isolates – Page 2 – Communicable Diseases Research

Interferon resistance of emerging SARS-CoV-2 variants

새로운 SARS-CoV-2 변이체의 인터페론 내성

Article

Published on 2022-08-092022-09-11
Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제,

QTQTN motif upstream of the furin-cleavage site plays a key role in SARS-CoV-2 infection and pathogenesis

푸린 절단 부위의 QTQTN 모티프는 SARS-CoV-2 감염 및 발병에 중요한 역할을 합니다

Article

Published on 2022-08-092022-09-11
Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

Isolation and characterization of phage display-derived scFv antibodies against human parechovirus 1 VP0 protein

Research

Published on 2022-08-042022-10-05
Journal: Scientific Reports [Category] 진단,

A comprehensive genomic study, mutation screening, phylogenetic and statistical analysis of SARS-CoV-2 and its variant omicron among different countries

국가별 SARS-CoV-2 및 그 변이체 오미크론에 대한 포괄적인 게놈 연구, 돌연변이 스크리닝, 계통 발생 및 통계 분석

Article

Published on 2022-08-012022-09-11
Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition Analysis anticipated approach assist average B.1.1.529 B.1.617.2 bioinformatics Brazil changes in Complete confidence conserved Corona coronavirus country COVID-19 Delta determined by domain domains Drug discovery Effect evaluate Evolution full-length genome Genes genetic diversity Genome genome sequence Genome sequences genomic genomic sequence help heterozygosity highest identify in viral in-silico information isolates Japan MSN Mutation mutation analysis offer omicron Omicron variant Omicron variants ORF1 ORF10 ORF1ab ORF7a Phylogenetic Phylogenetic tree Phylogeny polymorphism Population predict prevalent Protein provide resource SARS-CoV-2 selected sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shape Spike protein standard error statistical analysis strain the Spike the vaccine these viruses TRS unique Vaccine variant variants Variation variations viral genome viral genome sequence viruses was determined was used were used Wuhan-Hu-1
[DOI] 10.1016/j.jiph.2022.07.002 PMC 바로가기 [Article Type] Article

Optimization and evaluation of a live virus SARS-CoV-2 neutralization assay

살아있는 바이러스 SARS-CoV-2 중화 분석의 최적화 및 평가

Article

Published on 2022-07-282022-09-11
Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법,

[키워드] 24 hour 24 hours acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 added antibody application calculated cell monolayer cell suspension cells clinical isolates Coefficient of variance coronavirus correlated correlation Critical described dose ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated functional antibody response functional antibody responses growth immune evasion Immunity include Incubation period infecting Influenza Influenza virus inoculation isolates Live virus microneutralization neutralization Neutralization assay neutralization titers nucleocapsid protein optimization parameter Post-infection Precision protein level reduced replicating virus respiratory SARS-CoV-2 SARS-CoV-2 clinical isolate SARS-CoV-2 clinical isolates SARS-CoV-2 microneutralization assay SARS-CoV-2 neutralization severe acute respiratory syndrome Coronavirus the SARS-CoV-2 the strongest therapeutic Vaccine variance Vero E6 Vero E6 cell VERO E6 cells Viral Viral variants virus virus infection virus inhibition virus inoculum virus neutralization assays Virus titration was determined WHO
[DOI] 10.1371/journal.pone.0272298 PMC 바로가기 [Article Type] Article

The Cellular Characterization of SARS-CoV-2 Spike Protein in Virus-Infected Cells Using the Receptor Binding Domain Binding Specific Human Monoclonal Antibodies

수용체 결합 도메인 결합 특이적 인간 단일클론 항체를 사용하여 바이러스에 감염된 세포에서 SARS-CoV-2 스파이크 단백질의 세포 특성화

Article

Published on 2022-07-132022-09-11
Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] adopted antibody appearance appears attachment B cell B cells biological properties biological property can be used Cell cell-to-cell transmission characterization conformation conformational change convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient convalescent patient serum Convalescent patients cytoplasmic demonstrated early stage early stages electron microscopy epitope Epitopes Evidence exhibited FIVE focus furin future therapeutic Golgi complex host cell Human human monoclonal antibodies Human monoclonal antibody immunofluorescence microscopy immunological indicated infected cells infected with SARS-CoV-2 Infection Interaction isolate isolates Microscopy mitigate MONITOR monoclonal new virus occur offer Protein provided RBD reagent Receptor binding domain receptor binding domain (RBD) recognize required S protein S protein cleavage S protein RBD SARS- CoV-2 SARS-CoV-2 SARS-CoV-2 clinical isolates SARS-CoV-2 spike SARS-CoV-2-infected cell SARS-CoV-2-infected cells Singapore Specific spike staining the RBD the S protein therapeutic These data Transmission Vaccine variant virus infection virus particles virus-infected cell virus-infected cells was used were used while
[DOI] 10.1128/jvi.00455-22 PMC 바로가기 [Article Type] Article

Evaluation of Bi-Lateral Co-Infections and Antibiotic Resistance Rates among COVID-19 Patients in Lahore, Pakistan

Observational Study

Published on 2022-07-062022-10-05
Journal: Medicina [Category] 임상,

[키워드] Acinetobacter antibiotic Antibiotic resistance antibiotic stewardship Bacteria Bacterial bacterial co-infection Bacterial infections carbapenem resistant Enterobacteriaceae Care clinical sample collected Complication conducted coronavirus COVID-19 COVID-19 patient Critically ill cultures diagnosed diagnostic methods diffusion E. coli Enterobacteriaceae Enterococcus Escherichia coli gold standard highest hospital hospital acquired infections. Hospital admission illnesses increase in Infection infections Influenza inhibitory concentration isolate isolates material methicillin morbidity and mortality MRSA National oxygen Patient positive Prevalence protective role Rate resistance Result Risk factors shown Staphylococcus aureus susceptibility tested Treatment viral respiratory
[DOI] 10.3390/medicina58070904 PMC 바로가기 [Article Type] Observational Study

Neutralization capacity of antibodies elicited through homologous or heterologous infection or vaccination against SARS-CoV-2 VOCs

SARS-CoV-2 VOCs에 대한 동종 또는 이종 감염 또는 백신 접종을 통해 유도된 항체의 중화 능력

Article

Published on 2022-07-042022-09-11
Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술,

[키워드] Alpha antibody antigenic B.1 Beta Blood blood specimens Breakthrough infection breakthrough infections Clusters Combination Combined complex convalescent individual convalescent individuals Delta determined by elicited escape Gamma homologous homologous or heterologous Immune escape Immunity Infection isolates Last lead less neutralization Neutralization assay neutralization titer Neutralizing neutralizing capacity omicron Patient population immunity question raise SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 variant SARS-CoV-2 variants sera Seven specimen vaccinated individual vaccinated individuals vaccination Vaccinations variant variants VoC Zeta
[DOI] 10.1038/s41467-022-31556-1 PMC 바로가기 [Article Type] Article

Comparative characterization of SARS-CoV-2 variants of concern and mouse-adapted strains in mice

마우스에서 우려되는 SARS-CoV-2 변이체 및 마우스 적응 균주의 비교 특성화

Comparative Study

Published on 2022-07-012022-09-11
Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종,

[키워드] Alpha Alpha variant Amino acid Beta Beta variant caused changes in comparable Comparative cytokine cytokine assay Delta delta variant Evolution of SARS-CoV-2 global health Health highlighting Human indicated infect investigated isolates Laboratory lung Lung pathology Lungs MASCp6 mice Mild mouse-adapted strain mouse-adapted strains Mutation pathogenic pathogenicity raising RBD Receptor-binding domain Replication risk SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 mouse-adapted strains SARS-CoV-2 variant SARS-CoV-2 variants spillover risk sustained the RBD the receptor-binding domain variant variants variants of concern VoC VOCs wildtype
[DOI] 10.1002/jmv.27735 PMC 바로가기 [Article Type] Comparative Study

Receptor binding domain of SARS-CoV-2 from Wuhan strain to Omicron B.1.1.529 attributes increased affinity to variable structures of human ACE2

우한 균주에서 Omicron B.1.1.529까지의 SARS-CoV-2 수용체 결합 도메인은 인간 ACE2의 가변 구조에 대한 증가된 친화성을 특성으로 합니다.

Article

Published on 2022-07-012022-09-11
Journal: Journal of infection and public health [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술,

[키워드] ACE2 ACE2 receptor ACE2 receptors ACE2 variant ACE2 variants ACE2-RBD affinity analysed Analysis angiotensin Angiotensin-converting enzyme attribute B.1.1.529 binding binding domain binding efficiency binding energy Care caused changes in coding region complexes contributing to COVID-19 detect determine docking dynamic Dynamic simulation enzyme Genetic variant genetic variants global pandemic help highlight homology model Homology models Human human ACE2 human host Infectious disease Interaction isolates lead management molecular molecular dynamics nucleotide omicron pathogenic polymorphism Protein docking RBD RBD complex RBDs receptor Receptor binding domain Repository retrieved risk RMSD RMSF Safe SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 virus SARS‐CoV‐2 selected severity single nucleotide stability Structural variant structural variants Structure the RBD Total variant Variation was performed wildtype Wuhan Wuhan strain
[DOI] 10.1016/j.jiph.2022.06.004 PMC 바로가기 [Article Type] Article