Considering innate immune responses in SARS-CoV-2 infection and COVID-19SARS-CoV-2 감염 및 COVID-19에서 선천 면역 반응 고려Article Published on 2022-08-012022-09-12 Journal: Nature reviews. Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료법, 치료제, [키워드] adaptive antibody COVID-19 COVID-19 pandemic Immunity Impact innate immune response innate immune system media memory T cells Nature NIAID NIH organized Program Ralph review SARS-COV-2 infection thought [DOI] 10.1038/s41577-022-00744-x PMC 바로가기 [Article Type] Article
Chromosomal-level reference genome assembly of the North American wolverine (Gulo gulo luscus): a resource for conservation genomics북미 울버린(Gulo gulo luscus)의 염색체 수준 참조 게놈 어셈블리: 보존 유전체학을 위한 리소스Article Published on 2022-07-292022-09-11 Journal: G3 (Bethesda, Md.) [Category] 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 aggression aggression genes aggressive behavior baseline Canada chromosomal-level assembly Climate change Complete conservation genomics contig coronavirus Coronavirus-2 Coronaviruses environmental disruption Final Genes Genetic Genome genome assembly genomes Gulo gulo Gulo gulo luscus heterozygous Infection innate immune system Innate immunity involved long-reads male management modality naïve North nucleotide Nunavut parasitic diseases Pathogens reference genome resource SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown Single nucleotide variant specimen Support susceptibility viral pathogen viral pathogens wolverine wolverine. [DOI] 10.1093/g3journal/jkac138 PMC 바로가기 [Article Type] Article
Human surfactant protein D facilitates SARS-CoV-2 pseudotype binding and entry in DC-SIGN expressing cells, and downregulates spike protein induced inflammation인간 계면활성제 단백질 D는 DC-SIGN 발현 세포에서 SARS-CoV-2 유사형 결합 및 진입을 촉진하고 스파이크 단백질 유도 염증을 하향 조절합니다Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] ACE2 Analysis Anti-viral binding carbohydrate cause Cell cell interaction cell line cell surface receptor cells chemokine chemokines collectins controls COVID-19 cytokine cytokine response Cytokines DC-SIGN dendritic cell domain downregulate downregulated eight epithelial expressing facilitate fragment of HEK 293T HEK293T cell HEK293T cells help Human IFN-α IL- 6 IL-1β IL-8 immune function immune response immunomodulatory effect increase independent independent of infection assay infection assays Inflammation inhibit SARS-CoV-2 innate immune innate immune system Interaction intercellular involved Macrophage macrophages MHC class MHC class II modulating mRNA expression mRNA level mRNA levels N-terminal naïve T cell naïve T cells NF-κB pathogen Pathogens pro-inflammatory cytokine pro-inflammatory cytokines Protein pseudotype RANTES receptors Replication rfhSP-D. RNA virus RT-qPCR SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 spike protein shown SIGN spike Spike protein surface receptor T cells the Spike THP-1 TNF-α treated Treatment Vero Cell Vero cells viral entry viruses [DOI] 10.3389/fimmu.2022.960733 PMC 바로가기 [Article Type] Article
Effect of cannabidiol on apoptosis and cellular interferon and interferon-stimulated gene responses to the SARS-CoV-2 genes ORF8, ORF10 and M proteinSARS-CoV-2 유전자 ORF8, ORF10 및 M 단백질에 대한 세포 사멸 및 세포 인터페론 및 인터페론 자극 유전자 반응에 대한 칸나비디올의 효과Article Published on 2022-07-152022-09-11 Journal: Life sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] 2′-5′-oligoadenylate synthetase (OAS) family activating acute respiratory syndrome acute respiratory syndrome coronavirus anti-viral response Apoptosis cannabidiol cause Cell cellular Combination component control cell control cells coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 Effect expressing expression HEK293 cell HEK293 cells IFNγ immune responses Innate innate immune response innate immune system Innate immunity interferon interferon-stimulated gene interferons M protein marker membrane protein OAS OAS1 OAS2 OAS3 OASL ORF10 ORF8 Plasmid plasmids Prophylaxis Protein readiness respond response SARS-CoV-2 SARS-CoV-2 gene SARS-CoV-2 genes severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the SARS-CoV-2 transfected cells transfected with treated Treatment vehicle viral gene viral genes viral infection [DOI] 10.1016/j.lfs.2022.120624 PMC 바로가기 [Article Type] Article
Signaling mechanisms of SARS-CoV-2 Nucleocapsid protein in viral infection, cell death and inflammation바이러스 감염, 세포 사멸 및 염증에서 SARS-CoV-2 뉴클레오캡시드 단백질의 신호 전달 메커니즘Review Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] activating acute respiratory syndrome acute respiratory syndrome coronavirus assembly caused cell cycle cell cycle arrest cell death complex complexes coronavirus COVID-19 Critical Cytokine storms Cytokines ENhance expression facilitate genomic RNA global public health GSDMD IFN-β in viral induce Infection Inflammation inhibit innate immune system life cycle mechanism N protein NF-κB NF-κB signaling NLRP3 NLRP3 inflammasome pathway Proinflammatory cytokine proinflammatory cytokines promote Protein pyroptosis Replication resulting RNA RNAi RNAi pathway SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid severe acute respiratory syndrome Coronavirus Signaling Smad3 stress granule stress granules survival Transcription undergo viral genome viral life cycle viral replication Viral RNA virus worldwide pandemic [DOI] 10.7150/ijbs.72663 PMC 바로가기 [Article Type] Review
Leveraging metabolic modeling to identify functional metabolic alterations associated with COVID-19 disease severity대사 모델링을 활용하여 COVID-19 질병 중증도와 관련된 기능적 대사 변경 식별Article Published on 2022-07-112022-09-11 Journal: Metabolomics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute disease alteration approach claimed COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 pandemic COVID-19 sample COVID-19 samples disease Disease progression disease severity driver dysfunction functional Genome Genome-scale metabolic modeling healthcare highlight histidine hospital Hospitalization Host identify immunopathology Increased Infection Inflammation Inflammatory Inflammatory response innate immune response innate immune system Invasion investigated ketone lung damage machine machine learning marker mechanism metabolic pathway metabolism metabolite metabolomics muscular Musculoskeletal offer pathway Pathway enrichment analysis patients plasma metabolome positive Predictive Prevalence Prevent reduce SARS-CoV2 SARS-CoV2 infection severe COVID-19 Severe infection Tryptophan University of Virginia viral replication Virginia weakness with COVID-19 [DOI] 10.1007/s11306-022-01904-9 PMC 바로가기 [Article Type] Article
Marine mollusc extracts-Potential source of SARS-CoV-2 antivirals해양 연체 동물 추출물-SARS-CoV-2 항바이러스제의 잠재적 공급원Review Published on 2022-07-012022-09-11 Journal: Reviews in Medical Virology [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Adenovirus Antiviral antiviral action antiviral activity causative agent clinically coronavirus coronavirus disease Coronavirus disease 2019 demonstrated effective Evidence Hemolymph herpes simplex herpes simplex virus human coronavirus human coronaviruses in silico in vitro innate immune system Mollusca molluscs. Pacific oyster Pacific oyster (Crassostrea gigas) phylum PROTECT SARS-CoV-2 SARS-CoV-2 antivirals severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 silico studies treat virus virus particle viruses [DOI] 10.1002/rmv.2310 PMC 바로가기 [Article Type] Review
Artemisinin inhibits neutrophil and macrophage chemotaxis, cytokine production and NET release Research Published on 2022-06-302022-10-05 Journal: Scientific Reports [Category] 진단, [키워드] Activation antimalarial Artemisinin ATPase block calcium cause Cell chemokine chemotactic chemotaxis condition Critical cysteine residue cytokine production Cytokines death Excessive activation identify Immune cell in vivo Infection inhibit inhibited inhibition inhibitor innate immune system Invasion isoform life-threatening lung Macrophage mechanism murine NET NETs neutrophil Neutrophil extracellular trap pathogen invasion promote released Reticulum selective Sepsis SERCA suppressed therapy thought tissue tissue injury [DOI] 10.1038/s41598-022-15214-6 [Article Type] Research
A Game of Infection – Song of Respiratory Viruses and Interferons감염의 게임 - 호흡기 바이러스와 인터페론의 노래Review Published on 2022-06-292022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 치료제, [키워드] 2019 coronavirus disease acute respiratory syndrome Antiviral Antiviral strategies antiviral strategy cause caused coronavirus coronavirus – COVID-19 coronavirus disease Coronavirus-2 COVID-19 COVID-19 pandemic CoVs death deaths disease pathogenesis driving effective flu game Health Host Host immune response host immune responses immune responses Infection Influenza influenza A influenza A virus Influenza virus influenza viruses innate immune innate immune response innate immune responses innate immune system Innate immunity mechanism outcome pandemic Pandemics pathogen Pathogenesis Pathogens recorded Research respiratory SARS-CoV-2 Severe acute respiratory syndrome singular Song Spanish flu swine flu therapeutic Topic translated virus virus infection Virus-host interaction Virus-host interactions while writing [DOI] 10.3389/fcimb.2022.937460 PMC 바로가기 [Article Type] Review
The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 Infection세포 면역의 견고함이 SARS-CoV-2 감염의 운명을 결정합니다Review Published on 2022-06-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] addition Administered Analysis antibody secreting cells antiviral cytokine antiviral cytokines antiviral immunity antiviral response appearance approach autosomal recessive axis B cell booster dose breadth CD4+ CD4+ T cell CD8+ Cell cellular Cellular immune response cellular immunity component contribute coordinating correlated COVID-19 COVID-19 patient Critical cross-protection Cytokines cytotoxic lymphocytes cytotoxic T lymphocytes described disease Disease progression disease severity dysregulated evasion Evolution follicular functional Germinal center global pandemic greater helper T cells humoral IFN-γ immune protection immune system Immunity in some infected cells Infection infection control inflammatory cascade innate immune system killing knowledge long-lasting lymphocyte Lymphocytes magnitude memory modulating neutralizing antibody pathogenic inflammation phenotypic pro-inflammatory cytokine pro-inflammatory cytokines protective immunity reported responsible robustness SARS-CoV-2 SARS-CoV-2 virus secreting severe COVID-19 severity Stage stages T cell T cell response T cell responses T cells T helper cell T helper cells Tfh Tfh cells the SARS-CoV-2 virus thought TNF-α vaccination Vaccine viral replication X-linked [DOI] 10.3389/fimmu.2022.904686 PMC 바로가기 [Article Type] Review