Preclinical evaluation of safety and immunogenicity of a primary series intranasal COVID-19 vaccine candidate (BBV154) and humoral immunogenicity evaluation of a heterologous prime-boost strategy with COVAXIN (BBV152)Article Published on 2022-12-082023-07-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] BBV154 ChAd vaccine COVID-19 vaccine Heterologous iNCOVACC intranasal vaccine mucosal vaccine. SARS-CoV-2 [DOI] 10.3389/fimmu.2022.1063679 PMC 바로가기
COVID-19 intranasal vaccines: current progress, advantages, prospects, and challengesCOVID-19 비강내 백신: 현재 진행 상황, 이점, 전망 및 과제Review Published on 2022-11-302022-09-12 Journal: Human vaccines & immunotherapeutics [Category] MERS, SARS, 진단, [키워드] added Administered administration Antibody Response Cell-mediated immunity cellular immunity country COVID-19 COVID-19 pandemic COVID-19 vaccine disease highlight immune response Immunity induce injected injection intramuscular intranasal intranasal vaccine limit MOST mucosal mucosal immunity Multiple nasal pandemic Prevent Protective Replication robust SARS-CoV-2 SARS-CoV-2 vaccine secretory IgA shown stimulate Vaccine Vaccines virus infection virus transmission [DOI] 10.1080/21645515.2022.2045853 PMC 바로가기 [Article Type] Review
Protection against SARS-CoV-2 transmission by a parenteral prime-Intranasal boost vaccine strategyArticle Published on 2022-10-012022-11-15 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Administered airway boost Booster vaccine CAF®01 cationic clearance effective elicit elicited European evaluated HexaPro highlight Horizon IgA response immune response intranasal intranasal vaccine lower airway Lung pathology mucosal mucosal immune Neutralizing antibodies onward transmission Parenteral PROTECT protection regimen Research response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission Serum neutralizing antibody severe disease spike supported Transmission trimer union upper airway upper airways upper respiratory tract Vaccine virus virus transmission [DOI] 10.1016/j.ebiom.2022.104248 PMC 바로가기
Intranasal COVID-19 vaccines: From bench to bedReview Published on 2022-01-242023-06-15 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, [키워드] adjuvant COVID-19 intranasal vaccine mucosal SARS-CoV-2 [DOI] 10.1016/j.ebiom.2022.103841 PMC 바로가기 [Article Type] Review
Mucosal Vaccines, Sterilizing Immunity, and the Future of SARS-CoV-2 Virulence점막 백신, 멸균 면역 및 SARS-COV-2 독성의 미래Review Published on 2022-01-192022-09-01 Journal: Viruses [Category] SARS, 진단, [키워드] animal reservoirs antigens BNT162b2 coin Coronaviruses COVID-19 Endemic Future hospital Human IgA IgG Immunity implication induce Infection intramuscular intranasal vaccine mRNA-1273 mucosal mucosal secretions mucosal vaccines Neutralizing Neutralizing antibodies neutralizing antibody Occurrence oral vaccines patients Prevent priming pros public health reservoirs respiratory respiratory virus respiratory viruses SARS-CoV-2 SARS-CoV-2 vaccine Spread sterilizing immunity systemic Transmission vaccination Vaccination strategy Vaccine vaccinees virulence viruses [DOI] 10.3390/v14020187 PMC 바로가기 [Article Type] Review
Intranasal vaccination with protein bodies elicit strong protection against Streptococcus pneumoniae colonization단백질체를 이용한 비강 백신 접종은 폐렴구균의 군집 형성에 대한 강력한 보호 효과를 유도합니다.Article Published on 2021-11-162024-08-24 Journal: Vaccine [Category] 폐렴구균 감염증, [키워드] colonization intranasal vaccine Protein bodies Streptococcus pneumoniae [DOI] 10.1016/j.vaccine.2021.10.006
A Combination Adjuvant for the Induction of Potent Antiviral Immune Responses for a Recombinant SARS-CoV-2 Protein Vaccine재조합 SARS-CoV-2 단백질 백신에 대한 강력한 항바이러스 면역 반응 유도를 위한 조합 보조제Immunology Published on 2021-09-162022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] activate Adaptive immune response adaptive immune responses adjuvant adjuvants antibody Antibody titers Antigen B.1.351 breadth candidate cellular response Combination cross-protection effective elicited ENhance Heterologous homologous Immune profile immune responses Immunity IMPROVE induction intranasal intranasal vaccine mice mucosal mucosal adjuvant N501Y mutation nanoemulsion (NE) neutralizing antibody titers NLRP3 P.1 variants passive transfer potent recombinant response RIG-I RIG-I agonist RNA robust SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants Spike protein TLR TLRs transfer vaccination variant variants variety Viral viral challenge virus-neutralizing antibody [DOI] 10.3389/fimmu.2021.729189 PMC 바로가기 [Article Type] Immunology
Oral Bacteria Combined with an Intranasal Vaccine Protect from Influenza A Virus and SARS-CoV-2 Infection비강내 백신과 결합된 구강 박테리아는 인플루엔자 A 바이러스 및 SARS-CoV-2 감염으로부터 보호합니다Research Article Published on 2021-08-172022-09-12 Journal: mBio [Category] MERS, SARS, 신종인플루엔자, 진단, [키워드] activating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immune response adaptive immune responses adjuvant Administered administration Antibiotics Antibody Response Bacteria Bacterial bacterial pathogen Combined commensal bacteria coronavirus Critical demonstrated Disruption gut microbiota healthy immune responses Immunity induce Infection Influenza Influenza virus intranasal intranasal vaccine intranasally less lysozyme mucosal mucosal immunity mucosal surface MYD88 nasal oral oral cavity PAMPs pathogen-associated molecular pattern PROTECT SARS-CoV-2 severe acute respiratory syndrome Coronavirus signaling pathway significantly lower Vaccine Vaccines virus infection [DOI] 10.1128/mBio.01598-21 PMC 바로가기 [Article Type] Research Article
Intranasal Administration of RBD Nanoparticles Confers Induction of Mucosal and Systemic Immunity against SARS-CoV-2Article Published on 2021-07-092022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] activated addition Administered administration alternative route Antibody Response BAL CD4 CD8 Cell COVID-19 Defense domain evaluated evidenced Host IgA IgA response IgG IgG1 IgG2a immune system Immunity immunization immunized mice immunogen induction intranasal intranasal route intranasal vaccine intranasally Local lung mice mucosa mucosal nano-delivery vaccine nanoparticle Neutralizing antibodies platform primary site PROTECT RBD respiratory tract response robust SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike glycoprotein serum IgG significantly higher stimulated systemic upper respiratory airway vaccination virus [DOI] 10.3390/vaccines9070768 PMC 바로가기 [Article Type] Article
Localized and Systemic Immune Responses against SARS-CoV-2 Following Mucosal ImmunizationArticle Published on 2021-02-062022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] antigens avian coronavirus Bronchoalveolar lavage Coronaviruses COVID-19 cytokine elicit elicited expressing global pandemic Heterologous heterologous vaccine homologous Homologous vaccine IFN-γ IL-2 immune response Immunity immunization intranasal intranasal vaccine Local Localized lung mice mucosal mucosal immune nanovaccine neutralizing antibody nucleocapsid Plasmid Protective response responses against robust SARS-CoV-2 SARS-CoV-2 spike secreting serum spleen Support systemic T-cell T-cell Response TNFα transmission of SARS-CoV-2 USA Vaccine vaccinia [DOI] 10.3390/vaccines9020132 PMC 바로가기 [Article Type] Article