Integrins – Page 2 – Communicable Diseases Research

Can the SARS-CoV-2 Spike Protein Bind Integrins Independent of the RGD Sequence?

Cellular and Infection Microbiology

Published on 2021-11-182022-10-31
Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS,

[키워드] ACE2 analyzed angiotensin-converting enzyme 2 Betacoronavirus betacoronaviruses bind binding bioinformatics Can canonical changes in collected Computational study conformational change conserved coronavirus 2 coronavirus strains domain ENhance entry receptor explain expression Factor help Host host cell identify independent independent of integrin integrin-binding motif Integrins ligands mapped motif motifs Mutation occur Other phylogenetically predicted RaTG13 recent recorded Region RGD rotaviruses SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein sequence sequence similarity shown solvent spike Spike protein Spike proteins spike receptor-binding domain suggested the SARS-CoV-2 the spike protein viral pathogens virus
[DOI] 10.3389/fcimb.2021.765300 PMC 바로가기 [Article Type] Cellular and Infection Microbiology

Integrin activation is an essential component of SARS-CoV-2 infection

인테그린 활성화는 SARS-COV-2 감염의 필수 구성 요소입니다

Article

Published on 2021-10-142022-09-01
Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 진단,

Emerging therapeutic opportunities for integrin inhibitors

Reviews

Published on 2021-09-172022-10-05
Journal: Nature Reviews Drug Discovery [Category] 바이오마커,

Enrichment of SARS-CoV-2 Entry Factors and Interacting Intracellular Genes in Tissue and Circulating Immune Cells

SARS-COV-2 진입 인자의 농축 및 조직에서 세포 내 유전자 상호 작용 및 순환 면역 세포

Article

Published on 2021-09-022022-09-10
Journal: Viruses [Category] SARS, 유전자 메커니즘,

Integrins: An Important Link between Angiogenesis, Inflammation and Eye Diseases

Review

Published on 2021-07-062022-10-31
Journal: Cells [Category] COVID-19, SARS,

SARS-CoV-2 uses major endothelial integrin αvβ3 to cause vascular dysregulation in-vitro during COVID-19

SARS-COV-2는 주요 내피 인테그린 αVβ3을 사용하여 COVID-19 동안 혈관 조절 조절을 유발합니다.

Research Article

Published on 2021-06-232022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS,

[키워드] accelerate Anti-viral binding site bloodstream Candidates cardiovascular complications Characteristics cilengitide COVID-19 COVID-19 infection COVID-19 infections COVID-19 pandemic dysregulation Effect effort ENCODE endothelial endothelial cells Endothelium epithelium etiological expressed Final Host host protein in viral in-silico In-vitro infection rate integrin Integrins Interaction International leakage microbial motif Mutagenesis pathogen pathogenicity reproductive SARS-CoV-2 Spike protein Transmissibility unique Vascular vascular endothelial cell vascular endothelial cells vasculature Viral viral propagation
[DOI] 10.1371/journal.pone.0253347 PMC 바로가기 [Article Type] Research Article

Circulating Adaptive Immune Cells Expressing the Gut Homing Marker α4β7 Integrin Are Decreased in COVID-19

Gut Homing Marker α4β7 Integrin을 발현하는 순환 적응 면역 세포는 COVID-19에서 감소합니다

Immunology

Published on 2021-04-202022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive B cell cause characterized circulating contribute convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 decrease Decreased epithelial cells expressing expression flow cytometry Frequency Gastrointestinal symptom gastrointestinal symptoms Gut gut homing healthy control healthy controls homing IgA IgA-expressing Immune cell immune cells immune responses immune system integrin Integrins intestinal intestinal epithelial cell intestinal epithelial cells Lymphocytes Manifestations marker memory T Patient Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes priming recruited respiratory Result SARS-CoV-2 SARS-COV-2 infection Symptom systemic immune response systemic immune responses T cell trafficking target these cell These cells tissue virus was reduced while wide range of symptoms
[DOI] 10.3389/fimmu.2021.639329 PMC 바로가기 [Article Type] Immunology

RGD-Binding Integrins Revisited: How Recently Discovered Functions and Novel Synthetic Ligands (Re-)Shape an Ever-Evolving Field

Review

Published on 2021-04-042022-10-31
Journal: Cancers [Category] COVID-19,

[키워드] αvβ3 αvβ6 accumulated Angiogenesis approach approaches binding Cancer cancer progression Cell cells Clinical studies clinical trials compounds diagnostic disease dose elevated Exosomes expression fibrosis field function functions high accuracy integrin integrin targeted therapy Integrins investigated knowledge Ligand ligands Metastasis molecular molecular imaging motif non-cancerous novel nuclear optical other diseases patient selection pharmacological progression receptors respiratory RGD-binding integrins SARS-CoV-2 SARS-COV-2 infection selective Sepsis Signal transduction simple subtype Subtypes synthetic synthetic integrin ligands target therapeutic target therapeutic targets therapy translation translational Treatment protocol treatment strategy Trial vascular normalization therapy viral infections
[DOI] 10.3390/cancers13071711 PMC 바로가기 [Article Type] Review

Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death

COVID-19 투석 환자의 종단 단백질 프로파일링은 사망의 중증도 및 예측 인자를 나타냅니다

Research Article

Published on 2021-03-112022-09-10
Journal: eLife [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] adhesion molecules analyses Biomarkers Blood blood protein blood proteins blood sample CCL2 CCL7 changed circulating Clinical severity Combination correlated COVID-19 COVID-19 patient COVID-19 patients CTSD Cytokines damage death determine dialysis differentially expressed disease disease severity displaying drug end-stage kidney disease epithelial fatal COVID-19 fatal disease GDF15 help high risk hospitalised Human identifying IL18BP IL6 in some increased risk Inflammation Injury innate immune activation integrin Integrins Interaction involved joint kidney Kidney disease Kidney failure KRT19 linear mixed model longitudinal machine-learning marker Mild mild illness monocyte neutrophil neutrophil activation non-hospitalised non-infected Older other diseases pathology Patient patients patients with COVID-19 predict predictor problems profile Protein proteinase Proteins proteomic proteomics recruitment resource reveal severe COVID-19 severe disease severe disease progression severity similarities statistical survival analysis targets These data tissue tissue injury tissues
[DOI] 10.7554/eLife.64827 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 mediated neuroinflammation and the impact of COVID-19 in neurological disorders

Article

Published on 2021-02-192023-06-16
Journal: Cytokine & growth factor reviews [Category] MERS, SARS,