Local and Systemic Immunity Are Impaired in End-Stage-Renal-Disease Patients Treated With Hemodialysis, Peritoneal Dialysis and Kidney Transplant Recipients Immunized With BNT162b2 Pfizer-BioNTech SARS-CoV-2 VaccineBNT162b2 화이자-바이오엔텍 SARS-CoV-2 백신을 접종한 혈액투석, 복막투석, 신장이식 환자 말기 신장질환 환자의 국소 및 전신 면역 손상Article Published on 2022-07-222022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] analyzed anti-S anti-S IgG antibodies antibody binding antibody unit BNT162b2 cellular component clinical control group COVID-19 COVID-19 in patient COVID-19 vaccine dose effective End-stage renal disease ESRD Guidance HD group healthy individual Hemodialysis high mortality rate highest IFN-γ IgA IgG Immunity Immunoglobulin G Impaired Interferon-gamma investigated kidney transplant recipient Local Messenger RNA MONITOR mRNA participant Patient patients performed Peritoneal dialysis Pfizer Pfizer-BioNTech positive produced recipient required Research Responder SARS-CoV-2 Seroconversion seroconversion rate seronegative patient seropositive subjects systemic tested therapy Transplant transplantation Trial registration Vaccine vaccine response [DOI] 10.3389/fimmu.2022.832924 PMC 바로가기 [Article Type] Article
Correlation of single-nucleotide polymorphism at interferon-gamma R1 (at Position – 56) in positive purified protein derivative health workers with COVID-19 infectionArticle Published on 2022-07-012023-07-10 Journal: International journal of mycobacteriology [Category] COVID19(2023년), [키워드] COVID-19 Interferon-gamma polymorphism purified protein derivative Tuberculosis [DOI] 10.4103/ijmy.ijmy_133_22
Cellular and Humoral Immune Response to a Third Dose of BNT162b2 COVID-19 Vaccine – A Prospective Observational StudyBNT162b2 COVID-19 백신의 3차 접종에 대한 세포 및 체액 면역 반응 - 전향적 관찰 연구Observational Study Published on 2022-07-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] addition administration All participant All participants anti-SARS-CoV-2 antibody binding binding antibody blood sample Blood samples BNT162b2 booster booster dose cellular Cellular immune response Combination COVID-19 detectable dose evaluate health-care humoral humoral and cellular immunity Humoral immunity immune response Immunity immunological infection rate infection rates interferon Interferon-gamma median Neutralizing antibodies neutralizing antibody observational study of BNT162b2 participant peptide peptides prime-boost regimen Prospective prospective observational study protocols provided quantitative assay questionnaire Questionnaires real-world data response SARS-CoV-2 second dose Seroprevalence significant increase significantly third dose vaccination Vaccine was measured were measured [DOI] 10.3389/fimmu.2022.896151 PMC 바로가기 [Article Type] Observational Study
Immune features of COVID-19 convalescent individuals revealed by a single-cell RNA sequencing단일 세포 RNA 시퀀싱으로 밝혀진 COVID-19 회복기 개인의 면역 기능Article Published on 2022-07-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] Activation addition B cell B cell subset B cells Bioinformatics analysis biological processe biological processes CD4 CD8 Cell cell receptor cell-cell adhesion clonal expansions Cluster convalescence convalescent convalescent COVID-19 patient convalescent COVID-19 patients convalescent individual convalescent individuals convalescent patient Convalescent patients COVID-19 Critical declined decreased expression differentiation downregulation effector memory feature function functions GNLY HLA class I HLA class II HLA class II genes humoral immune response Humoral immunity immune protection immune response immune responses increased expression infections Innate innate immune responses Innate immunity Interferon-gamma involved leukocyte mapped marginal zone mechanism Migration moderate natural infection neutrophil Peripheral blood peripheral blood samples phenotypic reflected Regulation Reinfection retained RNA SARS-CoV-2 SARS-CoV-2-specific immune response SARS-CoV-2-specific immune responses severe cases single cell RNA sequencing Single-cell RNA sequencing subjects subset sustained T cell T cell activation T cell response T/B cell receptor repertoire. TCR upregulation was increased weakened with COVID-19 zone [DOI] 10.1016/j.intimp.2022.108767 PMC 바로가기 [Article Type] Article
Humoral and cellular responses to vaccination with homologous CoronaVac or ChAdOx1 and heterologous third dose with BNT162b2동종 CoronaVac 또는 ChAdOx1을 사용한 백신 접종 및 BNT162b2를 사용한 이종 3차 접종에 대한 체액 및 세포 반응Comment Published on 2022-06-012022-09-12 Journal: The Journal of Infection [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Abstract antibodies BNT162b2 booster cellular response ChAdOx1 CoronaVac COVID-19 dose Heterologous homologous Interferon-gamma Neutralizing SARS-CoV-2 vaccination Vaccine [DOI] 10.1016/j.jinf.2022.02.026 PMC 바로가기 [Article Type] Comment
Adaptive Immune Responses and Immunity to SARS-CoV-2SARS-CoV-2에 대한 적응 면역 반응 및 면역Review Published on 2022-05-042022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] activated Activation adaptive Adaptive immune response adaptive immune responses Adaptive immunity Antigen antigen-presenting cell antigen-presenting cells B cell B cell receptors B.1.1.529 B.1.617.2 backbone biological interaction Blood Blood donors Breakthrough infection breakthrough infections cellular Cellular immune response cellular immunity cellular response Clonality competence COVID-19 COVID-19 pandemic defend Defense defense mechanism Delta demonstrated heparinized blood Host humoral Humoral response humoral responses IgA immune immune reaction immune responses Immunity Immunocompromised Immunocompromised patient Immunocompromised patients Immunological memory immunology induce Infection interferon gamma interferon gamma. Interferon-gamma knowledge long-lasting maturation mechanism memory mucosal nasal omicron pandemic peptides Research response SARS-CoV SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 T cell memory shown stimulated T cell T cell memory T cells the SARS-CoV-2 translate undetectable Vaccine Vaccines variants variants of concern Viral antigen viral particle virus [DOI] 10.3389/fimmu.2022.848582 PMC 바로가기 [Article Type] Review
Serum cytokine/chemokine profiles predict hepatitis B reactivation in HBV/HCV co-infected subjects receiving direct-acting antiviral agentsArticle Published on 2022-05-012023-06-12 Journal: Journal of the Formosan Medical Association = Taiw [Category] B형 간염, [키워드] acute flare C–C motif chemokine ligand 2 Co-infection Interferon-gamma TNF-alpha. [DOI] 10.1016/j.jfma.2021.09.002
Identifying Immunological and Clinical Predictors of COVID-19 Severity and Sequelae by Mathematical Modeling수학적 모델링을 통한 COVID-19 심각도 및 후유증의 면역학적 및 임상적 예측인자 식별Article Published on 2022-04-202022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] absolute neutrophil count Analysis Aritficial Intelligence biochemical biochemical markers Biochemical parameters Blood urea nitrogen C-reactive protein clinical Cohort control subject control subjects coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical curated cytokine Cytokines dataset differential expression disease severities Efficacy exploratory ferritin granzyme B highlight identify identifying IFN-γ IL-1 IL-10 IL-15 IL-1ra IL-6 immunological Increased Initially interferon Interferon-gamma interleukin investigated Lactate lactate dehydrogenase Liver injury machine machine learning methodology modeling multiplex Multiplex assay Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples Necrosis neutrophil nitrogen outcome pandemic pathophysiology pathway Patient PD-L1 potential therapeutic targets predict Predictive predictive models Predictive value predictor radiological receptor RNA RNA seq ROC ROC analysis serum severe cases severity the disease transcriptomics tumor necrosis urea validation cohort variant [DOI] 10.3389/fimmu.2022.865845 PMC 바로가기 [Article Type] Article
Commercial Interferon-gamma release assay to assess the immune response to first and second doses of mRNA vaccine in previously COVID-19 infected versus uninfected individuals이전에 COVID-19에 감염된 개인과 감염되지 않은 개인에서 mRNA 백신의 1차 및 2차 접종에 대한 면역 반응을 평가하기 위한 상업용 인터페론-감마 방출 분석Article Published on 2022-04-012022-09-12 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] analysed Anti-spike IgG antibody blood sample BNT162b2 BNT162b2 vaccine CD4+ CD8+ T cell collected COVID-19 dose doses first dose IFNγ IFNγ release assay immune response Immunological response individual Interferon-gamma MONITOR mRNA vaccine Quantitative SARS-CoV-2 second dose significant difference T cells T-cell immunity uninfected vaccination [DOI] 10.1016/j.diagmicrobio.2021.115573 PMC 바로가기 [Article Type] Article
Persistence of Immune Response in Health Care Workers After Two Doses BNT162b2 in a Longitudinal Observational Study종단 관찰 연구에서 BNT162b2 2회 투여 후 의료 종사자의 면역 반응 지속Observational Study Published on 2022-03-042022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] age All participants Analysis antibody average binding binding antibody BNT162b2 BNT162b2 vaccine booster dose booster doses booster vaccinations Care cellular Cellular immune response Course COVID-19 disease declining described detectable dose Efficacy evaluated Follow-up groups Health Health care Health care worker hospital humoral humoral and cellular immunity humoral immune response immune response immunological Immunological memory individual interferon Interferon-gamma longitudinal mRNA mRNA-based vaccine Neutralizing antibodies obesity observational study of BNT162b2 Older age participant Participants peptide peptides persistence Pfizer Quantitative response response rate resulting SARS-CoV-2 SARS-COV-2 infection second dose semi-quantitative Serological testing shown vaccination Vaccine worker [DOI] 10.3389/fimmu.2022.839922 PMC 바로가기 [Article Type] Observational Study