A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions액세서리 단백질이 결실된 생약독화 SARS-CoV-2 백신 후보Article Published on 2022-07-272022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] Antiviral approved biosafety cultures deleted Deletion hamster hamsters immunization interferon interferon signaling K18-hACE2 live-attenuated vaccine mNeonGreen Mouse models neutralization ORF ORF3a ORFs Phosphorylation primary human airway PROTECT Protein replicate Replication reporter Research SARS-CoV-2 SARS-CoV-2 vaccine sequence Stat1 Transmission vaccine production Vero-E6 cell Viral viral transcription virus wild-type SARS-CoV-2 wild-type virus [DOI] 10.1038/s41467-022-31930-z PMC 바로가기 [Article Type] Article
Matrix Metalloproteinases Expression Is Associated with SARS-CoV-2-Induced Lung Pathology and Extracellular-Matrix Remodeling in K18-hACE2 MiceArticle Published on 2022-07-262023-07-10 Journal: Viruses [Category] COVID19(2023년), [키워드] COVID-19 extra-cellular matrix (ECM) K18-hACE2 matrix-metalloproteases (MMP). SARS-CoV-2 [DOI] 10.3390/v14081627 PMC 바로가기
Development of transgenic models susceptible and resistant to SARS-CoV-2 infection in FVB background miceFVB 배경 마우스에서 SARS-CoV-2 감염에 민감하고 내성이 있는 형질전환 모델 개발Article Published on 2022-07-262022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome coronavirus atrophy caused Cerebellum cerebrum coronavirus 2 coronavirus disease COVID-19 COVID-19 pandemic development disease exhibited Goblet cell goblet cells hACE2 histopathological finding histopathological findings hyperplasia K18-hACE2 K18-hACE2 mice lung Lungs mice Mild mild pneumonia overcome Pneumonia reduction respiratory SARS-CoV-2 SARS-COV-2 infection sensitivities Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe pneumonia small intestine spleen strain susceptibility susceptible Therapeutics transgenic mice transgenic model Vaccine viral titer weight loss White pulp [DOI] 10.1371/journal.pone.0272019 PMC 바로가기 [Article Type] Article
A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection단일 T 세포 에피토프를 사용한 세 번째 백신 접종은 SARS-CoV-2 감염의 쥐 모델에서 보호를 제공합니다Article Published on 2022-07-082022-09-12 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] absence approach booster vaccination CD8 characterized cytokine production develop dose dose regimen elicit epitope epitope peptide fraction IMPROVE K18-hACE2 mechanism memory T cells murine model Neutralizing antibodies peptide repeated SARS-CoV-2 SARS-COV-2 infection spike T cell T cell response Transgenic mouse understanding vaccination Vaccine vaccine dose [DOI] 10.1038/s41467-022-31721-6 PMC 바로가기 [Article Type] Article
A mRNA Vaccine Encoding for a RBD 60-mer Nanoparticle Elicits Neutralizing Antibodies and Protective Immunity Against the SARS-CoV-2 Delta Variant in Transgenic K18-hACE2 MiceRBD 60-mer 나노입자를 암호화하는 mRNA 백신은 형질전환 K18-hACE2 마우스에서 SARS-CoV-2 Delta 변이체에 대한 중화 항체 및 보호 면역을 유발합니다Article Published on 2022-07-062022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Against Antigen COVID-19 pandemic Delta delta variant displaying domain effective elicit encoding flexible hACE2 K18-hACE2 messenger Messenger RNA mRNA mRNA vaccine nanoparticle Neutralizing neutralizing antibody Neutralizing antibody response platform protective immunity provide RBD RBDs Receptor binding domain Receptor-binding domain RNA vaccine robust SARS-CoV-2 SARS-CoV-2 variant severe disease Spread the RBD the SARS-CoV-2 Transgenic mouse Vaccine [DOI] 10.3389/fimmu.2022.912898 PMC 바로가기 [Article Type] Article
Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strainsSARS-CoV-2 Omicron 계통 균주에 의한 감염에 대한 S309 및 AZD7442 단일클론 항체 치료의 회복력Article Published on 2022-07-022022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acting Antibody neutralization AstraZeneca Cell culture changes in Combination correlation analyses Correlation analysis Effect Efficacy Express FcγR hACE2 human ACE2 humans in vitro In vitro studies in vitro study in vivo Infection Interaction K18-hACE2 Lineage Lung infection mAb mechanism mice monoclonal antibody monoclonal antibody therapies monoclonal antibody treatment monotherapy neutralization neutralization potency Neutralizing activity omicron Omicron variant Omicron variants Prevent Prophylactic Protective reduced reductions reductions in Resilience retained S309 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 isolates SARS-CoV-2 variant Spike protein strain suggested susceptible the spike protein therapeutic therapy transgenic mice treat Treatment variant variants Viral viral burden [DOI] 10.1038/s41467-022-31615-7 PMC 바로가기 [Article Type] Article
Alcohol Increases Lung Angiotensin-Converting Enzyme 2 Expression and Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Subunit 1-Induced Acute Lung Injury in K18-hACE2 Transgenic Mice알코올은 폐 안지오텐신 전환 효소 2 발현을 증가시키고 중증 급성 호흡기 증후군을 악화시킨다Article Published on 2022-07-012022-09-11 Journal: The American journal of pathology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alcohol Alcohol Abuse alcohol consumption alveolar Alveolar space angiotensin angiotensin-converting enzyme 2 Biomarker blood cell body weight Bronchoalveolar lavage fluid chronic coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Course Cytokine storm decrease dramatic increase enzyme Ethanol Express Factor human ACE2 receptor Human angiotensin-converting enzyme 2 Immune cell immune cells increase Inflammasome Interaction K18-hACE2 lung tissue mechanism mice Mortality NF-κB NLR NLRP3 overexpression pandemic parenchymal proinflammatory protein 3 recruitment reported respiratory respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus spike Spike protein STAT3 Stress subunit syndrome Therapeutic approach therapeutic approaches transgenic mice White blood cell worsening [DOI] 10.1016/j.ajpath.2022.03.012 PMC 바로가기 [Article Type] Article
The Delta SARS-CoV-2 Variant of Concern Induces Distinct Pathogenic Patterns of Respiratory Disease in K18-hACE2 Transgenic Mice Compared to the Ancestral Strain from WuhanDelta SARS-CoV-2 변종은 우한의 조상 균주와 비교하여 K18-hACE2 형질전환 마우스에서 호흡기 질환의 뚜렷한 병원성 패턴을 유도합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis B cells Brain caused CD45 Cell cells clinical disease concern coronavirus COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines Cytokines Delta delta variant dendritic cell dendritic cells disease dissemination hACE2 help Immune escape immune response Increased Infection infiltration Inflammatory inflammatory monocytes intestinal wall intestine K18-hACE2 K18-hACE2 mice K18-hACE2 transgenic mice kidney lung Lungs manifestation mice Monocytes mouse model multiple tissues no significant difference observation Pathogenesis pathogenicity pattern perivascular inflammation Proinflammatory cytokine proinflammatory cytokines provide respiratory SAME AS SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe COVID-19 shown significant difference significantly lower strain T cells the disease therapeutic intervention therapeutic interventions Therapies tissue damage tissue pathology Transmissibility Treatment strategies two groups variant Wuhan [DOI] 10.1128/mbio.00683-22 PMC 바로가기 [Article Type] Article
Intranasal inoculation of an MVA-based vaccine induces IgA and protects the respiratory tract of hACE2 mice from SARS-CoV-2 infectionMVA 기반 백신의 비강내 접종은 IgA를 유도하고 SARS-CoV-2 감염으로부터 hACE2 마우스의 호흡기를 보호합니다Article Published on 2022-06-142022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome administration Antigen Beta Blood CD3 CD8 coronavirus coronavirus 2 coronavirus vaccine COVID-19 COVID-19 pandemic current effective expressing firefly luciferase hACE2 IFN-γ IgA IgG immune responses Immunity immunized Immunoglobulin immunoglobulin A Immunoglobulin G induce Infection Infectious virus intramuscular intramuscular vaccination intramuscularly intranasal intranasally K18-hACE2 less luciferase Luminescence lung Lungs mice modified vaccinia virus morbidity mucosal mucosal immunity nasal turbinate nasal turbinates neutralized Neutralizing antibodies neutralizing antibody omicron Prevent prevented priming PROTECT protective immune response pseudovirus pseudoviruses raise remained respiratory respiratory immunity respiratory tract S protein S proteins SARS-CoV-2 SARS-COV-2 infection serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity T cells the S protein Transmission upper respiratory tract vaccination Vaccine vaccinia virus variants Viral while Wuhan [DOI] 10.1073/pnas.2202069119 PMC 바로가기 [Article Type] Article
Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vesselsArticle Published on 2022-06-132022-10-04 Journal: Cellular and Molecular Life Sciences [Category] COVID19(2023년), SARS, 신약개발, [키워드] ACE2 acute phase Analysis binding Brain Brain infection Cell clinical symptom clinically complex COVID-19 disease drug Drug repurposing drugs Endothelial cell entry receptor Human human Angiotensin-converting enzyme Immune cell infiltration IMPROVE Infection infection with SARS-CoV-2 Inflammation Inflammatory inhibit SARS-CoV-2 involved K18-hACE2 K18-hACE2 mice long-lasting melatonin Neuro-vasculature Neurological symptom Neurological symptoms Perspective Prevent prevented prevention reducing SARS-CoV-2 SARS-CoV-2 entry small vessel survival symptoms of COVID-19 the disease therapeutic Treatment triggered vessels [DOI] 10.1007/s00018-022-04390-3 PMC 바로가기 [Article Type] Article