Lisinopril increases lung ACE2 levels and SARS-CoV-2 viral load and decreases inflammation but not disease severity in experimental COVID-19Pharmacology Original Research Published on 2024-07-122024-09-05 Journal: Frontiers in Pharmacology [Category] update2024, [키워드] ACEi angiotensin-converting enzyme inhibitors COVID-19 K18-hACE2 Lisinopril SARS-CoV-2 [DOI] 10.3389/fphar.2024.1414406 PMC 바로가기 [Article Type] Pharmacology Original Research
Neuropathological lesions in intravenous BCG-stimulated K18-hACE2 mice challenged with SARS-CoV-2Research Article Published on 2024-05-312024-09-05 Journal: Veterinary Research [Category] update2024, [키워드] BCG stimulation K18-hACE2 neuroinvasion SARS-CoV-2 [DOI] 10.1186/s13567-024-01325-7 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in MiceArticle Published on 2022-11-012022-11-15 Journal: Emerging Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome ancestral antibody Australia challenge coronavirus coronavirus disease COVID-19 cross-protection cross-reactivity Delta elicited homologous immunogenicity Infection K18-hACE2 K18-hACE2 mice mice Neutralizing Neutralizing antibodies neutralizing antibody omicron Omicron BA.1 remained respiratory infections SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants severe acute respiratory syndrome coronavirus 2 Strains vaccine-preventable diseases viruses zoonoses [DOI] 10.3201/eid2811.220718 PMC 바로가기
Immunological and Pathological Peculiarity of Severe Acute Respiratory Syndrome Coronavirus 2 Beta VariantArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] Activation acute respiratory syndrome Analysis Beta Beta variant blockade cascade cause CCL2 Characteristics Comparative analysis coronavirus coronavirus 2 COVID-19 COVID-19 pandemic CXCR2 cytokine cytokine release death Disease progression early stage evidenced IL-1β immunological induce Infection Inflammatory cytokine investigated K18-hACE2 late stage Lung pathology mice molecular mechanism Mortality neutrophil recruitment outbreak pathological pathological condition pathology phenotype presymptomatic provide reduced respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 variant secreted cytokine Strains the SARS-CoV-2 Transcriptome transcriptomes Transmissibility Treatment variant viral infection weight loss [DOI] 10.1128/spectrum.02371-22 PMC 바로가기
Mouse models of COVID-19 recapitulate inflammatory pathways rather than gene expressionArticle Published on 2022-09-262022-11-16 Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, [키워드] ACE2 Analysis approach bioinformatics Concordance COVID-19 debatable differentially expressed gene expressed expression Gene Expression hACE2 Human immune signature Immunity immunopathology inflammatory pathway K18-hACE2 lung damage Lungs mice mouse model orthologue overlap promoter SARS-CoV-2 single copy transcriptional profile transcriptional response Treatment Viral load virus wild-type [DOI] 10.1371/journal.ppat.1010867 PMC 바로가기
Spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory miceArticle Published on 2022-09-132022-11-16 Journal: Cell Reports [Category] SARS, 변종, [키워드] accompanied ACE2 acute respiratory syndrome attenuation. BALB/c mice cause coronavirus CP: Microbiology disease disease severity Interaction K18-hACE2 Laboratory mice Mutation omicron Omicron variant pseudovirus responsible robust SARS-CoV-2 spike Spike protein the receptor-binding domain the spike protein variant variants of concern Viral load virus [DOI] 10.1016/j.celrep.2022.111359 PMC 바로가기
RBD-VLP Vaccines Adjuvanted with Alum or SWE Protect K18-hACE2 Mice against SARS-CoV-2 VOC ChallengeArticle Published on 2022-08-312022-11-15 Journal: mSphere [Category] SARS, 변종, 진단, [키워드] alleviate alum aluminum Antigen approved Beta Brain challenge Combination composed contributed country COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines cross-reactive demonstrated development distribution dose Efficacy evaluated functional HBsAg help hepatitis B hydroxide immunization immunized immunogenic Inflammation K18-hACE2 K18-hACE2 mice lung mice mRNA mRNA vaccination mRNA vaccine neutralizing antibody offer pandemic Pfizer platform profile PROTECT protein subunit vaccine provided RBD RBD IgG RBD-VLP Receptor binding domain SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SpyCatcher SpyTag survival SWE Vaccine Vaccines Viral RNA VLP VLP vaccine VoC Wuhan [DOI] 10.1128/msphere.00243-22 PMC 바로가기
Passive immunization with equine RBD-specific Fab protects K18-hACE2-mice against Alpha or Beta variants of SARS-CoV-2Article Published on 2022-08-152022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] ACE2 receptor binding addition administration antibody Beta clearance contributed country COVID-19 COVID-19 pandemic creating delta variant disease dose doses Efficacy emergence EpF(ab’)2 equine Equine F(ab’)2 Fab HBsAg immunization implementation increased survival Infection intranasal K18-hACE2 K18-hACE2 transgenic mice mice monoclonal antibody treatment neutralize omicron outcome pandemic passive immunization peripheral circulation phenotype polyclonal polyclonal antibodies PROTECT RBD SARS-CoV-2 SARS-COV-2 infection Severe case severe disease severe SARS-CoV-2 strain survival tested therapeutic Therapeutic treatment tissues transgenic Treatment variant variant of concern (VOC) variants variants of concern variants of SARS-CoV-2 Viral RNA virus VoC [DOI] 10.3389/fimmu.2022.948431 PMC 바로가기
BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike proteinSARS-CoV-2의 BSL2 호환 치명적인 마우스 모델 및 Spike 단백질을 표적으로 하는 치료제 평가를 위한 우려 변종Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 transgenic mice acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animal model antibody both virus both viruses brains BSL-2 BSL-2 mouse model BSL2 BSL3 BST2 can be used CCL5 change competent concern conditions coronavirus COVID-19 COVID19 CXCL10 disease Disease progression drugs Encephalitis evaluate experimental therapeutics facilitate faster generate GFP glycoprotein hACE2 host-pathogen interactions in vivo increased expression Infection interferon IRF7 K18-hACE2 K18-hACE2 transgenic mice lethal infection LILRB4 lung Lungs mass vaccination mice modulate mouse model mutations Neonatal neuronal infection neurotropism pathogenicity prophylactic treatment Protein pseudotyped Pseudotyped virus Receptor binding domain replaced REPLACED BY Replication reported SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variants SARS-CoV-2 viruses SARS2 severe acute respiratory syndrome Coronavirus Spike protein stomatitis successive wave successive waves the SARS-CoV-2 the Spike the spike protein therapeutic Therapeutics transgenic transgenic mice Transmission vaccination Vaccine development variant variants of concern vesicular vesicular stomatitis vesicular stomatitis virus virulence virus VoC VSV VSV (vesicular stomatitis virus) [DOI] 10.3389/fimmu.2022.919815 PMC 바로가기 [Article Type] Article
An S1-Nanoparticle Vaccine Protects against SARS-CoV-2 Challenge in K18-hACE2 MiceArticle Published on 2022-07-272023-07-09 Journal: Journal of Virology [Category] COVID19(2023년), [키워드] K18-hACE2 nanoparticle vaccine SARS-CoV-2 [DOI] 10.1128/jvi.00844-22 PMC 바로가기