Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challengeBCG의 정맥 투여는 치명적인 SARS-CoV-2 공격으로부터 마우스를 보호합니다Brief Definitive Report Published on 2022-02-072022-09-10 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] addition Administered alteration Analysis bacille Calmette-Guérin BCG BCG vaccination Cell cellular compartment clinically COVID-19 cytokine cytokine production Host immunopathology increase in Inflammatory inflammatory cell innate response intravenous Intravenous administration long-lasting mechanism mice Multivariate analysis myeloid cell nonspecific Pathogens pediatric phenomenon promote PROTECT provide pulmonary immune response recruitment reduced viral load reduced viral loads reducing reductions reductions in reported SARS-CoV-2 SARS-COV-2 infection subcutaneous route tissue pathology transgenic mice Tuberculosis vaccination variant Viral Viral load virus while [DOI] 10.1084/jem.20211862 PMC 바로가기 [Article Type] Brief Definitive Report
The Influence of Obesity and Weight Loss on the Bioregulation of Innate/Inflammatory Responses: Macrophages and ImmunometabolismReview Published on 2022-01-302022-10-31 Journal: Nutrients [Category] Coronavirus, SARS, [키워드] absence adipose anti-inflammatory effect anti-inflammatory macrophage characterized COVID-19 Defense demonstrated Effect excessive inflammatory response Immunocompromise immunometabolism individual Infection Inflammation Inflammatory Inflammatory diseases Inflammatory response influence inherent innate response Intervention Loss low-grade inflammation Macrophage macrophages obese obesity pathogen question reduction in Research response responses Result susceptibility tissue viral infections weight weight loss [DOI] 10.3390/nu14030612 PMC 바로가기 [Article Type] Review
Expansion of CD56 dim CD16 neg NK Cell Subset and Increased Inhibitory KIRs in Hospitalized COVID-19 PatientsCD56 DIM CD16 Neg NK 세포 서브 세트의 확장 및 입원 COVID-19 환자에서 증가 된 억제 KIR.Article Published on 2021-12-282022-09-10 Journal: Viruses [Category] SARS, 바이오마커, [키워드] acute respiratory syndrome coronavirus alteration CD16 CD56 coronavirus COVID-19 COVID-19 infection COVID-19 patients Cytokines cytotoxicity Defense deficiency Depletion distribution elevated ENhance expansion Frequency hospitalized COVID-19 patient hospitalized COVID-19 patients IFN-γ impairment Increased induce Infection Inflammatory cytokines inhibitory innate response KIR KIR receptor KIR receptors NK cell NK cell subsets NK cells no difference no differences phenotype produced respiratory SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus subset virus [DOI] 10.3390/v14010046 PMC 바로가기 [Article Type] Article
The Betacoronavirus PHEV Replicates and Disrupts the Respiratory Epithelia and Upregulates Key Pattern Recognition Receptor Genes and Downstream Mediators, Including IL-8 and IFN-λResearch Article Published on 2021-12-222022-10-30 Journal: mSphere [Category] Coronavirus, [키워드] Air-liquid interface airway epithelium ALI-REC Alpha Antiviral basal cells Betacoronavirus CCL2 CCL5 Cell culture cell cultures cells change chemokine chemokines ciliated cells coronavirus Culture CXCL10 CXCL8 Cytokines cytopathic disease Donor driving epithelia epithelial lining evaluated expression expression level Gene Expression goblet cells homeostasis IFN-λ1 IFN-stimulated gene IFN-λ IFN-λ1 IL-1β IL-6 IL-8 in vitro in vivo Including Increased infect Infection innate immune gene innate immune response Innate immunity innate response interleukin-1β investigated modulation molecular mechanism morphologically Necrosis Neonatal neurotropic OAS1 outcome pattern PHEV primary site Proinflammatory cytokine proliferative Recognition replicate replicated respiratory respiratory epithelia respiratory epithelial cell resulting RIG Stat1 tissue TLR TLR3 TLR7 TNF-α tracheal transcription factor Transcriptional upregulation triggered turn upper respiratory tract upregulation virus vomiting [DOI] 10.1128/mSphere.00820-21 PMC 바로가기 [Article Type] Research Article
Anti-Inflammatory Effects of Immunostimulation in Patients with COVID-19 PneumoniaArticle Published on 2021-12-092022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Admission association Biomarker Blood cell supernatant cellular changes in Characteristics chemokines clinical conditions Control COVID-19 cytokine disease severity Effect gene expression pattern Genetic groups IFN-γ IL-4 immune response immunomodulation immunomodulator immunostimulation in vitro in-hospital mortality Inflammatory Influenza innate response intubation rate investigated molecular Neutrophil-to-lymphocyte ratio NLR not differ outcome outcomes Patient pidotimod plasma plasma concentration Pneumonia RCTs Recognition Respiratory failure SARS-CoV-2 Standard of care Standard-of-care systemic corticosteroid therapy toll like receptor Transcription treated upregulated viral infection Viral pneumonia virus were assessed with COVID-19 [DOI] 10.3390/jcm10245765 PMC 바로가기 [Article Type] Article
The crosstalk between viral RNA- and DNA-sensing mechanisms바이러스 RNA 및 DNA 감지 메커니즘 간의 누화Review Published on 2021-12-012022-09-11 Journal: Cellular and Molecular Life Sciences [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] adaptors amplify Antiviral COVID-19 Crosstalk Cytokines cytosolic detect Diseases DNA DNA and RNA DNA sensing endosomal highlight Host Human induce Infection innate immune system Innate immunity innate response interferon-stimulated gene interferon-stimulated genes mechanism nucleic acids overlap pandemic disease proinflammatory cytokines receptor recognize restrict RNA RNA sensing significantly Type type I interferon Viral diseases viral infection Viral infection. viral infections viral nucleic acid viral nucleic acids Viral RNA virus [DOI] 10.1007/s00018-021-04001-7 PMC 바로가기 [Article Type] Review
The Bacterial Mucosal Immunotherapy MV130 Protects Against SARS-CoV-2 Infection and Improves COVID-19 Vaccines Immunogenicity박테리아 점막 면역요법 MV130, SARS-CoV-2 감염으로부터 보호하고 COVID-19 백신 면역원성 개선Immunology Published on 2021-11-182022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] administration Against Bacteria Bacterial boost C57BL/6 CD8 cell activation Clinical efficacy COVID-19 COVID-19 vaccine heat-inactivated Heterologous IgA antibodies immunogenicity Immunotherapy IMPROVE Innate immunity innate response inoculated intramuscularly intranasal intranasally K18-hACE2 mice mice mucosal polybacterial mucosal immunotherapy Prophylactic Prophylaxis PROTECT Protein responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus shown susceptible the SARS-CoV-2 the vaccine vaccination Vaccine vaccine immunogenicity Vaccines viral infection viral infections viral respiratory infections [DOI] 10.3389/fimmu.2021.748103 PMC 바로가기 [Article Type] Immunology
Current Understanding of the Innate Control of Toll-like Receptors in Response to SARS-CoV-2 InfectionReview Published on 2021-10-222022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] affected anti-inflammatory drug approved caused component Control coronavirus disease COVID-19 current Cytokine storm drug Effectiveness healthcare hyperinflammation Hyperinflammatory immune response Infection inflammatory immune response Innate innate response invading pathogens involved knowledge microbial pandemic patients with COVID-19 phenotype recognize response responsible SARS-CoV-2 SARS-COV-2 infection severity of COVID-19 therapeutic TLR TLRs Toll-like receptor Toll-like receptor (TLR) understanding [DOI] 10.3390/v13112132 PMC 바로가기 [Article Type] Review
The PERK/PKR-eIF2α Pathway Negatively Regulates Porcine Hemagglutinating Encephalomyelitis Virus Replication by Attenuating Global Protein Translation and Facilitating Stress Granule FormationCellular Response to Infection Published on 2021-10-132022-10-30 Journal: Journal of Virology [Category] Coronavirus, MERS, [키워드] activate activated activating Activation acute respiratory syndrome addition antiviral drugs antiviral role Betacoronavirus cause caused Cell Characteristics coronavirus coronavirus Coronavirus replication coronavirus-infected cell coronavirus-infected cells Coronaviruses decrease disease Diseases double-stranded eIF2α eIF2α Encephalomyelitis Endoplasmic reticulum endoplasmic reticulum stress ER stress facilitate Facilitating Formation Granule high mortality rate Host Human in vitro in vivo infected cells Infection inhibited innate response Interaction interferon invading pathogen mechanism MERS-CoV Middle East modulate nerve cell neurotropic new treatment strategy Occurrence outcome pathogenic pathway Phosphorylation PKR porcine hemagglutinating encephalomyelitis virus promoted Protein protein translation regulate regulated Replication repressed respiratory syndrome coronavirus reveal SARS-CoV SARS-CoV-2 signaling pathway specific treatment stress granule suppressed target translation attenuation triggered turn unfolded protein response UPR viral proliferation viral replication virus [DOI] 10.1128/JVI.01695-21 PMC 바로가기 [Article Type] Cellular Response to Infection
Obesity Correlates With Pronounced Aberrant Innate Immune Responses in Hospitalized Aged COVID-19 Patients비만은 입원한 노인 COVID-19 환자의 비정상적인 선천성 면역 반응과 관련이 있습니다Comparative Study Published on 2021-10-112022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response Admission Admissions advanced age age aging Antibody titers BMI caused changes in Chronic low-grade inflammation circulating Concentration coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 cytokine cytokine response Cytokines death defined dysregulated elevated Frequency hospitalizations hospitalized COVID-19 patient hospitalized COVID-19 patients host response IgG antibody IgG antibody titers immune Immune cell immune cells immune responses individual Infection Inflammatory cytokine inflammatory cytokine production Innate Innate immunity innate response intensive care intensive care unit mediators mitogen monocyte Monocytes obesity occur patients Prevalence respiratory response responsible risk risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe coronavirus disease severe disease significant negative correlation subset These data [DOI] 10.3389/fimmu.2021.760288 PMC 바로가기 [Article Type] Comparative Study