biosafety level Biosafety Level 3 BSL2 BSL3 Cell cell-based ELISA correlation COVID-19 pandemic cVNT death detect determine Efficacy ELISA gold gold standard immune response Inhibition assays Laboratory level 3 molecular mVNT. neutralization Neutralization assay neutralization test performed RBD Safe SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 RBD binding SARS-CoV-2 specific antibody sensitivity serological Serological assay species specificity surrogate Vaccine Viral viral neutralization Virus neutralization virus neutralization assays [DOI] 10.1016/j.vaccine.2022.02.044 PMC 바로가기 [Article Type] Article
Molecular Interactions of Tannic Acid with Proteins Associated with SARS-CoV-2 InfectivityArticle Published on 2022-02-272022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] 3CLpro ACE2 acid acute respiratory syndrome angiotensin-converting enzyme 2 approach bind binding biochemical building cell membrane Combination Compound coronavirus coronavirus disease COVID-19 Effect Extracellular higher affinity Host Infectivity inhibit Inhibition assays inhibitors Interaction involved Ligand molecular molecular docking molecular dynamics organism pandemic physicochemical polyphenols Prevent protease RBD Receptor binding domain Replication SARS-CoV-2 SARS-CoV-2 cell serine 2 Spike protein Structural properties target target receptor targets the SARS-CoV-2 TMPRSS2 transmembrane [DOI] 10.3390/ijms23052643 PMC 바로가기 [Article Type] Article
In vitro data suggest that Indian delta variant B.1.617 of SARS-CoV-2 escapes neutralization by both receptor affinity and immune evasion시험관 내 데이터에 따르면 SARS-CoV-2의 인도 델타 변이체 B.1.617은 수용체 친화성과 면역 회피 모두에 의해 중화를 피합니다Article Published on 2022-01-012022-09-11 Journal: Allergy [Category] SARS, 변종, [키워드] ACE2 affinity Anti-RBD IgG antibodies antibody B.1.351 B.1.617 binding binding affinity Binding assays BLI BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine cell receptor convalescent correlated COVID-19 convalescent donor COVID-19 convalescent donors delta variant display E484K ectodomain Effect ELISA glycoprotein higher affinity immune evasion Immunity immunization immunized Inhibition assays Interaction Interferometry L452R less main receptor mRNA vaccine mutant mutated Mutation natural infection neutralization occur P.1 Point mutation produced RBD RBD-ACE2 RBDs receptor Receptor-binding domain recognize reduced SARS-CoV-2 SARS-CoV-2 variant sera shown single mutant subject Substitution substitutions the binding affinity the RBD the receptor-binding domain the Spike Transmissibility vaccination Vaccine variant variants variants of concern Virus neutralization wild-type wild-type virus [DOI] 10.1111/all.15065 PMC 바로가기 [Article Type] Article
Active components in Ephedra sinica stapf disrupt the interaction between ACE2 and SARS-CoV-2 RBD: Potent COVID-19 therapeutic agentsEphedra Sinica STAPF의 활성 성분은 ACE2와 SARS-COV-2 RBD 사이의 상호 작용을 방해합니다 : 강력한 COVID-19 치료제Article Published on 2021-10-052022-08-31 Journal: Journal of ethnopharmacology [Category] MERS, SARS, 치료제, [키워드] 293T-ACE2 4-hydroxy-6-methoxyquinoline-2-carboxylic acid (PubChem CID: 22017520) 4-hydroxyquinoline-2-carboxylic acid (PubChem CID: 3845) 4,6-dihydroxyquinoline-2-carboxylic acid (PubChem CID: 440752) ACE2 ACE2-RBD activity alleviate angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Asia Asthma binding domain Calu calu-3 cells carboxylic acid carried cells Chinese Cold component Compound compounds cough COVID-19 COVID-19 therapeutic agent Deterioration disrupt disrupting docking domain effort ephedra Ephedra sinica Ethanol HPLC hydrogen Hydrogen bond hydroxy indicated inhibit inhibit SARS-CoV-2 inhibiting Inhibition assays inhibitory activity Interaction Isolation knock-out Lung diseases material mechanism molecular docking NMR observé potent potential therapeutic agent potential therapeutic agents PPI PPI inhibitor Prevent protein-protein interaction provided pseudoviruses PubChem quinoline Quinoline-2-carboxylic acid S protein SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 virus SARS-CoV-2 virus infection Spike protein SPR Structure structures suggested surface plasmon surface plasmon resonance Symptom TCM the SARS-CoV-2 therapeutic agents these compound these compounds Traditional Chinese medicine treat viropexis virus infection were used [DOI] 10.1016/j.jep.2021.114303 PMC 바로가기 [Article Type] Article
A Convenient and Biosafe Replicon with Accessory Genes of SARS-CoV-2 and Its Potential Application in Antiviral Drug DiscoverySARS-CoV-2의 보조 유전자와 항바이러스 약물 발견에 대한 잠재적 응용을 포함하는 편리하고 생물학적으로 안전한 복제품Article Published on 2021-10-012022-09-11 Journal: Virologica Sinica [Category] SARS, 치료제, [키워드] absence Accessory Analysis anti-SARS-CoV-2 antiviral drug Antiviral drug screening antiviral drugs application BAC Bacterial bacterial artificial chromosome benefit biosafety level Biosafety Level 3 BSL3 can be used cause cDNA Cell chromosome Containment costly Deletion disease drug effective drug effective drugs exonuclease expression genetics Genome genome replication Infection infectious inhibition assay Inhibition assays inhibitors Laboratory level 3 Live virus luciferase reporter gene methyltransferase Nsp12 nsp14 pandemic of COVID-19 pathogenicity Potential profile Replication replicon reporter gene Research research and development reverse genetics RNA RNA polymerase S protein SARS-CoV-2 sgRNA subgenomic RNA subgenomic RNAs this system transfection viral cDNA virion assembly virus wild-type virus [DOI] 10.1007/s12250-021-00385-9 PMC 바로가기 [Article Type] Article
Comprehensive virtual screening of 4.8 k flavonoids reveals novel insights into allosteric inhibition of SARS-CoV-2 M PRO4.8K 플라보노이드의 포괄적 인 가상 스크리닝Article Published on 2021-07-292022-09-10 Journal: Scientific Reports [Category] SARS, 변종, 치료제, [키워드] absence active site affected Analysis antiviral activity AutoDock AutoDock vina Comprehensive Computational biology and bioinformatics Coronaviruses criteria curated database docking Drug discovery flavonoid flavonoids hinge movement in silico inactive inhibit inhibition assay Inhibition assays inhibitors Interpretation lack limitation mechanism molecular molecular dynamics mutant Pathways plasticity protease reason reported reveal robust SARS-CoV SARS-CoV-2 SARS-CoV-2 main protease structural biology triggered Usage Virtual screening [DOI] 10.1038/s41598-021-94951-6 PMC 바로가기 [Article Type] Article